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| 1 | Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics显示文摘交往受体的蛋白质 kinase-3 (RIP3 或 RIPK3 ) 是执行 “ 的细胞的机械的必要部分; programmed”或 “ regulated”坏死。这里,我们证明那规划坏死响应许多化学疗法的代理人被激活并且贡献导致化疗的房间死亡。然而,我们证明那 RIP3 表情经常在化学疗法的死亡期间由于它的 transcriptional 开始地点, MLKL 的这样 RIP3 依赖的激活和下游地规划的坏死附近的 genomic methylation 是在癌症房间的 silenced 大部分被镇压。不过,有 hypomethylating 代理人的治疗恢复 RIP3 表示,并且从而以一种 RIP3 依赖的方式把敏感提升到 chemotherapeutics。RIP3 表示在 85% 乳癌病人与正常织物相比在肿瘤被减少,建议那 RIP3 缺乏断然在肿瘤生长 / 发展期间被选择。因为 hypomethylating 代理人在病人是相当容忍得好的,我们建议病人们可以从收到 hypomethylating 代理人与常规 chemotherapeutics 在治疗以前导致 RIP3 表示有益于的那 RIP3 缺乏的癌症。 | Gi-Bang Koo Michael J Morgan Da-Gyum Lee Woo-Jung Kim Jung-Ho Yoon Ja Seung Koo Seung I1 Kim Soo Jung Kim Mi Kwon Son Soon Still Hong Jean M Mulcahy Levy Daniel A Pollyea Craig T Jordan Pearlly Yan David Frankhouser Deedra Nicolet Kati Maharry Guido Marcucci Kyeong Sook Choi Hyeseong Cho ndrew Thorbum You-Sun Kim | 2015 | Cell Research2015，25，6： | 20 |
| 2 | Role of microbial dysbiosis in the pathogenesis of esophageal mucosal disease:A paradigm shift from acid to bacteria?显示文摘Genomic sequencing,bioinformatics,and initial speciation(e.g.,relative abundance)of the commensal microbiome have revolutionized the way we think about the“human”body in health and disease.The interactions between the gut bacteria and the immune system of the host play a key role in the pathogenesis of gastrointestinal diseases,including those impacting the esophagus.Although relatively stable,there are a number of factors that may disrupt the delicate balance between the luminal esophageal microbiome(EM)and the host.These changes are thought to be a product of age,diet,antibiotic and other medication use,oral hygiene,smoking,and/or expression of antibiotic products(bacteriocins)by other flora.These effects may lead to persistent dysbiosis which in turn increases the risk of local inflammation,systemic inflammation,and ultimately disease progression.Research has suggested that the etiology of gastroesophageal reflux disease-related esophagitis includes a cytokine-mediated inflammatory component and is,therefore,not merely the result of esophageal mucosal exposure to corrosives(i.e.,acid).Emerging evidence also suggests that the EM plays a major role in the pathogenesis of disease by inciting an immunogenic response which ultimately propagates the inflammatory cascade.Here,we discuss the potential role for manipulating the EM as a therapeutic option for treating the root cause of various esophageal disease rather than just providing symptomatic relief(i.e.,acid suppression). | Steve M D'Souza Kevin Houston Lauren Keenan Byung Soo Yoo Parth J Parekh David A Johnson | 2021 | World Journal of Gastroenterology2021，27，18： | 8 |
| 3 | 如何设计高质量针刺临床研究:基于证据的专家共识显示文摘本针刺随机对照试验(Randomised controlled trials, RCT)专家共识是基于目前针刺试验面临的最普遍、最关键问题,由临床医生、研究人员、从事针灸和外科的临床试验专家、统计专家、临床流行病学和方法学专家以及患者组成的国际临床研究小组联合制订。该共识将有助于临床试验资助者、注册者以及期刊编辑等评估针刺RCT方案及研究结果的相关性、重要性和质量。 | 张誉清 焦睿珉 Claudia M Witt 劳力行 刘建平 Lehana Thabane Karen J Sherman Mike Cummings Dawn P Richards Eun-Kyung Anna Kim Tae-Hun Kim Myeong Soo Lee Michael E Wechsler Benno Brinkhaus Jun J Mao Caroline A Smith 岗卫娟 刘保延 刘志顺 刘岩 郑晖 吴佳霓 AloBSO Carrasco-Labra Mohit Bhandari Philip J Devereaux 景向红 Gordon Guyatt | 2022 | 英国医学杂志中文版2022，25，6： | 7 |
| 4 | Efficacy and safety of ecabet sodium on functional dyspepsia:A prospective,double-blinded,randomized,multi-center controlled trial显示文摘瞄准:在减轻机能性消化不良的症状比较 ecabet 钠和 cimetidine。方法:我们执行了一个多中心,未来,使随机化,双 blinded 控制了试用在病人把 ecabet 钠和 cimetidine 的临床的功效与机能性消化不良作比较。二 -- 有完成 Rome-II 标准的消化不良的症状的 172 个病人从 7 个中心被注册。在学习组(115 个病人) , 1.5 g ecabet 钠一天被给两次。在控制组(121 个病人) , 400 mg cimetidine 一天被给两次。生命的质量的症状和参数在基线被分析,在开始治疗以后的 3, 14,和 28 d。结果:二 -- 136 个病人完成了临床的试用。在治疗的 4 wk 以后,在有消化不良的症状的病人的改进的率不在二个组之间是不同的(77.4% 在 ecabet 组织,分别地, 79.3% 在 cimetidine 组织 P >
