A pair of transporters controls mitochondrial Zn^(2+) levels to maintain mitochondrial homeostasis

查看全文 作　　者：Tengfei [1]Ma;Liyuan [1,2]Zhao;Jie [1]Zhang;Ruofeng [1,2]Tang;Xin [1]Wang;Nan [1]Liu;Qian [1,2]Zhang;Fengyang [1,2]Wang;Meijiao [1]Li;Qian [1]Shan;Yang [1]Yang;Qiuyuan [1]Yin;Limei [1]Yang;Qiwen [1,2]Gan;Chonglin [1]Yang

机构地区：[1]State Key Laboratory of Conservation and Utilization of Bio-resources in Yunnan and Center for Life Sciences,School of Life Sciences,Yunnan University,Kunming 650091,China;[2]State Key Laboratory of Molecular Developmental Biology,Institute of Genetics and Developmental Biology,Chinese Academy of Sciences,Beijing 100101,China

出　　处：《Protein & Cell》索引2022年第13卷第3期,共23页

基　　金：This work was supported by grants from the National Science Foundation of China(91954204 and 31730053);the National Basic Research Program of China(2017YFA0503403);Yunnan Province Science and Technology Department(#202001BB050077 and#202105AB160003). 摘　　要：Zn^(2+)is required for the activity of many mitochondrial proteins,which regulate mitochondrial dynamics,apoptosis and mitophagy.However,it is not understood how the proper mitochondrial Zn^(2+)level is achieved to maintain mitochondrial homeostasis.Using Caenorhabditis elegans,we reveal here that a pair of mitochondrion-localized transporters controls the mitochondrial level of Zn^(2+).We demonstrate that SLC-30A9/ZnT9 is a mitochondrial Zn^(2+)exporter.Loss of SLC-30A9 leads to mitochondrial Zn^(2+)accumulation,which damages mitochondria,impairs animal development and shortens the life span.We further identify SLC-25A25/SCaMC-2 as an important regulator of mitochondrial Zn^(2+)import.Loss of SLC-25A25 suppresses the abnormal mitochondrial Zn^(2+)accumulation and defective mitochondrial structure and functions caused by loss of SLC-30A9.Moreover,we reveal that the endoplasmic reticulum contains the Zn^(2+)pool from which mitochondrial Zn^(2+)is imported.These findings establish the molecular basis for controlling the correct mitochondrial levels for normal mitochondrial structure and functions. 关键词：mitochondria Zn^(2+)transporter C.elegans ER-mitochondrial contact development

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A pair of transporters controls mitochondrial Zn^(2+) levels to maintain mitochondrial homeostasis

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