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| 1 | The Calcineurin B-Like Calcium Sensors CBL1 and CBL9 Together with Their Interacting Protein Kinase ClPK26 Regulate the Arabidopsis NADPH Oxidase RBOHF显示文摘象反应的氧种类(ROS ) 和 Ca2+ 一样的第二个送信人的刺激特定的累积对许多在植物发信号和规定过程中央。然而,管理发信号的 Ca2+ 和 ROS 的相互的相互关系的机制开始仅仅正在出现。呼吸爆炸 oxidase 相当或相同的事物(RBOH ) 的 NADPH oxidases 家庭是当和他们的交往的 kinases (CIPK ) 的 Calcineurin 象 B 一样(CBL )Ca2+ 传感器蛋白质被显示了在表明过程的许多 Ca2+- 工作时,贡献 ROS 的产生的批评部件。在这研究,我们识别在两个都表明系统之间的直接功能的相互作用。我们报导交往 CBL 蛋白质 kinase CIPK26 明确地在酵母与 RBOHF 的 N 终端领域交往二混血儿的分析并且与在植物房间的全身的 RBOHF 蛋白质。另外,在有 CIPK26 的 CBL1 或 CBL9 的 vitro 和合作表示的 CIPK26 phosphorylates RBOHF 强烈在 HEK293T 房间由 RBOHF 提高 ROS 生产。一起,这些调查结果识别在调停 CBLCIPK 的 Ca2+ 在植物发信号并且 ROS 发信号之间的直接互联并且为 NADPH oxidase RBOHF 的 synergistic 激活提供证据由对它由 CBL1/9CIPK26 建筑群的 EF 传递和导致 Ca2+ 的 phosphorylation 直接 Ca2+ 有约束力。 | Maria Magdalena Drerup Kathrin Schlückinga Kenji Hashimoto Prabha Manishankar Leonie Steinhorst Kazuyuki Kuchitsu Jōrg Kudl | 2013 | Molecular Plant2013，6，2： | 35 |
| 2 | Helicobacter pylori vac A genotype is a predominant determinant of immune response to Helicobacter pylori CagA显示文摘AIM To evaluate the frequency of Helicobacter pylori(H. pylori) Cag A antibodies in H. pylori infected subjects and to identify potential histopathological and bacterial factors related to H. pylori Cag A-immune response.METHODS Systematic data to H. pylori isolates, blood samples, gastric biopsies for histological and molecular analyses were available from 99 prospectively recruited subjects. Serological profile(anti-H. pylori, anti-Cag A) was correlated with H. pylori isolates(cag A, EPIYA, vac A s/m genotype), histology(Sydney classification) and mucosal interleukin-8(IL-8) m RNA and protein expression. Selected H. pylori strains were assessed for H. pylori Cag A protein expression and IL-8 induction in co-cultivation model with AGS cells.RESULTS Thirty point three percent of microbiologically confirmed H. pylori infected patients were seropositive for Cag A. Majority of H. pylori isolates were cag A gene positive(93.9%) with following vac A polymorphisms: 42.4% vac A s1m1, 23.2% s1m2 and 34.3% s2m2. Anti-Cag AIg G seropositivity was strongly associated with atrophic gastritis, increased mucosal inflammation according to the Sydney score, IL-8 and cag A m RNA expression. V a c A s a n d m p o l y m o r p h i s m s w e r e t h e m a j o r determinants for positive(vac A s1m1) or negative(vac A s2m2) anti-Cag A serological immune response, which also correlated with the in vitro inflammatory potential in AGS cells. In vitro co-cultivation of representative H. pylori strains with AGS cells confirmed functional Cag A translocation, which showed only partial correlation with Cag A seropositivity in patients, supporting vac A as major co-determinant of the immune response.CONCLUSION Serological immune response to H. pylori cag A + strain in H. pylori infected patients is strongly associated with vac A polymorphism, suggesting the crucial role of bacterial factors in immune and clinical phenotype of the infection. | Alexander Link Cosima Langner Wiebke Schirrmeister Wiebke Habendorf Jochen Weigt Marino Venerito Ina Tammer Dirk Schlüter Philipp Schlaermann Thomas F Meyer Thomas Wex Peter Malfertheiner | 2017 | World Journal of Gastroenterology2017，23，26： | 12 |
