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| 1 | Incretins and selective renal sodium-glucose co-transporter 2 inhibitors in hypertension and coronary heart disease显示文摘Hyperglycemia is associated with an increased risk of cardiovascular disease,and the consequences ofintensive therapy may depend on the mechanism of the anti-diabetic agent(s)used to achieve a tight control.In animal models,stable analogues of glucagon-like peptide-1(GLP-1)were able to reduce body weight and blood pressure and also had favorable effects on ischemia following coronary reperfusion.In a similar way,dipeptidyl peptidase IV(DPPIV)showed to have favorable effects in animal models of ischemia/reperfusion.This could be due to the fact that DPPIV inhibitors were able to prevent the breakdown of GLP-1 and glucose-dependent insulinotropic polypeptide,but they also decreased the degradation of several vasoactive peptides.Preclinical data for GLP-1,its derivatives and inhibitors of the DPPIV enzyme degradation suggests that these agents may be able to,besides controlling glycaemia,induce cardio-protective and vasodilator effects.Notwithstanding the many favorable cardiovascular effects of GLP-1/incretins reported in different studies,many questions remain unanswered due the limited number of studies in human beings that aim to examine the effects of GLP-1 on cardiovascular endpoints.For this reason,long-term trials searching for positive cardiovascular effects are now in process,such as the CAROLINA and CARMELINA trials,which are supported by small pilot studies performed in humans(and many more animal studies)with incretin-based therapies.On the other hand,selective renal sodium-glucose co-transporter 2 inhibitors were also evaluated in the prevention of cardiovascular outcomes in type 2 diabetes.However,it is quite early to draw conclusions,since data on cardiovascular outcomes and cardiovascular death are limited and long-term studies are still ongoing.In this review,we will analyze the mechanisms underlying the cardiovascular effects of incretins and,at the same time,we will present a critical position about the real value of these compounds in the cardiovascular system and its protection. | Ramiro A Sanchez Hugo Sanabria Cecilia de los Santos Agustin J Ramirez | 2015 | World Journal of Diabetes2015，6，11： | 5 |
| 2 | Outcome in obscure gastrointestinal bleeding after capsule endoscopy显示文摘AIM: To investigate the clinical impact of capsule endoscopy(CE) after an obscure gastrointestinal bleeding(OGIB) episode, focusing on diagnostic work-up, followup and predictive factors of rebleeding. METHODS: Patients who were referred to Hospital del Mar(Barcelona, Spain) between 2007 and 2009 for OGIB who underwent a CE were retrospectively analyzed. Demographic data, current treatment with non-steroid antiinflammtory drugs or anticoagulant drugs, hemoglobin levels, transfusion requirements, previous diagnostic tests for the bleeding episode, as well as CE findings(significant or non-significant), work-up and patient out-comes were analyzed from electronic charts. Variables were compared by χ 2 analysis and Student t test. Risk factors of rebleeding were assessed by Log-rank test, Kaplan-Meier curves and Cox regression model. RESULTS: There were 105 patients [45.7% women, median age of 72 years old(interquartile range 56-79)] and a median follow-up of 326 d(interquartile range 123-641) included in this study. The overall diagnostic yield of CE was 58.1%(55.2% and 63.2%, for patients with occult OGIB and overt OGIB, respectively). In 73 patients(69.5%), OGIB was resolved. Multivariate analysis showed that hemoglobin levels lower than 8 g/dL at diagnosis [hazard ratios(HR) = 2.7, 95%CI: 1.9-6.3], patients aged 70 years and above(HR = 2.1, 95%CI: 1.2-6.1) and significant findings in CE(HR = 2.4, 95%CI: 1.1-5.8) were independent predictors of rebleeding. CONCLUSION: One third of the patients presented with rebleeding after CE; risk factors were hemoglobin levels < 8 g/dL, age ≥ 70 years or the presence of significant lesions. | Alex Caas-Ventura Lucia Márque Xavier Bessa Josep Maria DedeuDepartment of Gastroenterology Hospital del Mar Research Institute Pompeu Fabra University Marc Puigvehí Sílvia Delgado-Aros Ines Ana Ibáez Agustin Seoane Luis Barranco Felipe Bory Montserrat Andreu Begoa González-Suárez | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，11： | 4 |
