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| 1 | Mapping wetland changes in China between 1978 and 2008显示文摘Four wetland maps for all China have been produced,based on Landsat and CBERS-02B remote sensing data between 1978 and 2008 (1978,1990,2000 and 2008).These maps were mainly developed by manual interpretation and validated by substantial field investigation in 2009.Based on these maps,we analyzed the 2008 wetland distribution in China and discussed wetland changes and their drivers over the past 30 years.(i) There were about 324097 km 2 of wetlands in 2008,for which inland marshes or swamps were the most common wetland type (35%),with lakes (26%) second.Most of the wetlands were in Heilongjiang,Inner Mongolia,Qinghai and Tibet,occupying about 55% of the national wetland area.(ii) From 1978 to 2008,China's wetland area continually and significantly decreased,by about 33% based on changes in the wetland map.This was in sharp contrast to the increase in artificial wetlands,which increased by about 122%.Inland marshes accounted for the main loss of total wetlands from 1978 to 2000.From 2000 through 2008,riverine and lacustrine wetlands constituted the main wetland loss.Fortunately however,the rate of wetland loss decreased from 5523 to 831 km 2 /a.(iii) The change ratio of lost natural wetlands (including inland and coastal wetlands) to non-wetlands has decreased slightly over the past 30 years.From 1978 to 1990,nearly all natural wetlands (98%) lost were transformed into non-wetlands.However,the ratio declined to 86% from 1990 to 2000,and to 77% from 2000 to 2008.(iv) All Chinese provinces were divided into three groups according to patterns of wetland changes,which could relate to the driving forces of such changes.Tibet was completely different from other provinces,as it was one representative example in which there was a net wetland increase,because of global warming and decreased human activity since 1990.Increased economic development caused considerable wetland loss in most eastern provinces,and artificial wetlands increased. | NIU ZhenGuo ZHANG HaiYing WANG XianWei YAO WenBo ZHOU DeMin ZHAO KuiYi ZHAO Hui LI NaNa HUANG HuaBing LI CongCong YANG Jun LIU CaiXia LIU Shuang WANG Lin LI Zhan YANG ZhenZhong QIAO Fei ZHENG YaoMin CHEN YanLei SHENG YongWei GAO XiaoHong ZHU WeiHong WANG WenQing WANG Hong WENG YongLing ZHUANG DaFang LIU JiYuan LUO ZhiCai CHENG Xiao GUO ZiQi GONG Peng | 2012 | Chinese Science Bulletin2012，57，22： | 51 |
| 2 | Telomerase activity in gastric cancer and its clinical implications显示文摘INTRODUCTIONThedevelopmentofcarcinomaresultsfrommultipleindependentgeneticchangesthatactivateprotooncogenesorinactivatetheac... | ZHAN Wen Hua, MA Jin Ping, PENG Jun Sheng, GAO Jing Song, CAI Shi Rong, WANG Jian Ping, ZHENG Zhang Qing and WANG Lei | 1999 | World Journal of Gastroenterology1999，5，4： | 25 |
| 3 | Management Recommendations on Sleep Disturbance o Patients with Parkinson's Disease显示文摘INTRODUCTION Sleep disturbance is one of the most common nonmotor symptoms in Parkinson's disease (PD).Sleep disturbance affects 40-98% of PD patients in the world. In China, the prevalence of PD patients with sleep disturbance ranges from 47.66% to 89.10%. Sleep disturbance usually has adverse impact on the quality of life of PD patients. Apossible pathogenesis of PD with sleep disturbance include thalamocortical pathway degeneration and changes of neurotransmitter systems. The etiology of sleep disturbance is multifactorial,involving degeneration of areas regulating sleep,sleep structure affected by drugs,sleep disturbance induced by drug,and sleep fragmentation by multiple factors. | Chun-Feng Liu Tao Wang Shu-Qin Zhan De-Qin Geng Jian Wang Jun Liu Hui-Fang Shang Li-Juan Wang Piu Chan Hai-Bo Chen Sheng-Di Chen Yu-Ping Wang Zhong-Xin Zhao K Ray Chaudhuri | 2018 | Chinese Medical Journal2018，，24： | 26 |
