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| 1 | Update on ischemia-reperfusion injury in kidney transplantation: Pathogenesis and treatment显示文摘Ischemia/reperfusion injury is an unavoidable relevant consequence after kidney transplantation and influences short term as well as long-term graft outcome. Clinically ischemia/reperfusion injury is associated with delayed graft function, graft rejection, chronic rejection and chronic graft dysfunction. Ischemia/reperfusion affects many regulatory systems at the cellular level as well as in the renal tissue that result in a distinct inflammatory reaction of the kidney graft. Underlying factors of ischemia reperfusion include energy metabolism, cellular changes of the mitochondria and cellular membranes, initiation of different forms of cell death-like apoptosis and necrosis together with a recently discovered mixed form termed necroptosis. Chemokines and cytokines together with other factors promote the inflammatory response leading to activation of the innate immune system as well as the adaptive immune system. If the inflammatory reaction continues within the graft tissue, a progressive interstitial fibrosis develops that impacts long-term graft outcome. It is of particular importance in kidney transplantation to understand the underlying mechanisms and effects of ischemia/reperfusion on the graft as this knowledge also opens strategies to prevent or treat ischemia/reperfusion injury after transplantation in order to improve graft outcome. | Maurizio Salvadori Giuseppina Rosso Elisabetta Bertoni | 2015 | World Journal of Transplantation2015，5，2： | 43 |
| 2 | Minimally invasive treatment of cholecysto-choledocal lithiasis:The point of view of the surgical endoscopist显示文摘The rate of choledocholithiasis in patients with symptomatic cholelithiasis is estimated to be approximately 10%-33%,depending on the patient's age.Development of Endoscopic Retrograde Cholangiopancreatography and Laparoscopic Surgery and improvement of diagnostic procedures have influenced new approaches to the management of common bile duct stones in association with gallstones.At present available minimally-invasive treatments of cholecysto-choledocal lithiasis include:single-stage laparoscopic treatment,perioperative endoscopic treatment and endoscopic treatment alone.Published data evidence that,associated endoscopic-laparoscopic approach necessitates increased number of procedures per patient while single-stage laparoscopic treatment is associated with a shorter hospital stay.However,current data does not suggest clear superiority of any one approach with regard to success,mortality,morbidity and cost-effectiveness.Considering the variety of therapeutic options available for management,a critical appraisal and decision-making is required.endoscopic retrograde cholangiopancreatography/EST should be adopted on a selective basis,i.e.,in patients with acute obstructive suppurative cholangitis,severe biliary pancreatitis,ampullary stone impaction or severe comorbidity.In a setting where all facilities are available,decision in the selection of the therapeutic option depends on the patients,the number and size of choledocholithiasis stones,the anatomy of the cystic duct and common bile duct,the surgical history of patients and local expertise. | Giovanni D De Palma | 2013 | World Journal of Gastrointestinal Surgery2013，5，6： | 36 |
| 3 | Can we further optimize therapeutic hypothermia for hypoxic-ischemic encephalopathy?显示文摘Perinatal hypoxic-ischemic encephalopathy is a leading cause of neonatal death and disability.Therapeutic hypothermia significantly reduces death and major disability associated with hypoxic-ischemic encephalopathy;however,many infants still experience lifelong disabilities to movement,sensation and cognition.Clinical guidelines,based on strong clinical and preclinical evidence,recommend therapeutic hypothermia should be started within 6 hours of birth and continued for a period of 72 hours,with a target brain temperature of 33.5 ±0.5℃ for infants with moderate to severe hypoxic-ischemic encephalopathy.The clinical guidelines also recommend that infants be re warmed at a rate of 0.5℃ per hour,but this is not based on strong evidence.There are no randomized controlled trials investigating the optimal rate of rewarming after therapeutic hypothermia for infants with hypoxic-ischemic encephalopathy.Preclinical studies of rewarming are conflicting and results were confounded by treatment with sub-optimal durations of hypothermia.In this review,we evaluate the evidence for the optimal start time,duration and depth of hypothermia,and whether the rate of rewarming after treatment affects brain injury and neurological outcomes. | Anthony Davies Guido Wassink Laura Bennet Alistair J.Gunn Joanne O.Davidson | 2019 | Neural Regeneration Research2019，14，10： | 20 |
