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| 1 | Therapeutic options for intermediate-advanced hepatocellular carcinoma显示文摘Hepatocellular carcinoma (HCC) is one of the most common malignancies, ranking the sixth in the world, with 55% of cases occurring in China. Usually, patients with HCC did not present until the late stage of the disease, thus limiting their therapeutic options. Although surgical resection is a potentially curative modality for HCC, most patients with intermediate-advanced HCC are not suitable candidates. The current therapeutic modalities for intermediate-advanced HCC include: (1) surgical procedures, such as radical resection, palliative resection, intraoperative radiofrequency ablation or cryosurgical ablation, intraoperative hepatic artery and portal vein chemotherapeutic pump placement, two-stage hepatectomy and liver transplantation; (2) interventional treatment, such as transcatheter arterial chemoembolization, portal vein embolization and image-guided locoregional therapies; and (3) molecularly targeted therapies. So far, how to choose the therapeutic modalities remains controversial. Surgeons are faced with the challenge of providing the most appropriate treatment for patients with intermediate-advanced HCC. This review focuses on the optional therapeutic modalities for intermediateadvanced HCC. | Zong-Ming Zhang Jin-Xing Guo Zi-Chao Zhang Nan ]iang Zhen-Ya Zhang Li-Jie Pan | 2011 | World Journal of Gastroenterology2011，17，13： | 9 |
| 2 | The effect of Fe-Mn minerals and seawater interface and enrich-ment mechanism of ore-forming elements of polymetallic crusts and nodules from the South China Sea显示文摘Ferromanganese crusts and nodules are important submarine mineral resources that contain various metal elements with significant economic value. In this study, polymetallic crusts and nodules obtained from the South China Sea(SCS) were determined by using X-ray power diffraction(XRD), Raman spectroscopy(RS), Fourier transform infrared spectroscopy(FTIR), and X-ray photoelectron spectroscopy(XPS) to systematically investigate and analyze the mineralogical and spectral characteristics of the Fe-Mn minerals. XRD measurements revealed that the SCS polymetallic crusts and nodules were composed of vernadite, quartz, and plagioclase. The nodules also contained todorokite. The Fe-phase minerals of the SCS crusts and nodules were composed of amorphous Fe oxide/hydroxide, and the Mn-and Fe-phases minerals exhibited relatively poor degrees of crystallization. FTIR results showed that the Fe-Mn minerals in the crusts and nodules included a large number of surface hydroxyl groups. These surface hydroxyl groups contained protons that could provide reactive sites for complexation of ore-forming elements in seawater. XPS results indicated that the surfaces of the Fe-Mn minerals mainly contained Fe, Mn, and O. Fe was present in the trivalent oxidation state, while Mn, which may contain several bivalent oxidation state, was present in the tetravalent and trivalent oxidation states. The SCS polymetallic crusts and nodules were compared with Pacific seamount crusts, and results showed that the surface hydroxyl(-OH) groups of the SCS crusts and nodules numbered more than the lattice oxygen(O^(2-)). But the lattice oxygen of Pacific seamount crusts numbered more than the surface hydroxyl groups. This characteristic indicated that the degree of crystallization of Fe-Mn minerals from the Pacific Ocean was higher than that of minerals from the South China Sea. Comprehensive studies showed that ore-forming elements in the interface between seawater and the Fe-Mn minerals in the submarine ferromanganese crusts and nodules employed the following enrichment mechanisms:(1) the metal ion complexed with the surface hydroxyl of Fe-Mn minerals to form hydroxyl complexes, which were connected by coordination bonds or stable inner-sphere complexes that exchanged protons on the mineral surfaces;(2) the charged surfaces of the minerals and metal cations formed outer-sphere complexes, which made up the electrostatic double layer, through electrostatic adsorption; and(3) the metal cations isomorphously exchanged the Mn and Fe ions of the mineral lattice structure. | GUAN Yao SUN Xiaoming IANG Xiaodong SA Rina ZHOU Li HUANG Yi LIU Yating LI Xiaojie LU Rongfei WANG Chi | 2017 | Acta Oceanologica Sinica2017，36，6： | 4 |
| 3 | 中国大陆地区的3.5亚系PRRSV起源于中国台湾地区的3.2亚系显示文摘猪繁殖与呼吸综合征病毒(Porcine reproductive and respiratory syndrome virus,PRRSV)是引起猪繁殖与呼吸综合征(PRRS)的病原,该病毒分为两个基因型,以LV 株为代表的欧洲型(基因1型)和以VR2332 株为代表的美洲型(基因2型)。根据ORF5基因,基因2型PRRSV被划分为9个系,目前,在中国已检测到5个系,包括1,3,5,8和9 系。1998年,中国台湾报道首株3系PRRSVMD-001。 | Zhang WenLi Zhang HongL iang Hu Xu | 2019 | 中国预防兽医学报2019，41，8： | 4 |