| 3 | Different antibiotic susceptibility between antrum and corpus of the stomach,a possible reason for treatment failure of Helicobacter pylori infection显示文摘AIM:To assess whether antibiotic resistance varies between the antrum and corpus of the stomach of patients that are either Helicobacter pylori(H.pylori)therapy-naive or pre-treated.METHODS:H.pylori strains were isolated from antrum and corpus biopsies from 66 patients that received a diagnostic gastroduodenoscopy for variant clinical indications.Antimicrobial susceptibility to amoxicillin,clarithromycin,tetracycline,metronidazole,levofloxacin and rifabutin was tested with the E-test method on IsoSensitest agar with 10 vol%defibrinated horse blood.In patients with a different antibiotic susceptibility pattern between the isolates from the antrum and corpus,DNA fingerprinting via random amplified polymorphic DNA analysis was performed to detect differences among DNA patterns of H.pylori isolates.RESULTS:Primary,secondary and tertiary resistance to clarithromycin was 6.9%,53.8%and 83.3%,retrospectively.Metronidazole and levofloxacin resistance also increased according to the number of previous treatments(17.2%,69.2%,83.3%;13.8%,23.1%,33.3%).Tertiary resistance to rifabutin was detected in12.5%of patients.In none of the 66 patients a resistance against amoxicillin or tetracycline was detectable.Discordant antibiotic susceptibility between antrum and corpus isolates for different antibiotics was seen in 15.2%(10/66)of the patients.Two out of those ten patients were naive to any H.pylori antibiotic treatment.The remaining eight patients previously received at least one eradication therapy.DNA fingerprinting analysis revealed no substantial differences among DNA patterns between antrum and corpus isolates in the majority of patients suggesting an infection with a single H.pylori strain.CONCLUSION:Different antibiotic susceptibility between antrum and corpus biopsies is a common phenomenon and a possible explanation for treatment failure.Resistant H.pylori strains may be missed if just one biopsy from one anatomic site of the stomach is taken for H.pylori susceptibility testing. | Michael Selgrad Ina Tammer Cosima Langner Jan Bornschein Julia Mei?le Arne Kandulski Mariya Varbanova Thomas Wex Dirk Schlüter Peter Malfertheiner | 2014 | World Journal of Gastroenterology2014，20，43： | 10 |
| 4 | 青藏高原中东部第四纪冰碛物暴露年龄的测定及其意义显示文摘青藏高原上大面积的冰盖通常会对亚洲乃至全球气候产生深远的影响。青藏高原第四纪冰川形成的时间和范围成为人们关注的热点。本研究利用就地成因的宇宙核素暴露年龄测定方法,对唐古拉山和理塘地区的第四纪冰碛物进行了^10Be、^28Al和^21Ne暴露年龄测定,首次获得了青藏高原的第四纪冰川核素暴露年龄。三种核素暴露年龄的一致性显示每期冰碛物沉积有一个确定的暴露时期,测试结果表明唐古拉山和理塘地区出现了两期第四纪冰期,一期形成于距今1.6~8万年,另一期形成于距今16-18万年。 | 赵志中 乔彦松 Joerg SCHFER 王燕 王敏 Christian SCHLüCHTER | 2006 | 地学前缘2006，13，5： | 9 |
| 5 | The deubiquitinase OTUB1 augments NF-κB-dependent immune responses in dendritic cells in infection and inflammation by stabilizing UBC13显示文摘Dendritic cells(DCs)are indispensable for defense against pathogens but may also contribute to immunopathology.Activation of DCs upon the sensing of pathogens by Toll-like receptors(TLRs)is largely mediated by pattern recognition receptor/nuclear factor-κB(NF-κB)signaling and depends on the appropriate ubiquitination of the respective signaling molecules.However,the