| 4 | Hepatocellular carcinoma in non-cirrhotic liver: A comprehensive review显示文摘Hepatocellular carcinoma(HCC) is the most common type of primary liver cancer, which in turns accounts for the sixth most common cancer worldwide.Despite being the 6 th most common cancer it is the second leading cause of cancer related deaths. HCC typically arises in the background of cirrhosis, however,about 20% of cases can develop in a non-cirrhotic liver. This particular subgroup of HCC generally presents at an advanced stage as surveillance is not performed in a non-cirrhotic liver. HCC in non-cirrhotic patients is clinically silent in its early stages because of lack of symptoms and surveillance imaging; and higher hepatic reserve in this population. Interestingly, F3 fibrosis in non-alcoholic fatty liver disease, hepatitis B virus and hepatitis C virus infections are associated with high risk of developing HCC. Even though considerable progress has been made in the management of this entity, there is a dire need for implementation of surveillance strategies in the patient population at risk, to decrease the disease burden at presentation and improve the prognosis of these patients. This comprehensive review details the epidemiology, risk factors, clinical features,diagnosis and management of HCC in non-cirrhotic patients and provides future directions for research. | Aakash Desai Sonia Sandhu Jin-Ping Lai Dalbir Singh Sandhu | 2019 | World Journal of Hepatology2019，11，1： | 19 |
| 5 | Coupling strategies for silicon photonics integrated chips[Invited]显示文摘Over the last 20 years, silicon photonics has revolutionized the field of integrated optics, providing a novel and powerful platform to build mass-producible optical circuits. One of the most attractive aspects of silicon photonics is its ability to provide extremely small optical components, whose typical dimensions are an order of magnitude smaller than those of optical fiber devices. This dimension difference makes the design of fiberto-chip interfaces challenging and, over the years, has stimulated considerable technical and research efforts in the field. Fiber-to-silicon photonic chip interfaces can be broadly divided into two principle categories:in-plane and out-of-plane couplers. Devices falling into the first category typically offer relatively high coupling efficiency, broad coupling bandwidth(in wavelength), and low polarization dependence but require relatively complex fabrication and assembly procedures that are not directly compatible with wafer-scale testing.Conversely, out-of-plane coupling devices offer lower efficiency, narrower bandwidth, and are usually polarization dependent. However, they are often more compatible with high-volume fabrication and packaging processes and allow for on-wafer access to any part of the optical circuit. In this paper, we review the current state-of-the-art of optical couplers for photonic integrated circuits, aiming to give to the reader a comprehensive and broad view of the field, identifying advantages and disadvantages of each solution. As fiber-to-chip couplers are inherently related to packaging technologies and the co-design of optical packages has become essential, we also review the main solutions currently used to package and assemble optical fibers with silicon-photonic integrated circuits. | RICCARDO MARCHETTI COSIMO LACAVA LEE CARROLL KAMIL GRADKOWSKI PAOLO MINZIONI | 2019 | Photonics Research2019，7，2： | 19 |
| 6 | Research advances in the detection of miRNA显示文摘MicroRNAs (miRNAs) are a family of endogenous, small (approximately 22 nucleotides in length), noncoding, functional RNAs. With the development of molecular biology, the research of miRNA biological function has attracted significant interest, as abnormal miRNA expression is identified to contribute to serious human diseases such as cancers. Traditional methods for miRNA detection do not meet current demands. In particular, nanomaterial-based methods, nucleic acid amplification-based methods such as rolling circle amplification (RCA), loop-mediated isothermal amplification (LAMP), strand-displacement amplification (SDA) and some enzyme-free amplifications have been employed widely for the highly sensitive detection of miRNA. MiRNA functional research and clinical diagnostics have been accelerated by these new techniques. Herein, we summarize and discuss the recent progress in the development of miRNA detection methods and new applications. This review will provide guidelines for the development of follow-up miRNA detection methods with high sensitivity and specificity, and applicability to disease diagnosis and therapy. | Jiawei Ye Mingcheng Xu Xueke Tian Sheng Cai Su Zeng | 2019 | Journal of Pharmaceutical Analysis2019，9，4： | 15 |
