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Light-induced protein translocation by genetically encoded unnatural amino acid in Caenorhabditis elegans

查看全文 作　　者：Hao [1]Chang;Mei [1,2]Han;Wenming [3]Huang;Guifeng [2,4]Wei;Juanjuan [5]Chen;Peng [5]R.Chen;Runsheng [4]Chen;Junlong [5]Zhang;Tao [1,3]Xu;Pingyong [6]Xu 高影响力作者 机构地区：[1]National Laboratory of Biomacromolecules,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China;[2]University of Chinese Academy of Sciences,Beijing 100049,China;[3]College of Life Science and Technology,Huazhong University of Science and Tech-nology,Wuhan 430074,China;[4]Laboratory of Non-coding RNA,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China;[5]College of Chemistry and Molecular Engi-neering,Peking University,Beijing 100871,China;[6]Key Laboratory of Interdisciplinary Research,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China高影响力机构 出　　处：《Protein & Cell》索引2013年第4卷第12期,共4页高影响力期刊 基　　金：This project was supported by the National Basic Research Program(973 Program)(Nos.2010CB912303 and 2010CB833701);the National Natural Science Foundation of China(Grant Nos.90913022 and 31170818);the project from Chinese Academy of Sciences(KSCX2-EW-Q-11). 摘　　要：Dear Editor,Living systems such as Caenorhabditis elegans are organized by interaction networks of biopolymer and small mol-ecules.The molecular engineering of specifi c targets to monitor and control these biological molecules has led to significant advances in our understand-ing of how biological systems are organ-ized,maintain themselves and disin-tegrate(Prescher and Bertozzi,2005).For instance,green fl uorescent protein(GFP)derived from jellyfi sh Aequorea Victoria helps us to accurately locate and observe proteins over long term periods.In addition,many novel LOV(light,oxy-gen,or voltage)domains such as LOV2-Jαand Vivid offer the possibility of cell-based motility management and tissue-based gene expression control(Wu et al.,2009;Wang et al.,2012). 关 键 词：instance MAINTAIN ADDITION
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