|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 新型冠状病毒基因组序列的网络平台与基因分型显示文摘新型冠状病毒(SARS-CoV-2)是引起2019新型冠状病毒肺炎(COVID-19)的病原体,目前COVID-19仍在世界范围内大规模流行。随着学者对SARS-CoV-2研究的不断深入,以及各大数据库的序列资源共享,一些学者开发了SARS-CoV-2相关序列分析网络在线平台,并发表了对SARS-CoV-2基因分型、命名的规则。'GISAID'是目前SARS-CoV-2基因组序列共享和储存最大的数据库,'Nextstrain'和'CoV-GLUE'是国际最常用的SARS-CoV-2序列分析平台。目前有四种比较通用的SARS-CoV-2的基因分型方法,在本文中分别简称为:'中国分型法'、'Pangolin分型法'、'GISAID分型法'和'Nextstrain分型法'。这四种分型方法的定义不尽相同,但又有相似之处。本综述对目前SARS-CoV-2在线分析网络平台和不同的基因分型方法进行了较为系统的介绍、对比和总结。 | 宋洋 许文波 | 2021 | 病毒学报2021，37，1： | 21 |
| 2 | 新型冠状病毒感染患者院内死亡危险因素的Meta分析显示文摘背景新型冠状病毒感染(COVID-19)在全世界大规模流行,已经演变成一场全球的灾难性公共卫生危机;目前关于COVID-19患者院内死亡危险因素的结论尚不统一。目的通过Meta分析探讨COVID-19患者院内死亡的相关危险因素。方法计算机检索Cochrane Library、ScienceDirect、PubMed、Medline、万方数据知识服务平台、中国知网、维普期刊资源整合服务平台,搜索已发表的关于COVID-19患者院内死亡的病例对照研究,检索时限为建库至2021-10-01。筛选文献、提取资料并评价文献质量,采用Stata 15.1软件进行Meta分析,采用Meta回归探索可能的异质性来源。结果最终纳入80篇文献,共405157例患者,其中存活组349923例(86.37%),死亡组55234例(13.63%)。根据纽卡斯尔-渥太华量表(NOS)评分,均为高质量文献。Meta分析结果显示,男性(OR=1.49,95%CI(1.41,1.57),P<0.001)、年龄大(WMD=10.44,95%CI(9.79,11.09),P<0.001)、呼吸困难(OR=2.09,95%CI(1.80,2.43),P<0.001)、疲劳(OR=1.49,95%CI(1.31,1.69),P<0.001)、肥胖(OR=1.46,95%CI(1.43,1.50),P<0.001)、吸烟(OR=1.18,95%CI(1.14,1.23),P<0.001)、脑卒中(OR=2.26,95%CI(1.41,3.62),P<0.001)、肾脏疾病(OR=3.62,95%CI(3.26,4.03),P<0.001)、心血管疾病(OR=2.34,95%CI(2.21,2.47),P<0.001)、高血压(OR=2.23,95%CI(2.10,2.37),P<0.001)、糖尿病(OR=1.84,95%CI(1.74,1.94),P<0.001)、肿瘤(OR=1.86,95%CI(1.69,2.05),P<0.001)、肺部疾病(OR=2.38,95%CI(2.19,2.58),P<0.001)、肝脏疾病(OR=1.65,95%CI(1.36,2.01),P<0.001)、白细胞计数升高(WMD=2.03,95%CI(1.74,2.32),P<0.001)、中性粒细胞计数升高(WMD=1.77,95%CI(1.49,2.05),P<0.001)、总胆红素升高(WMD=3.19,95%CI(1.96,4.42),P<0.001)、天冬氨酸氨基转移酶升高(WMD=13.02,95%CI(11.70,14.34),P<0.001)、丙氨酸氨基转移酶升高(WMD=2.76,95%CI(1.68,3.85),P<0.001)、乳酸脱氢酶升高(WMD=166.91,95%CI(150.17,183.64),P<0.001)、尿素氮升高(WMD=3.11,95%CI(2.61,3.60),P<0.001)、肌酐升高(WMD=22.06,95%CI(19.41,24.72),P<0.001)、C反应蛋白升高(WMD=76.45,95%CI(71.33,81.56),P<0.001)、白介素6升高(WMD=28.21,95%CI(14.98,41.44),P<0.001)、红细胞沉降率升高(WMD=8.48,95%CI(5.79,11.17),P<0.001)是COVID-19患者院内死亡的危险因素;肌痛(OR=0.73,95%CI(0.62,0.85),P<0.001)、咳嗽(OR=0.87,95%CI(0.78,0.97),P=0.013)、呕吐(OR=0.73,95%CI(0.54,0.98),P=0.030)、腹泻(OR=0.79,95%CI(0.69,0.92),P=0.001)、头痛(OR=0.55,95%CI(0.45,0.68),P<0.001)、哮喘(OR=0.73,95%CI(0.69,0.78),P<0.001)、体质指数降低(WMD=-0.58,95%CI(-1.10,-0.06),P=0.029)、淋巴细胞计数降低(WMD=-0.36,95%CI(-0.39,-0.32),P<0.001)、血小板计数降低(WMD=-38.26,95%CI(-44.37,-32.15),P<0.001)、D-二聚体升高(WMD=0.79,95%CI(0.63,0.95),P<0.001)、凝血酶原时间升高(WMD=0.78,95%CI(0.61,0.94),P<0.001)、白蛋白降低(WMD=-1.88,95%CI(-2.35,-1.40),P<0.001)、降钙素原升高(WMD=0.27,95%CI(0.24,0.31),P<0.001)、肌钙蛋白升高(WMD=0.04,95%CI(0.03,0.04),P<0.001)是COVID-19患者院内死亡的保护因素。Meta回归结果显示,国家对性别、肾脏疾病、心血管疾病、哮喘、白细胞计数、中性粒细胞计数、血小板计数、血红蛋白、尿素氮的异质性均有统计学意义(P<0.05)。结论男性、年龄大、呼吸困难、疲劳、肥胖、吸烟、脑卒中、肾脏疾病、心血管疾病、高血压、糖尿病、肿瘤、肺部疾病、肝脏疾病,白细胞计数、中性粒细胞计数、总胆红素、天冬氨酸氨基转移酶、丙氨酸氨基转移酶、乳酸脱氢酶、尿素氮、肌酐、C反应蛋白、白介素6、红细胞沉降率升高可能是COVID-19患者院内死亡的危险因素,肌痛、呕吐、腹泻、头痛、哮喘、体质指数降低、淋巴细胞计数降低、血小板计数降低、D-二聚体升高、凝血酶原时间升高、白蛋白降低、降钙素原升高、肌钙蛋白升高可能是COVID-19患者院内死亡的保护因素。本研究所得出的结论,尚需更多高质量、多中心、大样本、真实世界的研究进一步证实。 | 张炜宗 袁红 孙金栋 於华敏 史明娟 胡海强 何海英 叶利 章慧慧 白幸华 沈超峰 屠思佳 汪洋 王刚 赵晓峰 余涛 李彩荣 张志 周栋徕 蔡梦阳 宁乐 | 2023 | 中国全科医学2023，26，5： | 7 |