| 7 | Challenges and perspectives for manganese-based oxides for advanced aqueous zinc-ion batteries显示文摘Li-ion batteries(LIBs)with excellent cycling stability and high-energy densities have already occupied the commercial rechargeable battery market.Unfortunately,the high cost and intrinsic insecurity induced by organic electrolyte severely hinder their applications in large-scale energy storage.In contrast,aqueous Zn-ion batteries(ZIBs)are being developed as an ideal candidate because of their cheapness and high security.Benefiting from high operating voltage and acceptable specific capacity,recently,manganese-based oxides with different various crystal structures have been extensively studied as cathode materials for aqueous ZIBs.This review presents research progress of manganese-based cathodes in aqueous ZIBs,including various manganese-based oxides and their zinc storage mechanisms.In addition,we also discuss some optimization strategies that aim at improving the electrochemical performance of manganese-based cathodes,and the design of flexible aqueous ZIBs based on manganese-based cathodes(MZIBs).Finally,this review summarizes some valuable research directions,which will promote the further development of aqueous MZIBs. | Yinlei Zhao Yunhai Zhu Xinbo Zhang | 2020 | InfoMat2020，2，2： | 14 |
| 8 | 湖北省水库大坝安全监测现状及对策显示文摘结合湖北省水库除险加固及大坝安全监测工作,介绍了湖北省水库大坝安全监测的发展历程及现状,分析了当前存在的问题及开展水库大坝安全监测的必要性,并提出了加强大坝安全监测的对策与举措。 | 帅移海 李俊辉 高红民 | 2010 | 水电能源科学2010，28，8： | 13 |
| 9 | New Goals and Strategies of Chinese Medicine in Prevention and Treatment of Chronic Kidney Disease显示文摘Chronic kidney disease(CKD) is a clinical syndrome with a series of clinical manifestations and metabolic disorders caused by many diseases, which are characterized by progressive deterioration or irreversible damage of renal structures and functions. With the progress of epidemiological research, CKD has brought about huge economic and psychological burdens. There is a considerable risk of cardiovascular events or death than progression to end-stage renal disease for patients. Particular attentions should be paid to the new goals of reducing cardiovascular events and all-cause mortality. It is important to analyze the etiology and pathogenesis according to patients' ages, regions, primary disease as well as different stages of disease, and choose the appropriate therapeutic strategies accordingly. In clinical practice, due to the uncertainty of therapeutic effects ofmodern medicine based on the risk factors, it is necessary to use Chinese medicine(CM) to delay the disease progression and reduce comorbidities. Turbid toxin and blood stasis are two critical pathological factors worthy of concerns in the theory of CM. In addition, appropriate use of CM may help improve the quality of life of patients with CKD. | GUO Chuan LI Shen RAO Xiang-rong | 2019 | Chinese Journal of Integrative Medicine2019，25，3： | 13 |
| 10 | Model predictive control and improved low-pass filtering strategies based on wind power fluctuation mitigation显示文摘The rapid development of renewable energy sources such as wind power has brought great challenges to the power grid. Wind power penetration can be improved by using hybrid energy storage(ES) to mitigate wind power fluctuation. We studied the strategy of smoothing wind power fluctuation and the strategy of hybrid ES power distribution. Firstly, an effective control strategy can be extracted by comparing constant-time low-pass filtering(CLF), variable-time low-pass filtering(VLF), wavelet packet decomposition(WPD), empirical mode decomposition(EMD) and model predictive control algorithms with fluctuation rate constraints of the identical grid-connected wind power. Moreover, the mean frequency of ES as the cutoff frequency can be acquired by the Hilbert Huang transform(HHT), and the time constant of filtering algorithm can be obtained. Then, an improved low-pass filtering algorithm(ILFA) is proposed to achieve the power allocation between lithium battery(LB) and supercapacitor(SC), which can overcome the over-charge and over-discharge of ES in the traditional low-pass filtering algorithm(TLFA). In addition, the optimized LB and SC power are further obtained based on the SC priority control strategy combined with the fuzzy control(FC) method. Finally, simulation results show that wind power fluctuation can be effectively suppressed by LB and SC based on the proposed control strategies, which is beneficial to the development of wind and storage system. | Yushu SUN Xisheng TANG Xiaozhe SUN Dongqiang JIA Zhihuang CAO Jing PAN Bin XU | 2019 | Journal of Modern Power Systems and Clean Energy2019，7，3： | 13 |
