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| 1 | Erythropoietin Receptor Expression in Non‐Small Cell Lung Carcinoma: A Question of Antibody Specificity显示文摘 | W. MarkBrown PerryMaxwell Alastair N.J.Graham AnitaYakkundi Elaine A.Dunlop ZhanzhongShi Patrick G.Johnston Terence R.J.Lappin | 2009 | STEM CELLS2009，，3： | 1 |
| 2 | Mechanistic target of rapamycin inhibitors:successes and challenges as cancer therapeutics显示文摘Delineating the contributions of specific cell signalling cascades to the development and maintenance of tumours has greatly informed our understanding of tumorigenesis and has advanced the modern era of targeted cancer therapy.It has been revealed that one of the key pathways regulating cell growth,the phosphatidylinositol 3-kinase/mechanistic target of rapamycin(PI3K/mTOR)signalling axis,is commonly dysregulated in cancer.With a specific,well-tolerated inhibitor of mTOR available,the impact of inhibiting this pathway at the level of mTOR has been tested clinically.This review highlights some of the promising results seen with mTOR inhibitors in the clinic and assesses some of the challenges that remain in predicting patient outcome following mTOR-targeted therapy. | Muireann NíBhaoighill Elaine A.Dunlop | 2019 | Cancer Drug Resistance2019，2，4： | 0 |
| 3 | FGF-2 is required to prevent astrogliosis in the facial nucleus after facial nerve injury and mechanical stimulation of denervated vibrissal muscles显示文摘Recently,we have shown that manual stimulation of paralyzed vibrissal muscles after facial-facial anastomosis reduced the poly-innervation of neuromuscular junctions and restored vibrissal whisking.Using gene knock outs,we found a differential dependence of manual stimulation effects on growth factors.Thus,insulin-like growth factor-1 and brain-derived neurotrophic factor are required to underpin manual stimulation-mediated improvements,whereas FGF-2 is not.The lack of dependence on FGF-2 in mediating these peripheral effects prompted us to look centrally,i.e.within the facial nucleus where increased astrogliosis after facial-facial anastomosis follows 'synaptic stripping'.We measured the intensity of Cy3-fluorescence after immunostaining for glial fibrillary acidic protein(GFAP) as an indirect indicator of synaptic coverage of axotomized neurons in the facial nucleus of mice lacking FGF-2(FGF-2^(-/-) mice).There was no difference in GFAP-Cy3-fluorescence(pixel number,gray value range17-103) between intact wildtype mice(2.12± 0.37×10~7) and their intact FGF-2^(-/-) counterparts(2.12±0.27×10~7) nor after facial-facial anastomosis +handling(wildtype:4.06±0.32×10~7;FGF-2^(-/-):4.39±0.17×10~7).However,after facial-facial anastomosis,GFAP-Cy3-fluorescence remained elevated in FGF-2^(-/-)-animals(4.54±0.12×10~7),whereas manual otimulation reduced the intensity of GFAP-immunofluorescence in wild type mice to values that were not significantly different from intact mice(2.63±0.39×10).We conclude that FGF-2 is not required to underpin the beneficial effects of manual stimulation at the neuro-muscular junction,but it is required to minimize astrogliosis in the brainstem and,by implication,restore synaptic coverage of recovering facial motoneurons. | Arzu Hizay Mark Seitz Maria Grosheva Nektarios Sinis Yasemin Kaya Habib Bendella Levent Sarikcioglu Sarah A.Dunlop Doychin N.Angelov | 2016 | The Journal of Biomedical Research2016，30，2： | 0 |
| 4 | Raman Analysis of 30 MeV C_(60) Irradiated N-doped Carbon显示文摘In the present work, we used the technique of “low energy ion implantation + swift; heavy ion irradiation ”to investigate huge electronic excitations induced modification in N-doped graphite-like-carbon. | WangZhiguang A.Dunlop ZhaoZhiming SongYin JinYunfan ZhangChonghong LiuJie SunYoumei | 2003 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2003，，1： | 0 |
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