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| 1 | Prognostic significance of tumor immune microenvironment and immunotherapy:Novel insights and future perspectives in gastric cancer显示文摘Despite a decrease in gastric cancer incidence, the development of novel biologic agents and combined therapeutic strategies, the prognosis of gastric cancer remains poor. Recently, the introduction of modern immunotherapy, especially using immune checkpoint inhibitors, led to an improved prognosis in many cancers. The use of immunotherapy was also associated with manageable adverse event profiles and promising results in the treatment of patients with gastric cancer, especially in heavily pretreated patients. These data have led to an accelerated approval of some checkpoint inhibitors in this setting. Understanding the complex relationship between the host immune microenvironment and tumor and the immune escape phenomenon leading to cancer occurrence and progression will subsequently lead to the identification of prognostic immune markers. Furthermore, this understanding will result in the discovery of both new mechanisms for blocking tumor immunosuppressive signals and pathways to stimulate the local immune response by targeting and modulating different subsets of immune cells. Due to the molecular heterogeneity of gastric cancers associated with differentclinico-biologic parameters, immune markers expression and prognosis, novel immunotherapy algorithms should be personalized and addressed to selected subsets of gastric tumors, which have been proven to elicit the best clinical responses. Future perspectives in the treatment of gastric cancer include tailored dual immunotherapies or a combination of immunotherapy with other targeted agents with synergistic antitumor effects. | Daniela Cornelia Lazǎr Mihaela Flavia Avram Ioan Romosan Mǎrioara Cornianu Sorina Tǎan Adrian Goldis | 2018 | World Journal of Gastroenterology2018，24，32： | 24 |
| 2 | A Two-Phase Cinematic PIV Method for Bubbly Flows 显示文摘 | Oakley T R Loth E Adrian R J | 1997 | Journal of Fluids Engineering1997，，119： | 1 |
| 3 | Tumor necrosis factor stimulates amylin secretion but inhibits insulin from islet β-cells by independent pathways显示文摘 | Ding X Z Flatt P R Adrian T E | 1996 | Regulatory Peptides1996，64，3： | 1 |
| 4 | Flexible active power control of distributed power generation systems during grid faults显示文摘 | Pedro R Adrian V T Remus T | 2007 | IEEE Transactions on Industrial Electronics2007，54，5： | 1 |
| 5 | Particle dispersion in isotropic turbulence under Stokes drag and Basset force with gravitational setting显示文摘 | MEI R W ADRIAN R J HANRATTY T J | 1991 | J Fluid Mech1991，225，： | 1 |
| 6 | Analysis and interpretation of instantaneous turbulent velocity fields显示文摘 | Adrian R J Christerksen K T Liu Z C | 2000 | Experiments in Fluids2000，29，3： | 1 |
| 7 | Measurement of instantaneous Eulerian acceleration fields by particle image accelerometry: method and accuracy 显示文摘 | CHRISTENSEN K T ADRIAN R J | 2002 | Experiments in Fluids2002，33，6： | 1 |
| 8 | Inhibition of pancreas and gallbladder by pancreatic polypeptide 显示文摘 | Greenberg G R McCloy R F Adrian T E | 1978 | Lancet1978，312，： | 1 |
| 9 | Chronic pancrea- titis and diabetes mellitus: plasma and gastroduodenal mucosal profiles of regulatory peptides ( gastrin, motilin, secretin, cho-lecystokinin, gastric inhibitory polypeptide, somatostatin, VIP, substance P, pancreatic polypeptide, glucagon, enterogluea- gon, neurotensin) 显示文摘 | Domschke S Bloom S R Adrian T E | 1988 | Hepatogastroenterology1988，35，5： | 1 |
| 10 | Effects of ice duration on plankton succession during spring in a shallow poly- mictic lake 显示文摘 | Adrian R Walz N Hintze T | 1999 | Freshwater Biology1999，41，3： | 1 |
| 11 | Exposure of cultured human proximal tubular cells to cadmium,mercury,zinc and bismuth:toxicity and metallothionein induction显示文摘 | Vicente R Adrian T M William J | 1998 | Chemico Biological Interactions1998，115，1： | 1 |
| 12 | Particle dispersion in isotropic turbulence under stokes drag and Basset force with gravitational setting显示文摘 | Renwei Mei R J Adrian T J Hanratty | | Journal of Fluid Mechanics0，225，3： | 1 |
| 13 | 显示文摘 | Graham K T Robert L N Adrian L R T | 2003 | Nature2003，425，： | 1 |
| 14 | Analysis and interpretation of instantaneous turbulent velocity fields显示文摘 | Adrian R J Christensen K T Liu Z C | 2000 | Experiments in Fluids2000，29，3： | 1 |
| 15 | Analy-sis and interpretation of instantaneous turbulent velocity fields显示文摘 | ADRIAN R J CHRISTENSEN K T LIU Z C | | 0，，： | 1 |
| 16 | A review of potentially low-cost sorbents for heavy metals显示文摘 | BAILERY S E OLIN T J BRICK R M ADRIAN D D | 1999 | Water Research1999，33，11： | 1 |
| 17 | Direct measurement of dimethylsul-foniopropionate(DMSP)in reef-building corals using quantitative nuclear magnetic resonance(q NMR)spectroscopy显示文摘 | Dianne M T Jean-Baptiste R Adrian L | 2013 | J Exp Mar Biol Ecol2013，443，： | 1 |
| 18 | Genome type analysis of adenovirus infants enterms 显示文摘 | Adrian T Wigand R | 1989 | Arch 31 a potential causative agent o{ ' '' '' ' Virol1989，105，12： | 1 |
| 19 | Laser peening technology 显示文摘 | Michael R H Adrian T D Anne G D | 2003 | Advanced Materials & Processes2003，161，8： | 1 |
| 20 | Lipoxygenase inhibition by flavonoids : semiempirical study of the structure- activity relation 显示文摘 | Modesto R R Adrian T C Maria C P | 2004 | J Molecul Struct ( Theochem )2004，674，13： | 1 |
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