|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Scavenger receptor BI: A multi-purpose player in cholesterol and steroid metabolism显示文摘Scavenger receptor class B type Ⅰ (SR-BI) is an important member of the scavenger receptor family of integral membrane glycoproteins. This review highlights studies in SR-BI knockout mice, which concern the role of SR-BI in cholesterol and steroid metabolism. SR-BI in hepatocytes is the sole molecule involved in selective uptake of cholesteryl esters from high-density lipoprotein (HDL). SR-BI plays a physiological role in binding and uptake of native apolipoprotein B (apoB)-containing lipoproteins by hepatocytes, which identif ies SR-BI as a multipurpose player in lipid uptake from the blood circulation into hepatocytes in mice. In adrenocortical cells, SR-BI mediates the selective uptake of HDL-cholesteryl esters, which is eff iciently coupled to the synthesis of glucocorticoids (i.e. corticosterone). SR-BI knockout mice suffer from adrenal glucocorticoid insuff iciency, which suggests that functional SR-BI protein is necessary for optimal adrenal steroidogenesis in mice. SR-BI in macrophages plays a dual role in cholesterol metabolism as it is able to take up cholesterol associated with HDL and apoBcontaining lipoproteins and can possibly facilitate cholesterol efflux to HDL. Absence of SR-BI is associated with thrombocytopenia and altered thrombosis susceptibility, which suggests a novel role for SR-BI in regulating platelet number and function in mice. Transgenic expression of cholesteryl ester transfer protein in humanized SR-BI knockout mice normalizes hepatic delivery of HDL-cholesteryl esters. However, other pathologies associated with SR-BI def iciency, i.e. increased atherosclerosis susceptibility, adrenal glucocorticoid insuffi ciency, and impaired platelet function are not normalized, which suggests an important role for SR-BI in cholesterol and steroid metabolism in man. In conclusion, generation of SR-BI knockout mice has signif icantly contributed to our knowledge of the physiological role of SR-BI. Studies using these mice have identif ied SR-BI as a multi-purpose player in cholesterol and steroid metabolism because it has distinct roles in reverse cholesterol transport, adrenal steroidogenesis, and platelet function. | Menno Hoekstra Theo JC Van Berkel Miranda Van Eck | 2010 | World Journal of Gastroenterology2010，16，47： | 11 |
| 2 | The Or Gene Enhances Carotenoid Accumulation and Stability During Post-Harvest Storage of Potato Tubers显示文摘在主食庄稼的维生素原 A 类胡萝卜素不在存储期间是很稳定的,他们的损失损害营养的质量。阐明位于类胡萝卜素累积和稳定性下面的基本机制,我们调查了表示了花椰菜橘子的转基因的土豆 tubers (或) 基因。我们发现 Or transgene 不仅支持了叶红素水平的保留,而且连续地在冷存储的 5months 期间刺激了它的累积。相反,类胡萝卜素的增加的层次都没在存储的一样的时期期间在向量唯一的控制或一个黄肉的变化的 tubers 被观察。增加的类胡萝卜素累积被发现与扣押的 lipoproteincarotenoid 的形成被联系结构,以及与提高的许多 phytoene synthase,在类胡萝卜素 biosynthetic 小径的关键酶。而且,存储的维生素原 A 类胡萝卜素被显示在模仿的消化期间稳定并且为由人的肠的吸收性的房间的举起可存取。Proteomic 分析识别了蛋白质的三个主要的功能的组(即热吃惊蛋白质, glutathione-S-transferases,和糖类新陈代谢的蛋白质) 那在或调整类胡萝卜素累积是潜在地重要的。我们的结果证明类胡萝卜素隐遁能力的那条规定是类胡萝卜素稳定性被调整的重要机制。我们的调查结果建议在主食庄稼的合适的水池结构形成的那正式就职可以向庄稼提供在植物生长和收获以后的存储期间支持或稳定维生素原 A 累积的一个唯一的能力。 | Li Li Yong Yang Qiang Xu Katherine Owsiany Ralf Welsch Chureeporn Chitchumroonchokchai Shan Lu Joyce Van Eck Xiu-Xin Deng Mark Failla Theodore W. Thannhauser | 2012 | Molecular Plant2012，5，2： | 8 |
| 3 | Phased,chromosome-scale genome assemblies of tetraploid potato reveal a complex genome,transcriptome,and predicted proteome landscape underpinning genetic diversity显示文摘Cultivated potato is a clonally propagated autotetraploid species with a highly heterogeneous genome.Phased assemblies of six cultivars including two chromosome-scale phased genome assemblies revealed extensive allelic diversity,including altered coding and transcript sequences,preferential allele expression,and structural variation that collectively result in a highly complex transcriptome and predicted proteome,which are distributed across the homologous chromosomes.Wild species contribute to the extensive allelic diversity in tetraploid