| 4 | NEW METHOD OF SIMULATING CONCENTRATED DRAIN HOLES IN SEEPAGE CONTROL ANALYSIS显示文摘In this paper, based upon the basic solution of sink, the approximate solution of single drain hole in finite elements is derived by use of the superposition principle. Then, the theoretical solution is extended to the case of some drain holes in one finite element, and the method is used in seepage control analysis with quick convergence and high accuracy. On the other hand, if the positions of the drain holes are changed, only some control factors of drain holes are changed, but the finite element grid need not to be reformed. Therefore, the method is more suitable in optimal research of seepage control. | Zhan Mei li, Su Bao yu , Liu Jun yong, Shen Zhen zhong College of Water Conservancy and Hydropower Engineering, Hohai University, Nanjing 210098, P.R.China (Received Aug.1, 1998) | 1999 | Journal of Hydrodynamics1999，11，3： | 22 |
| 5 | Advances in the study of uncertainty quantification of large-scale hydrological modeling system显示文摘因为它不仅被物理因素而且由人的尺寸影响,地区性的水文学系统是极其复杂的。并且水文学模型在模仿复杂系统起一个很重要的作用。然而,由于它的复杂性和困难为模型可靠性和无常分析没有有效方法。在水文学建模的无常来自四个重要方面:在输入数据和参数的无常,在模型结构的无常,在分析方法的无常并且起始并且边界条件。这份报纸系统地在分析根据无常来源在大规模复杂水文学模型接近的无常的学习考察了最近的进展。另外,在为复杂水文学模型的无常分析的缺点和不足被指出。然后新无常 quantification 站台 PSUADE 和它的无常 quantification 方法被介绍,它将为大规模复杂水文学模型的无常分析是一个强大的工具和平台。最后,无常 quantification 上的一些未来观点被提出。 | SONG Xiaomeng ZHAN Chesheng KONG Fanzhe XIA Jun | 2011 | Journal of Geographical Sciences2011，21，5： | 21 |
| 6 | Clinical trial with traditional Chinese medicine intervention ''tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment'' for chronic hepatitis B-associated liver failure显示文摘AIM:To study the clinical efficacy of traditional Chinese medicine(TCM)intervention'tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment'('TTK')for treating liver failure due to chronic hepatitis B.METHODS:We designed the study as a randomized controlled clinical trial.Registration number of Chinese Clinical Trial Registry is Chi CTR-TRC-12002961.A total of 144 patients with liver failure due to infection with chronic hepatitis B virus were enrolled in this randomized controlled clinical study.Participants were randomly assigned to the following three groups:(1)a modern medicine control group(MMC group,36patients);(2)a'tonifying qi and detoxification'('TQD')group(72 patients);and(3)a'tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment'('TTK')group(36patients).Patients in the MMC group received general internal medicine treatment;patients in the'TQD'group were given a TCM formula'tonifying qi and detoxification'and general internal medicine treatment;patients in the'TTK'group were given a TCM formula of'TTK'and general internal medicine treatment.All participants were treated for 8 wk and then followed at 48 wk following their final treatment.The primaryefficacy end point was the patient fatality rate in each group.Measurements of various virological and biochemical indicators served as secondary endpoints.The one-way analysis of variance and the t-test were