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| 1 | Mechanism of immune tolerance induced by donor derived immature dendritic cells in rat high-risk corneal transplantation显示文摘AIM: To study the role of immature dendritic cells (imDCs) on immune tolerance in rat penetrating keratoplasty (PKP) in high -risk eyes and to investigate the mechanism of immune hyporesponsiveness induced by donor-derived imDCs. ·METHODS: Seventy-five SD rats (recipient) and 39 Wistar rats (donor) were randomly divided into 3 groups: control, imDC and mature dendritic cell (mDC) group respectively. Using a model of orthotopic corneal transplantation in which allografts were placed in neovascularized high -risk eyes of recipient rat. Corneal neovascularization was induced by alkaline burn in the central cornea of recipient rat. Recipients in imDC group or mDC group were injected donor bone marrow-derived imDCs or mDCs of 1 ×10 6 respectively 1 week before corneal transplantation via tail vein. Control rat received the same volume of PBS. In each group, 16 recipients were kept for determination of survival time and other 9 recipients were executed on day 3, 7 and 14 after transplantation. Cornea was harvested for hematoxylin - eosin staining and acute rejection evaluation, Western blot was used to detect the expression level of Foxp3. ·RESULTS: The mean survival time of imDC group was significantly longer than that of control and mDC groups (all P <0.05). The expression level of Foxp3 on CD4 + CD25 + T cells of imDC group (2.24 ±0.18) was significantly higher than that in the control (1.68 ±0.09) and mDC groups (1.46±0.13) (all P <0.05).·CONCLUSION: Donor -derived imDC is an effective treatment in inducing immune hyporesponsiveness in rat PKP. The mechanism of immune tolerance induced by imDC might be inhibit T lymphocytes responsiveness by regulatory T cells. | Xiao-Wei Gao Yan Fu Wen-Jing Li An-Jie Du Xia Li Xu-Dong Zhao | 2013 | International Journal of Ophthalmology(English edition)2013，6，3： | 11 |
| 2 | Clinical correlates of common corneal neovascular diseases: a literature review显示文摘A large subset of corneal pathologies involves the formation of new vessels(neovascularization), leading to compromised visual acuity. This article aims to review the clinical causes and presentations of corneal neovascularization(CNV) by examining the mechanisms behind common CNV-related corneal pathologies, with a particular focus on herpes simplex stromal keratitis,contact lenses-induced keratitis and CNV secondary to keratoplasty. Moreover, we reviewed CNV in the context of different types of corneal transplantation and keratoprosthesis, and summarized the most relevant treatment available so far. | Nizar Saleh Abdelfattah Mohamed Amgad Amira A Zayed Hamdy Salem Ahmed E Elkhanany Heba Hussein Nawal Abd El-Baky | 2015 | International Journal of Ophthalmology(English edition)2015，8，1： | 10 |
| 3 | Host immune cellular reactions in corneal neovascularization显示文摘Corneal neovascularization(CNV) is a global important cause of visual impairment. The immune mechanisms leading to corneal heme- and lymphangiogenesis have been extensively studied over the past years as more attempts were made to develop better prophylactic and therapeutic measures. This article aims to discuss immune cells of particular relevance to CNV, with a focus on macrophages, Th17 cells, dendritic cells and the underlying immunology of common pathologies involving neovascularization of the cornea. Hopefully, a thorough understanding of these topics would propel the efforts to halt the detrimental effects of CNV. | Nizar S.Abdelfattah Mohamed Amgad Amira A Zayed | 2016 | International Journal of Ophthalmology(English edition)2016，9，4： | 5 |