| 3 | 毫米波穴位照射治疗新型冠状病毒肺炎的临床效果显示文摘目的 回顾性观察中西医结合治疗联合毫米波穴位照射治疗非危重型新型冠状病毒肺炎患者的临床疗效.方法 选择2020年2月2日-2月19日湖北省红安县人民医院收治的47例新型冠状病毒肺炎患者,中西医结合给予氧疗、抗病毒、对症支持及中成药口服治疗,并每日给予2次毫米波穴位治疗.收集患者毫米波治疗仪使用当天(T1)、第3天(T2)、第10天(T3)及第14天(T4)氧合指数、血氧饱和度等呼吸功能指标,肺部CT变化,每天咳嗽次数和相关血液检测结果.结果 47例患者经中西医结合治疗联合毫米波治疗后,氧合指数及血氧饱和度在第3天(T2)、第10天(T3)及第14天(T4)各时间点与T1比较均显著升高(P<0.05);除T2外,各时间点患者肺部CT 3级百分比与T1比较,差异均有统计学意义(P<0.05);各时间点咳嗽次数及体温与T1比较,差异均有统计学意义(P<0.05);乳酸脱氢酶(LDH)缓慢降低,T4与T1比较,差异具有统计学意义(P<0.05),白细胞、淋巴细胞、血红蛋白、钾、钠、氯较入院时无显著差异;14天(T4)时4例患者检测为阳性,核酸转阴率91.5%.结论 中西医结合毫米波肺部及穴位辐射治疗,在改善新冠肺炎患者氧合指数等临床症状以及促进核酸转阴方面,显示较好疗效,有一定的临床应用价值. | 倪家骧 李敏 梁岚萍 李石良 杨立强 胡俊杰 赵睿 王小平 窦智 李秀华 曹国庆 唐元章 | 2020 | 中华医院感染学杂志2020，30，17： | 6 |
| 4 | 新型冠状病毒感染致肾脏损伤机制进展显示文摘继2003年爆发严重急性呼吸系统综合征(Severe acute respiratory syndrome,SARS)和2013年爆发中东呼吸综合征(Middle East respiratory syndrome,MERS)之后,2019年底发生的新型冠状病毒(SARS-CoV-2)疫情已构成全球大流行。许多感染者最终因多种器官衰竭死亡,其中肾损伤是病毒的主要并发症之一。肾脏损伤对于新冠肺炎患者病情判断及预后评估意义重大,肾素-血管紧张素系统(Renin-Angiotensin-System,RAS)、血管紧张素转换酶Ⅱ(angiotensin converting enzyme 2,ACE2)、细胞因子风暴、细胞外基质金属蛋白酶诱导因子(extracellular matrix metalloproteinase inducer 147,CD147)等与SARS-CoV-2致肾损伤机制密切相关。 | 吕灵璐 柳赟昊 张玲 | 2020 | 公共卫生与预防医学2020，31，4： | 5 |
| 5 | 上海地区328例新型冠状病毒肺炎患者实验室数据分析显示文摘目的分析常用感染与炎症指标及细胞因子检测在新型冠状病毒肺炎(COVID-19)疾病进展中的意义。方法选取2020年1—2月上海市公共卫生临床中心COVID-19患者328例,按疾病程度分为轻型及普通型组和重型及危重型组。回顾性比较各组患者的C反应蛋白(CRP)、红细胞沉降率(ESR)、高敏C反应蛋白(hs-CRP)、肝素结合蛋白(HBP)、乳酸脱氢酶(LDH)、降钙素原(PCT)、白细胞(WBC)计数、淋巴细胞(LPC)计数、白细胞介素(IL)-1β、IL-2、IL-4、IL-5、IL-6、IL-8、IL-10、IL-12P70、IL-17、肿瘤坏死因子-α(TNF-α)、α-干扰素(IFN-α)和γ-干扰素(INF-γ)等20项感染与炎症相关血液学指标的差异。结果与轻型及普通型组比较,重型及危重型组患者年龄更高[68.5(11.5)岁,P<0.01]、住院天数更长[21(10)d,P<0.01]、出院率更低(32.14%,P<0.01);与轻型及普通型组比较,重型及危重型组CRP[55(84.5)mg/L,P<0.01]、hs-CRP[43.58(76.46)mg/L,P<0.01]、HBP[61.37(111.01)ng/mL,P<0.01]、LDH[354.5(150.5)U/L,P<0.01]、PCT[0.09(0.21)mg/L,P<0.01]、IL-5[0.49(1.6)pg/mL,P=0.01]、IL-6[10.78(56.24)pg/mL,P<0.01]、IL-8[12.97(19.4)pg/mL,P<0.01]及IL-10[0.82(1.94)pg/mL,P=0.03]水平升高,LPC[0.77(0.5)×10^9/L,P<0.01]、IL-4[0(0)pg/mL,P<0.01]及IL-17[0(0)pg/mL,P=0.01]水平降低。结论轻型及普通型COVID-19患者的感染与炎症相关指标与重型及危重型患者间存在明显差异。CRP、HBP、hs-CRP和PCT的异常升高提示COVID-19患者病情可能转向重症,LPC、IL-4、IL-6、IL-8和IL-10水平对预测患者病情进展,特别是炎症风暴的发生有重要意义。 | 魏剑浩 郭倩 李海聪 郜梦露 徐盛 戚伟强 凌云 韩伟靖 刘一力 朱召芹 | 2020 | 检验医学2020，35，8： | 4 |
