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| 1 | Cytomegalovirus frequency in neonatal intrahepatic cholestasis determined by serology, histology, immunohistochemistry and PCR显示文摘AIM: To determine cytomegalovirus (CMV) frequency in neonatal intrahepatic cholestasis by serology, histological revision (searching for cytomegalic cells), immunohistochemistry, and polymerase chain reaction (PCR), and to verify the relationships among these methods.METHODS: The study comprised 101 non-consecutive infants submitted for hepatic biopsy between March 1982 and December 2005. Serological results were obtained from the patient's f iles and the other methods were performed on paraffin-embedded liver samples from hepatic biopsies. The following statistical measures were calculated: frequency, sensibility, specif ic positive predictive value, negative predictive value, and accuracy.RESULTS: The frequencies of positive results were as follows: serology, 7/64 (11%); histological revision, 0/84; immunohistochemistry, 1/44 (2%), and PCR, 6/77 (8%). Only one patient had positive immunohistochemical fi ndings and a positive PCR. The following statistical measures were calculated between PCR and serology: sensitivity, 33.3%; specificity, 88.89%; positive predictive value, 28.57%; negative predictive value, 90.91%; and accuracy, 82.35%. CONCLUSION: The frequency of positive CMV varied among the tests. Serology presented the highest positive frequency. When compared to PCR, the sensitivity and positive predictive value of serology were low. | Maria Angela Bellomo-Brandao Paula D Andrade Sandra CB Costa Cecilia AF Escanhoela Jose Vassallo Gilda Porta Adriana MA De Tommaso Gabriel Hessel | 2009 | World Journal of Gastroenterology2009，15，27： | 8 |
| 2 | Bone marrow-derived monocyte infusion improves hepatic fibrosis by decreasing osteopontin,TGF-β1,IL-13 and oxidative stress显示文摘AIM To evaluate the therapeutic effects of bone marrowderived CD11b+CD14+ monocytes in a murine model of chronic liver damage. METHODS Chronic liver damage was induced in C57BL/6 mice by administration of carbon tetrachloride and ethanol for 6 mo. Bone marrow-derived monocytes isolated by immunomagnetic separation were used for therapy. The cell transplantation effects were evaluated by morphometry,biochemical assessment,immunohistochemistry and enzyme-linked immunosorbent assay. RESULTS CD11b+CD14+ monocyte therapy significantly reduced liver fibrosis and increased hepatic glutathione levels. Levels of pro-inflammatory cytokines,including tumor necrosis factor-α,interleukin(IL)-6 and IL-1β,in addition to pro-fibrotic factors,such as IL-13,transforming growth factor-β1 and tissue inhibitor of metalloproteinase-1 also decreased,while IL-10 and matrix metalloproteinase-9 increased in the monocytetreated group. CD11b+CD14+ monocyte transplantation caused significant changes in the hepatic expression of α-smooth muscle actin and osteopontin. CONCLUSION Monocyte therapy is capable of bringing about improvement of liver fibrosis by reducing oxidative stress and inflammation,as well as increasing antifibrogenic factors. | Veruska Cintia Alexandrino de Souza Thiago Almeida Pereira Valéria Wanderley Teixeira Helotonio Carvalho Maria Carolina Accioly Brelaz de Castro Carolline Guimaraes D’assuncao Andreia Ferreira de Barros Camila Lima Carvalho Virgínia Maria Barros de Lorena Vláudia Maria Assis Costa Alvaro Aguiar Coelho Teixeira Regina Celia Bressan Queiroz Figueiredo Sheilla Andrade de Oliveira | 2017 | World Journal of Gastroenterology2017，23，28： | 6 |
| 3 | Cumulative positive fluid balance is a risk factor for acute kidney injury and requirement for renal replacement therapy after liver transplantation显示文摘AIM To analyze whether fluid overload is an independent risk factor of adverse outcomes after liver transplantation(LT).METHODS One hundred and twenty-one patients submitted to LT were retrospectively evaluated.Data regarding perioperative and postoperative variables previously associated with adverse outcomes after LT were reviewed.Cumulative fluid balance(FB) in the first 12 h and 4 d after surgery were compared with major adverse outcomes after LT.RESULTS Most of the patients were submitted to a liberal approach of fluid administration with a mean cumulative FBover 5 L and 10 L,respectively,in the first 12 h and 4 d after LT.Cumulative FB in 4 d was independently associated with occurrence of both AKI and requirement for renal replacement therapy(RRT)(OR = 2.3;95%CI:1.37-3.86,P = 0.02 and OR = 2.89;95%CI:1.52-5.49,P = 0.001 respectively).Other variables on multivariate analysis associated with AKI and RRT were,respectively,male sex and Acute Physiology and Chronic Health Disease Classification System(APACHE II) levels and sepsis or septic shock.Mortality was shown to be independently related to AST and APACHE II levels(OR = 2.35;95%CI:1.1-5.05,P = 0.02 and 2.63;95%CI:1.0-6.87,P = 0.04 respectively),probably reflecting the degree of graft dysfunction and severity of early postoperative course of LT.No effect of FB on mortality after LT was disclosed.CONCLUSION Cumulative positive FB over 4 d after LT is independently associated with the development of AKI and the requirement of RRT.Survival was not independently related to FB,but to surrogate markers of graft dysfunction and severity of postoperative course of LT. | Liana Codes Ygor Gomes de Souza Ricardo Azevedo Cruz D'Oliveira Jorge Luiz Andrade Bastos Paulo Lisboa Bittencourt | 2018 | World Journal of Transplantation2018，8，2： | 4 |
| 4 | 显示文摘 | Lima M D de Andrade M J Bergmann C P | 2008 | J Mater Chem2008，18，： | 1 |
| 5 | An improved har- mony search algorithm for synchronization of discrete-time chaotic systems 显示文摘 | Santos Coelho L d de Andrade Bernert D L | 2009 | Chaos Solitons and Fractals2009，41，15： | 1 |
| 6 | Renal failure is a risk factor for cefepime-induced encephalopathy显示文摘 | Garces EO Andrade de Anzambuja MF da Silva D | 2008 | J Nephrol2008，21，4： | 1 |
| 7 | Caracterizacao morfol6 gica de acessos do ge nero Stylosanthes no banco ativo de germoplasma da Embrapa Cerrados-colecao 1994/1995 显示文摘 | Karia C T de Andrade R P Charchar M J D | 2002 | Embrapa Cerrados Boletim de Pesquisa e Desenvolvimento2002，72，： | 1 |
| 8 | Endotra- cheal tube biofilm and entilator-associated pneumonia with mechanical ventilation 显示文摘 | De Souza PR De Andrade D Cabral DB | 2014 | Microsc Res Teeh2014，77，4： | 1 |
| 9 | Electrically, chemically, and photonically powered torsional and tensile actuation of hybrid carbon nanotube yam muscles显示文摘 | Marcio D L Li Na Monica Jung de Andrade | 2012 | Science2012，338，6116： | 1 |
| 10 | Renal failureis a risk factor for cefepime-induced encephalopathy显示文摘 | Garces EO Andrade de Anzambuja MF da Silva D | 2008 | J Nephrol2008，21，4： | 1 |
| 11 | Allelic associations of two pelymorphic microsatellites in introm 40 of the human von Willebrand factor gene显示文摘 | Pena S D de Souza K T de Andrade M | 1994 | Pro Natl Acad Sci USA1994，91，2： | 1 |
| 12 | Microbiological condi- tions of hospital beds before and after terminal cleaning显示文摘 | de Andrade D Angerami EL Padovani CR | 2000 | Rev Saude Publica2000，34，2： | 1 |
| 13 | A bacteriological stud y of hospital beds before and after disinfeetlon with phenolic disin- fectant显示文摘 | de Andrade D Angerami EL Padovani CR | 2000 | Rev Panam Salud Publica2000，7，3： | 1 |
| 14 | An im- proved harmony search algorithm for synchronization of discrete-time chaotic systems显示文摘 | dos Santos Coelho L de Andrade Bemert D L | 2009 | Chaos Solitons and Frac- tals2009，41，5： | 1 |
| 15 | Alteration of cortical excita- bility in patient s wit h fibromyalgia显示文摘 | Mhalla A de Andrade D C Baudic S | 2010 | Pain2010，149，3： | 1 |
| 16 | Anti-inflammatory effects of ellagic acid on acute lung injury induced by acid in mice 显示文摘 | Corn41io Favarin D Martins Teixeira M Lemos de Andrade E | 2013 | Mediators Inflamm2013，2013，16： | 1 |
| 17 | The first record in the Americas of an autochthonous case of Leishmania ( Leishmania ) infantum chagasi in a domestic cat ( Felix catus ) from Cotia County, S?o Paulo State, Brazil显示文摘 | Elisa San Martin Mouriz Savani Maria Cec??lia Gibrail de Oliveira Camargo Mar??lia Russi de Carvalho Ricardo Andrade Zampieri Marcos Gonzaga dos Santos Sandra Regina Nicoletti D’áuria Jeffrey J Shaw Lucile Maria Floeter-Winter | 2004 | Veterinary Parasitology2004，，3： | 1 |
| 18 | Determination of Synthetic Dyes in Selected Foodstuffs by High Performance Liquid Chromatogra- phy with UV-DAD Detection 显示文摘 | ALVES S P BRUM D M BRANCO De Andrade E C | 2008 | Food Chemistry2008，，： | 1 |
| 19 | Associa- tion between SLC2A9 transporter gene variants and uric acid phenotypes in African American and white families显示文摘 | RULE A D DE ANDRADE M MATSUMOTO M | 2011 | Rheumatology (Oxford)2011，50，5： | 1 |
| 20 | Complex high-frequency magnetization dynamics and magnetoimpedance in thin films显示文摘 | DA SILVA R B VIEGAS A D C CORREA M A DE ANDRADE A M H SOMMER R L | 2006 | Physica B: Condensed Matter2006，384，12： | 1 |
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