| 4 | Effect of corneal graft diameter on therapeutic penetrating keratoplasty for fungal keratitis显示文摘AIM: To evaluate the effect of corneal graft diameter on therapeutic penetrating keratoplasty(PKP) for fungal keratitis. METHODS: A total of 116 patients (116 eyes) suffered from fungal keratitis underwent PKP at the Affiliated Hospital of Medical College Qingdao University from May 2006 to May 2010. They were divided into two groups according to the corneal graft diameter. 64 eyes' corneal graft diameter was 8.00mm or larger and 52 eyes' graft diameter was smaller than 8.00mm. The follow-up time was 2 years. The postoperative visual acuity and complications were documented and compared. RESULTS: Sixty-two (96.88%) eyes and fifty (96.15%) eyes preserved eyeballs respectively in two groups. There was no statistical difference in postoperative visual acuity (P =0.961), corneal graft clear rate (P =0.132) or the incidence of recurred fungal infection (P =0.770) between two groups. But there was a higher incidence of graft rejection (P =0.020) and secondary glaucoma (P =0.039) in group with corneal graft diameter 8.00mm or larger. CONCLUSION: PKP is an effective treatment approach for fungal keratitis. There is a higher incidence of complications in large-diameter PKP for fungal keratitis.Effective, preventive and therapeutic measures can improve the prognosis. | Cui Li Gui-Qiu Zhao Cheng-Ye Che Jing Lin Na Li Wen-Yan Jia Qiu-QiuZhang Nan Jiang Li-Ting Hu | 2012 | International Journal of Ophthalmology(English edition)2012，5，6： | 5 |
| 5 | Transplantation of tissue-engineered human corneal epithelium in limbal stem cell deficiency rabbit models显示文摘·AIM:To evaluate the biological functions of tissue- engineered human corneal epithelium (TE-HCEP) by corneal transplantation in limbal stem cell deficiency (LSCD) rabbit models.·METHODS:TE-HCEPs were reconstructed with DiI-labeled untransfected HCEP cells and denuded amniotic membrane (dAM) in air-liquid interface culture, and their morphology and structure were characterized by hematoxylin-eosin (HE) staining of paraffin-sections, immunohistochemistry and electron microscopy. LSCD models were established by mechanical and alcohol treatment of the left eyes of New Zealand white rabbits, and their eyes were transplanted with TE-HCEPs with dAM surface outside by lamellar keratoplasty (LKP). Corneal transparency, neovascularization, thickness, and epithelial integrality of both traumatic and post transplantation eyes were checked once a week by slit-lamp corneal microscopy, a corneal pachymeter, and periodic acid-Schiff (PAS) staining. At day 120 post surgery, the rabbits in each group were sacrificed and their corneas were examined by DiI label observation, HE staining, immunohistochemistry and electron microscopy.·RESULTS:After cultured for 5 days on dAM, HCEP cells, maintaining keratin 3 expression, reconstructed a 6-7 layer TE-HCEP with normal morphology and structure. The traumatic rabbit corneas, entirely opaque, conjunctivalized and with invaded blood vessels, were used as LSCD models for TE-HCEP transplantation. After transplantation, obvious edema was not found in TE-HCEP-transplanted corneas which became more and more transparent, the invaded blood vessels reduced gradually throughout the monitoring period. The corneas decreased to normal thickness on day 25, while those of dAM eyes were over 575μm in thickness during the monitoring period. A 4-5 layer of epithelium consisting of TE-HCEP originated cells attached tightly to the anterior surface of stroma was reconstructed 120 days after TE-HCEP transplantation, which was similar to the normal control eye in morphology and structure. In contrast, intense corneal edema, turbid, invaded blood vessels were found in dAM eyes, and no multilayer epithelium was found but only a few scattered conjunctiva-like cells appeared. ·CONCLUSION:The TE-HCEP, with similar morphology and structure to those of innate HCEP, could reconstruct a multilayer corneal epithelium with normal functions in restoring corneal transparency and thickness of LSCD rabbits after transplantation. It may be a promising HCEP equivalent for clinical therapy of corneal epithelial disorders. | Bin Xu Ting-Jun Fan Jun Zhao Ai Sun Rui-Xin Wang Xiu-Zhong Hu Hao-Ze Yu Xian-Yuan Fan and Xiao-Hui Xu | 2012 | International Journal of Ophthalmology(English edition)2012，5，4： | 4 |