| 6 | Dynamic blood single-cell immune responses in patients with COVID-19显示文摘The 2019 coronavirus disease(COVID-19)outbreak caused by the SARS-CoV-2 virus is an ongoing global health emergency.However,the virus'pathogenesis remains unclear,and there is no cure for the disease.We investigated the dynamic changes of blood immune response in patients with COVID-19 at different stages by using 5'gene expression,T cell receptor(TCR),and B cell receptors(BCR)V(D)J transcriptome analysis at a single-cell resolution.We obtained single-cell mRNA sequencing(scRNA-seq)data of 341,420 peripheral blood mononuclear cells(PBMCs)and 185,430 donotypic T cells and 28,802 donotypic B cells from 25 samples of 16 patients with COVID-19 for dynamic studies.In addition,we used three control samples.We found expansion of dendritic cells(DCs),CD14+monocytes,and megakaryocytes progenitor cells(MP)/platelets and a reduction of naive CD4+T lymphocytes in patients with COVID-19,along with a significant decrease of CD8+T lymphocytes,and natural killer cells(NKs)in patients in critical condition.The type I interferon(IFN-I),mitogen-activated protein kinase(MAPK),and ferroptosis pathways were activated while the disease was active,and recovered gradually after patient conditions improved.Consistent with this finding,the mRNA level of IFN-I signal-induced gene IFI27 was significantly increased in patients with COVID-19 compared with that of the controls in a validation cohort that included 38 patients and 35 controls.The concentration of interferon-a(IFN-a)in the serum of patients with COVID-19 increased significantly compared with that of the controls in an additional cohort of 215 patients with COVID-19 and 106 controls,further suggesting the important role of the IFN-I pathway in the immune response of COVID-19.TCR and BCR sequences analyses indicated that patients with COVID-19 developed specific immune responses against SARS-CoV-2 antigens.Our study reveals a dynamic landscape of human blood immune responses to SARS-CoV-2 infection,providing clues for therapeutic potentials in treating COVID-19. | Lulin Huang Yi Shi Bo Gong Li Jiang Zhixin Zhang Xiaoqi Liu Jialiang Yang Yongquan He Zhilin Jiang Ling Zhong Juan Tang Chunfang You Qi Jiang Bo Long Tao Zeng Mei Luo Fanwei Zeng Fanxin Zeng Shuqiang Wang Xingxiang Yang Zhenglin Yang | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 4 |
| 7 | 新型冠状病毒病(COVID-19)并发心肌损伤的研究现状显示文摘新型冠状病毒病(coronavirus disease 2019,COVID-19)是由急性呼吸综合征新型冠状病毒(SARS-CoV-2)引起的一种感染性极强的严重呼吸系统综合征,目前已形成世界性大爆发,给人类健康和全球经济带来了极大的影响。现有研究表明,COVID-19除了影响呼吸系统外,还对心血管系统有侵害作用,引起心肌损伤,预后较差。本文就现有的COVID-19并发心肌损伤的病原学、潜在的发病机制、相关临床表现特征、治疗原则及预后等方面研究进行论述,旨在加深临床医师对COVID-19并发心肌损伤的认识。 | 姜超 罗东雷 郭靖涛 舒红军 | 2020 | 心脏杂志2020，32，4： | 2 |
| 8 | 新型冠状病毒肺炎诊断研究进展显示文摘新型冠状病毒肺炎(COVID-19)疫情以来,疾病的高传染性使确诊人数剧增,同时死亡人数也在日益增加。现全球已有200余个国家或地区出现感染病例。疾病的早诊可以有效控制疾病传播,同时使感染者得到有效的隔离和救治,提高生存率。目前,中国COVID-19的控制取得了阶段性胜利。本文对COVID-19的临床表现、实验室检查、影像学特征、分子学和血清学确诊方法及中国COVID-19诊疗方案多个修订版本诊断标准的变化进行综述,以期提高人们对该病的认识,为未来的研究提供更多的支持。 | 吴昊 郑锐 | 2021 | 国际呼吸杂志2021，41，2： | 2 |
