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| 1 | 欧洲胃肠内镜学会和美国胃肠内镜学会指南预测胆囊切除术患者可疑胆总管结石的临床效果显示文摘【据《Endoscopy》2020年2月在线报道】题:欧洲胃肠内镜学会和美国胃肠内镜学会指南预测胆囊切除术患者可疑胆总管结石的临床效果(作者Jagtap N等)最新版欧洲胃肠内镜学会(ESGE)和美国胃肠内镜学会(ASGE)指南推荐要根据肝功能和腹部超声检查对可疑胆总管结石患者进行风险分层。来自印度海得拉巴亚洲胃肠病研究所的Jagtap等进行了一项研究,评估和验证了ESGE和ASGE新的风险分层标准预测胆总管结石的临床效用。 | 李家速 刘枫 JAGTAP N YASHAVANTH HS TANDAN M | 2020 | 临床肝胆病杂志2020，36，5： | 3 |
| 2 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 3 | Two new saponins,congmuyenosides A and B,from the leaves of Aralia elata collected in heilongjiang,china 显示文摘 | Kuang HS Sun H Zhang N | 1996 | Chem Pharm Bull1996，44，11： | 2 |
| 4 | Production of alkylesters from tallow and grease using lipase immobilized in a phyllosilicate sol-gel显示文摘 | HS U A F JONES K MARMERW N | 2001 | Journal of the American Oil Chemists Society2001，78，6： | 1 |
| 5 | Epidemiologieal survey of ossi- fication of the ligamentum flavum in thoraeic spine: CT imaging observation of 993 eases显示文摘 | Lang N Yuan HS Wang HL | 2013 | Eur Spine J2013，22，4： | 1 |
| 6 | Compassion fatigue, burnout and compassion satisfaction among family physicians in the Negev area - a cross-sectional study 显示文摘 | El-Bar N Levy A Wald HS | 2013 | Isr J Health Policy Res2013，2，1： | 1 |
| 7 | Survival and viability of nonculturable Escherichia coli and Vibrio cholerae in the estuarine and marine environment显示文摘 | Xu HS Roberts N Singleton FL | 1982 | Microbial Ecology1982，8，4： | 1 |
| 8 | The relationship between disc degeneration and flexibility of the lumbar spine 显示文摘 | Tanaka N An HS Lim TH | 2001 | Spine J2001，1，1： | 1 |
| 9 | Assay of advanced glycation endproducts (AGEs) : surveying AGEs by chromatographic assay with derivatization by6-aminoquinolgyl-N-hydroxysuccinimidyl- carbamate and application Nepsilon-carboxymethyl-lysine- andNepsilon-(1-carboxyethyl) lysine-modified albumin显示文摘 | Abmed N Argirov OK Minbas HS | 2002 | Biochern J2002，364，1： | 1 |
| 10 | Meta-analysis of the risk for anastomotic leakage, the postoperative mortality caused by leakage in relation to the overall postoperative mortality 显示文摘 | Snijders HS Wouters MW van Leersum N J | 2012 | Eur J Surg Oncol2012，38，11： | 1 |
| 11 | High degree of correlation be- tween whole blood and PBMC expression level's of miR-155 and miR-146a in healthy controls and rheumatoid arthritis patients 显示文摘 | Mookherjee N El-Gabalawy HS | 2013 | J Immunol Methods2013，400，1： | 1 |
| 12 | Energy metabolism in children with newly diagnosed acute lymphoblastic leukemia显示文摘 | Stallings VA Vaisman N Chan HS | 1989 | Pediatr Res1989，26，： | 1 |
| 13 | Regulation of human papillomavirus type 16 E7 activity through direct protein interaction with the E2 transcriptional activator显示文摘 | Gammoh N Grm HS Massimi P | 2006 | J Virol2006，80，4： | 1 |
| 14 | Degenerative spondylolisthesis does not affect the outcome of unilateral laminotomy with bilateral decompression in patients with lumbar stenosis显示文摘 | Chang HS Fujisawa N Tsuchiya T | 2014 | Spine2014，39，5： | 1 |
| 15 | TYMS and DPYD polymorphisms in a Turkish population显示文摘 | Suzen HS Yuce N Guvenc G | 2005 | Eur J Clin Pharmacol2005，61，12： | 1 |
| 16 | Mechanism of vasoconstrictioninduced by chronic inhibition of nitric oxide in rats显示文摘 | Bank N Aynedjian HS Khan GA | 1994 | Hypertension1994，24，3： | 1 |
| 17 | A plant signal peptidehepatitis B surface antigen fusion protein with enhanced stability and immunogenicity expressed in plant cells显示文摘 | Sojikul P Buehner N Mason HS | 2003 | Proc Nail Acad Sci USA2003，100，5： | 1 |
| 18 | The Epstein-Barr Vlms latent membrane protein-1 induces expression of the epidermal growth factor receptor 显示文摘 | Miller WE Earp HS Raabb-Traub N | 1995 | J Virol1995，69，7： | 1 |
| 19 | Human Papil- lomavirus E6/E7 -- Specific siRNA Potentiates the Effect of Radiotherapy for Cervical Cancer in Vitro and in Vivo 显示文摘 | Jung HS Rajasekaran N Song SY | 2015 | Int J Mol Sci2015，16，6： | 1 |
| 20 | Crosstalk between the human papillomavirus E2 transcriptional activator and the E6 oncoprotein显示文摘 | Grm HS Massimi P Gammoh N | 2005 | Oncogene2005，24，33： | 1 |
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