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| 1 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 2 | Reduction of atherosclerosis in cholesterol-fed rabbits and decrease of expressions of intracellular adhesion molecule-1 and vascular endothelial growth factor in foam cells by a water-soluble fraction of Polygonum multiflorum显示文摘 | Yang PY Almofti MR Lu L Kang H Zhang J Li TJ Rui YC Sun LN Chen WS | 2006 | 第二军医大学学报2006，27，6： | 7 |
| 3 | Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3-1igase signaling effector DWARF3显示文摘 | Li-Hua Zhao X Edward Zhou Wei Yi Zhongshan Wu Yue Liu Yanyong Kang Li Hou Parker W de Waal Suling Li Yi Jiang Adrian Scaffidi Gavin R Flematti Steven M Smith Vinh Q Lam Patrick R Griffin YonghongWang Jiayang Li Karsten Melcher H Eric Xu | 2015 | Cell Research2015，25，11： | 7 |
| 4 | Open versus laparoscopic surgery for mid or low rectal cancer after neoadjuvant chemoradiotherapy (COREAN trial): short-term outcomes of an open-label randomised controlled trial显示文摘 | Sung-Bum Kang Ji Won Park Seung-Yong Jeong Byung Ho Nam Hyo Seong Choi Duck-Woo Kim Seok-Byung Lim Taek-Gu Lee Dae Yong Kim Jae-Sung Kim Hee Jin Chang Hye-Seung Lee Sun Young Kim Kyung Hae Jung Yong Sang Hong Jee Hyun Kim Dae Kyung Sohn Dae-Hyun Kim Jae H | 2010 | Lancet Oncology2010，，7： | 5 |
| 5 | The structural basis of the dominant negative phenotype of the Gαi1β1Y2 G203A/A326S heterotrimer显示文摘 | Ping LIU Ming-zhu JIA X Edward ZHOU Parker W DE WAAL Bradley M DICKSON Bo LlU Li HOU Yan-ting YIN Ya n-yong KANG Yi SHI Karsten MELCHER H Eric XU Yi JIANG | 2016 | Acta Pharmacologica Sinica2016，37，9： | 3 |
| 6 | 中国成年女性初潮年龄与高血压风险的关系:大型国家代表性群体研究结果显示文摘本研究纳入中国高血压调查中年龄≥18岁的女性234867例,旨在探索中国成年女性初潮年龄与高血压风险的相关性。参与者被要求完成标准问卷,血压测量和体格检查由经过培训的医务人员完成。采用Spearman相关性分析探索初潮年龄和其他个体特征的相关性。采用logistic回归根据初潮年龄计算高血压发生的OR。结果显示,中国女性平均初潮年龄为14.8岁。 | 袁源(摘译) 郑武洪(审校) Chen L Zhang L Chen Z Wang X Zheng C Kang Y Zhou H Wang Z Gao R | 2021 | 中华高血压杂志2021，29，10： | 3 |
| 7 | T-DNA insertional mutagenesis for activation tagging in rice显示文摘 | JEONG D H AN S KANG H G | 2002 | Plant Physiol2002，130，4： | 3 |
| 8 | Docosahexaenoic acid suppresses arachidonic acid-induced proliferation of LS-174T human colon carcinoma cells显示文摘AIM:To investigate the impact of arachidonic acid (AA) and docosahexaenoic acid (DHA) and their combination on colon cancer cell growth.METHODS:The LS-174T colon cancer cell line was used to study the role of the prostaglandin precursor AA and the omega-3 polyunsaturated fatty acid DHA on cell growth. Cell viability was assessed in XTT assays. For analysis of cell cycle and cell death,flow cytometry and DAPI staining were applied. Expression of cyclooxygenase-2 (COX-2),p21 and bcl-2 in cells incubated with AA or DHA was examined by real-time RT-PCR. Prostaglandin E2 (PGE2) generation in the presence of AA and DHA was measured