| 9 | 急性呼吸窘迫综合征中的性别差异显示文摘急性呼吸窘迫综合征(ARDS)是临床常见的危重症,是指由各种原因导致的急性低氧性呼吸衰竭,伴胸部影像学显示的双侧弥漫性肺浸润影。有研究表明性别可能在ARDS的发生、严重程度和预后中具有重要作用,但是由于ARDS的复杂性,其性别差异仍存在争议。本文根据ARDS的病因分类,对由脓毒症、创伤和呼吸道病毒所致ARDS的流行病学进行总结,探讨性别对ARDS的发生、严重程度和临床结局的影响,并简要阐述性别影响ARDS的可能机制,以期为临床治疗ARDS提供新的思路。 | 杨翠 丛竹凯 朱曦 | 2022 | 中华危重病急救医学2022，34，2： | 2 |
| 10 | 新型冠状病毒肺炎下肾脏损伤相关的Meta分析显示文摘目的评价肾脏损害对新型冠状病毒肺炎(coronavirus disease 2019,COVID-19)患者病情进展及预后的影响。方法全面检索中国知网、万方中国学术期刊库、Pubmed、EMBASE和Cochrane数据库,检索时段设定为2019年12月至2020年6月。对文献进行资料提取,应用RevMan 5.2进行分析。结果纳入文献15篇,共计COVID-19病例11448例。Meta分析结果显示,COVID-19患者合并急性肾损伤(acute kidney injury,AKI)后接受重症监护病房(intensive care unit,ICU)治疗的比例明显高于未合并AKI患者(OR=10.83,95%CI 9.43~12.45,Z=33.53,P<0.001),其中,亚洲组COVID-19患者合并AKI占比3.4%,接受ICU治疗占比74.1%,亚组分析显示亚洲组COVID-19患者合并AKI后接受ICU治疗的比例明显高于未合并AKI患者(OR=18.66,95%CI 9.85~35.34,Z=8.98,P<0.001);欧美组COVID-19患者合并AKI占比36.5%,接受ICU治疗的占比53.3%,亚组分析显示欧美组COVID-19患者合并AKI后接受ICU治疗的比例明显高于未合并AKI患者(OR=10.58,95%CI 9.18~12.21,Z=32.40,P<0.001);COVID-19合并AKI患者的死亡风险明显高于未合并AKI患者(OR=56.46,95%CI 15.86~200.96,Z=6.23,P<0.001);COVID-19合并肾损害患者病情恶化及死亡的风险高于未合并肾损害患者(OR=6.40,95%CI 4.14~9.90,Z=8.36,P<0.001),亚组分析显示COVID-19合并尿蛋白阳性患者病情恶化及死亡的风险高于未合并尿蛋白阳性患者(OR=6.27,95%CI 3.88~10.14,Z=7.49,P<0.001),COVID-19合并血肌酐升高患者病情恶化及死亡的风险高于未合并血肌酐升高患者(OR=7.13,95%CI 2.58~19.72,Z=3.79,P<0.001)。结论COVID-19患者合并AKI或仅是合并尿蛋白阳性、血肌酐升高都是病情加重甚至死亡的危险因素,建议在COVID-19患者的诊疗上,通过优化诊疗方案,避免或减少可能增加肾脏负担的措施,并密切关注患者的肾脏损伤情况,在肾脏损伤出现的早期即予以保护和治疗,避免AKI的发生。对已发生的AKI,应及时予以替代治疗,缓解肾脏损害,避免患者病情进一步加重甚至死亡。 | 李天宇 甘文渊 陈文莉 | 2021 | 中华肾脏病杂志2021，37，6： | 1 |
| 11 | 不同新型冠状病毒株感染相关肝损害的差异及其影响因素分析显示文摘目的分析不同新型冠状病毒肺炎(COVID-19)病毒株感染相关肝损害是否存在差异以及肝损害的相关影响因素。方法回顾性收集浙江省确诊的阿尔法病毒株和德尔塔变异株感染的COVID-19患者的流行病学、临床症状、实验室检查以及治疗转归的资料,比较2组肝损害发生率,分析肝损害的影响因素。采用独立样本的t检验或Mann-Whitney U、χ^(2)检验或Fisher精确检验,logsitic回归分析进行统计学分析。结果共纳入了阿尔法病毒株感染患者788例,德尔塔变异株感染者381例。阿尔法组患者接种疫苗的比例为0,而德尔塔组接种疫苗比例为85.30%(P<0.001),阿尔法组患者发热(80.71%比40.94%,P<0.001)比例显著高于德尔塔组、发生危重症的比例显著高于德尔塔组,分别为9.90%和1.57%(P<0.001),德尔塔组病毒转阴时间显著长于阿尔法组(22 d比11 d,P<0.001),阿尔法组患者肝损害的发生率显著高于德尔塔组(20.05%比13.91%,P=0.011)。单因素分析发现肝脏损害风险增加与阿尔法病毒株感染、男性、体质量指数、慢性肝病、发热、腹泻、气促、重症/危重症、肌酸激酶(CK)升高、国际标准化比值(INR)升高和中性粒细胞/淋巴细胞比值升高显著相关,而有咽痛症状的患者发生肝损害的风险显著降低。多因素分析发现气促[OR,2.667(CI:1.389~5.122);P=0.003]、CK升高[OR,2.544(CI:1.414~4.576);P=0.002]和INR升高[OR,1.721(CI:1.074~2.758);P=0.024]是肝损害高危因素,而有咽痛症状[OR,0.424(CI:0.254~0.709);P=0.001]患者发生肝脏损害的风险降低。结论虽然德尔塔变异株毒力比阿尔法病毒株强,但是浙江省感染德尔塔变异株的患者大部分接种过COVID-19疫苗,临床症状更轻,且肝脏损害的发生率及程度也更低。疫苗接种后虽然仍有感染的风险,但是可以减轻症状,显著降低重症和危重症的发生率。 | 俞国栋 连江山 叶婵媛 丁丰 陆颖锋 郝绍瑞 俞炯 杨益大 | 2022 | 中华肝脏病杂志2022，30，5： | 1 |
