|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Possible implications of animal models for the assessment of visceral pain显示文摘Acute pain,provoked generally after the activation of peripheral nociceptors,is an adaptive sensory function that alerts the individual to avoid noxious stimuli.However,uncontrolled acute pain has a maladaptive role in sensory activity leading to development of a chronic pain state which persists even after the damage is resolved,or in some cases,in the absence of an initial local acute injury.Huge numbers of people suffer from visceral pain at least once during their life span,leading to substantial health care costs.Although studies reporting on the mechanism of visceral pain are accumulating,it is still not precisely understood.Therefore,this review aims to elucidate the mechanism of visceral pain through an evaluation of different animal models and their application to develop novel therapeutic approaches for treating visceral pain.To assess the nociceptive responses in viscera,several visceral pain models such as inflammatory,traction,stress and genetic models utilizing different methods of measurement have been devised.Among them,the inflammatory and traction models are widely used for studying the visceral pain mechanism of different disease conditions and post-operative surgery in humans and animals.A hapten,2,4,6-trinitrobenzene sulfonic acid(TNBS),has been extensively used as an inflammatory agent to induce visceral pain.The traction model seems to cause a strong pain stimulation and autonomic reaction and could thus be the most appropriate model for studying the underlying visceral pain mechanism and for probing the therapeutic efficacies of various anesthetic and analgesics for the treatment of visceral pain and hyperalgesia. | Bharata Regmi Manoj K.Shah | 2020 | Animal Models and Experimental Medicine2020，3，3： | 3 |
| 2 | Effect of Storage Temperature on Vitamin C, Total Phenolics,UPLC Phenolic Acid Profile and Antioxidant Capacity of Eleven Potato(Solanum tuberosum) Varieties显示文摘Storage of potato tubers at low temperature affects their metabolism and may alter their phytochemical properties. There is a need to elucidate the changes in antioxidant compounds, activity and enzymes during storage of tubers. Eleven Indian potato varieties were evaluated for antioxidant parameters, after 0, 30, 60 and 90 days of storage at room temperature, 15 °C and 4 °C. Total phenolics(0.0786–0.1546 mg gallic acid equivalents·g^(-1)FW) and vitamin C content(0.0828–0.2416 mg·g^(-1)FW) varied among the varieties and were different with storage temperature; their levels fluctuated during storage but remained above the initial level until the last day of observation. Phenolic acid profiling by UPLC identified 12 compounds among which the most abundant was chlorogenic acid followed by gallic acid, sinapic acid and ellagic acid. Except para-coumaric acid which decreased at 4 °C, all the phenolic acids increased with storage. Caffeic acid, chlorogenic acid, protocatechuic acid and gallic acid mostly correlated with total phenolic content(r = 0.456, 0.482, 0.588 and 0.620, respectively). Antioxidant activity against both DPPH and ABTS radicals increased during the initial days of storage and then dropped to a level comparable or lower than the original value,irrespective of the storage temperature. Correlation study revealed that chlorogenic acid, gallic acid and ferulic acid mostly contributed to antioxidant activity. Activity of both antioxidant enzymes, superoxide dismutase and ascorbate peroxidase, increased initially but then decreased to values lower than the initial level and were not influenced by storage temperature. Correlation with antioxidant activity indicated that the enhancement of reactive oxygen scavenging species in cold stored tubers could result mainly from ascorbate peroxidase activity. Our results demonstrate that storage temperature adversely influences the metabolism and the content of antioxidant compounds in potato tubers, with subsequent increase on their antioxidant capacity. | Joseph Hubert Yamdeu Galani Pooja M.Mankad Avadh K.Shah Nilesh J.Patel Rajeshkumar R.Acharya Jayant G.Talati | 2017 | Horticultural Plant Journal2017，3，2： | 2 |
