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| 1 | Predicting Protein Subcellular Localization: Past, Present, and Future显示文摘Functional characterization of every single protein is a major challenge of the postgenomic era. The large-scale analysis of a cell's proteins, proteomics, seeks to provide these proteins with reliable annotations regarding their interaction partners and functions in the cellular machinery. An important step on this way is to determine the subcellular localization of each protein. Eukaryotic cells are divided into subcellular compartments, or organelles. Transport across the membrane into the organelles is a highly regulated and complex cellular process. Predicting the subcellular localization by computational means has been an area of vivid activity during recent years. The publicly available prediction methods differ mainly in four aspects: the underlying biological motivation, the computational method used, localization coverage, and reliability, which are of importance to the user.This review provides a short description of the main events in the protein sorting process and an overview of the most commonly used methods in this field. | Pierre Dnnes Annette Hglund | 2004 | Genomics, Proteomics & Bioinformatics2004，2，4： | 4 |
| 2 | Randomized phase Ⅱ trial of Erlotinib alone or with Carboplatin and Paclitaxel in patients who were never or light former smokers with advanced lung adenocarcinoma:CALGB 30406 trial显示文摘 | J(a)nne PA Wang X Socinski MA | | 0，，17： | 1 |
| 3 | Investigating the myth of the relationship between teaching and research in higher education: A review of empirical research显示文摘 | An Verburgh Jan Elen Sari Lindblom-Yl?nne | 2007 | Studies in Philosophy and Education2007，，5： | 1 |
| 4 | Covalent modification of the androgen receptor by small ubiquitin-like modifier 1(SUMO-1)显示文摘 | Poukka H Karvonen U J(a)nne O A | 2000 | Proc Natl Acad Sci USA2000，97，14： | 1 |
| 5 | Mechanisms of acquired resistance to epidermal growth receptor tyrosine kinase inhibitors in non-small cell lung cancer显示文摘 | Engelman JA J(o)nne PA | | 0，，10： | 1 |
| 6 | Metaanalysis of the significance of matrix metalloproteineses for lymphnode disease in patients with head and neck squamous cell carcinoma显示文摘 | Wiegand S Dünne AA Müller HH | 2005 | Cancer2005，104，1： | 1 |
| 7 | Mutation of L4 ribosomal protein conferring unusual macrolide resistance in two independent clinical isolates of Staphylococcus aureUs 显示文摘 | Nne - laure Prunie Selma L | 2005 | Microbial Drug Resistance2005，11，1： | 1 |
| 8 | Activity and safety of crizotinib in patients with ALK -positive non-small-cell lung cancer: updated results from a phase 1 study显示文摘 | D Ross Camidge Yung-Jue Bang Eunice L Kwak A John Iafrate Marileila Varella-Garcia Stephen B Fox Gregory J Riely Benjamin Solomon Sai-Hong I Ou Dong-Wan Kim Ravi Salgia Panagiotis Fidias Jeffrey A Engelman Leena Gandhi Pasi A J?nne Daniel B Costa Geoffrey | 2012 | Lancet Oncology2012，，10： | 1 |
| 9 | WIPI proteins: essential PtdIns3P effectors at the nascent autophagosome 显示文摘 | Proikas-Cezanne T Takacs Z D?觟nnes P | 2015 | J Cell Sci2015，128，2： | 1 |
| 10 | The biology and treatment of EML4-ALK non-small cell lung cancer显示文摘 | Takaaki Sasaki Scott J. Rodig Lucian R. Chirieac Pasi A. J?nne | 2010 | European Journal of Cancer2010，，10： | 1 |
| 11 | Fluorescence-based imaging of autophagy progression by human WIPI protein detection 显示文摘 | Thost A K D?觟nnes P Kohlbacher O | 2015 | Methods2015，75，： | 1 |
| 12 | EGFR mutations in lung cancer: correlation with clinicalresponse to gefitinib therapy显示文摘 | PAEZ J G J: NNE P A LEE J C | 2004 | Science2004，304，5676： | 1 |
| 13 | The biology and treatment of EML4-ALK non-small cell lung cancer显示文摘 | Sasaki T Rodig S J Chirieac L R J?nne P A | 2010 | Eur J Cancer2010，46，： | 1 |
| 14 | Structural Basis for Vertebrate Filamin Dimerization显示文摘 | Regina Pudas Tiila-Riikka Kiema P. Jonathan G. Butler Murray Stewart Jari Yl?nne | 2005 | Structure2005，，1： | 1 |
| 15 | EGFR mutations in lung cancer:correlation with clinical response to gefitinib therapy显示文摘 | Paez JG J(a)nne PA Lee JC | 2004 | Science2004，304，： | 1 |
| 16 | Basic treatment considerations us-ing chemotherapy for patients with smal cel lung cancer显示文摘 | Johnson BE J?nne PA | | 0，，02： | 1 |
| 17 | Mining mid-level features for image classi- fication 显示文摘 | Fernandobasura Fromontelisa Tuytelaarsti- nne | 2014 | Int J Comput Vis2014，，108： | 1 |
| 18 | What makes a student group successful? student-student and student- teacher Interaction in a problem-based learning environ- ment显示文摘 | Lindblom-Y1 nne S Pihlajam ki H Kotkas T | 2002 | Learning Environments Research2002，6，1： | 1 |
| 19 | Extent of surgical intervention in case of N0 neck in head and neck cancer patients: an analysis of data collection of 39 hospitals显示文摘 | A. A. Dünne B. J. Folz C. Kuropkat J. A. Werner | 2004 | European Archives of Oto-Rhino-Laryngology2004，，6： | 1 |
| 20 | An 显示文摘 | GjФnnes J CHR J Simensen | 1970 | Acta Metall1970，18，： | 1 |
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