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| 1 | Hydrogen sutfide protects colon cancer cells from chemopreventative agent β-phenylethyl isothiocvanate induced apoptosis显示文摘AIM: Hydrogen sulfide (H2S) is a prominent gaseous constituent of the gastrointestinal (GI) tract with known cytotoxic properties. Endogenous concentrations of H2S are reported to range between 0.2-3.4 mmol/L in the GI tract of mice and humans. Considering such high levels we speculate that, at non-toxic concentrations, H2S may interact with chemical agents and alter the response of colonic epithelium cells to such compounds. The GI tract is a major site for the absorption of phytochemical constituents such as isothiocyanates, flavonoids, and carotenoids, with each group having a role in the prevention of human diseases such as colon cancer. The chemopreventative properties of the phytochemical agent β-phenyethyl isothiocyanate (PEITC) are well recognized. However, little is currently known about the physiological or biochemical factors present in the GI tract that may influence the biological properties of ITCs. The current study was undertaken to determine the effects of H2S on PEITC mediated apoptosis in colon cancer cells.METHODS: Induction of apoptosis by PEITC in human colon cancer HCT116 cells was assessed using classic apoptotic markers namely SubG1 population analysis,caspase-3 like activity and nuclear fragmentation and condensation coupled with the MTT (3-(4,5-dimethylthiazol2-yl)-2,5-diphenyl tetrasodium bromide) viability assay and LDH leakage.RESULTS: PEITC significantly induced apoptosis in HGT116cells as assessed by SubG1 population formation, nuclear condensation, LDH leakage and caspase-3 activity after 24 h, these data being significant from control groups (P<0.01). In contrast, co-treatment of cells with physiological concentrations of H2S (0.1-1 mmol/L) prevented PEITC mediated apoptosis as assessed using the parameters described.CONCLUSION: PEITC effectively induced cell death in the human adenocarcinoma cell line HCT116 in vitro through classic apoptotic mechanisms. However, in the presence of H2S, apoptosis was abolished. These data suggest that H2S may play a significant role in the response of colonic epithelial cells to beneficial as well as toxic agents present within the GI tract. | Peter Rose Philip K Moore Shen Han Ming Ong Choon Nam Jeffrey S Armstrong Matt Whiteman | 2005 | World Journal of Gastroenterology2005，11，26： | 13 |
| 2 | 内皮Notch信号的抑制阻碍脂肪酸转运并导致成年心脏的代谢和血管重塑显示文摘营养成分在被肌肉细胞代谢利用之前通过内皮细胞转运。然而,对于内皮运输过程的调节知之甚少。Notch信号传导是发育过程中代谢和血管生成的关键调控因子。在该研究中,Jabs等研究了成年小鼠内皮Notch信号的遗传和药理学调控如何影响内皮脂肪酸转运、心脏血管生成和心脏功能。 | 刘青 叶鹏 Jabs M Rose AJ Lehmann LH Taylor J Moll I Sijmonsma TP Herberich SE Sauer SW Poschet G Federico G Mogler C Weis EM Augustin HG Yan M Gretz N Schmid RM Adams RH Gr9ne HJ Hell R Okun JG Backs J Nawroth PP Herzig S Fischer A | 2018 | 中华高血压杂志2018，26，3： | 6 |
| 3 | 柱压缩测量辐射不透明度靶的数值模拟显示文摘用数值模拟研究用高功率强激光驱动柱压缩产生温度密度梯度低的高温高密度等离子体的可能性 ,研究了可能获得的高温高密度等离子体状态的范围 ,并估计了此类靶中 Rayleigh-Taylor不稳定性和 Richtmyer-Meshkov不稳定性产生的危害程度。结果表明柱压缩可以产生比较均匀的等离子体状态 ,可以用于辐射不透明度的实验测量。 | 许琰 S J Rose | 2000 | 强激光与粒子束2000，12，5： | 3 |