| 3 | Is myopia a protective factor against central serous chorioretinopathy?显示文摘AIM: To evaluate if any association exists between central serous chorioretinopathy(CSCR) and the refractive status of the eye.· METHODS: This retrospective, institutional, case control study included 499 patients, wherein 262 patients diagnosed as acute CSCR, were compared with an age and gender matched control group of 237 patients. All patients were evaluated with a detailed systemic and ocular history, objective and subjective refractions for both eyes and complete ocular examination by a retina specialist, at all visits. Optical coherence tomography confirmed the diagnosis of CSCR.·RESULTS: The mean age was found to be 40±7y in the study group(Group 1) compared to 38±10y in the control group(Group 2). Most common refractive status in the study group, was emmetropia seen in 191 patients(72.9%), followed by hypermetropia seen in 47 patients(17.9%) and astigmatism seen in 21 patients(8.0%). Only3 subjects(1.1%) had myopia, which was less than or equal to 1.0 D, compared to 70 subjects(29.5%) in the control group, suggesting a statistically significant lower incidence of CSCR among the myopic patients(P <0.0001). With respect to the systemic factors, 26(9.9%)patients were using systemic steroids in the study group(Group 1) compared to none in the control group(Group 2)suggesting a statistically significant association of CSCR with systemic steroid use(P <0.05). No other significant systemic risk factors were noted.· CONCLUSION: Though CSCR is a multifactorial disease, myopia serves as a protective factor for CSCR.Thus, myopic eyes are less likely to develop CSCR.Since both retinal pigment epithelium(RPE) and choriocapillaris are postulated in the pathogenesis of CSCR, chorio-retinal thinning and atrophy seen in myopic eyes are less likely to cause CSCR. | George J.Manayath Saurabh Arora Hardik Parikh Parag K.Shah Sarvesh Tiwari Venkatapathy Narendran | 2016 | International Journal of Ophthalmology(English edition)2016，9，2： | 2 |
| 4 | Right and Left Ventricular Outflow Tract Tachycardias: Evidence for a Common Electrophysiologic Mechanism显示文摘 | SEIIWAI DANIEL J.CANTILLON ROBERT J.KIM STEVEN M.MARKOWITZ SUNEETMITTAL KENNETH M.STEIN BINDI K.SHAH RAVI K.YARLAGADDA JIM W.CHEUNG VIVIAN R.TAN BRUCE B.LERMAN | 2006 | Journal of Cardiovascular Electrophysiology2006，，10： | 1 |
| 5 | 初次修复后巩膜缝线侵入12年显示文摘1例33岁男性右眼突然视力下降.可见红色斑点。眼部病史为12年前在进行重金属冲压时右眼穿通伤。受伤后.患者接受了巩膜裂伤缝合术.经扁平部玻璃体切除术,眼内异物取出术和巩脱环扎术.应用4-0和5-0的Dacron缝线(Alcon Surgical Inc, Fort Worth, Tex)缝合6mm长的巩膜裂伤,并用5mm放射状巩膜海绵外垫压和240带环扎。 | Blake A.Cooper Kevin J.Blinder Gaurav K.Shah Isaac Boniuk 刘敬(译) 赵光喜(校) | 2005 | 美国医学会眼科杂志(中文版)2005，17，2： | 1 |
| 6 | Synthesis,characterization and antimicrobial activity of some new biquinoline derivatives containing a thiazole moiety显示文摘A series of new biquinoline derivatives containing a thiazole moiety were synthesized by a one-pot,base-catalyzed cyclocondensation reaction of 2-chloro-3-formyl quinoline,malononitrile and enaminone.All the synthesized compounds were characterized by elemental analysis,FT-IR,~1H NMR and ^(13)C NMR data.All the synthesized compounds were screened against three bacterial pathogens,namely Bacillus cereus,B.substilis and Escherichia coli and for antifungal activity against three fungal pathogens,Aspergillus niger,Fusarium oxisporum and Rhizopus using the disc diffusion method. | Nirav K.Shah Nimesh M.Shah Manish P.Patel Ranjan G.Patel | 2012 | Chinese Chemical Letters2012，23，4： | 1 |
| 7 | Multi-site spinal stimulation strategies to enhance locomotion after paralysis显示文摘With the advent of spinal cord epidural stimulation techniques,i.e.,electrically enabled motor control(e Emc)in combination with activity dependent locomotor training,humans with traumatic complete sensori-motor paralysis are able to initiate voluntary leg movements and achieve gains in postural control,and bladder and sexual function(Angeli et al.,2014).However,there are yet | Prithvi K.Shah Yury Gerasimenko | 2016 | Neural Regeneration Research2016，11，12： | 1 |