| 4 | Uniform surface polished method of complex holes in abrasive flow machining显示文摘Abrasive flow machining(AFM) is an effective method that can remove the recasting layer produced by wire electrical discharge machining(WEDM). However, the surface roughness will not be easily uniform when a complex hole is polished by this method. CFD numerical method is aided to design good passageways to find the smooth roughness on the complex hole in AFM. Through the present method, it reveals that the shear forces in the polishing process and the flow properties of the medium in AFM play the roles in controlling the roughness on the entire surface. A power law model was firstly set up by utilizing the effect of shear rates on the medium viscosities, and the coefficients of the power law would be found by solving the algebraic equation from the relations between the shear rates and viscosities. Then the velocities, strain rates and shear forces of the medium acting on the surface would be obtained in the constant pressure by CFD software. Finally, the optimal mold core put into the complex hole could be designed after these simulations. The results show that the shear forces and strain rates change sharply on the entire surface if no mold core is inserted into the complex hole, whereas they hardly make any difference when the core shape is similar to the complex hole. Three experimental types of mold core were used. The results demonstrate that the similar shape of the mold core inserted into the hole could find the uniform roughness on the surface. | Lung TSAI Kuo-Zoo L IANG Chun-Ho LIU | 2009 | 中国有色金属学会会刊:英文版2009，19，B09： | 2 |
| 5 | Alternativemoving window factor analysis for comparison analysis between comp lex chromatographic data 显示文摘 | Zeng ZD L iang YZ Wang YL | 2006 | J Chromatogr A2006，1107，： | 1 |
| 6 | Novel antigens for neurocys2 ticereosis: simp lemethod for p reparation and evaluation for serodiagnosis显示文摘 | ho A Plancarit A L iang MA | 1998 | Am J Trop hyg1998，59，2： | 1 |
| 7 | Dynamic modelling structure of a fruit tree forinertial shaker system design 显示文摘 | IAng Z | 2006 | Biosystems Engineering2006，93，1： | 1 |
| 8 | Performance of one- view breast tomosynthesis as a stand-alone breast cancer screening modality: results from the Malm8 Breast To- mosynthesis Screening Trial, a population-based study显示文摘 | IAng K Andersson 1 Rosso A | 2016 | Eur Radiol2016，26，1： | 1 |
| 9 | T plate osteosynthesis in dislocation proximal humerus fractures 显示文摘 | LILL H IANGE K PRASSE BADDE J | 1997 | Unfallchirurgic1997，23，5： | 1 |
| 10 | A one degree of freedom damped fruit tree medel显示文摘 | IAng Z | 2008 | Transactions of the ASABE2008，51，3： | 1 |
| 11 | Management of hepatitis B: summary of a clinical research workshop显示文摘 | Hoofnagle JH Doo E L iang TJ | 2007 | Hepatology2007，45，4： | 1 |
| 12 | Genetic characterization of mea- sles virus in China, 2004显示文摘 | Zhang Y J i Y J iang X | 2008 | Virol J2008，5，20： | 1 |
| 13 | Evolvingwindow orthogonal projections method for two way data resolution 显示文摘 | Xu C J J iang JH L iang YZ | 1999 | Analyst1999，124，： | 1 |
| 14 | Do risk factors for Alzheimer's disease predict dementia in Parkinson's diseas:An exploratory study显示文摘 | Levy G Iang MX Cote LJ | 2002 | Mor Disord2002，17，2： | 1 |
| 15 | An event-based approach to spatio-temporal data modeling in land subdivision system for spatio-temporal process of land subdivision显示文摘 | CHEN J J IANG J | 2000 | Geoinformatica2000，，4： | 1 |
| 16 | Association of the met abolic syndrome with vascular disease in an older Chinese population Guangzhou Biobank Cohort Study显示文摘 | Lao XQ Thomas GN J iang CQ et a l | 2006 | J Endocri- nol Invest2006，29，11： | 1 |
| 17 | Alkoxysilane Functionalized Polyurethane/Polysiloxane Copolymens: Synthesis and the Effect of End-capping Agent 显示文摘 | iang H Zheng Z Song W | 2007 | Polymer Bulletin2007，59，1： | 1 |
| 18 | Polyaniline- protonic Acid Doping to the Metallic Regime显示文摘 | Macdia rm id A G C h iang J C Huang W S | 1985 | Mol Cryst Liq Cryst1985，125，14： | 1 |
| 19 | Transeslerification reaction catalysed by Novozym435 in sup recritical carbon dioxide显示文摘 | YASMIN T J IANG T HAN B | 2006 | Molecular Catalysis B: Enzymatic2006，41，： | 1 |
| 20 | The chromatic spectrum of mixed hypergraphs 显示文摘 | J iang T Mubayi D Voloshin V | 2002 | Graphs Combin2002，，18： | 1 |
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