| 3 | Linear transceiver design in nonregenerative relays with channel state information显示文摘 | Medina O M Vidal J Agustin A | 2007 | IEEE Trans on Signal Processing2007，55，6： | 1 |
| 4 | A detailed study of the activity and deactivation of zeolites in hybrid Co/Si02-zeolite Fischer-Tropsch catalysts 显示文摘 | Agustin Martinez Joan Rollan Maria A Arribas | 2007 | Journal of Catalysis2007，249，2： | 1 |
| 5 | Non-regenerative MIMO relaying with channel state information 显示文摘 | Munoz O Vidal J Agustin A | 2005 | ICASSP IEEE Int Conf Acoust Speech Signal Process Proc2005，3，： | 1 |
| 6 | The decrease in pesticides in fruit and vegetables during commercial processing显示文摘 | Ma JC Antonio H Agustin A | 2005 | International Journal of Food Science and Technology2005，40，： | 1 |
| 7 | Pesticide residues in field-sprayed and processed fruits and vegetables显示文摘 | Ma JC Antonio H Agustin A | 2004 | Journal of the Science of Food and Agricuhure2004，84，10： | 1 |
| 8 | Robust detection and ordering of ellipses on a calibration pattern显示文摘 | Luis A Agustin S Javier S | 2005 | Pattern Recognition and Image Analysis2005，15，2： | 1 |
| 9 | Effects of posture on right-to-left shunt detection by contrast transcranial doppler 显示文摘 | Agustin S J Yumul MP Kalaw A J | 2011 | Stroke2011，42，： | 1 |
| 10 | Linear Transceiver Design in Non-regenerative Relays with Channel State Information显示文摘 | Munoz-Medina O Vidal J Agustin A | | 0，，06： | 1 |
| 11 | Pd and Pt catalysts supported on carbon-coated monoliths for low-temperature combustion of xylenes显示文摘 | Agustin F Perez-Cadenas Freek Kapteijn Jacob A Moulijn | 2006 | Carbon2006，44，12： | 1 |
| 12 | Cephalalgia Alopecia or Nummular Headache With Trophic Changes? A New Case With Prolonged Follow‐Up显示文摘 | Pablo Irimia Jose‐Alberto Palma Miguel Angel Idoate Agustin Espa?a Mario Riverol Eduardo Martinez‐Vila | 2013 | Headache: The Journal of Head and Face Pain2013，，6： | 1 |
| 13 | Effect of Propranolol on the factors promoting bacterial translocation in cirrhotic rats with ascites显示文摘 | Javier M Agustin A | 2000 | Hepatology2000，31，： | 1 |
| 14 | Influence of the physico-chemical properties of CeO2-zrO2 mixed oxides on the applied surface显示文摘 | IDRISS A NOELIA G H AGUSTIN B L AVELINA G G | 2010 | Science2010，256，： | 1 |
| 15 | Linear transceiver design in non-regenerative relays with channel state information显示文摘 | MEDINA M VIDAL J AGUSTIN A | 2007 | IEEE Transactions on Signal Processing2007，55，6： | 1 |
| 16 | The effect of citric acid and microbial phytase on mineral utilization in broiler chicks显示文摘 | AGUSTIN B AGUST'IN V IGNAC10 A | 2003 | J Animal Feed Scieace and Technology2003，110，： | 1 |
| 17 | Endoscopic Treat- ment Versus Endoscopic Plus Pharmacologic Treatment for Acute Variceal Bleeding: A Meta-analysis显示文摘 | RAFAEL B AGUSTIN A DIEGO R | 2002 | Hepatology2002，35，： | 1 |
| 18 | Effects of nitrogen and sulfur application on grain yield, nutrient accumulation, and harvest indexes in maize显示文摘 | Agustin P Hemdn E E Femando H A | 2012 | Journal of Plant Nutrition2012，35，： | 1 |
| 19 | Beta-blockers in patients with cirrhosis and refractory ascites显示文摘 | Agustin A Javier Z | | 0，，： | 1 |
| 20 | Mutation of atranscription factor,TFCP2L3,causes progressive au-tosomal dominant hearing loss,DFNA28显示文摘 | Peters L M Anderson D W Griffith A J Grundfast KM San Agustin T B Madeo A C | 2002 | Hum MolGenet2002，11，： | 1 |
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