| 8 | Ownership and Operating Performance of Companies that Go Public显示文摘 | Mikkelson W H.M.Partch K.Shah | | 0，，： | 1 |
| 9 | 毛萼厚壳树植物成分对关节炎TNF-α靶点的预测显示文摘目的类风湿性关节炎(RA)是一种涉及主要关节滑膜衬里的自身免疫性疾病。目前的治疗方法有明显的副作用。我们的研究通过计算机模拟来评估毛萼厚壳树植物成分对肿瘤坏死因子-α(TNF-α)的靶向作用。方法利用AutoDock Vina进行分子对接实验,以研究毛萼厚壳树植物成分与TNF-α(PDB ID:2AZ5)晶体结构的结合模式;随后,研究相互作用的氨基酸残基及其对活性成分抑制潜力的影响;进一步使用SwissADME和pkCSM进行药代动力学分析和毒性筛选。结果对接实验结果表明,与标准药物沙利度胺(−7.4 kcal/mol)相比,羽扇豆醇(−9.4 kcal/mol)和α-香树脂醇(−9.4 kcal/mol)对TNF-α的亲和力最强。其活性化学成分与保守的催化残基具有更好的相互作用,从而抑制或阻断RA中的TNF-α相关信号通路。此外,根据ADMET研究,这些植物化学物质的药代动力学和毒性参数均在可接受的范围内。结论植物成分靶向TNF-α的结合潜力显示出良好的结果。尽管如此,本研究鼓励毛萼厚壳树的传统应用,并为药物开发和临床治疗提供了重要的信息。 | Subhash R.Yende Sapan K.Shah Sumit K.Arora Keshav S.Moharir Govind K.Lohiya | 2021 | Digital Chinese Medicine2021，4，3： | 1 |
| 10 | 巴基斯坦原发性耐多药结核病流行情况显示文摘背景:巴基斯坦是世界第6位结核病高负担国家。据世界卫生组织(WHO)估计,巴基斯坦结核病发病率为181/10万,全国每年新增结核病患者28.6万例。来自于医院的资料表明:巴基斯坦耐多药结核病(MDR-TB)问题已十分严重,急需在社区水平对耐多药结核病的严重程度开展评估。本研究为针对巴基斯坦耐药结核病流行状况开展的横段面研究,所使用的痰标本来自于巴基斯坦全国742例未经治疗的新诊断的肺结核患者。目的:评估巴基斯坦原发性耐药的流行情况结果:在672例痰培养阳性患者中,有76例(11.3%)出现了对1种或多种抗结核药物耐药。36例(5.4%)患者对链霉素(10μg/ml)耐药; 51例(7.6%)患者对异烟肼(1μg/ml)耐药;15例(2.2%)患者对利福平(5μg/ml)耐药;12例(1.8%)患者对乙胺丁醇(10μg/ml)耐药;22例(3.3%)患者对吡嗪酰胺耐药。有46例(6.8%)患者痰标本中分离的结核菌株耐1种抗结核药物, 10例(1.5%)同时耐2种抗结核药物,12例(1.8%)同时耐3种抗结核药物,6例(0.9%)同时耐4种抗结核药物,2例(0.3%)同时耐全部5种抗结核一线药。原发性耐多药率为1.8%,(n= 12)(异烟肼1μg/ml,利福平5μg/ml)。结论:研究结果表明,巴基斯坦原发性耐多药率<2%,需要进一步实施有效的DOTS策略。 | A.Javaid R.Hasan A.Zafar A.Ghafoor A.J.Pathan A.Rab A.Sadiq C.M.Akram I.Burki K.Shah M.Ansari N.Rizvi S.U.Khan S.R.Awan Z.A.Syed Z.H.lqbal Z.Shaheen N.ur Rehman 邢超 | 2008 | 国际结核病与肺部疾病杂志2008，3，2： | 0 |
| 11 | Outcomes of additional posterior to ridge diode laser versus conventional laser anterior to ridge in severe stage 3 retinopathy of prematurity-a randomized control trial显示文摘Background:Laser photocoagulation restricted to ablation of the avascular retina has been the conventional but not a completely effective treatment strategy in the management of threshold retinopathy of prematurity(ROP).The purpose of this study was to compare the structural outcomes of additional posterior to ridge diode laser compared to conventional diode laser to avascular retina alone in threshold stage III ROP.Methods:This was a prospective,randomized study involving infants diagnosed with threshold stage III ROP in one or both the eyes.The infants were randomized into control and study groups.Infants under the control group underwent conventional laser to avascular retina alone while infants under the study group received additional two rows of laser posterior to the ridge in the vascular retina.The infants were followed up at 2 weeks,1 month and up to 6 months after the laser procedure.Results:During the study period of 1 year,42 eyes of 24 infants were recruited into this study with 21 eyes in each group.The mean birth weight was 1,310.48±400.92 g in the test group and 1,341.9±396.2 g in the control group.The mean post conceptional age at the time of intervention was 36.43±2.79 weeks in test group and 36.29±2.55 weeks in the control group.At 1-month post laser,19 eyes in the study group showed regression of neovascularization laser compared to 18 eyes in the control group.However at the end of 3 and 6 months post laser,both groups had showed similar rates regression of neovascularization(19 of 21 eyes in both groups).Five eyes in the study group and six in the control group required additional laser treatment.Two eyes in the study group and one eye in the control group developed post laser vitreous hemorrhage.Conclusions:Posterior to ridge laser treatment for severe stage 3 ROP did not show any additional benefit compared to conventional laser. | Amrutha Sindhu Narendran Siddharth Parag K.Shah Venkatapathy Narendran Narendran Kalpana | 2017 | Annals of Eye Science2017，，1： | 0 |