ubiquitinating and deubiquitinating enzymes involved and their interactions are only incompletely understood.Here,we reveal that the deubiquitinase OTU domain,ubiquitin aldehyde binding 1(OTUB1)is upregulated in DCs upon murine Toxoplasma gondii infection and lipopolysaccharide challenge.Stimulation of DCs with the TLR11/12 ligand T.gondii profilin and the TLR4 ligand lipopolysaccharide induced an increase in NF-κB activation in OTUB1-competent cells,resulting in elevated interleukin-6(IL-6),IL-12,and tumor necrosis factor(TNF)production,which was also observed upon the specific stimulation of TLR2,TLR3,TLR7,and TLR9.Mechanistically,OTUB1 promoted NF-κB activity in DCs by K48-linked deubiquitination and stabilization of the E2-conjugating enzyme UBC13,resulting in increased K63-linked ubiquitination of IRAK1(IL-1 receptor-associated kinase 1)and TRAF6(TNF receptor-associated factor 6).Consequently,DC-specific deletion of OTUB1 impaired the production of cytokines,in particular IL-12,by DCs over the first 2 days of T.gondii infection,resulting in the diminished production of protective interferon-γ(IFN-γ)by natural killer cells,impaired control of parasite replication,and,finally,death from chronic T.encephalitis,all of which could be prevented by low-dose IL-12 treatment in the first 3 days of infection.In contrast,impaired OTUB1-deficient DC activation and cytokine production by OTUB1-deficient DCs protected mice from lipopolysaccharide-induced immunopathology.Collectively,these findings identify OTUB1 as a potent novel regulator of DCs during infectious and inflammatory diseases. | Floriana Mulas Xu Wang Shanshan Song Gopala Nishanth Wenjing Yi Anna Brunn Pia-Katharina Larsen Berend Isermann Ulrich Kalinke Antonio Barragan Michael Naumann Martina Deckert Dirk Schlüter | 2021 | Cellular & Molecular Immunology2021，18，6： | 4 |
| 6 | 非小细胞肺癌p63基因的表达与3q27-q29变化的关系研究显示文摘目的 研究p63基因在非小细胞肺癌中的蛋白表达水平及与 3号染色体长臂 3 q2 7 3 q2 9区域改变的关系。方法 采用组织芯片技术构建 12 2例原发性非小细胞肺癌石蜡包埋标本组织芯片 ,并应用免疫组织化学方法检测 p63基因蛋白表达情况。应用比较基因组杂交 (CGH)技术分析 70例原发性肺鳞癌和肺腺癌标本染色体的改变。同时分析p63基因的蛋白表达与 3号染色体长臂末端改变的关系。结果 12 2例非小细胞肺癌 p63免疫组化染色结果显示 :5 9例鳞癌中 5 1例 ( 86.44 % ) p63免疫组化染色为阳性 ;3例大细胞肺癌中 2例 ( 66.66% )为阳性 ;60例腺癌仅有 1例 ( 1.67% )为阳性。p63蛋白的阳性表达率与患者的年龄、性别、肿瘤的分级、肿瘤的转移以及预后生存率无关 (P >0 .0 5 )。 70例非小细胞肺癌CGH分析结果发现有3 2例 3 q2 7 q2 9区域出现DNA扩增 ,3 0例鳞癌中 2 4例出现 3 q2 7 q2 9区域DNA拷贝数目的增加 ,40例腺癌仅 8例发现 3q2 7 q2 9区域DNA获得。p63免疫组化阳性率与 3q2 7 q2 9区域的改变比较分析结果显示 :2 4例鳞癌 p63阳性者中 ,2 3例 ( 95 .83 % ) 3 q2 7 q2 9区域有显著的获得 ,1例 p63基因蛋白表达呈阳性的腺癌患者的 3 q2 7 q2 9区域有DNA拷贝数目的增加。 结论 研究结果提示 p63免疫组化阳性? | 余永伟 Mitchell E.Garber Karsten Schlens Manuela Pacyna-Gengelbach Iver Petersen | 2004 | 中国肺癌杂志2004，7，5： | 3 |
| 7 | Intragastric distribution and gastric emptying of solids and liquids in functional dyspepsia显示文摘 | A. M. Scott FRACP Dr. J. E. Kellow MD FRACP B. Shuter MSc H. Cowan RN A.-M. Corbett NMT J. W. Riley MD FRACP M. R. Lunzer FRCP FRACP R. P. Eckstein FRCPA R. H?schl MD S.-K. Lam MD FRCP FRACP M. P. Jones PhD | 1993 | Digestive Diseases and Sciences1993，，12： | 2 |
