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| 1 | 神经病理性疼痛诊疗专家共识显示文摘一、定义及分类 国际疼痛学会(International Association for the Study of Pain,IASP)于1994年将神经病理性疼痛(Neuropathic Pain,NP)定义为:“由神经系统的原发损害或功能障碍所引发或导致的疼痛(Paininitiated or caused by a primary lesion or dysfunction in the nervous system).2008年,IASP神经病理性疼痛特别兴趣小组(NeuPSIG)将该定义更新为:“由躯体感觉系统的损害或疾病导致的疼痛”(neuropathic pain is defined as pain caused by a lesion or disease of the somatosensory system)[1]. | 神经病理性疼痛诊疗专家组 樊碧发 | 2013 | 中国疼痛医学杂志2013，19，12： | 268 |
| 2 | 我国5岁以下儿童及其母亲贫血状况及相关因素分析显示文摘目的 : 分析我国城市与农村 5岁以下儿童贫血状况、影响因素以及儿童贫血与母亲贫血的关系。方法 : 用 HEMOCUE光度计 ,测定指血血红蛋白。统计分析方法采用描述性与多因素 Logistic回归分析方法。结果 : 城市 5岁以下儿童贫血患病率 1 2 .2 8% ,农村 2 6.71 % ,全国平均 2 1 .67%。母亲贫血率城市 1 1 .8% ,农村 2 6.2 8% ,全国平均 2 0 .1 4%。通过 Logistic回归分析 ,1 8m以内婴幼儿贫血因素有 :哺母乳 OR=3 .92 ,母亲贫血 OR=2 .2 3 ,低出生体重 OR=1 .65 ,未加蛋类 OR=1 .3 8,未加奶类 OR=1 .5 4。 1 8~ 60个月儿童贫血因素有 :母亲贫血 OR=2 .74,哺母乳 OR=1 .87,生长迟缓 OR=1 .85 ,低体重 OR=1 .60。结论 : 我国农村 5岁以下儿童及母亲贫血率均高于城市。儿童贫血与低出生体重、辅食添加、哺母乳和母亲的营养状况都有密切关系。 | 富振英 贾凤梅 何武 付罡 陈春明 | 2003 | 营养学报2003，25，1： | 72 |
| 3 | Guide for diagnosis and treatment of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is ranked as the 5th common type of cancer worldwide and is considered as the 3rd common reason for cancer-related deaths. HCC often occurs on top of a cirrhotic liver. The prognosisis determined by several factors; tumour extension, alpha-fetoprotein(AFP) concentration, histologic subtype of the tumour, degree of liver dysfunction, and the patient's performance status. HCC prognosis is strongly correlated with diagnostic delay. To date, no ideal screening modality has been developed. Analysis of recent studies showed that AFP assessment lacks adequate sensitivity and specificity for effective surveillance and diagnosis. Many tumour markers have been tested in clinical trials without progressing to routine use in clinical practice. Thus, surveillance is still based on ultrasound(US) examination every 6 mo. Imaging studies for diagnosis of HCC can fall into one of two main categories: routine non-invasive studies such as US, computed tomography(CT), and magnetic resonance imaging, and more specialized invasive techniques including CT during hepatic arteriography and CT arterial portography in addition to the conventional hepatic angiography. This article provides an overview and spotlight on the different diagnostic modalities and treatment options of HCC. | Magdy Hamed Attwa Shahira Aly El-Etreby | 2015 | World Journal of Hepatology2015，7，12： | 47 |
| 4 | Prognostic factors of refractory NSCLC patients receiving anlotinib hydrochloride as the third-or further-line treatment显示文摘Objective:Anlotinib hydrochloride is a multitarget tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor,fibroblast growth factor receptor,platelet-derived growth factor receptor,c-Kit,and c-MET;therefore,it exhibits both antitumor and anti-angiogenetic activities.A phase III trial has shown that anlotinib improved progression-free survival(PFS)and overall survival(OS)in patients with advanced non-small cell lung cancer(NSCLC),who presented with progressive disease or intolerance after standard chemotherapy.This study aimed to analyze the characteristics of patients receiving anlotinib treatment to determine the dominant