p53 in stem cells

查看全文 作　　者：Valeriya [1]Solozobova;Christine [1,2]Blattner

机构地区：[1]Institute of Toxicology and Genetics,Institute of Applied Biosciences;[2]Karlsruher Institute of Technology

出　　处：《World Journal of Biological Chemistry》索引2011年第2卷第9期,共13页

摘　　要：p53 is well known as a 'guardian of the genome' for differentiated cells,in which it induces cell cycle arrest and cell death after DNA damage and thus contributes to the maintenance of genomic stability.In addition to this tumor suppressor function for differentiated cells,p53 also plays an important role in stem cells.In this cell type,p53 not only ensures genomic integrity after genotoxic insults but also controls their proliferation and differentiation.Additionally,p53 provides an effective barrier for the generation of pluripotent stem celllike cells from terminally differentiated cells.In this review,we summarize our current knowledge about p53 activities in embryonic,adult and induced pluripotent stem cells. 关键词：P53 EMBRYONIC STEM CELLS ADULT STEM CELLS Induced PLURIPOTENT STEM CELLS Cell differentiation

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p53 in stem cells

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