| 8 | Proteome analysis of human mesenchymal stem cells undergoing chondrogenesis when exposed to the products of various magnesium-based materials degradation显示文摘Treatment of physeal fractures(15%–30%of all paediatric fractures)remains a challenge as in approximately 10%of the cases,significant growth disturbance may occur.Bioresorbable Magnesium-based implants represent a strategy to minimize damage(i.e.,load support until bone healing without second surgery).Nevertheless,the absence of harmful effects of magnesium-implants and their degradation products on the growth plate should be confirmed.Here,the proteome of human mesenchymal stem cells undergoing chondrogenesis was evaluated when exposed to the products of various Magnesium-based materials degradation.The results of this study indicate that the materials induced regulation of proteins associated with cell chondrogenesis and cartilage formation,which should be beneficial for cartilage regeneration. | Adela Helvia Martínez Sánchez Maryam Omidi Marcus Wurlitzer Marceline Manka Fuh Frank Feyerabend Hartmut Schlüter Regine Willumeit-Römer Bérengère J.C.Luthringer | 2019 | Bioactive Materials2019，4，1： | 2 |
| 9 | Warmeleitfahigkeit von schü ttungen bei naβigen temperaturen 显示文摘 | Zehner P Schlü nder E U | 1970 | Chem Ing Tech1970，42，： | 2 |
| 10 | 采用UV光诱导微孔发泡产生3D结构的胶印新方法显示文摘0引言近年来,科研人员研发出多种新型印刷技术和印刷油墨,以实现不同基底上制备凸起三维(3D)结构。本研究开发出一种基于光化学反应的新型发泡油墨,无须其他辅助工艺。 | Sandra Schlgl Martin Reischl Volker Ribitsch Wolfgang Kern 何文 | 2012 | 中国印刷与包装研究2012，4，2： | 2 |
| 11 | Norm-Conserving Pseudopotentials 显示文摘 | Hamann D R Schlüter M Chiang C | 1979 | Phys Rev Lett1979，43，： | 1 |
| 12 | Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease显示文摘 | SCHLCHINGER V BRITTEN M B ZEIHER AM | 2000 | Circulation2000，101，： | 1 |
| 13 | Molecular and cellular function of the proprotein convertase subtilisin/kexin type 9 (PCSK9)显示文摘 | Rainer Schulz Klaus-Dieter Schlüter Ulrich Laufs | 2015 | Basic Research in Cardiology2015，，： | 1 |
| 14 | Parkinson-like syndrome induced by continuous MPTP infusion:convergent roles of the ubiquitin-proteasome system and α-synuclein显示文摘 | Fornai F Schlüter OM Lenzi P | 2005 | Proc Natl Acad Sci USA2005，102，9： | 1 |
| 15 | Rational design of nanostructured copper-zinc oxide catalysts for the steam reforming of methanol显示文摘 | KNIEP B L RESSLER T RABIS A GIRGSDIES F BAENITZ M STEGLICH F SCHL(O)GL R | 2004 | Angew Chem Int Ed2004，43，1： | 1 |
| 16 | Indications and contraindications for vertebroplastyand kyphoplasty显示文摘 | Rllinghoff M Zarghooni K Schlüter-Brust K | 2010 | Arch Orthop Trauma Surg2010，130，6： | 1 |
| 17 | Single nucleotide polymorphisms derived from ancestral populations show no evidence for biased diversity estimates in Drosophila melanogaster显示文摘 | Schl(o)tterer C Harr B | | 0，，05： | 1 |
| 18 | S-nitrosation of mitochondrial connexin 43 regulates mitochondrial function显示文摘 | Daniel Soetkamp Tiffany T. Nguyen Sara Menazza Christine Hirschh?user Ulrike B. Hendgen-Cotta Tienush Rassaf Klaus D. Schlüter Kerstin Boengler Elizabeth Murphy Rainer Schulz | 2014 | Basic Research in Cardiology2014，，5： | 1 |
| 19 | Blomass burning aerosol emissions from vegetation fires:Particle number and mass emission factors and size distnibutions显示文摘 | Janh 11 S Andreae M O P schl U | | 0，，03： | 1 |
| 20 | Fluorescence imaging inside an internal combustion engine using tunable excimer lasers显示文摘 | Andresen P Meijer G Schlüter H | 1990 | Appl Opt1990，29，： | 1 |
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