populations who are fit for the treatment.Methods:Data were collected from March 2015 to January 2017 from a randomized,double-blind,placebo-controlled,multicenter,phase III trial of anlotinib(ALTER0303).A total of 437 patients were enrolled and randomly allocated(2:1)to the anlotinib and placebo groups.Kaplan–Meier analysis and log-rank test were performed to compare PFS and OS.Cox proportional hazards model was adopted for multivariate prognostic analysis.Results:Multivariate analysis indicated that high post-therapeutic peripheral blood granulocyte/lymphocyte ratio and elevated alkaline phosphatase levels were independent risk factors for PFS.Meanwhile,elevated thyroid-stimulating hormone,blood glucose,and triglyceride levels;hypertension;and hand–foot syndrome were independent protective factors of PFS.High posttherapeutic peripheral blood granulocyte/lymphocyte ratio,an Eastern Cooperative Oncology Group(ECOG)score≥2,and the sum of the maximal target lesion length at baseline were independent risk factors of OS,and hypertriglyceridemia was an independent protective factor of OS.Conclusions:This study preliminarily explored the possible factors that affected PFS and OS after anlotinib treatment in patients with advanced refractory NSCLC,and the baseline characteristics of the therapeutically dominant populations were then identified. | Jing Wang Yizhuo Zhao Qiming Wang Li Zhang Jianhua Shi Zhehai Wang Ying Cheng Jianxing He Yuankai Shi Hao Yu Yang Zhao Weiqiang Chen Yi Luo Xiuwen Wang Kejun Nan Faguang Jin Jian Dong Baolan Li Zhujun Liu Baohui Han Kai Li | 2018 | Cancer Biology & Medicine2018，15，4： | 46 |
| 5 | Protein induced by vitamin K absence or antagonist-Ⅱ versus alpha-fetoprotein in the diagnosis of hepatocellular carcinoma: A systematic review with meta-analysis显示文摘Background: As a promising biomarker of hepatocellular carcinoma(HCC), protein induced by vitamin K absence or antagonist-Ⅱ(PIVKA-Ⅱ) has been studied extensively. However, its diagnostic capability varies across HCC studies. This study aimed to compare the performance of PIVKA-Ⅱ with alpha-fetoprotein(AFP) in the diagnosis of HCC. Data sources: A systematic literature search was conducted to identify the studies from MEDLINE, Embase and Cochrane Library Databases, which were published up to December 20, 2017 to compare the diagnostic capability of PIVKA-Ⅱ and AFP for HCC. The data were pooled using random effects model. Pooled sensitivity and specificity were calculated. Summary receiver operating characteristic curve(ROC) was employed to evaluate the diagnostic accuracy of each marker. Results: Thirty-one studies were included. The pooled sensitivity(95% CI) of PIVKA-Ⅱ and AFP was 0.66(0.65–0.68) and 0.66(0.65–0.67), respectively in diagnosis of HCC; and the corresponding pooled specificity(95% CI) was 0.89(0.88–0.90) and 0.84(0.83–0.85), respectively. The area under the ROC curve(AUC) of PIVKA-Ⅱ and AFP was 0.856(0.817–0.895) and 0.770(0.728–0.811), respectively. Subgroup analysis showed that PIVKA-Ⅱ was superior to AFP in terms of the AUC for both small HCC( < 3 cm) [0.863(0.825–0.901) vs 0.717(0.658–0.776)] and large HCC( ≥ 3 cm) [0.854(0.811–0.897) vs 0.729(0.682–0.776)]; for American [0.926(0.897–0.955) vs 0.698(0.594–0.662)], European [0.772(0.743–0.801) vs 0.628(0.594–0.662)], Asian [0.838(0.812–0.864) vs 0.785(0.764–0.806)] and African [0.812(0.794–0.840) vs 0.721(0.675–0.767)] HCC patients; and for HBV-related [0.909(0.866–0.951) vs 0.714(0.673–0.755)] and mixed-etiology [0.847(0.821–0.873) vs 0.794(0.772–0.816)] HCC. Conclusion: This meta-analysis indicates that PIVKA-Ⅱ is better than AFP in terms of the accuracy for diagnosing HCC, regardless of tumor size, patient ethnic group, or HCC etiology. | Hao Xing Yi-Jie Zheng Jun Han Han Zhang Zhen-Li Li Wan-Yee Lau Feng Shen Tian Yang | 2018 | Hepatobiliary & Pancreatic Diseases International2018，17，6： | 34 |
| 6 | RECENT ADVANCES IN HYDRATE-BASED TECHNOLOGIES FOR NATURAL GAS STORAGE——A REVIEW显示文摘Interest in the possibility of storing and transporting natural gas in the form of clathrate hydrates has been increasing in recent years, particularly in some gas-importing and exporting countries.The technologies necessary for realizing this possibility may be classified into those relevant to the four serial processes (a) the formation of a hydrate, (b) the processing (dewatering, pelletizing, etc. ) of the formed hydrate, (c) the storage and transportation of the processed hydrate, and (d) the regasification (dissociation) of the hydrate. The technological development of any of these processes is still at an early stage. For hydrate formation, for example, various rival operations have been proposed. However,many of them have never been subjected to actual tests for practical use. More efforts are required for examining the different hydrate-formation technologies and for rating them by comparison. The general design of the processing of the formed hydrate inevitably depends on both the hydrate-formation process and the storage/transportation process, hence it has a wide variability. The major uncertainty in the storage-process design lies in the as-yet unclarified utility of the 'self-preservation' effect of the naturalgas hydrates. The process design as well as the relevant cost evaluation should strongly depend on whether the hydrates are well preserved at atmospheric pressure in large-scale storage facilities. The regasification process has been studied less extensively than the former processes. The state of the art of the technological development in each of the serial processes is reviewed, placing emphasis on the hydrate formation process. | Yasuhiko H.Mori | 2003 | 化工学报2003，54，z1： | 25 |
| 7 | 我国五省市、自治区慢性肾脏病患者心血管疾病的危险因素调查显示文摘目的了解我国慢性肾脏病(CKD)患者心血管疾病(CVD)的危险因素。方法利用我国五个省市、自治区七家三级甲等医院2002至2003年收治的1239例慢性肾脏病病人有关心血管疾病的资料库,用多因素Logistic回归分析该组患者人口学资料、生活方式、疾病和用药史、体检及实验室参数与各类心血管疾病的关系;同时对主要危险因素的普遍性进行分析。结果(1)血清C反应蛋白(CRP)显著增高(>10mg/L)是慢性肾脏病患者发生冠状动脉疾病(CAD)的危险因素(OR2.13,95%可信区间[CI]1.32~3.43);本组慢性肾脏病患者CRP>10mg/L者占21.5%。(2)女性(OR2.99,CI2.09~4.26)、贫血(OR2.06,CI1.19~3.57)和收缩期高血压(OR1.016,CI1.00~1.02)是左心室肥厚(LVH)的主要危险因素;本组慢性肾脏病病人收缩压控制在140mmHg以下者占54.2%,血红蛋白维持≥110g/L者仅15%。(3)钙磷乘积增加与慢性肾脏病患者的充血性心力衰竭(CHF)有关(OR1.023,CI1.01~1.03);本组病人中25.9%钙磷乘积≥55。(4)低白蛋白血症(OR6.01,CI1.25~28.96)和舒张压增高(OR1.049,CI1.00~1.09)是慢性肾脏病合并脑卒中(CVA)的主要危险因素;低白蛋白血症的患病率为37.3%。(5)传统危险因素如糖尿病增加慢性肾脏病患者CAD(OR2.34)、CHF(OR1.97)和脑卒中(OR4.40)的危险性;年龄增加是CAD(OR1.04)和脑卒中(OR1.22)的危险因素;而高血压则与左心室肥厚(OR1.016)、CHF(OR1.02)和脑卒中(OR1.04)的发生有关。结论慢性肾脏病患者具有不同于一般人群的心血管疾病危险因素,探讨对微炎症和营养不良的干预方法,加强对贫血、高血压和钙磷代谢紊乱的控制是改善我国慢性肾脏病患者心血管疾病预后的关键。 | 侯凡凡 马志刚 梅长林 戎殳 黄颂敏 刘先蓉 袁伟杰 郭云珊 王莉 何强 王秀玲 桑晓红 栗霄立 | 2005 | 中华医学杂志2005，85，11： | 25 |
