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| 1 | 红光/近红外光响应碳点在肿瘤治疗中的应用进展显示文摘碳点作为一种新型碳纳米材料,具有优异的光学特性、良好的生物相容性以及催化活性,在生物医学、能源、环境等领域展现出巨大的应用潜力。红光/近红外光响应碳点具有组织穿透深度大、生物体自发光干扰较小、对组织损伤小等优点,在生物医学研究领域倍受关注。本文首先介绍了影响碳点吸收/发光的因素,随后评述了近几年红光/近红外光响应碳点在肿瘤治疗中的新进展,主要包括光动力治疗、光热治疗、光动力/光热协同治疗等。同时,针对肿瘤微环境的特点,介绍了微环境响应型碳点及其在肿瘤治疗中的应用研究进展。最后,对碳点在肿瘤治疗领域存在的挑战进行了展望。 | 南福春 薛小矿 葛介超 汪鹏飞 | 2021 | 发光学报2021，42，8： | 12 |
| 2 | 氮掺杂碳点的合成与应用显示文摘碳纳米点(碳点)是一种新型的纳米发光材料,具有优异的发光性能、良好的生物相容性、低毒性、水溶性好和表面易功能化等特性,在光电器件、生物成像、光热治疗等领域展现了潜在应用价值。然而,合成碳点的前驱体材料多种多样,合成方法各有不同,导致其发光机理复杂多样。本文主要针对使用柠檬酸作为碳源、尿素或氨水作为氮源,采用微波和溶剂热的合成方法制备的氮掺杂碳点,探索碳点的发光机理和抑制碳点聚集诱导荧光猝灭的方法,并进一步研究碳点在固态照明、可见光光通讯、生物成像和光热治疗等领域的应用前景。 | 曲松楠 孙铭鸿 田震 鲍鑫 周正杰 周鼎 李迪 | 2019 | 发光学报2019，40，5： | 9 |
| 3 | Programmable deformation of patterned bimorph actuator swarm显示文摘Graphene-based actuators featuring fast and reversible deformation under various external stimuli are promising for soft robotics.However,these bimorph actuators are incapable of complex and programmable 3D deformation,which limits their practical application.Here,inspired from the collective coupling and coordination of living cells,we fabricated a moisture-responsive graphene actuator swarm that has programmable shape-changing capability by programming the SU-8 patterns underneath.To get better control over the deformation,we fabricated SU-8 micropattern arrays with specific geometries and orientations on a continuous graphene oxide film,forming a swarm of bimorph actuators.In this way,predictable and complex deformations,including bending,twisting,coiling,asymmetric bending,3D folding,and combinations of these,have been achieved due to the collective coupling and coordination of the actuator swarm.This work proposes a new way to program the deformation of bilayer actuators,expanding the capabilities of existing bimorph actuators for applications in various smart devices. | Jia-Nan Ma Yong-Lai Zhang Dong-Dong Han Jiang-Wei Mao Zhao-Di Chen Hong-Bo Sun | 2020 | National Science Review2020，7，4： | 5 |
| 4 | 碳点在生物医学领域中的应用显示文摘碳点作为新兴的碳纳米材料之一,由于具有低细胞毒性、强亲水性、良好的生物相容性、优异的光稳定性、可调的发光和易于修饰等独特的理化特性,在生物医学领域具有广泛的应用前景。本综述主要阐述了碳点在生物成像、药物/染料/蛋白/基因的递送和癌症诊断治疗等方面的应用,并探讨了其在生物医学领域应用的当前挑战和未来前景。 | 郑敏 刘坤梅 苏雅 | 2021 | 发光学报2021，42，8： | 4 |
| 5 | Precursor-dependent structural diversity in luminescent carbonized polymer dots(CPDs):the nomenclature显示文摘Carbon dots(CDs)have received immense attention in the last decade because they are easy-to-prepare,nontoxic,and tailorable carbon-based fluorescent nanomaterials.CDs can be categorized into three subgroups based on their morphology and chemical structure:graphene quantum dots(GQDs);carbon quantum dots(CQDs),and carbonized polymer dots(CPDs).The detailed structures of the materials can vary significantly,even within the same category.This property is particularly predominant in chemically synthesized CPDs,as their formation proceeds via the polymerization-carbonization of molecules or polymer precursors.Abundant precursors endow CPDs with versatile structures and properties.A wide variety of carbon nanomaterials can be grouped under the category of CPDs because of their observed diversity.It is important to understand the precursor-dependent structural diversity observed in CPDs.Appropriate nomenclature for all classes and types of CPDs is proposed for the better utilization of these emerging materials。 | Qingsen Zeng Tanglue Feng Songyuan Tao Shoujun Zhu Bai Yang | 2021 | Light(Science & Applications)2021，10，8： | 4 |