used to compare patient outcomes in the different treatment groups.RESULTS:At the 48-wk post-treatment time point,the patient fatality rates in the MMC,'TQD',and'TTK'groups were 51.61%,35.38%,and 16.67%,respectively,and the differences between groups were statistically significant(P<0.05).However,there were no significant differences in the levels of hepatitis B virus DNA or prothrombin activity among the three groups(P>0.05).Patients in the'TTK'group had significantly higher levels of serum total bilirubin compared to MMC subjects(339.40μmol/L±270.09μmol/L vs 176.13μmol/L±185.70μmol/L,P=0.014).Serum albumin levels were significantly increased in both the'TQD'group and'TTK'group as compared with the MMC group(31.30 g/L±4.77g/L,30.72 g/L±2.89 g/L vs 28.57 g/L±4.56 g/L,P<0.05).There were no significant differences in levels of alanine transaminase among the three groups(P>0.05).Safety data showed that there was one case of stomachache in the'TQD'group and one case of gastrointestinal side effect in the'TTK'group.CONCLUSION:Treatment with'TTK'improved the survival rates of patients with liver failure due to chronic hepatitis B.Additionally,liver tissue was regenerated and liver function was restored. | Han-Min Li Zhi-Hua Ye Jun Zhang Xiang Gao Yan-Ming Chen Xin Yao Jian-Xun Gu Lei Zhan Yang Ji Jian-Liang Xu Ying-He Zeng Fan Yang Lin Xiao Guo-Guang Sheng Wei Xin Qi Long Qing-Jing Zhu Zhao-Hong Shi Lian-Guo Ruan Jia-Yao Yang Chang-Chun Li Hong-Bin Wu Sheng-Duo Chen Xin-La Luo | 2014 | World Journal of Gastroenterology2014，20，48： | 20 |
| 7 | Effect of renin-angiotensin-aldosterone system gene polymorphisms on blood pressure response to antihypertensive treatment显示文摘背景 renin-angiotensin-aldosterone 系统(RAAS ) 为必要高血压的发展是重要的,并且许多 antihypertensive 药指向它。这研究被承担决定在 renin-angiotensin-aldosterone 系统的多型性是否与血压(BP ) 有关是对在有必要高血压的 54 个病人收到了的中国汉种族 population.Methods 的利尿的治疗的反应 hydrochlorothiazide (12.5 mg,从前每日) 作为为四个星期的 monotherapy。在 RAAS 基因的七多型性是由基因薄片技术的 genotyped。在在血压的这些多型性和变化之间的关系在 4 星期的 treatment.Results 以后被观察有 -6G 等位基因显示出的 angiotensinogen (AGT ) 的病人在心脏舒张的 BP (P= 0.025 ) 和吝啬的 BP (P=0.039 ) 的更大的减小比那些带的 AA 遗传型。病人带醛固酮 synthase (CYP11B2 ) CC 遗传型比那些带的 CT 和 TT 遗传型展出了更大的 BP 减小(收缩 BP:P= 0.030;心脏舒张的 BP:P= 0.026;意味着 BP:P=0.003 ) 。另外,有 CYP11B2 CC 遗传型和血管收缩素变换酶(王牌)的联合的病人 D 等位基因可能与二基因( P= 0.007 )的任何另外的 genotypic 联合比那些有收缩 BP 的更显著的减小 .Conclusions AGT-6G 等位基因,有王牌 D 等位基因的 CYP11B2 -344CC 遗传型和它的联合与对 hydrochlorothiazide 治疗的 BP 反应被联系。更大的研究被保证验证这发现。 | JIANG Xiao SHENG Hai-hui LIN Gang LI Jian LU Xin-zheng CHENG Yun-lin HUANG Jun XIAO Hua-sheng ZHAN Yi-yang | 2007 | Chinese Medical Journal2007，，9： | 17 |
| 8 | Foreign Value-added in China's Manufactured Exports:Implications for China's Trade Imbalance显示文摘经济学家们最近对国内增值实际上在中国的出口被包括的 weighting 变得感兴趣。正式,外国、国内的内容的比例能被用非竞争的输入产量桌子计算垂直专门化份额识别。因为中国有处理出口的大份额,然而,把如此的一个方法用于中国盒子将导致大测量偏爱,它利用进口中介的一个不相称地高的百分比。这份报纸,能被直接采用为哪个在处理和非处理的贸易进口了中介的 2008 贸易数据借助于各种各样的贸易模式识别,提供一个简化方法估计在工业级的生产出口包括的外国 / 国内的增值的份额。这份报纸为平常的出口发现处理出口的中国的垂直专门化份额在 2008 是大约 56% ,与大约 10% 相比。它也发现处理的富有经验的快扩大出口的部门有外国内容的高得多的份额。因为处理,出口说明关于中国出口,占优势的贸易统计,它集中于粗野价值而非出口和进口的增值的一半,显然说大话双边的贸易不平衡,特别在中国和美国之间。 | Jun Zhang Dongbo Tang Yubo Zhan | 2012 | China & World Economy2012，20，1： | 16 |