| 6 | Trends in the indications for penetrating keratoplasty in Shandong,2005-2010显示文摘AIM:To identify the current indications and the trend shifts for penetrating keratoplasty(PKP) in Shandong.METHODS:The medical charts of all patients who underwent PKP at Shandong Eye Institute from June 1,2005 to May 31,2010 were analysed retrospectively.RESULTS:A total of 875 patients(875 eyes) received PKP in this 5-year period,accounting for 61.6% of all corneal transplantation surgeries.The leading indications for PKP were infectious keratitis(37.1%),HSK(19.1%),keratoconus(11.2%),bullous keratopathy(8.5%),regrafting(6.7%) and corneal scarring(4.8%).The percentage of PKP for keratoconus declined year by year,whereas the percentage of bullous keratopathy had a mild annual increase.Fungal infections accounted for 65.2% of the infectious keratitis cases,remaining the leading cause of corneal infection.In addition,54.1% of bullous keratopathy cases were associated with cataract surgery.The leading initial diagnoses associated with regrafting were infectious keratitis(38.9%),HSK(18.6%) and corneal burn(16.9%).The major causes of regrafting included graft endothelial dysfunction(39.0%),graft ulcer(28.8%) and primary disease recurrence(15.3%).CONCLUSION:Infectious keratitis remained the leading indication for PKP in Shandong,and fungal infections were still the major cause of corneal infections.There was an increasing trend in the percentage of PKP cases indicated for bullous keratopathy but a decline in the same for keratoconus.Even with a decline in the overall proportion among all corneal transplantation surgeries,PKP is still the major corneal transplant choice in Shandong. | Jun-Yi Wang, Jing Zhao | 2011 | International Journal of Ophthalmology(English edition)2011，4，5： | 4 |
| 7 | Morphometric study of endothelial wound-healing following penetrating keratoplasty显示文摘Twenty samples of endothelia removed from normal and post penetrating keratoplas-ty (0.5,1,2,3 months after penetrating keratoplasty) were observed by scanning electron mi-croscopy.The photographs of the endothelia in graft-host junction were analyzed by computer-assisted image analysis system,and the morphometric indexes examined were area of the cells,perimeters,density,figure coefficient,long axis,coefficient of variation of the area,and oth-ers.Results showed that the morphology and the density of the endothelial cells changed obvi-ously after operation and improved slowly but progressively with time although at 3 monthspostoperatively some differences still existed.By using the new techniques,the experiment con-firmed and enriched the theories on the corneal endothelial wound-healing,revealing some ofthe new characters of the endothelial wound-healing following penetrating keratoplasty. | 蒋华 宋振英 林庆华 | 1993 | Journal of Medical Colleges of PLA(China)1993，8，3： | 3 |
| 8 | Central corneal epithelium self-healing after ring-shaped glycerin-cryopreserved lamellar keratoplasty in Terrien marginal degeneration显示文摘Dear Sir, I am Dr Yan-Long Bi, from the Department of Ophthalmology, Tongji University Affiliated to Tongji University School of Medicine, Shanghai, China. I write to present a case report of total limbal stem cells deficiency after treatment with ring-shaped lamellar keratoplasty secondary to Terrien marginal degeneration. During 3 | Yan-Long Bi Felix Bock Qi Zhou Claus Cursiefen | 2013 | International Journal of Ophthalmology(English edition)2013，6，2： | 3 |