| 12 | COVID-19 and congenital heart disease:a case series of nine children显示文摘Background Coronavirus disease 2019(COVID-19)is the current pandemic disease without any vaccine or efficient treat-ment to rescue the patients.Underlying diseases predispose the patients to a more severe disease and to a higher mortality rate.However,little evidence exists about COVID-19 outcomes in the pediatric population with congenital heart disease(CHD).Here,we report nine children with COVID-19 and concomitant CHD.Methods Our study included nine children with COVID-19 and concomitant CHD who were admitted to Children Medical Center Hospital during March and April 2020.The patients were classified based on the final outcome(death),and their clinical sign and symptoms,type of CHD,and drugs administered were compared.Results Among the nine patients,two died and we compared different characteristics,laboratory results and clinical findings of these cases based on the mortality.The deceased patients had severe types of CHD,worse arterial blood gases,severe clinical symptoms,higher mean level of partial thromboplastin time and C-reactive protein,and required more medications.Conclusions The present study showed that the general consideration of mild COVID-19 in children does not include patients with CHD and that it is necessary to pay greater attention to children with CHD to determine guidelines for treatment of COVID-19 in these children.Owing to the scarcity of CHD and COVID-19,we reported only nine cases.However,further studies are highly required in this regard. | Elmira Haji Esmaeil Memar Babak Pourakbari Mojtaba Gorgi Meisam Sharifzadeh Ekbatani Amene Navaeian Mahmoud Khodabandeh Shima Mahmoudi Setareh Mamishi | 2021 | World Journal of Pediatrics2021，17，1： | 1 |
| 13 | 炎性指标与新型冠状病毒肺炎患者病情相关性的Meta分析显示文摘背景目前,临床尚缺乏大规模的临床研究和循证证据证明炎性指标与新型冠状病毒肺炎(COVID-19)患者病情的关系。目的分析炎性指标与COVID-19患者病情的相关性,以期提高临床对COVID-19的诊治水平。方法计算机检索PubMed、Scopus、Web of Science、Embase、中国知网(CNKI)、万方数据知识服务平台、维普网(VIP)和中国生物医学文献数据库(CBM),筛选报道COVID-19患者炎性指标的相关文献,检索时间为2020-01-01至2020-05-05。采用Stata 12.0软件进行Meta分析,比较轻型组与重型组患者白细胞计数(WBC)、C反应蛋白(CRP)、降钙素原(PCT)、红细胞沉降率(ESR)、白介素6(IL-6)、白介素10(IL-10)及肿瘤坏死因子α(TNF-α),死亡组与存活组患者WBC、CRP、PCT、ESR、IL-6。结果共纳入45项回顾性研究,共包括7834例COVID-19患者。Meta分析结果显示,重型组患者WBC〔加权均值差(WMD)=1.02,95%CI(0.66,1.39)〕、CRP〔WMD=33.56,95%CI(26.10,41.01)〕、PCT〔WMD=0.08,95%CI(0.05,0.11)〕、ESR〔WMD=10.62,95%CI(5.58,15.67)〕、IL-6〔WMD=29.51,95%CI(19.29,39.74)〕、IL-10〔WMD=2.13,95%CI(1.97,2.28)〕高于轻型组(P<0.05)。死亡组患者WBC〔WMD=4.03,95%CI(3.56,4.50)〕、CRP〔WMD=74.18,95%CI(56.63,91.73)〕、PCT〔WMD=0.26,95%CI(0.11,0.42)〕、ESR〔WMD=10.94,95%CI(4.79,17.09)〕、IL-6〔WMD=59.88,95%CI(19.46,100.30)〕高于存活组(P<0.05)。结论炎性指标升高可能是COVID-19患者病情加重或死亡的危险因素,故炎性指标可作为COVID-19患者住院期间病情恶化的早期预警指标。 | 吉攀 朱洁云 钟枝梅 李红园 庞杰龙 李柏成 张剑锋 | 2020 | 实用心脑肺血管病杂志2020，28，11： | 1 |