| 9 | Integration of a statistical emulator approach with the SCE-UA method for parameter optimization of a hydrological model显示文摘Parameter optimization of a hydrological model is an indispensable process within model development and application.The lack of knowledge regarding the efficient optimization of model parameters often results in a bottle-neck within the modeling process,resulting in the effective calibration and validation of distributed hydrological models being more difficult to achieve.The classical approaches to global parameter optimization are usually characterized by being time consuming,and having a high computation cost.For this reason,an integrated approach coupling a meta-modeling approach with the SCE-UA method was proposed,and applied within this study to optimize hydrological model parameter estimation.Meta-modeling was used to determine the optimization range for all parameters,following which the SCE-UA method was applied to achieve global parameter optimization.The multivariate regression adaptive splines method was used to construct the response surface as a surrogate model to a complex hydrological model.In this study,the daily distributed time-variant gain model(DTVGM) applied to the Huaihe River Basin,China,was chosen as a case study.The integrated objective function based on the water balance coefficient and the Nash-Sutcliffe coefficient was used to evaluate the model performance.The case study shows that the integrated method can efficiently complete the multi-parameter optimization process,and also demonstrates that the method is a powerful tool for efficient parameter optimization. | SONG XiaoMeng ZHAN CheSheng XIA Jun | 2012 | Chinese Science Bulletin2012，57，26： | 13 |
| 10 | Seroepidemiological Investigation of Lyme Disease and Human Granulocytic Anaplasmosis among People Living in Forest Areas of Eight Provinces in China显示文摘Objective Lyme disease and Human granulocytic anaplasmosis are tick‐borne diseases caused by Borrelia burgdorferi and Anaplasma phagocytophilum respectively. We have investigated infection and co-infection of the two diseases in the population of forest areas of eight provinces in China by measuring seroprevalence of antibodies against B. burgdorferi and A. phagocytophilum. Methods Forest areas in 8 provinces were chosen for investigation using whole sampling and questionnaire survey methods. 3 669 serum samples from people in the forest areas were tested for the presence of antibodies by indirect immunofluorescent assay (IFA). Results Seroprevalence against B. burgdorferi was 3% to 15% and against A. phagocytophilum was 2% to 18% in the study sites in the 8 provinces in China. We also found co-infection of B. burgdorferi and A. phagocytophilum in 7 of the 8 provinces (the exception being the Miyun area in Beijing). The seroprevalence for both B. burgdorferi and A. phagocytophilum was significantly higher among people exposed to ticks than among people who were not exposed to ticks. Conclusion We conclude that both pathogens are endemic in the forest areas in the eight provinces, but the prevalence of B. burgdorferi and A. phagocytophilum differs between the provinces. | HAO Qin GENG Zhen HOU Xue Xia TIAN Zhen YANG Xiu Jun JIANG Wei Jia SHI Yan ZHAN Zhi Fei LI Guo Hua YU De Shan WANG Hua Yong XU Jian Guo WAN Kang Lin | 2013 | Biomedical and Environmental Sciences2013，26，3： | 13 |