| 9 | Clinical analysis of tear film after lamellar keratoplasty显示文摘AIM:To study the tear film stability after lamellar keratoplasty.· METHODS:Five female and eight male patients with lamellar keratoconus,aged from 18 to 32,were involved.After lamellar keratoplasty,SchirmerⅠtest(SⅠt),tear break-up time(BUT) test,fluorescein staining test were used to judge the effect of the surgery at different time point.· RESULTS:The SⅠt were greatly increased in 7 days post operation (11.86±2.28-25.14±1.97,19.86±1.61) (P <0.05),there is no significant difference between 2nd month,3rd month post-operative and pre-operation(11.86±2.28-14.57±1.48,8.14±0.86) (P >0.05).The mean break-up time decreased in 7 days post operation (5.00±1.31-2.71±0.18,2.57±0.20,2.71±0.36,2.43±0.20)(P <0.05).The mean scores of fluorescence increased post-operatively (0.14±0.14-8.00±0.00,8.00±0.00,8.00±0.00,7.57±0.20) (P <0.01).· CONCLUSION:Lamellar keratoplaty influence the tear film stability,artificial tears and improving corneal epithelium cured medicine should be used after surgery. | Wan-Rong Huang Qiu-Lian Chen Jin-Hong Cai and Yue Zhang | 2012 | International Journal of Ophthalmology(English edition)2012，5，1： | 2 |
| 10 | Comparison of long-term results after manual and femtosecond assisted corneal trephination in deep anterior lamellar keratoplasty for keratoconus显示文摘AIM: To compare long-term postoperative outcomes of manual and femtosecond assisted corneal trephination in deep anterior lamellar keratoplasty(FS-DALK) for keratoconus.METHODS: In the retrospective study, 17 consecutive eyes that underwent vertical side cut incision FS-DALK and 22 eyes that underwent trephine incision DALK were collected over a 2-year period. Main measurements included postoperative uncorrected-visual acuity(UCVA), corrected distance visual acuity(CDVA), refractive sphere and cylinder, manifest refraction spherical equivalent(MRSE), flat and steep corneal keratometry(K1 and K2), endothelial cell density(ECD), and time of epithelium healing and suture removal.RESULTS: Groups were comparable for diagnosis and preoperative visual acuity. Follow-up averaged 23 mo(range, 12-36 mo). At 12 mo, the mean UCVA was better in the manual-DALK group(P=0.039), and the refractive sphere was lower in the FS-DALK group(P=0.040). MRSE between groups differed at 1, 6, and 12 mo postoperatively(P=0.047, 0.025, 0.042, respectively). Mean CDVA, cylinder, K1, K2,corneal astigmatism, ECD, and time of epithelium healing were similar between groups. Stability of MRSE, ECD, and K1 returned sooner after FS-DALK. Initial loosened suture removal time was earlier in the manual-DALK group(P=0.042) while complete suture removal time was similar(P=0.122).CONCLUSION: Manual and femtosecond assisted corneal trephination in DALK are options for advanced keratoconus. FS-DALK do not result in improved visual acuity but it is more stable during the follow-up period. FSDALK in the present form show limited benefit, so surgical design and parameters still need to be optimized and explored. | Hua Li Min Chen Yan-Ling Dong Jing Zhang Xian-Li Du Jun Cheng Hua Gao Li-Xin Xie | 2020 | International Journal of Ophthalmology(English edition)2020，13，4： | 2 |
| 11 | Spontaneous wound dehiscence after penetrating keratoplasty显示文摘Spontaneous wound separation may be developed even months after suture removal especially in the context of long-term corticosteroid therapy. A 68-yearold Caucasian woman presented to our cornea clinic with spontaneous wound dehiscence after her third penetrating keratoplasty(PKP) which was performed three years ago. An Ahmed glaucoma valve(New World Medical, Ranchos Cucamonga, CA) was inserted ten months after the third PKP, which successfully controlled intraocular pressure(IOP). At the examination, the last sutures were removed eight months ago and she was using flourometholone 0.1%(Sina Darou, Tehran, Iran)with a dose of once a day. There was one quadrant of wound dehiscence from 8 to 11 o`clock associated with anterior wound gape and severe corneal edema.Resuturing was performed for the patient. At the one month examination, the corneal edema was resolved and best corrected visual acuity was 20/200 mainly due to previous glaucomatous optic neuropathy. Caution about the prolonged use of corticosteroids is necessary. Topical immunosuppressives could be a promising choice in this field. | Alireza Foroutan Seyed Ali Tabatabaei Mahmoud Jabbarvand Behrouz Reza Zarei Mohammad Soleimani | 2014 | International Journal of Ophthalmology(English edition)2014，7，5： | 1 |
