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| 1 | Prognostic significance of tumor immune microenvironment and immunotherapy:Novel insights and future perspectives in gastric cancer显示文摘Despite a decrease in gastric cancer incidence, the development of novel biologic agents and combined therapeutic strategies, the prognosis of gastric cancer remains poor. Recently, the introduction of modern immunotherapy, especially using immune checkpoint inhibitors, led to an improved prognosis in many cancers. The use of immunotherapy was also associated with manageable adverse event profiles and promising results in the treatment of patients with gastric cancer, especially in heavily pretreated patients. These data have led to an accelerated approval of some checkpoint inhibitors in this setting. Understanding the complex relationship between the host immune microenvironment and tumor and the immune escape phenomenon leading to cancer occurrence and progression will subsequently lead to the identification of prognostic immune markers. Furthermore, this understanding will result in the discovery of both new mechanisms for blocking tumor immunosuppressive signals and pathways to stimulate the local immune response by targeting and modulating different subsets of immune cells. Due to the molecular heterogeneity of gastric cancers associated with differentclinico-biologic parameters, immune markers expression and prognosis, novel immunotherapy algorithms should be personalized and addressed to selected subsets of gastric tumors, which have been proven to elicit the best clinical responses. Future perspectives in the treatment of gastric cancer include tailored dual immunotherapies or a combination of immunotherapy with other targeted agents with synergistic antitumor effects. | Daniela Cornelia Lazǎr Mihaela Flavia Avram Ioan Romosan Mǎrioara Cornianu Sorina Tǎan Adrian Goldis | 2018 | World Journal of Gastroenterology2018，24，32： | 24 |
| 2 | Positron emission tomography scanning in the evaluation of hepatocellular carcinoma显示文摘 | M.Akram Khan Connie S Combs Elizabeth M Brunt Val J Lowe Michael K Wolverson Harvey Solomon Brian T Collins Adrian M.Di Bisceglie | 2000 | Journal of Hepatology2000，，5： | 2 |
| 3 | CD28 costimulation improves expansion and persistence of chimeric antigen receptor-modified T cells in lymphoma patients显示文摘 | Savoldo Barbara Ramos Carlos Almeida Liu Enli Mims Martha P Keating Michael J Carrum George Kamble Rammurti T Bollard Catherine M Gee Adrian P Mei Zhuyong Liu Hao Grilley Bambi Rooney Cliona M Heslop Helen E Brenner Malcolm K Dotti Gianpie | 2011 | Journal of Clinical Investigation2011，，5： | 1 |
| 4 | 3D structure of Alzheimer's amyloid-β(1-42) fibrils显示文摘 | L(U)HRS T RITTER C ADRIAN M | 2005 | Proc Natl Acad Sci USA2005，102，17： | 1 |
| 5 | Effects of epidermal growth factor on neonatal pancreatic growth in the guinea pig显示文摘 | HERRINGTON M K JOEKEL C S ADRIAN T E | 1998 | International journal of pancreatology:official journal of the International Association of Pancreatology1998，24，1： | 1 |
| 6 | Model predictivecontrol of integrated unit operations:Control of a dividedwall column显示文摘 | ADRIAN T SCHOENMAKER S H BOLL M | 2004 | Chem Eng Process2004，43，： | 1 |
| 7 | Performance-based design in earthquake engineering:A multi-disciplinary review显示文摘 | Adrian M C Nelson T K L | 2001 | Engineering Structures2001，23，： | 1 |
| 8 | 3D structure of Alzheimer' s amyloid-β (1-42) fibrils显示文摘 | Lüihrs T Ritter C Adrian M | 2005 | Proc Natl Acad Sci USA2005，102，17： | 1 |
| 9 | Neuropeptide Y distribution in the rat brain显示文摘 | ALLEN Y S ADRIAN T E ALLEN J M | 1983 | Science1983，221，： | 1 |
| 10 | Sonophotocatalytic/H2O2 degradation of phenolic compounds in agro-industrial effiuents显示文摘 | Adrian M T Silva Ekaterini Nouli Angela C | 2007 | Catalysis Today2007，124，30： | 1 |
| 11 | Recycling of fibre-reinforced polymeric waste by pyrolysis: Themogrevimetric and bench-scale investigations 显示文摘 | Adrian M Cunliffe Nicola Jones Paul T | 2003 | J Anal Appl Pyrolysis2003，，70： | 1 |
| 12 | 3D structure of Alzheimer' s amyloid-beta(l-42) fibrils显示文摘 | Luhrs T Ritter C Adrian M | 2005 | Proc Natl Aead Sci U S A2005，102，17： | 1 |
| 13 | Cholecystokinin effect on human lymphocyte ionized calcium and mitogenesis 显示文摘 | McMillen M A Ferrara A Adrian T E | 1995 | J Surg Res1995，58，2： | 1 |
| 14 | Positive correlation between symptoms and circulating motilin, pancreaticpolypeptide and gastrin concentrations in functional bowel disorders 显示文摘 | Perston D M Adrian T E Christofides N D | 1995 | Gut1995，26，： | 1 |
| 15 | Epitaxial CeO2 buffer layers for YBa2Cu3O7-δ films on sapphire 显示文摘 | MAUL M SCHULTE B HAUSSLER P FRANK G STEINBORN T FUESS H ADRIAN H | 1993 | J Appl Phys1993，74，4： | 1 |
| 16 | Hair analysis: Another approach for the assessment of human exposure to selected persistent organochlorine pollutants 显示文摘 | Adrian C Maria T Aristidis M T Paul S | 2002 | Chemosphere2002，46，： | 1 |
| 17 | Sonophotocatalytic/H2O2 degradation of phenolic compounds in agro-industrial effluents 显示文摘 | Adrian M T Silva Ekaterini Nouli Angela C | 2007 | Catalysis Today2007，124，30： | 1 |
| 18 | Exposure of cultured human proximal tubular cells to cadmium,mercury,zinc and bismuth:toxicity and metallothionein induction显示文摘 | Vicente R Adrian T M William J | 1998 | Chemico Biological Interactions1998，115，1： | 1 |
| 19 | Nanomaterials in Soils显示文摘 | MICHAEL A W NGUYEN H T ADRIAN S M | 2008 | Geoderma2008，146，12： | 1 |
| 20 | Analy- sis and interpretation of instantaneous turbulent velocity fields显示文摘 | ADRIAN M J CHRISTENSEN K T LIU Z C | 2000 | Experiments in Fluids2000，29，3： | 1 |
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