Fullerenes as unique nanopharmaceuticals for disease treatment

查看全文 作　　者：MA HuiLi & LIANG Xing-Jie Chinese Academy of Sciences Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety;National Center for Nanoscience and Technology,Beijing 100190,China

出　　处：《Science China Chemistry》索引2010年第53卷第11期,共8页

基　　金：the National Natural Science Foundation of China (30970784);National Key Basic Research Program of China (2009CB930200);Chinese Academy of Sciences 'Hundred Talents Program' (07165111ZX);China-Finland Bilateral Nanotechnology Collaboration (2008DFA01510) for financial supports 摘　　要：As unique nanoparticles,fullerenes have attracted much attention due to their unparalleled physical,chemical and biological properties.Various functionalized fullerenes with OH,NH2,COOH,and peptide modifications were developed.It summarized the biological activities of fullerenes derivatives in cancer therapy with high efficiency and low toxicity,as reactive oxygen species scavenger and lipid peroxidation inhibitor,to inhibit human immunodeficiency virus and to suppress bacteria and microbial at low concentration.In addition,the mechanism for fullerene to enter cells and biodistribution of fullerene in vivo was also discussed.This research focuses on the current understanding of fullerenes-based nanomaterials in the potential clinical application as well as biological mechanism of fullerenes and its derivatives in disease therapy. 关键词：FULLERENE NANOPARTICLE NANOMEDICINE clinical application BIOLOGICAL effect

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Fullerenes as unique nanopharmaceuticals for disease treatment

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