| 11 | Cotton bollworm resistance to Bt transgenic cotton: A case analysis显示文摘Cotton bollworm (Helicoverpa armigera) is one of the most serious insect pests of cotton. Transgenic cotton expressing Cry toxins derived from a soil bacterium, Bacillus thuringiensis (Bt), has been produced to target this pest. Bt cotton has been widely planted around the world, and this has resulted in efficient control of bollworm populations with reduced use of synthetic insecticides. However, evolution of resistance by this pest threatens the continued success of Bt cotton. To date, no field populations of bollworm have evolved significant levels of resistance; however, several laboratory-selected Cry-resistant strains of H. armigera have been obtained, which suggests that bollworm has the capacity to evolve resistance to Bt. The development of resistance to Bt is of great concern, and there is a vast body of research in this area aimed at ensuring the continued success of Bt cotton. Here, we review studies on the evolution of Bt resistance in H. armigera, focusing on the biochemical and molecular basis of Bt resistance. We also discuss resistance management strategies, and monitoring programs implemented in China, Australia, and India. | LIU ChenXi, LI YunHe, GAO YuLin, NING ChangMing & WU KongMing State Key Laboratory of Plant Disease and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Science, Beijing 100193, China | 2010 | Science China(Life Sciences)2010，53，8： | 10 |
| 12 | Intratumor heterogeneity,microenvironment,and mechanisms of drug resistance in glioma recurrence and evolution显示文摘Glioma is the most common lethal tumor of the human brain.The median survival of patients with primary World Health Organization grade IV glioma is only 14.6 months.The World Health Organization classification of tumors of the central nervous system categorized gliomas into lower-grade gliomas and glioblastomas.Unlike primary glioblastoma that usually develop de novo in the elderly,secondary glioblastoma enriched with an isocitrate dehydrogenase mutant typically progresses from lower-grade glioma within 5-10 years from the time of diagnosis.Based on various evolutional trajectories brought on by clonal and subclonal alterations,the evolution patterns of glioma vary according to different theories.Some important features distinguish the normal brain from other tissues,e.g.,the composition of the microenvironment around the tumor cells,the presence of the blood-brain barrier,and others.The underlying mechanism of glioma recurrence and evolution patterns of glioma are different from those of other types of cancer.Several studies correlated tumor recurrence with tumor heterogeneity and the immune microenvironment.However,the detailed reasons for the progression and recurrence of glioma remain controversial.In this review,we introduce the different mechanisms involved in glioma progression,including tumor heterogeneity,the tumor microenvironment and drug resistance,and their pre-clinical implements in clinical trials.This review aimed to provide new insights into further clinical strategies for the treatment of patients with recurrent and secondary glioma. | Zhaoshi Bao Yongzhi Wang Qiangwei Wang Shengyu Fang Xia Shan Jiguang Wang Tao Jiang | 2021 | Frontiers of Medicine2021，15，4： | 10 |
