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| 1 | Broadband achromatic metalens in terahertz regime显示文摘Achromatic focusing is essential for broadband operation, which has recently been realised from visible to infrared wavelengths using a metasurface. Similarly, multi-terahertz functional devices can be encoded in a desired metasurface phase profile. However, metalenses suffer from larger chromatic aberrations because of the intrinsic dispersion of each unit element. Here, we propose an achromatic metalens with C-shaped unit elements working from 0.3 to 0.8 THz with a bandwidth of approximately 91% over the centre frequency. The designed metalens possesses a high working efficiency of more than 68% at the peak and a relatively high numerical aperture of 0.385. We further demonstrate the robustness of our Cshaped metalens, considering lateral shape deformations and deviations in the etching depth. Our metalens design opens an avenue for future applications of terahertz meta-devices in spectroscopy, time-offlight tomography and hyperspectral imaging systems. | Qingqing Cheng Meilin Ma Dong Yu Zhixiong Shen Jingya Xie Juncheng Wang Nianxi Xu Hanming Guo Wei Hu Shuming Wang Tao Li Songlin Zhuang | 2019 | Science Bulletin2019，64，20： | 16 |
| 2 | Improvement of X-Band Polarization Radar Melting Layer Recognition by the Bayesian Method and ITS Impact on Hydrometeor Classification显示文摘Using melting layer(ML)and non-melting layer(NML)data observed with the X-band dual linear polarization Doppler weather radar(X-POL)in Shunyi,Beijing,the reflectivity(ZH),differential reflectivity(ZDR),and correlation coefficient(CC)in the ML and NML are obtained in several stable precipitation processes.The prior probability density distributions(PDDs)of the ZH,ZDR and CC are calculated first,and then the probabilities of ZH,ZDR and CC at each radar gate are determined(PBB in the ML and PNB in the NML)by the Bayesian method.When PBB>PNB the gate belongs to the ML,and when PBBPNB the gate belongs to the ML,and when PBB | Jianli MA Zhiqun HU Meilin YANG Siteng LI | 2020 | Advances in Atmospheric Sciences2020，37，1： | 4 |
| 3 | Early T-cell precursor leukemia:a subtype of high risk childhood acute lymphoblastic leukemia显示文摘Acute lymphoblastic leukemia includes T-cell acute lymphoblastic leukemia(T-ALL)and B-cell acute lymphoblastic leukemia(B-ALL).In children,T-ALL usually has a worse prognosis than B-ALL,although childhood T-ALL prognoses have improved remarkably.The varying outcomes among T-ALL cases suggest that an unrecognized biological heterogeneity may contribute to chemo-resistance.Deep exploration of T-lymphocyte development in recent years has found a subgroup of patients with a phenotype that resembles early T-cell precursor,which confers a much poorer prognosis than any other form of T-ALL.This novel subtype of T-ALL was called early T-cell precursor acute lymphoblastic leukemia(ETP-ALL).Flow cytometry data from T-ALL patients enrolled in Shanghai Children’s Medical Center between July 2002 and October 2010 were assessed according to Dr.Campana’s protocol.Among total 89 T-ALL cases,74 cases had enough immunophenotype data available to differentiate between ETP(CD1a^(-),CD8^(-),CD5^(dim),at least one marker of stem cell or myeloid lineage)and non-ETP.From these 74 subjects,12 ETP-ALL cases(16.2%)were identified.The event-free survival(EFS)rate at 66.8 months was 11.1%±10.1% for ETP-ALL and 57.6%±5.6% for non-ETP-ALL(P=0.003).The overall survival rates were 13.3%±11.0% for ETP-ALL and 64.7%±6.3% for non-ETP-ALL(P=0.002).Our findings demonstrate that early T-cell precursor leukemia is a very high-risk subtype of acute lymphoblastic leukemia with poor prognosis. | Meilin Ma Xiang Wang Jingyan Tang Huiliang Xue Jing Chen Ci Pan Hua Jiang Shuhong Shen | 2012 | Frontiers of Medicine2012，6，4： | 2 |