| 12 | Combined Descemet stripping automated endothelial keratoplasty and intravitreal dexamethasone implant for concomitant pseudophakic bullous keratopathy and cystoid macular edema显示文摘Dear Editor,Endothelial cell density decreases with age and in various ocular conditions,including corneal endotheliitis,uveitis,pseudoexfoliation syndrome,and birth injury(1)The reduction of endothelial cell density is exacerbated over time after intraocular surgery(1)Descemet stripping automated endothelial keratoplasty(DSAEK)is considered the primary procedure for patients with only endothelial dysfunction. | Gabriella Cirigliano Marco R Pastore Alberto A Perrotta Chiara De Giacinto Daniele Tognetto | 2019 | International Journal of Ophthalmology(English edition)2019，12，5： | 1 |
| 13 | Clinical application of a shape-preserving rapid corneal donor dehydrater显示文摘AIM:To describe the design and clinical application of a corneal donor dehydrator which can quickly dehydrate corneas and keep its original shape.METHODS:The corneal donor material is placed on stainless steel beads with different diameters in the dehydrating box to make the cornea the same shape as the steel ball.Then,the cornea is placed inside the dehydrater for rapid dehydrating using the internal cleaning and ventilation system.Totally 83 eyes underwent deep anterior lamellar keratoplasty(DALK)using corneal donor tissue preserved with corneal dehydrater,and 60 patients(60 eyes)received DALK by the same surgeon using corneal donor tissue preserved with glycerol were included in the control group.The best corrected visual acuity(BCVA),the thickness and transparency of the corneal buttons were recorded.RESULTS:After the completion of dehydrating,all the donor corneas maintained a normal shape without any shrinkage or distortion,and the average intraoperative rehydration time was 43.3±12.1 s during operation.The mean BCVA of the dehydrater group was 0.30±0.18 at 1 wk and 0.32±0.16 at 1 mo,which were statistically better than that of the control group(P<0.001).The score of corneal buttons transparency were lower than that of the control group with statistical difference(P<0.001).The thickness of corneal buttons at 1 wk and at 1 mo in the dehydrater group was significantly better than that of the control group respectively(P<0.001).One week after operation,no corneal button turbidity or edema was observed in both groups.CONCLUSION:The dehydrater can quickly dehydrate the corneal material in a clean and airtight environment and maintain the original shape of the corneal donor during the dehydrating process.This dehydrater is recommended for long-term high-quality preservation in areas where corneal materials cannot be used within a reasonable time period. | Yu Sun Xiao-Lin Qi Xiao Lin Xiao-Yu Zhang Li Gao Hua Gao | 2022 | International Journal of Ophthalmology(English edition)2022，15，5： | 1 |
| 14 | Long-term outcomes of endothelial keratoplasty in Chinese eyes at a University Hospital显示文摘Background:Endothelial keratoplasty(EK)is used increasingly for the management of cases with endothelial dysfunction.Long-term outcomes of the surgery are not widely reported in the literature.We report our experience of EK in Chinese eyes at a University teaching hospital.Methods:Retrospective analysis was performed for all cases of EK performed between 2005 and 2009.Data analyzed included indication for surgery,associated surgical procedures,complications,best-corrected visual acuity(BCVA)and overall graft survival.Results:Overall,22 eyes of 21 patients underwent EK(13 males,8 females,mean age 71.8±11.3 years).Pseudophakic bullous keratopathy was the leading indication for surgery(n=12)followed by Fuchs’endothelial dystrophy(n=4),or both(n=3).Other indications for surgery included failed penetrating keratoplasty(n=2)and endothelial decompensation due to multiple surgeries(n=1).Triple procedure was performed in 5(22.7%)cases.Complications were noted in the form of postoperative interface hemorrhage(n=2,9%)and graft dislocation(n=1,4.5%).The mean postoperative endothelial cell density was 1069±585.8 