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| 1 | Inhibition effects of nitrogen compounds on the hydrodesulfurization of dibenzothiophene显示文摘 | LAREDO S G C DE LOS REYES H J A LUIS CANO D J | 2001 | Applied Catalysis2001，207，12： | 1 |
| 2 | Relation of osteoealcin with insulin resistance and histopathological changes of non alcoholic fatty liver disease显示文摘 | ALLER R CASTRILLON J L P DE LUIS D A | 2011 | Ann Hepatol2011，10，1： | 1 |
| 3 | Role of -55CT polymorphism of UCP3 gene on non alcoholic fatty liver disease and insulin resistance in patients with obesity显示文摘 | Aller R De Luis D A Izaola O | | 0，，04： | 1 |
| 4 | Development of Cu-based oxygen carriers for chemical-looping combustion显示文摘 | Luis F de D Francisco G L Juan A | 2004 | Fuel2004，83，13： | 1 |
| 5 | Total homocysteine levels relation with chronic complications of diabetes,body composition,and other cardiovascular risk factors in a population of patients with diabetes mellitus type 2显示文摘 | de Luis D A Fernandez N Arranz M L | | 0，，01： | 1 |
| 6 | Atherosclerosis and osteoporosis显示文摘 | Perez CJL de Luis D Duenas-Laita A | 2008 | Minerva Med2008，99，1： | 1 |
| 7 | Rejection after conversion to a proliferation signal inhibitor in chronic heart transplantation显示文摘 | Francisco González‐Vílchez José A. Vázquez de Prada María J. Paniagua Luis Almenar Sonia Mirabet Manuel Gómez‐Bueno Beatriz Díaz‐Molina Jose M. Arizón Juan Delgado Félix Pérez‐Villa María G. Crespo‐Leiro Luis Martínez‐Dolz Eulalia Roig Javier Segovia José | 2013 | Clin Transplant2013，，6： | 1 |
| 8 | Association of Heli- co-bacter Pylori infection with cardiovascular and cerebrovas- culardisease in diabetic patients 显示文摘 | de Luis D A Lahera M Canton R et ai | 1998 | Diabetes Care1998，21，： | 1 |
| 9 | lmprove-ment in lipid and haemostasis patterns after helicobacter pyloriinfec- tion eradication in type 1 diabetic patients显示文摘 | de Luis D A Garcia Avello A Lasuncion M A | 1999 | Clin Nutr1999，18，： | 1 |
| 10 | Biocompatibility, Inflammatory Response, and Recannalization Characteristics of Nonradioactive Resin Microspheres: Histological Findings显示文摘 | José I. Bilbao Alba Martino Esther Luis Lourdes Díaz-Dorronsoro Alberto Alonso-Burgos Antonio Martínez de la Cuesta Bruno Sangro José A. García de Jalón | 2009 | CardioVascular and Interventional Radiology2009，，4： | 1 |
| 11 | Helicobacter pylori infection and insulin dependent diabetes melitus显示文摘 | DE LUIS D A DE LA CALLE H ROY G | 1998 | Daibetes Res Clin Pract1998，39，2： | 1 |
| 12 | Relation of Trp64Arg Polymorphism of Beta 3-Adrenergic Receptor Gene to Adipocytokines and Fat Distribution in Obese Patients 显示文摘 | DE LUIS D A ALLER R IZAOLA O el al | 2008 | Ann Nutr Metab2008，52，4： | 1 |
| 13 | Total homocysteine levels relation with chronic compli- cations of diabetes, body composition, and other cardiovascular risk factors in a population of patients with diabetes mellitus type 2显示文摘 | de Luis D A Fernandez N Arranz M L Aller R Izaola O Ro- mero E | 2005 | J Diabetes Complications2005，19，： | 1 |
| 14 | Effect of a hypocaloric diet on serum visfatin in obese non-diabetic patients显示文摘 | DE LUIS D A GONZALEZ SAGRADO M CONDE R | 2008 | Nutrition2008，24，6： | 1 |
| 15 | Relevance of insulin-like growth factor 1 receptor gene expression as a prognostic factor in non-small-cell lung cancer显示文摘 | M. Teresa Agulló-Ortu?o C. Vanesa Díaz-García Alba Agudo-López Carlos Pérez Ana Cortijo Luis Paz-Ares Fernando López-Ríos Francisco Pozo Javier de Castro Hernán Cortés-Funes José A. López Martín | 2015 | Journal of Cancer Research and Clinical Oncology2015，，： | 1 |
| 16 | Total homocysteine levels relation with chronic complications of diabetes, body composition, and other cardiovascular risk factors in a population of patients with diabetes mellitus type 2显示文摘 | de Luis D A Fernandez N Arranz M L | 2005 | J Diabetes Complications2005，19，1： | 1 |