| 4 | The PSCA polymorphisms derived from genome-wide association study are associated with risk of gastric cancer: a meta-analysis显示文摘 | Danni Shi Shizhi Wang Dongying Gu Dongmei Wu Meilin Wang Haiyan Chu Na Tong Lan Ma Dongyan Zhong Zhengdong Zhang | 2012 | Journal of Cancer Research and Clinical Oncology2012，，8： | 2 |
| 5 | Genome-wide analysis of long noncoding RNA signature in human colorectal cancer显示文摘 | Yao Xue Gaoxiang Ma Dongying Gu Lingjun Zhu Qiuhan Hua Mulong Du Haiyan Chu Na Tong Jinfei Chen Zhengdong Zhang Meilin Wang | 2014 | Gene2014，，： | 1 |
| 6 | Distribution of functional microorganisms and its significance for iron, sulphur, and nitrogen cycles in reservoir sediments显示文摘The biogeochemical cycles of sulphur(S),iron(Fe)and nitrogen(N)elements play a key role in the reservoir ecosystem.However,the spatial positioning and interrelationship of S,Fe and N cycles in the reservoir sediment profile have not been explored to a greater extent.Here,we measure the gradients of Fe^(2+),SO_(4)^(2-),NO_(3)^(-),NH_(4)^(+),DOC,TC and TN in the pore water of the sediment,and combining the vertical distribution of the functional microorganisms involved in S,Fe and N cyclings in the sediments to determine the redox stratification in the sediment.It is found that the geochemical gradient of S,Fe and N of the reservoir sedimentary column is mainly defined by the redox process involved in the related functional microorganisms.According to the type of electron acceptor,the sediment profile is divided into 3 redox intervals,namely aerobic respiration(0–10 cm),denitrification/iron reduction(10–28 cm)and sulfate reduction(28–32 cm).In the aerobic respiration zone,NH_(4)^(+)is oxidized by aerobic AOB to NO_(3)^(-)(0–5 cm),and Fe^(2+)is oxidized by microaerobic FeRB to Fe^(3+)(3–10 cm).In the denitrification/iron reduction zone,Acinetobacter and Pseudomonas,as the dominant NRB genera,may use nitrate as an electron acceptor to oxidize Fe^(2+)(11–16 cm).The dominant genera in SOB,such as Sulfururvum,Thiobacillus and Thioalkalispira,may use nitrate as an electron acceptor to oxidize sulfide,leading to SO_(4)^(2-)accumulation(14–24 cm).In the sulfate reduction zone,SO_(4)^(2-)is reduced by SRB.This study found that functional microorganisms forming comprehensive local ecological structures to adapt to changing geochemical conditions,and which would be potentially important for the degradation and preservation of C and the fate of many nutrients and contaminants in reservoirs. | Shuang Bai Meilin Yang Zheng Chen Ming Yang Jing Ma Xue-Ping Chen Fushun Wang | 2021 | Acta Geochimica2021，40，6： | 1 |
| 7 | The early stroke patients by nursing intervention on the rehabilitation effect of 显示文摘 | Ma Meilin Zhao Gaimei | 2013 | Inner Mongolia traditional Chinese medicine2013，32，22： | 1 |
| 8 | Heritable expansion of the genetic code in mouse and zebrafish显示文摘 | Yuting Chen Ji Ma Wenqing Lu Meilin Tian Marion Thauvin Chonggang Yuan Michel Volovitch Qian Wang Jeff Holst Mingyao Liu Sophie Vriz Shixin Ye Lei Wang Dali Li | 2017 | Cell Research2017，27，2： | 1 |
| 9 | Biological functions and potential implications of circular RNAs显示文摘Circular RNAs(circRNAs) are characterized by a covalent closed-loop structure with an absence of both 5′ cap structure and 3′ polyadenylated tail. Numerous studies have found that circRNAs play an important role in various diseases and have a variety of biological regulatory mechanisms, including acting as microRNA sponges,interacting with proteins, modulating the expression of related genes and translating into peptides or proteins.CircRNAs have also been used as biomarkers for a number of diseases, which could improve clinical practice.This review summarizes the most recent advances in biogenesis and knowledge of the biological functions of circRNAs as well as the related bioinformatics databases. We specifically describe developments in understanding of circRNA functions in the field of environmental exposure-induced diseases. Finally, we focus on potential clinical implications of circRNAs to facilitate their clinical transformation into disease treatment. | Lan Ma Haiyan Chu Meilin Wang Zhengdong Zhang | 2023 | The Journal of Biomedical Research2023，37，2： | 0 |