cells/mm2.The mean postoperative pachymetry was 675.8±108.5μm.The mean preoperative and postoperative intraocular pressure was 11.3±3.2 and 13.9±4.5 mmHg respectively.At the last follow-up(mean,47.4±13.7 months),BCVA was≥20/70 in 9(40.9%)cases.Causes of poor BCVA included primary graft failure(n=4),graft decompensation(n=4),advanced glaucoma(n=2)and irreversible graft rejection(n=2).Graft remained clear in 12(54.5%)cases at the last follow-up.Average graft survival was 19.7±17.7 months(median 17.5 months).Conclusions:Nearly half of the EK grafts in our study survived over a period of five years.Graft failure,glaucoma and graft rejection were the main causes of poor graft survival. | Alvin L Young Rachel PW Kwok Vishal Jhanji Lulu L Cheng Srinivas K Rao | 2014 | Eye and Vision2014，1，1： | 1 |
| 15 | Novel technique of penetrating keratoplasty in high-risk grafts with significant corneal neovascularization显示文摘Dear Editor,We write to introduce a novel technique of penetrating keratoplasty(PK)with lower risk of graft rejection in high-risk grafts.Corneal transplantation may be required in a variety of conditions such as keratoconus,pseudophakic bullous keratopathy(PBK),and corneal scars or dystrophies[1]. | Mohammad Soleimani Nader Mohammadi Mansoor Shahriari Morteza Karimi Ahmed Alshaheeb Atefeh Khalili Mohammad Hossein Zamani Kasra Cheraqpour | 2022 | International Journal of Ophthalmology(English edition)2022，15，9： | 1 |
| 16 | Impact of ultrasound and optical biometry on refractive outcomes of cataract surgery after penetrating keratoplasty in keratoconus显示文摘AIM: To analyse the impact of ultrasound and optical intraocular lens(IOL) calculation methods on refractive outcomes of cataract phacoemulsification performed after penetrating keratoplasty(PK) in keratoconus. METHODS: Phacoemulsification cataract surgery was performed on 42 eyes of 34 patients with keratoconus who had previously undergone PK. The IOL power was determined by using both standard and corneal topography-derived keratometry using the SRK/T formula. We used two independent methods-ultrasound biometry(UB) and interferometry [optical biometry(OB)] for IOL calculation. The analysed data from medical records included demographics, medical history, best corrected visual acuity(BCVA) on Snellen charts, technique of IOL calculation and calculation formula and its impact on final refractive result.RESULTS: BCVA ranged from 0.01 to 0.4(mean 0.09±0.19) before surgery and ranged from 0.2 to 0.7(mean 0.38±0.14) at 1 mo and from 0.2 to 1.0(mean 0.56±0.16)(P<0.05) at 3 mo, postoperatively. The refractive aim differed significantly from the refractive outcome in both the UB and OB groups(P<0.05). There was no statistically significant difference in the accuracy of the two biometry methods.CONCLUSION: The refractive aim in keratoconus eyes post-PK is not achieved with either ultrasound or OB. | Katarzyna Krysik Anita Lyssek-Boron Dominika Janiszewska-Bil Edward Wylegala Dariusz Dobrowolski | 2019 | International Journal of Ophthalmology(English edition)2019，12，6： | 1 |
| 17 | Graft survival and visual outcome after simultaneous penetrating keratoplasty and cataract extraction显示文摘AIM: To evaluate the indications, complications, and visual and graft survival outcomes in eyes that had undergone simultaneous cataract extraction and penetrating keratoplasty (PKP). ·METHODS: We described a retrospective study of 101 patients who had undergone simultaneous cataract extraction and PKP at King Khaled Eye Specialist Hospital between January 1, 2001, and December 31, 2002. All patients were followed up postoperatively with maximum follow-up 68 months. ·RESULTS: The mean age of patients was 61 years. The mean overall follow -up was 27 months. The most common indications for surgery were corneal scarring (45.5% ), previous failed graft (15.8% ), corneal ulcer (12.9% ), Fuchs endothelial dystrophy (8.9% ), stromal dystrophy (2.9% ), and other conditions (14.5% ). Overall, 69 grafts (68.3% ) remained clear at final follow -up. Previous glaucoma or