| 13 | A combined application of micro-vortex generator and boundary layer suction in a high-load compressor cascade显示文摘In the current study, the effects of a combined application between micro-vortex generator and boundary layer suction on the flow characteristics of a high-load compressor cascade are investigated. The micro-vortex generator with a special configuration and the longitudinal suction slot are adopted. The calculated results show that a reverse flow region, which is considered the main reason for occurring stall at 7.9° incidence, grows and collapses rapidly near the leading edge and leads to two critical points occurring on the end-wall with the increasing incidence in the baseline. As the micro-vortex generator is introduced in the baseline cascade, the corner separation is switched to a trailing edge separation by the thrust from the induced vortex. Meanwhile, the occurrence of failure is delayed due to the mixed low energy fluid and main flow. The synergistic effects between the micro-vortex generator and the boundary layer suction on the performance of the cascade are superior to the baseline at all the incidence conditions before the occurrence of failure, and the sudden deterioration of the cascade occurs at 10.3° incidence. The optimal results show that the farther upstream suction position, the lower total pressure loss of the cascade with vortex generator at the near stall condition. Moreover, the induced vortex with a leg can migrate the accumulated low energy fluid backward to delay the occurrence of stall. | Shan MA Wuli CHU Haoguang ZHANG Xiangjun LI Haiyang KUANG | 2019 | Chinese Journal of Aeronautics2019，32，5： | 9 |
| 14 | Risk Governance:Application to Urban Challenges显示文摘Urban areas face multiple risks: they range from natural hazard-induced disasters, fires, and building code violations to social risks such as vandalism, crime, and social disorientation, among others. These risks often interact with each other and cannot be dealt with in isolation. As a means to identify, assess, and manage multiple risks, the concept of ‘‘risk governance'' has been developed, which promises to provide integrative and comprehensive tools to deal with the many manifestations of risks.In this article, risk governance concept has been specifically applied to complex risk situations in urban areas. The concept of risk governance pertains to the many ways in which multiple actors, individuals and institutions, public and private, deal with risks. It includes formal institutions and regimes and informal arrangements. The article first develops an adaptive and integrative model of risk governance and applies this model to the urban environments.After a short summary of the roots of risk governance, key concepts, such as simple, uncertain, complex, and ambiguous risks, are discussed. The main emphasis is on each of the five phases of risk governance: pre-estimation,interdisciplinary assessment, risk evaluation, risk management, and risk communication. | Ortwin Renn Andreas Klinke Pia-Johanna Schweizer | 2018 | International Journal of Disaster Risk Science2018，9，4： | 8 |
| 15 | Reasonable choice of surgical procedures for patients with portal hypertension显示文摘OBJECTIVE: To assess individualized therapeutic protocol for patients with portal hypertension on thebasis of accumulated knowledge about the mechanism of portal hypertension.DATA SOURCES: Patients data on shunt and other surgical procedures from Ruijin Hospital, Shanghai,China and the published papers.RESULTS: The direction of blood flow of the collateral vessels in the gastro-splenic region is animportant factor in deciding surgical strategy because there is a close relationship between surgical riskand the classification of liver function. Clinically it is confirmed that each patient needs an individualizedsurgical procedure and that prophylactic operation is suitable for patients with splenomegaly, splenismassociated with serious esophageal varices and hemorrhagic tendency under endoscopy but acceptableliver function. The shunt diameter (SD) (SD=0.67×PVD) is determined in our patients according toindividualized hemodynamics. The rehemorrhagic rate after shunt being higher than that in others may berelated to lesioned gastric mucosa caused by portal hypertension or bleeding and temporary melena. Thisfinding is good for prevention of hepatic encephalopathy. The life quality and labor ability of patients willbe improved because of hepatopetal flow in the portal vein. With strict indications for reoperation,selective operation is performed as soon as possible when hemorrhage is controlled conservatively andliver function improved. Once the patient with cirrhosis associated with portal hypertension is scheduledfor liver transplantation, treatment of hemorrhage should aim to keep the patient in good condition and toavoid the protocol that may be disadvantageous to liver transplantation in the future.CONCLUSION: Surgical procedures for patients with portal hypertension should follow the principle ofindividualization. To obtain the best outcome, the choice of reasonable surgical procedure is expected. | Guang-Wen Zhou Zong-Yuan Tao Cheng-Hong Peng Hong-Wei Li the Surgical Department and Shanghai Digestive Surgical Institute, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China | 2003 | Hepatobiliary & Pancreatic Diseases International2003，2，3： | 8 |