| 10 | A Study on the Assessment and Integration of Multi-Source Evapotranspiration Products over the Tibetan Plateau显示文摘Evapotranspiration(ET)is a crucial variable in the terrestrial water,carbon,and energy cycles.At present,a large number of multi source ET products exist.Due to sparse observations,however,great challenges exist in the evaluation and integration of ET products in remote and complex areas such as the Tibetan Plateau(TP).In this paper,the applicability of the multiple collocation(MC)method over the TP is evaluated for the first time,and the uncertainty of multisource ET products(based on reanalysis,remote sensing,and land surface models)is further analyzed,which provides a theoretical basis for ET data fusion.The results show that 1)ET uncertainties quantified via the MC method are lower in RS-based ET products(5.95 vs.7.06 mm month^(-1))than in LSM ET products(10.22 vs.17.97 mm month^(-1))and reanalysis ET estimates(7.27 vs.12.26 mm month-1).2)A multisource evapotranspiration(MET)dataset is generated at a monthly temporal scale with a spatial resolution of 0.25°across the TP during 2005-15.MET has better performance than any individual product.3)Based on the fusion product,the total ET amount over the TP and its patterns of spatiotemporal variability are clearly identified.The annual total ET over the entire TP is approximately 380.60 mm.Additionally,an increasing trend of 1.59±0.85 mm yr^(-1)over the TP is shown during 2005-15.This study provides a basis for future studies on water and energy cycles and water resource management over the TP and surrounding regions. | Ming CHENG Lei ZHONG Yaoming MA Han MA Yaoxin CHANG Peizhen LI Meilin CHENG Xian WANG Nan GE | 2024 | Advances in Atmospheric Sciences2024，41，3： | 0 |
| 11 | Heme oxygenase-1/carbon monoxide signaling participates in the accumulation of triterpenoids of Ganoderma lucidum显示文摘Ganoderic triterpenoids(GTs)are the primary bioactive constituents of the Basidiomycotina fungus,Ganoderma lucidum.These compounds exhibit antitumor,anti-hyperlipidemic,and immune-modulatory pharmacological activities.This study focused on GT accumulation in mycelia of G.lucidum mediated by the heme oxygenase-1(HO-1)/carbon monoxide(CO)signaling.Compared with the control,hemin(10μmol/L)induced an increase of 60.1%in GT content and 57.1%in HO-1 activity.Moreover,carbon monoxide-releasing molecule-2(CORM-2),CO donor,increased GT content by 56.0%and HO-1 activity by 18.1%.Zn protoporphyrin IX(ZnPPIX),a specific HO-1 inhibitor,significantly reduced GT content by 26.0%and HO-1 activity by 15.8%,while hemin supplementation reversed these effects.Transcriptome sequencing showed that HO-1/CO could function directly as a regulator involved in promoting GT accumulation by regulating gene expression in the mevalonate pathway,and modulating the reactive oxygen species(ROS)and Ca2+pathways.The results of this study may help enhance large-scale GT production and support further exploration of GT metabolic networks and relevant signaling cross-talk. | Meilin CUI Yuchang MA Youwei YU | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，11： | 0 |