postoperative glaucoma had no statistically significant effects on graft outcome (P >0.05). The graft rejection rate (17.8% ) was a significant risk factor for failure (P =0.00). Age, gender, indications for surgery, corneal graft diameter, and intraoperative vitreous loss had no statistically significant effects on the PKP outcome (P >0.05). Postoperative visual acuity was significantly associated with preoperative visual acuity (P <0.01). ·CONCLUSION: The present study provides evidence that performing a combined procedure results in more rapid visual rehabilitation and good graft clarity. | Mansour M. Al-Mohaimeed | 2013 | International Journal of Ophthalmology(English edition)2013，6，3： | 1 |
| 18 | Changes in endothelial cell density following penetrating keratoplasty and deep anterior lamellar keratoplasty显示文摘· AIM: To compare the corneal endothelial cell density (ECD) of clear grafts after penetrating keratoplasty (PK) and deep anterior lamellar keratoplasty (DALK). · METHODS: The study included 44 and 54 patients treated with PK and DALK, respectively, between March 2006 and April 2010. Corneal ECD was examined using specular microscopy at postoperative 1, 3, 6, 12, and 18 months, and the values were compared. · RESULTS: Corneal ECD reduction in the PK group was 7.4%, 15.2%, 23.5%, and 28.9% at 3, 6, 12 and 18 months respectively after surgery, compared with 4.2 % in the first month (P <0.01). These figures were 3.0%, 6.7%, 7.2%, and 7.7% at 3, 6, 12 and 18 months respectively, compared with 2.2 % in the first month in the DALK group (P >0.05). · CONCLUSION: Compared with DALK,PK significantly reduced ECD of the clear grafts. These results suggest that survival of endothelial cells in grafts is better after DALK than after PK. · | Banu Torun Acar Ece Turan Vural Suphi Acar | 2011 | International Journal of Ophthalmology(English edition)2011，4，6： | 1 |
| 19 | 角膜移植术后抗排斥治疗进展显示文摘角膜移植术(keratoplasty)是指用健康透明的角膜组织置换病变混浊的角膜组织,恢复角膜的透明性和正常角膜组织结构的手术方法。角膜移植术是眼科重要的复明手术之一,也是眼科开口最大的手术,因此并发症发生的概率最高。自1906年由Zirm使用交叉压迫缝线法行部分穿透性角膜移植获得成功后,角膜移植术得到快速发展。随着人们对角膜解剖生理的进一步认识及手术技术的不断提高和完善,角膜移植术的成功率显著提高。 | 洪晶 | 2015 | 实用器官移植电子杂志2015，3，5： | 1 |
| 20 | Corneal transplantation outcomes after the extrusion of an intrastromal keratoprosthesis:a pilot study显示文摘This short report includes 5 eyes of 5 patients(mean age 63.2±12 years)who underwent a tectonic keratoplasty[deep anterior lamellar keratoplasty(DALK)or penetrating keratoplasty(PK)]in order to rehabilitate the eye after the extrusion of the non-perforating keratoprosthesis(Kpro)KeraKlear(KeraMed,USA).The non-perforating Kpro was extruded after a mean period of 21.4±21.8 months due to melting.In two cases,the keratoplasty was performed the same day of the non-perforating Kpro removal due to a severe melting,while in the other three cases it was performed one to 3 months later.Two eyes received a DALK,but in 3 eyes a macroscopic Descemet membrane perforation forced the conversion into a PK.The mean follow-up period after the keratoplasty was 16.8±6.6 months.No cases of rejection were recorded.All the 5 eyes achieved“anatomical success”(transparent graft,with no signs of infection or inflammation).Two eyes showed limited“functional success”because the achievement of the best visual potential was prevented by the development of glaucomatous optic atrophy during the follow-up period.In conclusion,this short report presents an unexpected success of a keratoplasty performed with a tectonic purpose after the extrusion of the non-perforating Kpro because the corneal graft remained transparent,without neovascularization or scarring during the follow-up period.This initial evidence shows some encouraging results regarding graft survival rate and the achievement of a useful visual rehabilitation with keratoplasty after a nonperforating Kpro failure instead of repeating the Kpro implantation. | Chiara Fariselli Ibrahim Toprak Olena Al-Shymali Jorge L.Alio del Barrio Jorge L.Alio | 2020 | Eye and Vision2020，7，1： | 0 |
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