using a PGE2-ELISA.RESULTS:AA increased cell growth,whereas DHAreduced viability of LS 174T cells in a time-and dose-dependent manner. Furthermore,DHA down-regulated mRNA of bcl-2 and up-regulated p21. Interestingly,DHA was able to suppress AA-induced cell proliferation and significantly lowered AA-derived PGE2 formation. DHA also down-regulated COX-2 expression. In addition to the effect on PGE2 formation,DHA directly reduced PGE2-induced cell proliferation in a dose-dependent manner. CONCLUSION:These results suggest that DHA can inhibit the pro-proliferative effect of abundant AA or PGE2. | Piet Habbel Karsten H Weylandt Katja Lichopoj Johannes Nowak Martin Purschke Jing-Dong Wang Cheng-Wei He Daniel C Baumgart Jing X Kang | 2009 | World Journal of Gastroenterology2009，15，9： | 2 |
| 9 | A Novel Timing Estimation Method for OFDM Systems显示文摘 | Park B Cheon H Kang C | | 0，，： | 2 |
| 10 | Highly zmproved qucmtum eggiciency in blend polymer leds显示文摘 | Kang I N Hwagn D H Shim H K etal | 1996 | Macromolecules1996，29，： | 2 |
| 11 | Coordnate augumentation in expression of genes encoding transcription factors and liver secretory proteins in hypooncotic state显示文摘 | Kang J Halland M Jones H | 1999 | Kidney Int1999，53，2： | 2 |
| 12 | Lanthanum-substituted bismuth titanate for use in non-volatile memories 显示文摘 | PARK B H KANG B S NOH T W | 1999 | Nature1999，401，： | 2 |
| 13 | 分子束外延高Mg掺杂GaN的发光特性显示文摘采用分子束外延技术在蓝宝石衬底上制备Mg掺杂的立方相p-GaN,并对其不同温度下的光致发光光谱进行了研究.实验观察到高Mg掺杂GaN中施主受主对发光的反常温度行为.理论分析表明,高Mg掺杂GaN中施主受主对的发光受到陷阱与受主间竞争俘获非平衡空穴过程和空穴隧穿输运过程的影响. | 宋航 Park S H Kang T W Kim T W | 1999 | 发光学报1999，20，2： | 2 |
| 14 | 直接抗病毒药物根除HCV后使肝纤维化快速和显著改善显示文摘【据Journal of Viral Hepatitis 2021年4月报道】题:直接抗病毒药物根除HCV后使肝纤维化快速和显著的改善(作者Kang Q等)目前,关于HCV根除后肝纤维化变化的相关研究数据有限。该研究探讨了HCV根除后肝脏硬度值、APRI、FIB-4、壳多糖酶3样蛋白1及高尔基体蛋白73水平的变化。 | KANG Q XU J LUO H 亢倩 徐小元 | 2021 | 临床肝胆病杂志2021，37，12： | 2 |
| 15 | Cecropin A - magainin 2 hybrid peptides having potent antimicrobial activity with low hemolytic effect显示文摘 | Shin S Y Kang J H Lee M K | 1998 | Biochem Mol Biol Int1998，44，6： | 1 |
| 16 | Urinary 1-hydroxypyrene and 2-naphthol concentration in male Koreans 显示文摘 | Kim H Chao SH Kang JW | 2001 | Int Arch Occup Environ Health2001，74，： | 1 |
| 17 | 显示文摘 | Choi W B Chung D S Kang J H | 1999 | Applied Physics Letters1999，75，20： | 1 |
| 18 | Malignancies of the appendix: beyond case series reports显示文摘 | McGory ML Maggard MA Kang H | 2005 | Dis Colon Rectum2005，48，12： | 1 |
| 19 | Growth kinetics of human mesenchymal stem cells from bone marrow and umbilical cord blood 显示文摘 | Kang TJ Yeom JE Lee H J | 2004 | Acta Haematol2004，112，4： | 1 |
| 20 | Discrete Cosine Transform-based Regularized High-resolution Image Reconstruction Algorithm 显示文摘 | Rhee S H Kang M G | 1999 | SPIE JournalOptical Engineering1999，38，8： | 1 |
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