| 12 | A novel and promising addition to the treatment arsenal for post-intubation subglottic stenosis: Holmium laser ablation and cryotherapy via flexible bronchoscopy显示文摘Dr.Jiao et al1 from Beijing Children’s Hospital present an impressive report on the novel use of a holmium laser and subsequent cryotherapy delivered via a flexible bronchoscopy as a treatment modality for post-intubation acquired subglottic stenosis in children.Excellent outcomes were achieved in 16 consecutive patients with serial procedures,including clinical cure(defined as:resolution of respiratory symptoms,significant improvement in subglottic stenosis grade,and tracheotomy decannulation)in 15 of 16 patients.They had no serious complications.This novel approach with promising results adds to the toolbox of methods available to address the vexing problem of post-intubation subglottic stenosis. | Claire M.Lawlor Rahul K.Shah | 2019 | Pediatric Investigation2019，3，1： | 0 |
| 13 | Development and validation of an LC-MS/MS method for tyrphostin A9显示文摘Here we have presented a sensitive and selective LC-MS/MS method for the quantification of tyrphostin A9, which is a selective inhibitor for platelet derived growth factor receptor tyrosine kinase and has been investigated in vitro as a potent oxidative phosphorylation uncoupler. The murine analytical method was developed for three biological matrices: cell culture media, 3T3-L1 cell lysate, and murine plasma. For each matrix the limit of detection and the limit of quantification were found to be 0.5 ng/mL and 1.0 ng/ mL, respectively. The range of standard curve for each matrix was 1.0-100 ng/mL, linearity was >0.99, and the precision and accuracy were within 20%. 3-(3,5-di-tert-butyl-4-hydroxyphenyl) propanoic acid was found to be the most suitable internal standard. The validated LC-MS/MS method was used to investigate stability and in vitro pharmacokinetics of tyrphostin A9. It was found that tyrphostin A9 is susceptible to hydrolysis, and the degradation product was identified as 3,5-di-tert-butyl-4- hydroxybenzaldehyde. Tyrphostin A9 was not stable in biological matrices, and the rate of its degradation in murine plasma was faster than that in cell culture media. In vitro pharmacokinetic studies revealed that tyrphostin A9 concentrations in the cell culture media declined in a bi-exponential manner and the concentrations inside the adipocytes remained constant, suggesting tyrphostin A9 has an intracellular binding site and is retained within the cell. The LC-MS/MS method presented here paves the way for further quantitative investigations involving tyrphostin A9. | Lyndsey F.Meyer Dhaval K.Shah | 2019 | Journal of Pharmaceutical Analysis2019，9，3： | 0 |
| 14 | A comparison of centrifugation and tangential flow filtration for nanoparticle purification: A case study on acetalated dextran nanoparticles显示文摘Tangential fiow filtration (TFF) is a purification method commonly used in a multitude of fields,including particle engineering.Currently,there is still a lack of comprehensive understanding of the effects of key TFF parameters on nanoparticle (NP) characteristics (purification outcomes).The present study aimed to investigate the influence of various factors on the characteristics of TFF-purified NP.The most commonly used NP purification method,centrifugation,was studied as a control.A design of experiment approach was implemented to investigate the influence of transmembrane pressure,flow rate,and initial drug loading on NP characteristics using paclitaxel as a model small molecule.Following the determination of optimized TFF parameters,the two purification methods were assessed using other model small molecules (i.e.tacrolimus and resveratrol).The results indicated that the TFF parameters and initial loading of the drug played important roles in the purified NP outcomes.Compared with the centrifugation method,TFF resulted in smaller NP with higher drug loading.TFF was able to circumvent issues associated with conventional centrifugation,while yielding similar results,and can potentially serve as a suitable large-scale purification method for polymeric NP. | Nishan K.Shah Ryan Ivone Jie Shen Samantha A.Meenach | 2020 | Particuology2020，18，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员