Advances in lung cancer screening and early detection

查看全文 作　　者：Caichen [1,2]Li;Huiting [1,2]Wang;Yu [2]Jiang;Wenhai [1]Fu;Xiwen [2]Liu;Ran [1,2]Zhong;Bo [2]Cheng;Feng [3]Zhu;Yang [1]Xiang;Jianxing [2,4]He;Wenhua [1,2,5]Liang

机构地区：[1]Department of Thoracic Oncology and Surgery,the First Affiliated Hospital of Guangzhou Medical University,China National Center for Respiratory Medicine,China State Key Laboratory of Respiratory Disease&National Clinical Research Center for Respiratory Disease,Guangzhou Institute of Respiratory Health,Guangzhou 510120,China;[2]Dongguan Affiliated Hospital of Southern Medical University,Dongguan People Hospital,Dongguan 523059,China;[3]Department of Internal Medicine,Detroit Medical Center Sinai-Grace Hospital,Detroit,Michigan 48235,USA;[4]Department of Thoracic Surgery,Nanfang Hospital of Southern Medical University,Guangzhou 510515,China;[5]Department of Oncology,the First People’s Hospital of Zhaoqing,Zhaoqing 526020,China

出　　处：《Cancer Biology & Medicine》索引2022年第19卷第5期,共18页

基　　金：This study was supported by the China National Science Foundation(Grant Nos.82022048 and 81871893);the Key Project of Guangzhou Scientific Research Project(Grant No.201804020030). 摘　　要：Lung cancer is associated with a heavy cancer-related burden in terms of patients’physical and mental health worldwide.Two randomized controlled trials,the US-National Lung Screening Trial(NLST)and Nederlands-Leuvens Longkanker Screenings Onderzoek(NELSON),indicated that low-dose CT(LDCT)screening results in a statistically significant decrease in mortality in patients with lung cancer,LDCT has become the standard approach for lung cancer screening.However,many issues in lung cancer screening remain unresolved,such as the screening criteria,high false-positive rate,and radiation exposure.This review first summarizes recent studies on lung cancer screening from the US,Europe,and Asia,and discusses risk-based selection for screening and the related issues.Second,an overview of novel techniques for the differential diagnosis of pulmonary nodules,including artificial intelligence and molecular biomarker-based screening,is presented.Third,current explorations of strategies for suspected malignancy are summarized.Overall,this review aims to help clinicians understand recent progress in lung cancer screening and alleviate the burden of lung cancer. 关键词：Lung cancer SCREENING low-dose CT early detection STRATEGIES biomarkers

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Advances in lung cancer screening and early detection

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