| 6 | 光热纳米材料在肿瘤治疗中的研究进展显示文摘基于纳米材料的肿瘤光热治疗是通过特定波长的近红外光照射,实现肿瘤细胞热消融的一项新技术。与传统治疗手段如手术切除、化疗、放疗等相比,光热疗法具有高效、不良反应小、有效抑制肿瘤转移等优点。光热纳米材料大致可分为无机和有机两大类,本文主要对这两类纳米材料进行综述,介绍其在肿瘤光热治疗及联合治疗中所发挥的重要作用,总结目前光热纳米材料的特点及临床应用的潜能。 | 武霖 李卓炘 张韫 邱江红 徐丽霞 蔡茸 杜凤移 | 2020 | 江苏大学学报(医学版)2020，30，3： | 3 |
| 7 | 氮掺杂碳纳米点的研究进展显示文摘碳纳米点由于具有独特的发光特性、良好的生物相容性、低毒性、良好的光稳定性等特性在近年来被广泛关注。这些特性使其在光电器件、可见光通讯、肿瘤治疗、生物成像等领域拥有潜在的应用价值。受到原料和合成方法的影响,碳纳米点材料体系多种多样。本文将系统地综述本课题组近年来以柠檬酸和尿素为主要原料合成的氮掺杂碳纳米点及其物理化学性质,探讨碳纳米点能带调控的方法及原理,并介绍碳纳米点的应用研究进展。 | 李迪 孟李 曲松楠 | 2020 | 中国光学2020，13，5： | 3 |
| 8 | 发光碳纳米点的带隙调控及应用(英文)显示文摘碳点作为一种新型的碳基荧光纳米粒子由于其可调谐发光、高光稳定性、生物相容性和低成本等独特优势而引起了很多关注。在过去的十几年中,碳点的制备和应用取得了巨大进展。然而,由于前体和合成方法的多样性,碳点的光致发光机理具有很大争议。现在人们普遍认为,碳点的光致发光源于电子在带隙的跃迁,并将荧光起源分别归结为碳核跃迁(π-π~*)、表面态跃迁(n-π~*)以及分子荧光团等。本文总结了碳点发光起源的几种可能和机制,分别讨论了通过调控碳点粒径以及进行表面工程处理的方法来实现碳纳米点带隙可调控的高效发光。介绍了通过表面工程、元素掺杂等手段提升碳纳米点光致发光量子产率及其在光电器件、信息存储、生物成像、光热治疗以及光动力治疗中的应用。 | 张博涵 田震 李迪 周鼎 鲍鑫 周正杰 曲松楠 | 2019 | 发光学报2019，40，6： | 2 |
| 9 | 发光可调控CDs@MOFs复合荧光材料制备及其在高显色白光LED中的应用显示文摘选用中性红和硫脲作为原料,制备出一种540 nm波长发射的新型黄光碳点(CDs)水溶液,具有激发依赖特性。选择Al-MOFs和Zn-MOFs分别作为CDs的载体基质,得到CDs@Al-MOFs和CDs@Zn-MOFs两种复合荧光材料,都显示出非激发依赖特性。而CDs@Al-MOFs和CDs@Zn-MOFs的最佳发射峰分别位于555 nm和612 nm,与CDs水溶液540 nm的发射波长相比,都出现不同程度的红移。通过对黄光CDs及其复合荧光材料进行TEM、XRD、FT-IR、XPS、UV-Vis和FL等系列表征,证明其发光机理是由CDs的表面态发光转变为分子态发光占主导地位。通过调整两种复合荧光材料的配比可获得不同发光性能的白光LED器件,当CDs@Al-MOFs与CDs@Zn-MOFs的质量比为1∶0.65时,器件的色温为3968 K、显色指数达82.4,表明该碳点基复合荧光材料在白光LED领域具有广阔的发展前景和应用价值。 | 何俊坚 洪卓宝 余林梁 胡广齐 刘晓瑭 | 2021 | 发光学报2021，42，7： | 1 |
| 10 | Smart nanoparticles for cancer therapy显示文摘Smart nanoparticles,which can respond to biological cues or be guided by them,are emerging as a promising drug delivery platform for precise cancer treatment.The field of oncology,nanotechnology,and biomedicine has witnessed rapid progress,leading to innovative developments in smart nanoparticles for safer and more effective cancer therapy.In this review,we will highlight recent advancements in smart nanoparticles,including polymeric nanoparticles,dendrimers,micelles,liposomes,protein nanoparticles,cell membrane nanoparticles,mesoporous silica nanoparticles,gold nanoparticles,iron oxide nanoparticles,quantum dots,carbon nanotubes,black phosphorus,MOF nanoparticles,and others.We will focus on their classification,structures,synthesis,and intelligent features.These smart nanoparticles possess the ability to respond to various external and internal stimuli,such as enzymes,pH,temperature,optics,and magnetism,making them intelligent systems.Additionally,this review will explore the latest studies on tumor targeting by functionalizing the surfaces of smart nanoparticles with tumor-specific ligands like antibodies,peptides,transferrin,and folic acid.We will also summarize different types of drug delivery options,including small molecules,peptides,proteins,nucleic acids,and even living cells,for their potential use in cancer therapy.While the potential of smart nanoparticles is promising,we will also acknowledge the challenges and clinical prospects associated with their use.Finally,we will propose a blueprint that involves the use of artificial intelligence-powered nanoparticles in cancer treatment applications.By harnessing the potential of smart nanoparticles,this review aims to usher in a new era of precise and personalized cancer therapy,providing patients with individualized treatment options. | Leming Sun Hongmei Liu Yanqi Ye Yang Lei Rehmat Islam Sumin Tan Rongsheng Tong Yang-Bao Miao Lulu Cai | 2023 | Signal Transduction and Targeted Therapy2023，8，12： | 0 |