| 12 | A Learning Evasive Email-Based P2P-Like Botnet显示文摘Nowadays, machine learning is widely used in malware detection system as a core component. The machine learning algorithm is designed under the assumption that all datasets follow the same underlying data distribution. But the real-world malware data distribution is not stable and changes with time. By exploiting the knowledge of the machine learning algorithm and malware data concept drift problem, we show a novel learning evasive botnet architecture and a stealthy and secure C&C mechanism. Based on the email communication channel, we construct a stealthy email-based P2 P-like botnet that exploit the excellent reputation of email servers and a huge amount of benign email communication in the same channel. The experiment results show horizontal correlation learning algorithm is difficult to separate malicious email traffic from normal email traffic based on the volume features and time-related features with enough confidence. We discuss the malware data concept drift and possible defense strategies. | Zhi Wang Meilin Qin Mengqi Chen Chunfu Jia Yong Ma | 2018 | China Communications2018，15，2： | 0 |
| 13 | Estimations of Land Surface Characteristic Parameters and Turbulent Heat Fluxes over the Tibetan Plateau Based on FY-4A/AGRI Data显示文摘Accurate estimates of land surface characteristic parameters and turbulent heat fluxes play an important role in the understanding of land-atmosphere interaction. In this study, Fengyun-4A (FY-4A) Advanced Geostationary Radiation Imager (AGRI) satellite data and the China Land Data Assimilation System (CLDAS) meteorological forcing dataset CLDAS-V2.0 were applied for the retrieval of broadband albedo, land surface temperature (LST), radiation flux components, and turbulent heat fluxes over the Tibetan Plateau (TP). The FY-4A/AGRI and CLDAS-V2.0 data from 12 March 2018 to 30 April 2018 were first used to estimate the hourly turbulent heat fluxes over the TP. The time series data of in-situ measurements from the Tibetan Observation and Research Platform were divided into two halves-one for developing retrieval algorithms for broadband albedo and LST based on FY-4A, and the other for the cross validation. Results show the root-mean-square errors (RMSEs) of the FY-4A retrieved broadband albedo and LST were 0.0309 and 3.85 K, respectively, which verifies the applicability of the retrieval method. The RMSEs of the downwelling/upwelling shortwave radiation flux and downwelling/upwelling longwave radiation flux were 138.87/32.78 W m^(−2) and 51.55/17.92 W m^(−2), respectively, and the RMSEs of net radiation flux, sensible heat flux, and latent heat flux were 58.88 W m^(−2), 82.56 W m^(−2) and 72.46 W m^(−2), respectively. The spatial distributions and diurnal variations of LST and turbulent heat fluxes were further analyzed in detail. | Nan GE Lei ZHONG Yaoming MA Yunfei FU Mijun ZOU Meilin CHENG Xian WANG Ziyu HUANG | 2021 | Advances in Atmospheric Sciences2021，38，8： | 0 |
| 14 | Differential regulation of JAK1 expression by ETS1 associated with predisposition to primary biliary cholangitis显示文摘Primary biliary cholangitis(PBC)is an autoimmune liver disease characterized by the destruction of intrahepatic small bile ducts and progressive cholestasis,eventually leading to liver cirrhosis and hepatic failure without appropriate treatment(Terziroli Beretta-Piccoli et al.,2019). | Peng Jiang Chan Wang Mingming Zhang Ye Tian Weifeng Zhao Junyi Xin Yexi Huang Zhibin Zhao Wenjuan Sun Jie Long Ruqi Tang Fang Qiu Xingjuan Shi Yi Zhao Li Zhu Na Dai Lei Liu Xudong Wu Jinshan Nie Bo Jiang Youlin Shao Yueqiu Gao Jianjiang Yu Zhigang Hu Zhidong Zang Yuhua Gong Yaping Dai Lan Wang Ningling Ding Ping Xu Sufang Chen Lu Wang Jing Xu Luyao Zhang Junyan Hong Ruonan Qian Hu Li Xuan Jiang Congwei Chen Wenyan Tian Jian Wu Yuzhang Jiang Chongxu Han Kui Zhang Hong Qiu Li Li Hong Fan Liming Chen Jianqiong Zhang Zhongsheng Sun Xiao Han Zhenhua Dai Erguang Li M.Eric Gershwin Zhexiong Lian Xiong Ma Michael F.Seldin Weichang Chen Meilin Wang Xiangdong Liu | 2023 | Journal of Genetics and Genomics2023，50，10： | 0 |
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