| 14 | 深圳市首例本土新型冠状病毒Omicron变异株BA.1和BA.2亚型的基因组特征分析显示文摘为了解本土新型冠状病毒(SARS⁃CoV⁃2)变异株的分子特征,本研究对深圳市首次确认的本土Omicron变异株的BA.1和BA.2亚型毒株进行了基因组特征分析。通过Illumina测序,2022年1月16号和1月18号分别获得了深圳市首次确认的本土Omicron变异株BA.1亚型和BA.2亚型毒株的基因组长度分别为29862nt和29391nt。与参考株Wuhan⁃Hu⁃1(NC_045512.2)比较,深圳BA.1亚型毒株hCoV⁃19/Shenzhen/IVDC⁃01⁃16/2022有60个核苷酸变异位点,深圳本土BA.2亚型毒株hCoV⁃19/Shenzhen/IVDC⁃01⁃18/2022有67个核苷酸变异位点。通过与GISAID数据库序列比对发现,深圳BA.1亚型毒株hCoV⁃19/Shenzhen/IVDC⁃01⁃16/2022与2021年12月加拿大的毒株hCoV⁃19/Canada/NB⁃CHUDGLD⁃1312⁃MM01207R/2021相似性最高,基因组序列一致性为100%。深圳本土BA.2亚型毒株hCoV⁃19/Shenzhen/IVDC⁃01⁃18/2022与2021年12月日本的毒株hCoV⁃19/Japan/IC⁃2879/2021相似性最高,基因组序列仅在ORF6基因上表现出1个核苷酸差异(C27297T)。开展本土的SARS⁃CoV⁃2病毒的分子监测,对预防与控制本地新型冠状病毒肺炎(COVID⁃19)暴发与流行具有重要意义。 | 屈雅丽 陈龙 唐秀娟 陈建成 吕秋莹 孙颖 魏欣仪 卢清菊 高玮 朱灿 李诗敏 周莎 张仁利 胡贵方 何雅青 | 2022 | 病毒学报2022，38，4： | 1 |
| 15 | 补偿收缩混凝土在预制装配式结构屋面防水中的应用显示文摘 | 张文渊 | 2000 | 中国建筑防水2000，，2： | 1 |
| 16 | Usefulness of the CONUT index upon hospital admission as a potential prognostic indicator of COVID-19 health outcomes显示文摘Background:In-hospital mortality in patients with coronavirus disease 2019(COVID-19)is high.Simple prognostic indices are needed to identify patients at high-risk of COVID-19 health outcomes.We aimed to determine the usefulness of the CONtrolling NUTritional status(CONUT)index as a potential prognostic indicator of mortality in COVID-19 patients upon hospital admission.Methods:Our study design is of a retrospective observational study in a large cohort of COVID-19 patients.In addition to descriptive statistics,a Kaplan-Meier mortality analysis and a Cox regression were performed,as well as receiver operating curve(ROC).Results:From February 5,2020 to January 21,2021,there was a total of 2969 admissions for COVID-19 at our hospital,corresponding to 2844 patients.Overall,baseline(within 4 days of admission)CONUT index could be scored for 1627(57.2%)patients.Patients’age was 67.3±16.5 years and 44.9%were women.The CONUT severity distribution was:194(11.9%)normal(0-1);769(47.2%)light(2-4);585(35.9%)moderate(5-8);and 79(4.9%)severe(9-12).Mortality of 30 days after admission was 3.1%in patients with normal risk CONUT,9.0%light,22.7%moderate,and 40.5%in those with severe CONUT(P<0.05).An increased risk of death associated with a greater baseline CONUT stage was sustained in a multivariable Cox regression model(P<0.05).An increasing baseline CONUT stage was associated with a longer duration of admission,a greater requirement for the use of non-invasive and invasive mechanical ventilation,and other clinical outcomes(all P<0.05).The ROC of CONUT for mortality had an area under the curve(AUC)and 95%confidence interval of 0.711(0.676-0746).Conclusion:The CONUT index upon admission is potentially a reliable and independent prognostic indicator of mortality and length of hospitalization in COVID-19 patients. | Adrian K.Bengelloun Guillermo J.Ortega Julio Ancochea Ancor Sanz-Garcia Diego A.Rodriguez-Serrano Guillermo Fernandez-Jimenez Rosa Giron Elena Avalos Joan B.Soriano J.Ignacio de Ulibarri | 2022 | Chinese Medical Journal2022，，2： | 0 |