| 8 | Functional foods-based diet as a novel dietary approach for management of type 2 diabetes and its complications: A review显示文摘Type 2 diabetes is a complicated metabolic disorder with both short- and long-term undesirable complications. In recent years, there has been growing evidence that functional foods and their bioactive compounds, due to their biological properties, may be used as complementary treatment for type 2 diabetes mellitus. In this review, we have highlighted various functional foods as missing part of medical nutrition therapy in diabetic patients. Several in vitro, animal models and some human studies, have demonstrated that functional foods and nutraceuticals may improve postprandial hyperglycemia and adipose tissue metabolism modulatecarbohydrate and lipid metabolism. Functional foods may also improve dyslipidemia and insulin resistance, and attenuate oxidative stress and inflammatory processes and subsequently could prevent the development of long-term diabetes complications including cardiovascular disease, neuropathy, nephropathy and retinopathy. In conclusion available data indicate that a functional foods-based diet may be a novel and comprehensive dietary approach for management of type 2 diabetes. | Parvin Mirmiran Zahra Bahadoran Fereidoun Azizi | 2014 | World Journal of Diabetes2014，5，3： | 18 |
| 9 | 外周血TNF-α、IL-6、IL-10和HMGB-1与慢性牙周炎伴口臭的相关性研究显示文摘目的:探讨牙周炎患者外周血中TNF-α、IL-6、IL-10和HMGB-1水平与口臭值(OR)和菌斑指数(PLI)的相关性。方法:采集20例重度慢性牙周炎伴口臭患者(Ⅰ组)、12例单纯口臭患者(Ⅱ组)、12例轻度牙周炎患者(Ⅲ组)和8例正常人(对照组)的外周血,并通过ELISA双抗夹心法测定其血清中TNF-α、IL-6、IL-10和HMGB-1的含量;采用鼻闻法检测各患者的OR,并检测记录其PLI;数据用SPSS 17.0软件进行统计分析。结果:Ⅰ组和Ⅲ组患者的TNF-α、IL-6和HMGB-1水平均显著高于对照组(P<0.05);Ⅰ组患者的各项指标均显著高于Ⅱ组(P<0.05);Ⅰ组和Ⅱ组患者的HMGB-1水平均高于Ⅲ组(P<0.05)。Ⅱ组患者的OR显著高于Ⅲ组(P<0.05);3组患者的OR均与其PLI呈明显正相关(P<0.05);Ⅰ组患者的OR和PLI均与TNF-α、IL-6、HMGB-1呈明显正相关(P<0.05);Ⅱ组患者的PLI与其HMGB-1呈明显正相关(P<0.05)。Ⅲ组患者的OR和PLI均与其HMGB-1呈明显正相关(P<0.05)。结论:TNF-α、IL-6和HMGB-1,特别是HMGB-1的超表达和过度释放可能是引起牙周炎慢性化和顽固性口臭的重要因素。 | 姜阳 何权敏 刘清蒙 | 2017 | 牙体牙髓牙周病学杂志2017，27，5： | 18 |
| 10 | Diagnostic value of gamma-glutamyltransferase/aspartate aminotransferase ratio, protein induced by vitamin K absence or antagonist II, and alpha-fetoprotein in hepatitis B virus-related hepatocellular carcinoma显示文摘BACKGROUND Researchers have investigated the diagnostic value of protein induced by vitamin K absence or antagonist II (PIVKA-II) and alpha-fetoprotein (AFP) in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), and obtained abundant clinical diagnostic data. However, PIVKA-II and AFP have unsatisfactory specificity and sensitivity in the diagnosis of early-stage HBV-related HCC. Gamma-glutamyltransferase (γ-GT) and aspartate aminotransferase (AST) are common biomarkers for evaluating liver function, and we hypothesized that the γ-GT/AST ratio in combination with PIVKA-II and AFP would improve the diagnosis of early-stage HBV-related HCC. AIM To evaluate the diagnostic value of γ-GT/AST ratio alone or in combination with PIVKA-II and AFP in HBV-related HCC. METHODS Serum levels of γ-GT, AST, PIVKA-II, and AFP were detected and analysed in 176 patients with HBV-related HCC and in 359 patients with chronic