| 4 | Colorectal cancer surveillance:What's new and what's next?显示文摘The accumulated evidence from two decades of randomized controlled trials has not yet resolved the question of how best to monitor colorectal cancer(CRC)survivors for early detection of recurrent and metachronous disease or even whether doing so has its intended effect.A new wave of trial data in the coming years and an evolving knowledge of relevant biomarkers may bring us closer to understanding what surveillance strategies are most effective for a given subset of patients.To best apply these insights,a number of important research questions need to be addressed,and new decision making tools must be developed.In this review,we summarize available randomized controlled trial evidence comparing alternative surveillance testing strategies,describe ongoing trials in the area,and compare professional society recommendations for surveillance.In addition,we discuss innovations relevant to CRC surveillance and outline a research agenda which will inform a more risk-stratified and personalized approach to follow-up. | Johnie Rose Knut Magne Augestad Gregory S Cooper | 2014 | World Journal of Gastroenterology2014，20，8： | 3 |
| 5 | Sequential feeding of whole wheat to growing broiler chickens 显示文摘 | Rose S P Fielden M Foote W R | 1995 | Br Poult Sci1995，36，： | 1 |
| 6 | A critical evaluation of sample extraction techniques for enhanced proteomic analysis of recalcitrant plant tissues 显示文摘 | SARAVANAN R S ROSE J K C | 2004 | Proteomics2004，4，： | 1 |
| 7 | Redicting Business Failure: A Macroeconomic Perspective 显示文摘 | Rose Peter S Andrews Wesley T Giroux Gary A P | 1982 | Journal of Accounting Auditing and Finance1982，，1： | 1 |
| 8 | Three tomato genes code for heat stress transcription factors with a region of remarkable homology to the DNA-binding domain of the yeast HSF 显示文摘 | SCHARF K D ROSE S ZOTT W | 1990 | The EMBO Journal1990，9，13： | 1 |
| 9 | Anterior cruciate ligamenl radiofrequency thermal shrinkage:As hort-term follow-up显示文摘 | Famg E Hunt S A Rose D J | 2005 | Arthroscopy2005，21，9： | 1 |
| 10 | Guidelines on the diagnosis and management of the thrombotic microangiopathic haemolytic anaemias 显示文摘 | Allford S L Hunt BJ Rose P | 2003 | Br J Haemotol2003，120，4： | 1 |
| 11 | Synthesis of New Macrocyclic Bispidinone Ionophores显示文摘 | Black D S C Horsham M A Rose M | 1995 | Tetrahedron1995，51，16： | 1 |
| 12 | Facade failure effects on blast propagation along city streets显示文摘 | SMITH P D ROSE T A KRAHE S L | 2003 | Structures and Buildings2003，156，4： | 1 |
| 13 | An in situ target strength model for Atlantic redfish 显示文摘 | Gauthier S Rose G A | 1998 | Journal of the Acoustical Society of America1998，103，5： | 1 |
| 14 | Three tomato genes code for heat stress transeription factors with a region of remarkable ho- mology to the DNA-binding domain of the yeast HSF 显示文摘 | Seharf K D Rose S Zott W | 1990 | EMBO J1990，9，： | 1 |
| 15 | Pediatric granulom- atous arthritis: an international registry显示文摘 | Rose CD Wouters CH Meiorin S | 2006 | Arthritis Rheum2006，54，： | 1 |
| 16 | Fluid inclusions in porphyry and skarn ore at Santa Rita,New Mexico显示文摘 | Ahmad S N Rose A V | 1980 | Economic Geology1980，75，： | 1 |
| 17 | In vitro differentiation of a cloned bovine mammary epithelial cell显示文摘 | ROSE B T ASO H YONEKURA S | 2002 | Journal of Dairy Research2002，69，3： | 1 |
| 18 | The heterogeneous evolution of multidrug-resistant Mycobacterium tuberculosis显示文摘 | Moller B Borrell S Rose G | 2013 | Trends Genet2013，29，3： | 1 |
| 19 | Tarring improves the efficacy of a DNA Vaccine against Corynebacterium pseudotuberculosis in sheep显示文摘 | CHAPLINP J DE ROSE R BOYLE J S | 1999 | Infect Immun1999，67，： | 1 |
| 20 | Physiological levels of pro- and anti-inflammatory mediators in cerebrospinal fluid and plasma:a normative study显示文摘 | Maier B Laurer HL Rose S | 2005 | J Neurotrauma2005，22，7： | 1 |
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