| 11 | Recent Advances in Hydrometallation of Alkenes and Alkynes via the First Row Transition Metal Catalysis显示文摘Hydrometallation of alkenes and alkynes provides a straightforward route to access alkyl- or alkenyl-metal reagents, which have a wide rangeof applications in organic transformations. In recent years, the first row transition metals (such as copper, nickel, cobalt, iron, etc.) have emerged highactivity and selectivity in this area with the aid of a variety of ligands. This review covers the recent advances in the hydrometallation of minimally func-tionalized unsaturated C--C bonds (including alkenes, alkynes, dienes, allenes, enynes, etc.), as well as transformations involving catalytic hydrometalla-tion process via the first row transition metal catalysis. | Jianhui Chen Jun Guo Zhan Lu | 2018 | Chinese Journal of Chemistry2018，36，11： | 12 |
| 12 | An efficient global sensitivity analysis approach for distributed hydrological model显示文摘水文学模型的敏感分析是为模型无常 quantification 的钥匙。然而,怎么有效地验证模型并且为分布式的水文学模型识别主导的参数是一个瓶颈完成参数优化。为这个原因,一条新途径在这份报纸,支持向量机器在被用来起初构造反应表面被建议。然后,它与 Sobol 方法集成基于 SVM 的反应表面,即 RSMSobol 方法,确定参数敏感。在这个工作,分布式的时间变体获得模型(DTVGM ) 被用于 Huaihe 河盆,它被用作一个盒子验证它的有效性和可行性。我们选择了三个客观函数(即水平衡系数 WB, Nash-Sutcliffe 效率系数 NS,和关联系数 RC ) 为敏感分析作为输出回答估计模型性能。参数 g1 和 g2 为所有目的是很重要的结果表演工作,并且他们是几乎对古典途径的一样。而且, RSMSobol 方法不能仅仅完成敏感的 quantification,并且也减少计算费用,与与古典途径相比的好精确性。并且这条途径将在为一个复杂建模系统的全球敏感分析有效、可靠。 | SONG Xiaomeng ZHAN Chesheng XIA Jun KONG Fanzhe | 2012 | Journal of Geographical Sciences2012，22，2： | 12 |
| 13 | The Development of A Fluorescence Polarization Immunoassay for Aflatoxin Detection显示文摘A fluorescence polarization immunoassay(FPIA)was developed for the analysis ofaflatoxins(AFs)using an anti-aflatoxin B1(AFB1)monoclonal antibody and a novel fluorescein-labeled AFB1tracer.The FPIA showed an IC50 value of 23.33ng/mL with a limit of detection of 13.12 ng/mL for AFB1.The cross-reactivities of AFB1,AFB2,AFG1,AFG2,AFM1,and AFM2 with the antibody were100%,65.7%,143%,23.5%,111.4%,and 2%,respectively.The group-specificity of anti-AFB1mAb indicated that the FPIA could potentially be used in a screening method for the detection of total AFs,albeit not AFG2 and AFM2.The total time required for analyzing 96 samples in one microplate was less than 5 min.This study demonstrates the potential usefulness of the FPIA as a rapid and simple technique for monitoring AFs. | SHENG Ya Jie EREMIN Sergei MI Tie Jun ZHANG Su Xia SHEN Jian Zhong WANG Zhan Hui | 2014 | Biomedical and Environmental Sciences2014，27，2： | 10 |
| 14 | Expert Consensus on Clinical Diagnostic Criteria for Fatal Familial Insomnia显示文摘 | Li-Yong Wu Shu-Qin Zhan Zhao-Yang Huang Bin Zhang Tao Wang Chun-Feng Liu Hui Lu Xiao-Ping Dong Zhi-Ying Wu Jie-Wen Zhang Ji-Hui Zhang Zhong-Xin Zhao Fang Han Yah Huang Jun Lu Serge Gauthier Jian-Ping Jia Yu-Ping Wang | 2018 | Chinese Medical Journal2018，，13： | 10 |
| 15 | Genomic landscape and genetic manipulation of the black soldier fly Hermetia illucens,a natural waste recycler显示文摘The black soldier fly(BSF),Hermetia illucens(Diptera:Stratiomyidae),is renowned for its bioconversion of organic waste into a sustainable source of animal feed.We report a high-quality genome of 1.1 Gb and a consensus set of 16,770 gene models for this beneficial species.Compared to those of other dipteran species,the BSF genome has undergone a substantial expansion in functional modules related to septic adaptation,including immune system factors,olfactory receptors,and cytochrome P450s.We further profiled midgut transcriptomes and associated microbiomes of BSF larvae fed with representative types of organic waste.We find that the pathways related to digestive system and fighting infection are commonly enriched and that Firmicutes bacteria dominate the microbial community in BSF across all diets.To extend its