hepatitis B. According to tumour size and serum level of HBV DNA, HBV-related HCC patients were divided into the following categories: Early-stage HCC patients, HCC patients, HBV DNA positive (HBV DNA+) HCC patients, and HBV DNA negative (HBV DNA-) HCC patients. Receiver-operating characteristic (ROC) curves were used to analyse and compare the diagnostic value of the single and combined detection of various biomarkers in different types of HBV-related HCC. RESULTS Tumour size was positively correlated with serum levels of PIVKA-II and AFP in HCC patients (r = 0.529, aP < 0.001 and r = 0.270, bP < 0.001, respectively), but there was no correlation between tumour size and the γ-GT/AST ratio (r = 0.073, P = 0.336). The areas under the receiver-operating characteristic curves (AUROCs) of the γ-GT/AST ratio in early-stage HCC patients, HBV DNA+ HCC patients and HBV DNA- HCC patients were not significantly different from that in the total HCC patients (0.754, 0.802, and 0.705 vs 0.779, respectively;P > 0.05). When PIVKA-II was combined with the γ-GT/AST ratio in the diagnosis of earlystage HCC, HCC, and HBV DNA+ HCC, the AUROCs of PIVKA-II increased, with values of 0.857 vs 0.835, 0.925 vs 0.913, and 0.958 vs 0.954, respectively. When AFP was combined with the γ-GT/AST ratio in the diagnosis of early-stage HCC, HCC, HBV DNA+ HCC, and HBV DNA- HCC, the AUROCs of AFP increased, with values of 0.757 vs 0.621, 0.837 vs 0.744, 0.868 vs 0.757, and 0.840 vs 0.828, respectively. CONCLUSION The γ-GT/AST ratio may be better than PIVKA-II and AFP in the diagnosis of early-stage HBV-related HCC, and its combination with PIVKA-II and AFP can improve the diagnostic value for HBV-related HCC. | Qiang Wang Qi Chen Xia Zhang Xiao-Lan Lu Qin Du Tao Zhu Guo-Yuan Zhang Dong-Sheng Wang Qu-Ming Fan | 2019 | World Journal of Gastroenterology2019，25，36： | 17 |
| 11 | Broadband achromatic metalens in terahertz regime显示文摘Achromatic focusing is essential for broadband operation, which has recently been realised from visible to infrared wavelengths using a metasurface. Similarly, multi-terahertz functional devices can be encoded in a desired metasurface phase profile. However, metalenses suffer from larger chromatic aberrations because of the intrinsic dispersion of each unit element. Here, we propose an achromatic metalens with C-shaped unit elements working from 0.3 to 0.8 THz with a bandwidth of approximately 91% over the centre frequency. The designed metalens possesses a high working efficiency of more than 68% at the peak and a relatively high numerical aperture of 0.385. We further demonstrate the robustness of our Cshaped metalens, considering lateral shape deformations and deviations in the etching depth. Our metalens design opens an avenue for future applications of terahertz meta-devices in spectroscopy, time-offlight tomography and hyperspectral imaging systems. | Qingqing Cheng Meilin Ma Dong Yu Zhixiong Shen Jingya Xie Juncheng Wang Nianxi Xu Hanming Guo Wei Hu Shuming Wang Tao Li Songlin Zhuang | 2019 | Science Bulletin2019，64，20： | 16 |