| 17 | The effects of duodenal-jeiunal exclusion on hormonal regulation of glucose metabolism in Goto-Kakizaki rats 显示文摘 | Pacheco D de Luis D A Romero A | 2007 | Am J Surg2007，194，2： | 1 |
| 18 | Clinicopathological differences,risk factors and prognostic scores for western patients with intestinal and diffuse-type gastric cancer显示文摘BACKGROUND In the molecular era,the Laurén system is still a cost-effective and widely implemented classification for gastric cancer(GC)and it has been recently associated with clinical,histological and molecular features of these tumors.Despite recent advances in the understanding of the molecular biology of GC,there is a need to develop new prognostic tools for patient stratification in clinical practice.Thus,the identification of easily available prognostic factors in patients with intestinal and diffuse-type tumors can significantly improve risk assessment and patient stratification in GC.AIM To identify clinicopathological differences,risk factors,and to develop costeffective prognostic scores for patients with intestinal and diffuse-type GC.METHODS Retrospective study of all patients undergoing surgery for GC at a tertiary referral center from 2001 to 2019.286 cases met inclusion criteria(intestinal:190,diffuse:96).Clinical data and gross findings were collected.All specimens were reviewed by two independent pathologists and a detailed protocol for histologic evaluation was followed.Five tissue microarrays(TMAs)were constructed and sections of the TMA block were immunostained for HERCEPTEST,MSH2,MSH6,MLH1 and PMS2.Statistical analyses were performed and prognostic scores were developed based on hazard ratios.RESULTS Intestinal and diffuse-type GC showed different epidemiological,clinicopathological and prognostic features.Diffuse tumors were significantly associated with younger age,less symptomatology,flat morphology,deeper invasion,perineural infiltration,advanced stage at diagnosis,administration of adjuvant therapy and poorer prognosis.Intestinal lesions were fungoid or polypoid,showed necrosis,desmoplasia,microsatellite instability and HERCEPTEST positivity and were diagnosed at earlier stages.Tumor depth,desmoplasia,macroscopic type and lymph node involvement were independently related to the Laurén subtype.Furthermore,intestinal and diffuse GC were associated with different risk factors for progression and death.Vascular invasion,perineural infiltration and growth pattern were important prognostic factors in intestinal-type GC.On the contrary,tumor size and necrosis were significant prognosticators in diffuse-type GC.Our recurrence and cancer-specific death scores for patients with intestinal and diffuse-type GC showed an excellent patient stratification into three(diffuse GC)or four(intestinal)prognostic groups.CONCLUSION Our findings support that Laurén subtypes represent different clinicopathological and biological entities.The development of specific prognostic scores is a useful and cost-effective strategy to improve risk assessment in GC. | Cristina Díaz del Arco Lourdes Estrada Muñoz Luis Ortega Medina Elena Molina Roldán MÁngeles Cerón Nieto Soledad García Gómez de las Heras M Jesús Fernández Aceñero | 2022 | World Journal of Gastrointestinal Oncology2022，14，6： | 1 |
| 19 | Ben- eficial effects of liraglutide on adipocytokines, insulin sensitivity parameters andcardiovascular risk biomarkers in patients with Type 2 diabetes: a prospective study显示文摘 | Diaz Soto G de Luis D A Conde Vicente R | 2014 | Diabetes Res Clin Pratt2014，104，1： | 1 |
| 20 | Inhibition effects of nitrogen compounds on the hydrodesulfurization of dibenzothiophene显示文摘 | LAREDO G C de los REYES J A LUIS CANO D J JES(U)S CASTILLO M J | 2001 | Appl Catal A2001，207，12： | 1 |
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