potential practical applications,we further developed an efficient CRISPR/Cas9-based gene editing approach and implemented this to yield flightless and enhanced feeding capacity phenotypes,both of which could expand BSF production capabilities.Our study provides valuable genomic and technical resources for optimizing BSF lines for industrialization. | Shuai Zhan Gangqi Fang Minmin Cai Zongqing Kou Jun Xu Yanghui Cao Liang Bai Yixiang Zhang Yongmao Jiang Xingyu Luo Jian Xu Xia Xu Longyu Zheng Ziniu Yu Hong Yang Zhijian Zhang Sibao Wang Jeffery K.Tomberlin Jibin Zhang Yongping Huang | 2020 | Cell Research2020，30，1： | 9 |
| 16 | Shape-Controlled Synthesis of Mn_(3)O_(4) Nanocrystals and Their Catalysis of the Degradation of Methylene Blue显示文摘Various sizes and shapes of Mn_(3)O_(4) nanocrystals have been prepared in a one-pot synthesis in extremely dilute solution by soft template self-assembly. To better control size and shape, the effects of varying the growth time, reaction temperature, surfactant, and manganese source were examined. The average size of octahedral Mn_(3)O_(4) crystallites was found to be related to the reaction time, while higher reaction temperature (150 °C) and the use of a cetyltrimethylammonium bromide/poly(vinylpyrrolidone) (CTAB/PVP) mixture allowed construction of a better-defined octahedral morphologies. When PVP or poly(ethylene oxide)-poly(propylene oxide) (P123) was used as template, large-scale agglomeration resulting in loss of the octahedral morphology occurred and crystallites with a quasi-spherical shape were obtained. The nano-octahedral crystallites were shown to be an efficient catalyst for the oxidation of methylene blue. | Pengqu Zhang Yonggong Zhan Bingxin Cai Chenchun Hao Jun Wang Chunxiao Liu Zhoujun Meng Zhoulan Yin Qiyuan Chen | 2010 | Nano Research2010，3，4： | 9 |
| 17 | Identification and characterization of a novel isoform of hepatopoietin显示文摘AIM: To isolate a novel isoform of human HPO (HPO-205)human fetal liver Marathon-reedy cDNA andcharacterize its primary biological function.METHODS: 5'-RACE (rapid amplification of cDNA 5' ends)was used to isolate a novel isoform of hHPO in this paperThe constructed pcDNAHPO-205, pcDNAHPO and pcDNA eukaryotic expression vectors were respectively transfectedby lipofectamine method and the stimulation of DNAsynthesis was observed by 3H-TdR incorporation assay.Proteins extracted from different cells were analyzed byWestern blot.RESULTS: A novel isoform of hHPO (HPO-205) encoding a205 amino acid ORF corresponding to a translatedproduction of 23 kDa was isolated and distinguished fromthe previous HPO that lacked the N-terminal 80 amino acids.The dnse-dspendent stimulation of DNA synthesis of HepG2hepatoma cells by HPO-205 demonstrated its similarbiological activity with HPO in vitro. The level of MAPK(Mitogen-activated protein kinase) phnsphorylarion byWestern blot analysis revealed that HPO-205 might have thestronger activity of stimulating hepatic cell proliferation thanthat of HPO.CONCLUSION: A novel isoform of hHPO (HPO-205) wasisolated from hepatic-derived cells. The comparison of HPO-205 and HPO will lead to a new insight into the structure andfunction of hHPO, and provide the new way of thinking todeeply elucidate the biological roles of HPO/ALR. | Jun Lu Wei-Min Cai,Institute of Infectious Disease,First Affiliated Hospital,Medical SchooI,Zhejiang University,Hangzhou 310003 China Wang-Xiang Xu Yi-Qun Zhan Xiao-Lin Cui Fu-Chu He Xiao-Ming Yang,Institute of Radiation Medicine,Academy of Military Medical Sciences,Beijing 100850,China | 2002 | World Journal of Gastroenterology2002，8，2： | 8 |