| 12 | Percutaneous transsplenic embolization of esophageal and gastrio-fundal varices in 18 patients显示文摘AIM: Clinical application and potential complication of percutaneous transsplenic varices embolization (PTSVE) of esophageal or gastrio-fundal varices in patients with hepatocellular carcinoma (HCC) complicated with portal vein cancerous thrombosis (PVCT).METHODS: 18 patients with HCC complicated with PVCT and esophageal or gastrio-fundal varices who underwent PTSVE were collected. The rate of success, complication, mortality of the procedure and postoperative complication were recorded and analyzed.RESULTS: PTSVE were successfully performed in 16 of 18cases, and the rate of success was 89%. After therapy erythrocyte counts decreased in all of the natunts. 5 of patients needed blood transfusion, 2 patients requiredsurgical intervention because of and 11 patients with ascites were alleviated by diuresis. Among these 18patients, the procedure-related mortality was 11% (2/18),one died of acute hepatic failure on the forth day after procedure, another died of acute renal failure on the fifth day. The patients were follow up for 112 mon exceptone. 13of them died of their tumors but none of them experienced variceal bleeding.CONCLUSION: PTSVE is a relatively safe and effective method to treat esophageal or gastrio-fundal varices in HCCpatients with PVCT when percutaneous transhepatic varices embolization (PTHVE) of varices is impossible. | Gao-Quan Gong Xiao-Lin Wang Jian-Hua Wang Zhi-Ping Yan Jie-Min Cheng Sheng Qian Yi Chen Department of Radiology,Zhongshan Hospital,Fudan University,Shanghai 200032,China | 2001 | World Journal of Gastroenterology2001，7，6： | 14 |
| 13 | Pancreatic stents for the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis should be inserted up to the pancreatic body or tail显示文摘AIM To investigate the location to which a pancreatic stent should be inserted to prevent post-endoscopic retrograde cholangiopancreatography(ERCP) pancreatitis(PEP).METHODS Over a ten-year period at our hospital, 296 patients underwent their first ERCP procedure and had a pancreatic stent inserted; this study included 147 patients who had ERCP performed primarily for biliary investigation and had a pancreatic stent inserted to prevent PEP. We dividedthese patients into two groups: 131 patients with a stent inserted into the pancreatic head(head group) and 16 patients with a stent inserted up to the pancreatic body or tail(body/tail group). Patient characteristics and ERCP factors were compared between the groups.RESULTS Pancreatic amylase isoenzyme(p-AMY) levels in the head group were significantly higher than those in the body/tail group [138.5(7.0-2086) vs 78.5(5.0-1266.5), P = 0.03] [median(range)]. No cases of PEP were detected in the body/tail group [head group, 12(9.2%)]. Of the risk factors for post-ERCP hyperamylasemia(≥ p-AMY median, 131 IU/L), procedure time ≥ 60 min [odds ratio(OR) 2.65, 95%CI: 1.17-6.02, P = 0.02) and stent insertion into the pancreatic head(OR 3.80, 95%CI: 1.12-12.9, P = 0.03) were identified as independent risk factors by multivariate analysis.CONCLUSION Stent insertion up to the pancreatic body or tail reduces the risk of post-ERCP hyperamylasemia and may reduce the risk of PEP. | Mitsuru Sugimoto Tadayuki Takagi Rei Suzuki Naoki Konno Hiroyuki Asama Yuki Sato Hiroki Irie Ko Watanabe Jun Nakamura Hitomi Kikuchi Yuichi Waragai Mika Takasumi Takuto Hikichi Hiromasa Ohira | 2018 | World Journal of Gastroenterology2018，24，22： | 13 |
