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| 1 | A simplified LC-MS/MS method for the quantification of the cardiovascular disease biomarker trimethylamine-N-oxide and its precursors显示文摘Trimethylamine-N-oxide(TMAO)has emerged as a potential biomarker for atherosclerosis and the development of cardiovascular diseases(CVDs).Although several clinical studies have shown striking associations of TMAO levels with atherosclerosis and CVDs,TMAO determinations are not clinical routine yet.The current methodology relies on isotope-labeled internal standards,which adds to pre-analytical complexity and costs for the quantification of TMAO and its precursors carnitine,betaine or choline.Here,we report a liquid chromatography-tandem mass spectrometry based method that is fast(throughput up to 240 samples/day),consumes low sample volumes(e.g.,from a finger prick),and does not require isotope-labeled standards.We circumvented the analytical problem posed by the presence of endogenous TMAO and its precursors in human plasma by using an artificial plasma matrix for calibration.We cross-validated the results obtained using an artificial matrix with those using mouse plasma matrix and demonstrated that TMAO,carnitine,betaine and choline were accurately quantified in’reallife’human plasma samples from healthy volunteers,obtained either from a finger prick or from venous puncture.Additionally,we assessed the stability of samples stored at-20℃and room temperature.Whereas all metabolites were stable at-20℃,increasing concentrations of choline were determined when stored at room temperature.Our method will facilitate the establishment of TMAO as a routine clinical biomarker in hematology in order to assess the risk for CVDs development,or to monitor disease progression and intervention effects. | Katharina Rox Silke Rath Dietmar H.Pieper Marius Vital Mark Bronstrup | 2021 | Journal of Pharmaceutical Analysis2021，11，4： | 3 |
| 2 | 老年人肾功能及药物治疗显示文摘 | Roxe,DM 王德全 | 1990 | 国外医学(老年医学分册)1990，11，6： | 2 |
| 3 | 盘磨机磨片间纸浆纤维剪切系数的确定显示文摘讨论了纸浆纤维在盘磨机打浆时所受到的剪切特性 ,并由此推导出平均剪切系数与磨片平均间隙、有用功及磨片几何尺寸之间的关系。 | 初嘉鹏 J-C ROX 欧建志 | 2001 | 大连轻工业学院学报2001，20，2： | 2 |
| 4 | Hormone-induced ovulation and artificial spawning of gulf of mexico sturgeon (Acipenser oxyrhynchus desotoi)显示文摘 | Parauka F M T roxe W J Chapman F A | | 0，，02： | 1 |
| 5 | Cardioversion of atrial fibrillation in the elderly 显示文摘 | Carlsson J Tebbe U Rox J for the ALKK-Study Group | 1996 | Am J Cardiol1996，78，： | 1 |
| 6 | Clinical Neuroimaging Features and Outcome in Molybdenum Cofactor Deficiency显示文摘 | Kayal Vijayakumar Rox Gunny Stephanie Grunewald Lucinda Carr Kling W. Chong Catherine DeVile Robert Robinson Niamh McSweeney Prab Prabhakar | 2011 | Pediatric Neurology2011，，： | 1 |
| 7 | Aquaporin-2 transcript is dif-ferentially regulated by dietary salt in Sprague-Dawley and DahlSS/Jr rats显示文摘 | Rox as B Farjah M DanzigerRS | 2002 | Biochem Biophys Res Commun2002，296，3： | 1 |
| 8 | Palliative care/hospice and the withdrawal of dialysis 显示文摘 | Keely KJ Roxe DM | 2000 | J Palliat Med2000，3，： | 1 |
| 9 | Decription d'Crganes mandibulaires nouveaux chez les Crustaces Decapodes显示文摘 | Le Rox A | 1968 | Comptes Rendus Hebdomadaires de 1''Academie des Sciences1968，266，： | 1 |
| 10 | Palliative care/hospice and the withdrawal of dialysis 显示文摘 | Neely KJ Roxe DM | 2003 | J Pall Med2003，3，： | 1 |
| 11 | The valuation of options for alternative stochastic proeess显示文摘 | Rox J C Ross S | 1976 | Journal of Stocbastic Processes1976，3，： | 1 |
| 12 | Circulating microRNAs in patients with coronary artery disease显示文摘 | Fichtlscherer S De Rosa S Fox H Schwietz T Fischer A Liebetrau C Weber M Hamm CN Roxe T Muller-Ardogan M Bonauer A Zeiher AM Dimmeler S | | 0，，： | 1 |
| 13 | Loss of expression of the PTEN gene protein product is associated with poor outcome in breast cancer显示文摘 | Depwski PL Rosenthal SI Roxs JS | 2001 | Mod Pathol2001，14，7： | 1 |
| 14 | 衰老与肾脏功能显示文摘本文阐述了老年人肾衰的12个危险因素,肾脏的5个功能及其诊断方法,并就确立肾功能后如何治疗作一简介。 | Roxe DM 王秀问 | 1992 | 国外医学(老年医学分册)1992，13，6： | 1 |
| 15 | The EUF-N contents of arable soils as an indicator of their yield potential显示文摘 | Rox M Nemeth K Harrach T | 1985 | Plant and Soil1985，83，： | 1 |
| 16 | Tumor Mz-PK levels in haematological malignancies显示文摘 | Oremek G M Rox S Mitrou P | 2003 | Anticancer Res2003，23，2： | 1 |
| 17 | Afterglows, redshlfts, and properties of swift gamma-ray bursts 显示文摘 | BERGER E KULKAMI S R ROX D B | 2005 | ApJ2005，634，1： | 1 |
| 18 | Quantitative tissue factor gene expression analysis in whole blood:development and evaluation of a real-time PCR platform显示文摘 | ROX JM MADLENER K | 2004 | Clin Chem2004，50，1： | 1 |
| 19 | 人生赢家进化论 与吉利博瑞车主的私房对话显示文摘这个飞速发展的时代不但培养出了优秀的自主品牌,也造就了许多出自平民的时代精英。我们身边不乏成功的各式范例,这些在人生路途中不断攀升的时代精英们,选择的路途与方向都不同,然而我们为他们找到了一个共同点——他们都是博瑞车主,都有着别样的车生活。范作昕真诚是最好的底色范作昕既是一位创业者,同时又是一名科技精英,目前经营的三家公司,都是他用勤劳的双手和真诚地付出所打拼出来的,而吉利博瑞汽车在他眼里,就是真诚的代名词。 | 龙雪锋 常鸣 Rox | 2016 | 摄影之友2016，0，7： | 0 |
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