| 17 | 深圳市一株境外输入新型冠状病毒C.1.2变异株的分子特征分析显示文摘为了了解境外输入的新型冠状病毒(SARS-CoV-2)变异株的分子特征,本研究对2021年6月深圳市一株从南非输入的SARS-CoV-2毒株进行了全基因组测序和序列分析。Illumina测序技术获得的SARS-CoV-2毒株基因组长度为29 567nt。根据'Pango lineages'分型法,本研究测定的毒株属于C.1.2系,该谱系属世界卫生组织定义的监测变异株(Variants Under Monitoring,VUM)成员之一。与参考株Wuhan-Hu-1(NC_045512.2)比较,本研究C.1.2系毒株共出现了58个核苷酸变异位点,其中56个变异位点位于编码区。氨基酸变异位点共有33个,氨基酸变异位点分布于6个开放阅读框,变异数由多到少依次为:S蛋白区12个,ORFlab蛋白区9个,ORF3a蛋白区2个,M区2个,ORF8区2个,E区1个。本研究测定的SARS-CoV-2毒株属我国大陆首例境外输入的C.1.2变异株。开展境外输入的SARS-CoV-2毒株基于基因组测序的分子监测,对防控由境外输入的SARS-CoV-2变异株引起本地新型冠状病毒肺炎(COVID-19)暴发与流行具有重要意义。 | 屈雅丽 陈龙 许文波 张仁利 聂凯 牛培华 陈建成 冯晔囡 武伟华 彭博 魏欣仪 李诗敏 吕秋莹 李玥 邓少玉 胡贵方 何雅青 | 2022 | 病毒学报2022，38，2： | 0 |
| 18 | Mortality of critical care interventions in the COVID-19:A systematic review显示文摘BACKGROUND The novel coronavirus severe acute respiratory syndrome coronavirus 2 is associated with a severe disease known as coronavirus disease 2019(COVID-19).A small percentage of patients with COVID-19 will require intensive care and possibly mechanical ventilation.The mortality of intensive care interventions in patients with COVID-19 remains unclear.AIM To identify mortality rate of COVID-19 patients receiving different interventions in the critical care unit.METHODS We searched OVID Medline,SCOPUS,MedRxIv,preprints.org,and Centers for Disease Control databases from November 2019 to April 10,2020 for articles on COVID-19.Teams of 2 independent reviewers reviewed titles and abstract for studies that reported mortality of human adults with COVID-19 and exposure to a critical care intervention[Intensive care admission,mechanical ventilation,acute hemodialysis,extracorporeal membrane oxygenation,or cardiopulmonary resuscitation(CPR)].We used a descriptive analysis and unweighted averages of mortality across studies.RESULTS Our search identified 6973 articles and 20 met inclusion:17 for intensive care,13 for mechanical ventilation,5 for hemodialysis,2 for extracorporeal membrane oxygenation,and 1 for CPR.Mortality associated with intensive care admission ranged from 9%-83%,with overall mortality 32.5%(95%CI:32.4%-32.6%).Mortality associated with intubation from 16.7%-100%with overall mortality 64.0%(95%CI:62.4%-65.5%).In patients requiring hemodialysis,mortality ranged from 0%-100%,with average mortality 75.3%(95%CI:72.6%-77.4%).CONCLUSION Patients with COVID-19 requiring intensive care have high mortality rates.Authorities can use this data to establish pharmacoeconomic studies to make decisions about allocation of scarce resources if necessary. | Joshua Davis Rebecca Leff Anuj Patel Sriram Venkatesan | 2021 | World Journal of Meta-Analysis2021，9，1： | 0 |