| 18 | Impact of environmental factors on water quality at multiple spatial scales and its spatial variation in Huai River Basin, China显示文摘Quantitative assessment of water quality and its spatial variation identification, as well as the discernment of primary factors affecting water quality are in its urgent in water environment management. In this study, four key water quality indicators,namely, ammonia nitrogen(NH_4^+-N), permanganate index(COD_(Mn)), total phosphorus(TP) and total nitrogen(TN) at 71 sampling sites were selected to evaluate water quality and its spatial variation identification. More concerns were emphasized on the anthropogenic factors(land use pattern) and natural factors(river density, elevation and precipitation) to quantify the overall water quality variations at different spatial scales. Results showed that the Yi-Shu-Si River sub-basin had a better water quality status than the Huai River sub-basin. The moderate polluted area nearly distributed in the upper and middle reaches of the Shaying River and Guo River. The high cluster centers which were surrounded with COD_(Mn), NH_4^+-N, TN and TP mainly also distributed in the upper and middle reaches of the Shaying River and Guo River. Redundancy analysis showed that the 200 m buffer area acted as the most sensitive area, which was easily subjected to pollution. The precipitation was identified as the most important variables among all the studied hydrological units, followed by farmland, urban land or elevation. The point source pollution was still existed although the non-point source pollution was also identified. The urban surface runoff pollution was severer than farmland fertilizer loss at the sub-basin scale in flood season, while the farmland showed 'small-scale' effects for explaining overall water quality variations. This research is helpful for identifying the overall water quality variations from the scale-process interactions and providing a scientific basis for pollution control and decision making for the Huai River Basin. | XIA Jun WANG LongFeng YU JingJie ZHAN CheSheng ZHANG YongYong QIAO YunFeng WANG YueLing | 2018 | Science China Earth Sciences2018，61，1： | 8 |
| 19 | Kindlin-2 expression in adult tissues correlates with their embryonic origins显示文摘Kindlin-2 functions in the maintenance of homeostasis and in human diseases.This study investigated the interrelationship between Kindlin-2 expression in tissues and the corresponding germ layers from which these tissues originated.Kindlin-2 expression was examined in normal adult human organs and human cancer tissues by immunohistochemical analyses.Analysis of Kindlin-2 mRNA levels in adult human organs in the Oncomine dataset revealed Kindlin-2 is highly expressed in mesoderm-derived organs.However,Kindlin-2 was negative or weakly expressed in endoderm/ectoderm-derived organs.Interestingly,the abnormal expression of Kindlin-2 was observed in a variety of human cancers.In agreement with its expression profile in humans,Kindlin-2 was also highly expressed in mesoderm-derived organs in mouse embryos with the exception of strong Kindlin-2 expression in ectoderm-derived spinal cord and ganglia,tissues that are highly mobile during embryonic development.Importantly,we demonstrated the expression level of Kindlin-2 in adult organs correlated with their embryonic dermal origins and deregulation of Kindlin-2 in tissues is associated with tumor progression.This finding will help us understand the dual role of Kindlin-2 in the regulation of tumor progression and embryonic development. | ZHAN Jun YANG Mei CHI XiaoChun ZHANG Jing PEI XueLian REN CaiXia GUO YongQing LIU Wei ZHANG HongQuan | 2014 | Science China(Life Sciences)2014，57，7： | 8 |