| 14 | 行(或列)对称矩阵的满秩分解及其算法显示文摘1 引言矩阵满秩分解是线性代数的基本分解方法之一,在广义逆矩阵的求解过程中起着重要的作用.矩阵A的满秩分解及A的Moore-Penrose逆不仅有着广泛的现实应用,而且也有理论研究意义,尤其是在数理统计,系统理论,优化计算和控制论等许多领域应用十分广泛.如用计算机对具有对称性质的图像进行采样。 | 王震 蔺小林 蒋耀林 | 2005 | 高等学校计算数学学报2005，27，S1： | 13 |
| 15 | 上海首例智能取代人工劳动争议仲裁开庭 失业or转型?显示文摘李开复说,10年内,人工智能将取代50%人类的工作。近日,国务院下发《新一代人工智能发展规划》,人工智能正式上升为国家战略。 | 程子彦 | 2017 | 中国经济周刊2017，0，36： | 13 |
| 16 | 基于贝叶斯网络的气井井筒完整性风险评价显示文摘井筒完整性失效是气井生产中的主要风险,为有效评价井筒完整性风险,应用贝叶斯网络的推理与学习能力,建立了基于贝叶斯网络和Noisy-OR gate模型的井筒完整性失效概率计算方法和风险评价模型。由故障树分析将井筒分为管柱、水泥环密封性、井口装置、水力屏障和其他部件5个评价单元,确定了各单元的主要风险因素,建立了井筒完整性失效的贝叶斯网络拓扑结构;由Noisy-OR gate模型和历史数据,确定了贝叶斯网络的条件概率参数;将基于贝叶斯网络的失效概率与层次分析法相结合,确定了风险评价指标和等级划分标准;建立了气井井筒完整性风险评价方法。结果表明,该方法实现了井筒完整性失效概率的定量计算、风险的定量评价和主要风险因素的反向推理,可为预防和控制井筒完整性失效提供决策依据,有助于降低井筒完整性失效风险。 | 张弘 申瑞臣 袁光杰 胡耀方 | 2017 | 中国安全生产科学技术2017，13，9： | 13 |
| 17 | 膝关节骨性关节炎关节镜下清理术,Yes or No?显示文摘对膝关节骨性关节炎(osteoarthritis,OA)采用关节镜下清理术的观点,近年一直存在赞同与否定的两种争议[1,2]。我们最近在参加一些国际专题研讨会时注意到,有的学术组织在膝关节骨性关节炎治疗纲要中甚至放弃了关节镜下清理手术。然而,回顾文献,在治疗选择手术与否的不同观点的争执中,显然忽视了对膝OA疾病本质的分析。对于膝OA的治疗手段,如果不是针对疾病的发生、 | 王予彬 朱文辉 | 2012 | 中国微创外科杂志2012，12，1： | 12 |
| 18 | 围绕主题意义的阅读教学实施——以Smart or Harmful阅读语篇为例显示文摘一、课例背景
本课例是2017年12月2日-4日在江苏省镇江市举办的第十二届初中英语课堂教学观摩培训活动上展示的一节阅读课,授课时长为35分钟,由安徽省合肥世界外国语学校王冠博老师执教,指导老师为合肥市教育科学研究院王德美老师、安徽省教育科学研究院赵杰老师。 | 赵杰 王冠博 | 2018 | 中小学外语教学2018，41，8： | 11 |
| 19 | 血清IGF-1、IGFBP-3水平和大肠癌关系的Meta分析显示文摘目的 综合评价血清胰岛素样生长因子 1(IGF- 1)、胰岛素样生长因子结合蛋白 3(IGFBP -3)水平和大肠癌的关系。方法 利用Meta分析法对 6篇关于血清IGF- 1、IGFBP- 3水平与大肠癌关系的研究文献进行定量综合分析。结果 对于IGF 1,合并OR =1.5 6 (95 %CI:1.14~ 2 .13) ;按实验方法不同分层 ,间接酶联免疫吸附试验 (ELISA)合并OR =1.92 (95 %CI:1.2 6~ 2 .93) ,IRMA法合并OR =1.2 3(95 %CI:0 .78~ 1.94 ) ;对于IGFBP 3,合并OR =0 .78(95 %CI:0 .4 3~ 1.4 4 ) ;按实验方法不同分层 ,ELISA法合并OR =0 .4 6 (95 %CI:0 .2 9~ 0 .74 ) ,免疫放射测定法 (IRMA)合并OR =1.4 4 (95 %CI:0 .93~ 2 .2 3)。结论 血清IGF -1高水平为大肠癌的独立危险因子 ,IGFBP- 3与大肠癌的关联不具有统计学意义 ;IGFBP -3与大肠癌关系的各研究之间异质性是由实验方法不同而引起 ,但该结论尚需大样本并同时进行两种方法的测量证实。 | 段琼红 王志刚 朱桂宝 卢祖洵 施侣元 聂绍发 | 2005 | 中华流行病学杂志2005，26，2： | 11 |
| 20 | X-RAY REPAIR CROSS-COMPLEMENTING GROUP 1 (XRCC1) Arg 399 Gln POLYMORPHISM AND AFLATOXIN B1 (AFB1)-RELATED HEPATOCELLULAR CARCINOMA (HCC) IN GUANGXI POPULATION显示文摘Objective: To explore the relationship of XRCC1 Arg 399 Gln polymorphism and AFB1-related hepatocellular carcinoma (HCC) risk in Guangxi population. Methods: The DNA samples from peripheral blood white blood cells were obtained from subjects including 140 HCC and 536 controls. The XRCC1 gene 399 codon polymorphism was detected by PCR-RFLP technique. Results: The frequency of XRCC1 399 Arg/Gln & Gln/Gln genotype in HCC patients (48.57%) was significantly higher that in normal controls (32.46%), and XRCC1 399 Arg/Gln & Gln/Gln genotype was associated with increased risk of HCC (adjusted odds ratios (OR)=2.18, 95% confidence interval (CI) 1.27~3.74). In addition, in the cohort of low/median level of AFB1 exposure, the codon 399 Gln allele was associated with a conspicuous significantly increasing risk for HCC (adjusted OR=2.06, 95% CI=1.01~4.20). Conclusion: The results indicate that the XRCC1 399 Gln allele is a potentially important determinant of susceptibility to AFB1-related HCC. | 龙喜带 马韵 韦义萍 邓卓霖 | 2005 | Chinese Journal of Cancer Research2005，17，1： | 10 |
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