| 19 | 护理学专业本科生新冠肺炎认知现状调查研究显示文摘目的了解护理学专业本科生对新冠肺炎的认知情况,为高校有针对性地制订疫情防控措施提供依据。方法采用便利抽样法,通过问卷星对湖州市两所高校的758名护理学专业本科生进行新冠肺炎相关知识与态度的横断面调查。结果护理学专业本科生新冠肺炎知识问卷得分为(6.1±1.5)分,得分率为76.1%,处于中等水平。不同年级护理学专业本科生新冠肺炎知识问卷得分比较差异有统计学意义(P<0.05)。93.1%的护理学专业本科生认为新冠肺炎造成的危害严重,65.3%的护理学专业本科生相信新冠疫苗上市应用后能有效控制疫情。结论尽管护理学专业本科生新冠肺炎认知水平较高,但也存在认知不全面的问题,且对新冠肺炎有不良心理反应。高校应继续加强新冠肺炎健康宣教,进一步提高护理学专业本科生新冠肺炎认知水平。 | 张利兵 | 2022 | 卫生职业教育2022，40，11： | 0 |
| 20 | Thirty-day mortality of patients with hip fracture during COVID-19 pandemic and pre-pandemic periods:A systematic review and metaanalysis显示文摘BACKGROUND Timely intervention in hip fracture is essential to decrease the risks of perioperative morbidity and mortality.However,limitations of the resources,risk of disease transmission and redirection of medical attention to a more severe infective health problem during coronavirus disease 2019(COVID-19)pandemic period have affected the quality of care even in a surgical emergency.AIM To compare the 30-d mortality rate and complications of hip fracture patients treated during COVID-19 pandemic and pre-pandemic times.METHODS The search of electronic databases on 1st August 2020 revealed 45 studies related to mortality of hip fracture during the COVID-19 pandemic and pre-pandemic times.After careful screening,eight studies were eligible for quantitative and qualitative analysis of data.RESULTS The pooled data of eight studies(n=1586)revealed no significant difference in 30-d mortality rate between the hip fracture patients treated during the pandemic and pre-pandemic periods[9.63%vs 6.33%;odds ratio(OR),0.62;95%CI,0.33,1.17;P=0.14].Even the 30-d mortality rate was not different between COVID-19 non-infected patients who were treated during the pandemic time,and all hip fracture patients treated during the pre-pandemic period(OR,1.03;95%CI,0.61,1.75;P=0.91).A significant difference in mortality rate was observed between COVID-19 positive and COVID-19 negative patients(OR,6.99;95%CI,3.45,14.16;P<0.00001).There was no difference in the duration of hospital stay(OR,-1.52,95%CI,-3.85,0.81;P=0.20),overall complications(OR,1.62;P=0.15)and incidence of pulmonary complications(OR,1.46;P=0.38)in these two-time frames.Nevertheless,the preoperative morbidity was more severe,and there was less use of general anesthesia during the pandemic time.CONCLUSION There was no difference in 30-d mortality rate between hip fracture patients treated during the pandemic and pre-pandemic periods.However,the mortality risk was higher in COVID-19 positive patients compared to COVID-19 negative patients.There was no difference in time to surgery,complications and hospitalization time between these two time periods. | Sujit Kumar Tripathy Paulson Varghese Sibasish Panigrahi Bijnya Birajita Panda Sandeep Velagada Samrat Smrutiranjan Sahoo Monappa A Naik Sharath K Rao | 2021 | World Journal of Orthopedics2021，12，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员