cultivars,demonstrating ancestral introgressions predating modern breeding efforts.As a clonally propagated autotetraploid that undergoes limited meiosis,dysfunctional and deleterious alleles are not purged in tetraploid potato.Nearly a quarter of the loci bore mutations are predicted to have a high negative impact on protein function,complicating breeder’s efforts to reduce genetic load.The StCDF1 locus controls maturity,and analysis of six tetraploid genomes revealed that 12 allelic variants of StCDF1 are correlated with maturity in a dosage-dependent manner.Knowledge of the complexity of the tetraploid potato genome with its rampant structural variation and embedded deleterious and dysfunctional alleles will be key not only to implementing precision breeding of tetraploid cultivars but also to the construction of homozygous,diploid potato germplasm containing favorable alleles to capitalize on heterosis in F1 hybrids. | Genevieve Hoopes Xiaoxi Meng John P.Hamilton Sai Reddy Achakkagari Fernanda de Alves Freitas Guesdes Marie E.Bolger Joseph J.Coombs Danny Esselink Natalie R.Kaiser Linda Kodde Maria Kyriakidou Brian Lavrijssen Natascha van Lieshout Rachel Shereda Heather K.Tuttle Brieanne Vaillancourt Joshua C.Wood Jan Mde Boer Nolan Bornowski Peter Bourke David Douches Herman Jvan Eck Dave Ellis Max J.Feldman Kyle M.Gardner Johannes C.P.Hopman Jiming Jiang Walter S.De Jong Joseph C.Kuhl Richard G.Novy Stan Oome Vidyasagar Sathuvalli Ek Han Tan Remco A.Ursum M.Isabel Vales Kelly Vining Richard G.F.Visser Jack Vossen G.Craig Yencho Noelle L.Anglin Christian W.B.Bachem Jeffrey B.Endelman Laura M.Shannon Martina V.Stromvik Helen H.Tai Bjorn Usadel C.Robin Buell Richard Finkers | 2022 | Molecular Plant2022，15，3： | 4 |
| 4 | Tomato fruit as a model for tissue-specific gene silencing in crop plants显示文摘Use of CRISPR-Cas9(Clustered Regularly Interspaced Short Palindromic Repeats(CRISPR)-CRISPR-associated 9)-mediated genome editing has proliferated for use in numerous plant species to modify gene function and expression,usually in the context of either transient or stably inherited genetic alternations.While extremely useful in many applications,modification of some loci yields outcomes detrimental to further experimental evaluation or viability of the target organism.Expression of Cas9 under a promoter conferring gene knockouts in a tissue-specific subset of genomes has been demonstrated in insect and animal models,and recently in Arabidopsis.We developed an in planta GFP(green fluorescent protein)assay system to demonstrate fruit-specific gene editing in tomato using a phosphoenolpyruvate carboxylase 2 gene promoter.We then targeted a SET-domain containing polycomb protein,SlEZ2,previously shown to yield pleiotropic phenotypes when targeted via ^(35)S-driven RNA interference and we were able to characterize fruit phenotypes absent additional developmental perturbations.Tissue-specific gene editing will have applications in assessing function of essential genes otherwise difficult to study via germline modifications and will provide routes to edited genomes in tissues that could not otherwise be recovered when their germline modification perturbs their normal development. | Ari Feder Sarah Jensen Anquan Wang Lance Courtney Lesley Middleton Joyce Van Eck Yongsheng Liu James J.Giovannoni | 2020 | Horticulture Research2020，7，1： | 2 |
| 5 | Investigation of Li-ion transport in Li7P3S11 and solid-state lithium batteries显示文摘The high Li-ion conductivity of the Li7P3S11 sulfide-based solid electrolyte makes it a promising candidate for all-solid-state lithium batteries. The Li-ion transport over electrode-electrolyte and electrolyteelectrolyte interfaces, vital for the performance of solid-state batteries, is investigated by impedance spectroscopy and solid-state NMR experiments. An all-solid-state Li-ion battery is assembled with the Li7P3S11 electrolyte, nano-Li2S cathode and Li-In foil anode, showing a relatively large initial discharge capacity of 1139.5 m Ah/g at a current density of 0.064 m A/cm^ 2 retaining 850.0 m Ah/g after 30 cycles. Electrochemical impedance spectroscopy suggests that the decrease in capacity over cycling is due to the increased interfacial resistance between the electrode and the electrolyte. 