0.05 ) 。同样,征兆的改进的率不在 3 d 和 14 d 是不同的。生命的质量的参数没在两个组在学习时期期间显著地变化。在两个组没有临床上重要的不利事件。结论:在有机能性消化不良的病人, ecabet 钠与 cimetidine 有类似的临床的功效。 | Jun Haeng Lee Jae J Kim Ki-Baik Hahm Dong Ho Lee Nayoung Kim Sung Kook Kim Jong Jae Park Seok Reyol Choi Jong Hun Lee Soo Teik Lee Eun Hyun Lee Jong Chul Rhee | 2006 | World Journal of Gastroenterology2006，12，17： | 3 |
| 5 | 新技术新装置提高炼能——石脑油催化裂解(ACO)生产低碳烯烃显示文摘源自蒸汽裂解和炼油厂的丙烯将无法满足未来对丙烯的需求,所以新技术的盛行也并非偶然。ACO工艺采用直馏石蜡基馏份作为原料,可以生产比传统热裂解工艺更多的烯烃,丙烯/乙烯比(P/E)之比高达1:1。如今,SK能源公司已建造了世界上第一个ACO装置,并在2010年最后一个季度投入生产。接下来,商业催化剂的性能会进一步被验证。 | Michael J Tallman Curtis Eng Sun Choi Deuk Soo Park | 2011 | 科技信息(石油与装备)2011，，1： | 2 |
| 6 | Living Donor Kidneys:Usefulness of Multi-Detector Row CT for Comp rehensive Evaluation显示文摘 | Jeong K Soo Y Heon J | 2003 | Radiology2003，229，： | 1 |
| 7 | The influence of the adiponectin gene on adiponectin concentrations and parameters of metabolic syndrome in ono-diabetie Korean women 显示文摘 | Yangsoo J Jey SC Soo JK | 2008 | Clinica Chimica Acta2008，391，12： | 1 |
| 8 | Redescription of Azpeytia shirakii Hurkmans(Diptera:Syrphidae) first recor ded genus and species in Korea显示文摘 | DEUK SOO C YONG J K HO-YEON H | 2007 | Entomological Research2007，37，1： | 1 |
| 9 | Poly(amide-ester)s from p-Aminobenzoic Acid显示文摘 | Samuel J Huang Soo Hyun Kim | 1998 | Polymer International1998，46，： | 1 |
| 10 | Effect of microstructure and relaxation behavior on the high temperature low cycle fatigue of near-α-Ti-l100显示文摘 | DUCK H L SOO W N SEUNG J C | 2000 | Materials Science and Engineering2000，291，： | 1 |
| 11 | New hybrid method for simultaneousimprovement of tensile and impact properties of carbon fiber reinforcedcomposites显示文摘 | Seong Y K Soo J B Jae R Y | 2011 | Carbon2011，49，15： | 1 |
| 12 | Perineural pretreatment of bee venom attenuated the development of allodynia in the spinal nerve ligation injured neuropathic pain model;an experimental study显示文摘 | Uk K W Soo C S Hyuk L J | 2014 | BMC complementary and alternative medicine2014，14，1： | 1 |
| 13 | Interferon-τ Prospects for Clinical Use in Autoimmune Disorders 显示文摘 | Soos J M Johnson H M | 1999 | BioDrugs1999，11，2： | 1 |
| 14 | CX3CR1+ interstitial dendritic cells form a contiguous network throughout the entire kidney显示文摘 | Soos T J Sims T N Barisoni L Lin K Littman D R Dustin M L | 2006 | Kidney lnt2006，70，： | 1 |
| 15 | A statistical model-based voice activity detection显示文摘 | Sohn J Soo Kim N Wonyong S | 1999 | IEEE Signal Processing Letters1999，6，1： | 1 |
| 16 | Evapotranspiration and crop coefficient of common reed at the surroundings of Lake Balaton, Hungary显示文摘 | Anda A da Silva J A T Soos G | 2014 | Aquatic Botany2014，116，： | 1 |
| 17 | Drug release mechanism of paclitaxel from a chitosan-lipid implant system:effect of swelling,degradation and morphology显示文摘 | Lim Soo P Cho J Grant J | 2008 | Eur J Pharm Biopharm2008，69，1： | 1 |
| 18 | Eradication of helieobaeter pylori for non-ulcer dyspepsia 显示文摘 | MOAYYEDI P SOO S DEEKS J | 2005 | Coehrane Database Syst Rev2005，19，02： | 1 |
| 19 | A generalized approach to the design of variable fractional-delay FIR digital filters 显示文摘 | Shu Jong J Y Pei Soo Chang | 2008 | Signal Processing2008，88，6： | 1 |
| 20 | 显示文摘 | Soo E W Wang J P Smith C J | 2001 | J Magn Magn Mater2001，235，： | 1 |
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