| 20 | Efficacy and safety of Shenyankangfu Tablet,a Chinese patent medicine,for primary glomerulonephritis:A multicenter randomized controlled trial显示文摘Background:Shenyankangfu Tablet(SYKFT)is a Chinese patent medicine that has been used widely to decrease proteinuria and the progression of chronic kidney disease.Objective:This trial compared the efficacy and safety of SYKFT,for the control of proteinuria in primary glomerulonephritis patients,against the standard drug,losartan potassium.Design,setting,participants and intervention:This was a multicenter,double-blind,randomized,controlled clinical trial.Primary glomerulonephritis patients,aged 18-70 years,with blood pressure≤140/90 mmHg,estimated glomerular filtration rate(eGFR)>45 mL/min per 1.73 ㎡,and 24-hour proteinuria level of 0.5-3.0 g,were recruited in 41 hospitals across 19 provinces in China and were randomly divided into five groups:SYKFT,losartan potassium 50 mg or 100 mg,SYKFT plus losartan potassium 50 mg or 100 mg.Main outcome measu res:The primary outcome was change in the 24-hour proteinuria level,after 48 weeks of treatment.Results:A total of 735 participants were enrolled.The percent decline of urine protein quantification in the SYKFT group after 48 weeks was 8.78%±2.56%(P=0.006)more than that in the losartan 50 mg group,which was 0.51%±2.54%(P=1.000)less than that in the losartan 100 mg group.Compared with the losartan potassium 50 mg group,the SYKFT plus losartan potassium 50 mg group had a 13.39%±2.49%(P<0.001)greater reduction in urine protein level.Compared with the losartan potassium 100 mg group,the SYKFT plus losartan potassium 100 mg group had a 9.77%±2.52%(P=0.001)greater reduction in urine protein.With a superiority threshold of 15%,neither was statistically significant.eGFR,serum creatinine and serum albumin from the baseline did not change statistically significant.The average change in TCM syndrome score between the patients who took SYKFT(-3.00[-6.00,-2.00])and who did not take SYKFT(-2.00[-5.00,0])was statistically significant(P=0.003).No obvious adverse reactions were observed in any group.Conclusion:SYKFT decreased the proteinuria and improved the TCM syndrome scores of primary glomerulonephritis patients,with no change in the rate of decrease in the eGFR.SYKFT plus losartan potassium therapy decreased proteinuria more than losartan potassium therapy alone.Trial registration number:NCT02063100 on ClinicalTrials.gov. | Jie Wu Shu-wei Duan Hong-tao Yang Yue-yi Deng Wei Li Ya-ni He Zhao-hui Ni Yong-li Zhan Shan Lin Zhi-yong Guo Jun Zhu Jing-ai Fang Xu-sheng Liu Li-hua Wang Rong Wang Nian-song Wang Xiao-hong Cheng Li-qun He Ping Luo Shi-ren Sun Ji-feng Sun Ai-ping Yin Geng-ru Jiang Hong-yu Chen Wen-hu Liu Hong-li Lin Meng Liang Lu Ma Ming Chen Li-qun Song Jian Chen Qing Zhu Chang-ying Xing Yun Li Ji-ning Gao Rong-shan Li Ying Li Hao Zhang Ying Lu Qiao-ling Zhou Jun-zhou Fu Qiang He Guang-yan Cai Xiang-mei Chen | 2021 | Journal of Integrative Medicine2021，19，2： | 8 |
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