1D exchange ^7Li NMR quantifies the interfacial Li-ion transport between the uncycled electrode and the electrolyte, resulting in a diffusion coefficient of 1.70(3) ×10^-14cm^2/s at 333 K and an energy barrier of 0.132 e V for the Li-ion transport between Li2S cathode and Li7P3S11 electrolyte. This indicates that the barrier for Li-ion transport over the electrode-electrolyte interface is small. However, the small diffusion coefficient for Li-ion diffusion between the Li2S and the Li7P3S11 suggests that these contact interfaces between electrode and electrolyte are relatively scarce, challenging the performance of these solid-state batteries. | Chuang Yu Swapna Ganapathy Ernst R.H.van Eck Lambert van Eijck Niek de Klerk Erik M.Kelder Marnix Wagemaker | 2019 | Journal of Energy Chemistry2019，28，11： | 2 |
| 6 | Is tolerance to summer flooding correlated with distribution patterns in river floodplains? A comparative study of 20 terrestrial grassland species 显示文摘 | Van Eck W H J M Van de Steeg H M Blom C W P M De Kroon H | 2004 | Oikos2004，107，： | 1 |
| 7 | C, eochemistry of major elements and trace metals in suspended matter of the Scheldt estuary,southwest Netherhmds显示文摘 | ZWOLSMAN John J G van ECK GUSBERTUS T M | 1999 | Marine Chemistry1999，66，： | 1 |
| 8 | Organogenesis from transformed tomato explants显示文摘 | Frary A Van Eck J | 2005 | Methods Mol Biol2005，286，： | 1 |
| 9 | Long-term cardiac survival after reoperative coronary artery bypass grafting显示文摘 | Noyez L van Eck F M | 2004 | Eur J Cardiothorac Surg2004，25，1： | 1 |
| 10 | Software survey: VOSviewer, a computer program for bibliometric mapping 显示文摘 | Van Eck N J Waltman L | 2010 | Scientometrics2010，84，2： | 1 |
| 11 | A Compari- son of Two Techniques for Bibliometric Mapping:Multidimensional Scaling and VOS显示文摘 | Van Eck NJ Waltman L Dekker R etal | 2010 | J Am Soc In- form Sci Tech2010，61，12： | 1 |
| 12 | Individualized anterior cruciate ligament surgery:a prospective study comparing anatomic single-and double-bundle reconstruction显示文摘 | Hussein M van Eck CF Cretnik A | 2012 | Am J Sports Med2012，40，8： | 1 |
| 13 | GIS and Models of Accessibility Potential:An Application in Planning显示文摘 | Ritsema Van Eck J R | 1995 | International Journal of Geographical Information Systems1995，9，1： | 1 |
| 14 | Some comments on the question whether cooccurrence data should be normalized显示文摘 | Waltman L Van Eck N J | 2007 | Journal of the American Society for Information Science and Technology2007，58，11： | 1 |
| 15 | GIS and mod- els of accessibility potential An application in planning显示文摘 | GEERTMAN S C M RITSEMA VAN ECK J R | 1995 | In ternational Journal of Geographical Information Systems1995，9，1： | 1 |
| 16 | The spatial con-figuration of airline networks in Europe显示文摘 | Burghouwt G Hakfoort J Ritsema Van Eck J | 2003 | Journal of Air Trans-port Management2003，9，5： | 1 |
| 17 | Some comments on the question whether co - occurrence data should be normalized 显示文摘 | Waltman L Van Eck N J | 2007 | Journal of the American Society for Information Science and Technology2007，58，11： | 1 |
| 18 | How to normalize cooccu-rrence data? An analysis of some well-known similarity measures显示文摘 | Van Eck N J Waltman L | 2009 | Journal of the American Society For Information Science and Technology2009，60，8： | 1 |
| 19 | Effect of human scavenger receptor class A overexpression in bone marrow-derived cells on cholesterol levels and atherosclerosis in ApoE- deficient mice 显示文摘 | van Eck M de Winther MP Herijgers N | 2000 | Arterioscler Thromb Vasc Biol2000，20，12： | 1 |
| 20 | The Internation- al Federation of Digital Seismograph Networks (FDSN) : An Integrated System of Seismological Observatories 显示文摘 | Suarez G van Eck T Giardini D | 2008 | Systems Journal IEEE2008，2，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员