| 16 | Designation and Development of Central Towns: A Case Study of Shiyan | LIU Aihua, PhD, College of Resources and Environment, Graduate School of Chinese Academy of Sciences Post-doctor, College of Economy, Nankai University and Tianjin Urban Planning and Design Institute, Tianjin, P. R. China. Research area: region planning, integrated urban-rural planning. XIE Zhengguan, Professor, College of Resources and Environment, Graduate School of Chinese Academy of Sciences, Beijing, P. R. China. Research area: urban geography and urban planning. ZHENG Yangyang, Assistant Planner, ICON United, Beijing, P. R. China. Research area: urban geography and urban planning. | 2012 | China City Planning Review2012，21，1： | 8 |
| 17 | Climate change and Chinese farmers: Perceptions and determinants of adaptive strategies显示文摘Farmers' perceptions, beliefs, adaptive strategies, and barriers regarding climate change are critical to promoting sustainable ecosystems and societal stability. This paper is based on an extensive survey of 1 500 farmers and their households in Henan Province in China during 2013–2014. Henan is the largest agricultural province in China with over 51 million farmers. The survey results showed that approximately 57% of the respondents perceived the direct impact of climate change during the past 10 years, with 70.3% believing that climate change posed a risk to their livelihood. Not surprisingly, most farmers reported that they have adopted new measures to mitigate the negative impacts of climate change. The main barriers hindering farmers' adopting adaptation measures were lack of funds and timely information. A multinomial logit model revealed that land ownership, knowledge of crop variety and the causes of climate change, as well as the belief of climate change, were all positively related to the likelihood of employing adaptive strategies. Moreover, the percentage of households engaging in agriculture activity, and years of engaging in farming were both negatively correlated with famer's likelihood of adopting adaptation strategies. More importantly, farmers with high incomes were less likely to adopt adaptive strategies and more willing to engage in other business activities. In conclusion, it is important to communicate climate change related information and government policies in rural areas, promote farmer associations and other educational outreach efforts to assist Chinese farmers to deal with climate change. | ZHAI Shi-yan SONG Gen-xin QIN Yao-chen YE Xin-yue Mark Leipnik | 2018 | Journal of Integrative Agriculture2018，17，4： | 7 |
| 18 | Treating comorbid anxiety and depression: Psychosocial and pharmacological approaches显示文摘Comorbid anxiety with depression predicts poor outcomes with a higher percentage of treatment resistance than either disorder occurring alone. Overlap of anxiety and depression complicates diagnosis and renders treatment challenging. A vital step in treatment of such comorbidity is careful and comprehensive diagnostic assessment. We attempt to explain various psychosocial and pharmacological approaches for treatment of comorbid anxiety and depression. For the psychosocial component, we focus only on generalized anxiety disorder based on the following theoretical models:(1) 'the avoidance model';(2) 'the intolerance of uncertainty model';(3) 'the meta-cognitive model';(4) 'the emotion dysregulation model'; and(5) 'the acceptance based model'. For depression, the following theoretical models are explicated:(1) 'the cognitive model';(2) 'the behavioral activation model'; and(3) 'the interpersonal model'. Integration of these approaches is suggested. The treatment of comorbid anxiety and depression necessitates specific psychopharmacological adjustments as compared to treating either condition alone. Serotonin reuptake inhibitors are considered first-line treatment in uncomplicated depression comorbid with a spectrum of anxiety disorders. Short-acting benzodiazepines(BZDs) are an important 'bridging strategy' to address an acute anxiety component. In patients with comorbid substance abuse, avoidance of BZDs is recommended and we advise using an atypical antipsychotic in lieu of BZDs. For mixed anxiety and depression comorbid with bipolar disorder, we recommend augmentation of an antidepressant with