Supramolecular self-assembly and controllable drug release of thermosensitive hyperbranched multiarm copolymers

查看全文 作　　者：GUO Bo,SUN XiaoYi,ZHOU YongFeng & YAN DeYue College of Chemistry and Chemical Engineering,Shanghai Jiao Tong University,Shanghai 200240,China

出　　处：《Science China Chemistry》索引2010年第53卷第3期,共8页

基　　金：supported by the National Basic Research Program (Grant Nos 2007CB808000 and 2009CB930400);the National Natural Science Foundation of China (Grant Nos 50633010,20774057,20874060 and 50873058);the Program for New Century Excellent Talents in University (Grant No NCET-07-0558);the Zhejiang Provincial Natural Science Foundation of China (Grant Nos Y4080421,Y405411);the Foundation for the Author of National Excellent Doctoral Dissertation of China,the Fok Ying Tung Education Foundation (Grant No 114029);the Basic Research Foundation (Grant No 07DJ14004) of Shanghai Science and Technique Committee;the Shanghai Leading Academic Discipline Project (Grant No B202) 摘　　要：A novel temperature-responsive hyperbranched multiarm copolymer with a hydrophobic hyperbranched poly(3-ethyl-3-(hydroxymethyl)oxetane)(HBPO) core and thermosensitive poly(N-isopropylacrylamide)(PNIPAM) arms was synthesized via the atom transfer radical polymerization(ATRP) of NIPAM monomers from a hyperbranched HBPO macroinitiator.It was found that HBPO-star-PNIPAM self-assembled into multimolecular micelles(around 60 nm) in water at room temperature according to pyrene probe fluorescence spectrometry,1H NMR,TEM,and DLS measurements.The micelle solution showed a reversible thermosensitive phase transition at a lower critical solution temperature(LCST)(around 32°C) observed by variable temperature optical absorbance measurements.Variable temperature NMR and DLS analyses demonstrated that the LCST transition originated from the secondary aggregation of the micelles driven by increasing hydrophobic interaction due to the dehydration of PNIPAM shells upon heating.The drug loading and release properties of HBPO-star-PNIPAM micelles were also investigated using prednisone acetate as a model drug.The micelles showed a much improved drug encapsulation efficiency and temperature-dependent sustainable release behavior due to the special micellar structure.The micelles exhibited no apparent cytotoxicity against human HeLa cells. 关键词：HYPERBRANCHED polymers THERMOSENSITIVE COPOLYMER SUPRAMOLECULAR self-assembly ATRP drug delivery

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Supramolecular self-assembly and controllable drug release of thermosensitive hyperbranched multiarm copolymers

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