| 11 | 深红至近红外碳点光热特性研究进展显示文摘碳点(CDs)作为一种新型光热纳米材料引起了肿瘤治疗领域的关注。然而,作为光热剂,碳点在深红(DR)至近红外(NIR)区域的光热转换效率有限。此外,碳点对肿瘤组织的靶向性也是急需解决的一个重要问题。本综述介绍了一些增强碳点深红或近红外吸收和光热转换效率的实用策略,包括尺寸调整、元素掺杂、表面修饰、半导体耦合和生物大分子包覆等。基于这些策略可以构建合适的碳点及其复合物,实现对肿瘤的靶向光热治疗。最后,我们希望建立高效的肿瘤识别和光热治疗一体化系统,实现碳点在肿瘤治疗中的临床应用,并为解决肿瘤相关问题和促进健康发展提供重要的科学意义和应用价值。 | 吴君 曲松楠 | 2024 | 发光学报2024，45，1： | 0 |
| 12 | A nanosystem of copper(II)-disulfiram for cancer treatment with high efficacy and few side effects显示文摘Developing chemotherapy drugs with high efficacy and few side effects has been a bottleneck problem that requires an efficient solution.The active cancer treatment ingredient disulfiram(DSF),inspired by the copper(II)diethyldithiocarbamate complex(CuET),can be used in a one-pot synthesis method to construct a CuET delivery nanosystem(CuET-ZIFCu@HA).Due to the high biocompatibility,targeting of CD44 overexpressed cancer cells,and acid response of zeolitic imidazolate framework(ZIF)materials of hyaluronic acid(HA),we realized that CuET-ZIFCu@HA could become an effective and highly selective cancer treatment.Both in vivo and in vitro experiments have demonstrated that CuET-ZIFCu@HA has robust anti-tumor properties without evident side effects.This research provided a promising strategy for DSF nanosystems that involves simple preparation and high efficacy,both of which are key to reusing DSF in cancer treatment. | Liping ZHAO Xiaoxia WANG Mingxia JIANG Xinghan WU Mogen ZHANG Xiuwen GUAN Jinlong MA Weifen ZHANG | 2021 | Frontiers of Materials Science2021，15，4： | 0 |
| 13 | In situ construction of BiVO_(4)(-)cellulose fibers@CDs(-)polyvinyl alcohol composites for tetracycline photocatalytic degradation显示文摘Non-biodegradable and toxic photocatalysts pose as secondary threats to the environmental security.In this work,non-toxic biocomposites were prepared using natural bamboo cellulose fibers(CF),polyvinyl alcohols(PVAs),BiVO_(4),and carbon dots(CDs)from biomaterials.Thereafter,their optical properties,chemical characterizations,and photocatalytic performances were evaluated.The novel BiVO_(4)(-)CF@CDs(-)PVA composites were prepared via the combined implementation of in situ and impregnation methods.The optical properties revealed that the CDs and fibers increased the range and intensity of light absorption.The PVAs were used as the shield and dispersant to enhance stability because they have numerous chemical groups.In view of the various possible paths of electron migration,the enhanced photocatalytic activity of BiVO_(4)(-)CF@CDs(-)PVA composites for tetracycline degradation was observed under visible light illumination.The origins of the structure,morphology,and optical mechanism in the enhancement of the photocatalytic ability of BiVO_(4)(-)CF@CDs(-)PVA composites were discussed and demonstrated. | WANG Tao LIU XiQing MA ChangChang WEI MaoBin HUO PengWei YAN YongSheng | 2021 | Science China(Technological Sciences)2021，64，3： | 0 |
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