either lamotrigine or an atypical agent. Combination and augmentation therapies in the treatment of comorbid conditions vis-à-vis monotherapy may be necessary for positive outcomes. Combination therapy with tricyclic antidepressants, gabapentin and selective serotonin/norepinephrine reuptake inhibitors(e.g., duloxetine) are specifically useful for comorbid chronic pain syndromes. Aripiprazole, quetiapine, risperidone and other novel atypical agents may be effective as augmentations. For treatment-resistant patients, we recommend a 'stacking approach' not dissimilar from treatment of hypertension In conclusion, we delineate a comprehensive approach comprising integration of various psychosocial approaches and incremental pharmacological interventions entailing bridging strategies, augmentation therapies and ultimately stacking approaches towards effectively treating comorbid anxiety and depression. | Jeremy D Coplan Cindy J Aaronson Venkatesh Panthangi Younsuk Kim | 2015 | World Journal of Psychiatry2015，5，4： | 7 |
| 19 | Current progress in developing metal oxide nanoarrays-based photoanodes for photoelectrochemical water splitting显示文摘Solar energy driven photoelectrochemical(PEC) water splitting is a clean and powerful approach for renewable hydrogen production. The design and construction of metal oxide based nanoarray photoanodes is one of the promising strategies to make the continuous breakthroughs in solar to hydrogen conversion efficiency of PEC cells owing to their owned several advantages including enhanced reactive surface at the electrode/electrolyte interface, improved light absorption capability, increased charge separation efficiency and direct electron transport pathways. In this Review, we first introduce the structure,work principle and their relevant efficiency calculations of a PEC cell. We then give a summary of the state-of the-art research in the preparation strategies and growth mechanism for the metal oxide based nanoarrays, and some details about the performances of metal oxide based nanoarray photoanodes for PEC water splitting. Finally, we discuss key aspects which should be addressed in continued work on realizing high-efficiency metal oxide based nanoarray photoanodes for PEC solar water splitting systems. | Yongcai Qiu Zhenghui Pan Haining Chen Daiqi Ye Lin Guo Zhiyong Fan Shihe Yang | 2019 | Science Bulletin2019，64，18： | 7 |
| 20 | Extractive distillation: Advances in conceptual design, solvent selection,and separation strategies显示文摘Extractive distillation(ED) is one of the most promising approaches for the separation of the azeotropic or closeboiling mixtures in the chemical industry. The purpose of this paper is to provide a broad overview of the recent development of key aspects in the ED process involving conceptual design, solvent selection, and separation strategies. To obtain the minimum entrainer feed flow rate and reflux ratio for the ED process, the conceptual design of azeotropic mixture separation based on a topological analysis via thermodynamic feasibility insights involving residue curve maps, univolatility lines, and unidistribution curves is presented. The method is applicable to arbitrary multicomponent mixtures and allows direct screening of design alternatives. The determination of a suitable solvent is one of the key steps to ensure an effective and economical ED process. Candidate entrainers can be obtained from heuristics or literature studies while computer aided molecular design(CAMD) has superiority in efficiency and reliability. To achieve optimized extractive distillation systems, a brief review of evaluation method for both entrainer design and selection through CAMD is presented. Extractive distillation can be operated either in continuous extractive distillation(CED) or batch extractive distillation(BED), and both modes have been well-studied depending on the advantages in flexibility and low capital costs. To improve the energy efficiency, several configurations and technological alternatives can be used for both CED and BED depending on strategies and main azeotropic feeds. The challenge and chance of the further ED development involving screening the best potential solvents and exploring the energy-intensive separation strategies are discussed aiming at promoting the industrial application of this environmentally friendly separation technique. | Shirui Sun Liping Lü Ao Yang Shun'an Wei Weifeng Shen | 2019 | Chinese Journal of Chemical Engineering2019，27，6： | 6 |
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