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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | Cytochrome P450 levels are altered in patients with esophageal squamous-cell carcinoma显示文摘AIM: To investigate the role of cytochrome P450 (CYP) in the carcinogenesis of squamous-cell carcinoma (SCC) in human esophagus by determining expression patterns and protein levels of representative CYPs in esophageal tissue of patients with SCC and controls. METHODS: mRNA expression of CYP2E1, CYP2C, CYP3A4, and CYP3A5 was determined using RT-PCR in both normal and malignant esophageal tissues of patients with untreated esophageal SCC (n = 21) and in controls (n = 10). Protein levels of CYP2E1, CYP2C8, CYP3A4, and CYP3A5 were measured by Western blot. RESULTS: Within the group of SCC patients, mRNA expression of CYP 3A4 and CYP2C was significantly lower in malignant tissue (-39% and -74%, respectively, P < 0.05) than in normal tissue. Similar results were found in CYP3A4 protein levels. Between groups, CYP3A4, CYP3A5, and CYP2C8 protein concentration was significantly higher in non-malignant tissue of SCC patients (4.8-, 2.9-, and 1.9-fold elevation, P < 0.05) than in controls. In contrast, CYP2E1 protein levels were significantly higher in controls than in SCC patients (+46%, P < 0.05). CONCLUSION: Significant differences exist in protein levels of certain CYPs in non-malignant esophageal tissue (e.g. CYP2C8, CYP3A4, CYP3A5, and CYP2E1) between SCC patients and healthy subjects and may contribute to the development of SCC in the esophagus. | I Bergheim E Wolfgarten E Bollschweiler AH Hlscher C Bode A Parlesak | 2007 | World Journal of Gastroenterology2007，13，7： | 6 |
| 3 | 茶叶摄入与中国成年人高密度脂蛋白胆固醇浓度纵向变化的关系显示文摘茶叶摄入与高密度脂蛋白胆固醇(high-density lipoprotein cholesterol,HDL-C)浓度的年龄相关变化之间的关系仍不清楚。该研究目的是探索茶摄入量与HDL-C浓度纵向变化之间的关系。研究人员通过调查问卷评估基线(2006年)的茶叶消费量,并在2006、2008、2010和2012年测量了未患有心血管病或癌症. | 刘莉 叶鹏 Huang S Li J Wu Y Ranjbar S Xing A Zhao H Wang Y Shearer GC Bao L Lichtenstein AH Wu S Gao X | 2018 | 中华高血压杂志2018，26，8： | 5 |
| 4 | Vertebroplasty versus conservative treatment in acute osteoporotic vertebral compression fractures (Vertos II): an open-label randomised trial显示文摘 | Caroline AH Klazen Paul NM Lohle Jolanda de Vries Frits H Jansen Alexander V Tielbeek Marion C Blonk Alexander Venmans Willem Jan J van Rooij Marinus C Schoemaker Job R Juttmann Tjoen H Lo Harald JJ Verhaar Yolanda van der Graaf Kaspar J van Everdingen Al | 2010 | 2010 (9746)2010，，9746： | 2 |
| 5 | Pseudo-rationale design of efficient TB vaccines: lesson from the mycobacterial 27-kDa lipoprotein 显示文摘 | Hovav AH Bercovier H | 2006 | Tuberculosis (Edinb)2006，86，34： | 1 |
| 6 | Silent myocardial ischemia:current perspectives and future directions显示文摘 | Ahmed AH Shankar K Eftekhari H | 2007 | Exp Clin Cardiol2007，12，： | 1 |
| 7 | Mitogenicity of the recombinant myco- bacterial 27-kilodalton lipoprotein is not connected to its anti- protective effect 显示文摘 | Hovav AH Davidoviteh L Nussbaum G Mullerad J Fish- man Y Bercovier H | 2004 | Infect Immun2004，72，6： | 1 |
| 8 | Diagnostic und Therapies Magenkarzinoms-Workflow显示文摘 | Grundmann RT Hlscher AH Bembenek A | 2009 | Zentralbl Chir2009，134，： | 1 |
| 9 | Laparoscopic management of bile duct and bowel injury during laparoscopic cholecystectomy显示文摘 | KWON AH INUI H KAMIYAMA Y | 2001 | World J Surg2001，25，： | 1 |
| 10 | Effect of fermentation on the in vitro protein digestibility of pearl millet显示文摘 | Ali MAM Tinay A H E Abdalla AH | 2003 | Food Chemistry2003，80，1： | 1 |
| 11 | percutrancous nephro- lithotomy urithultrasonography-gulded renel access in the lateral decubitus 显示文摘 | Karami H Arbab AH Rezaei A | 2009 | Flank position J Endourol2009，23，： | 1 |
| 12 | A clinicl pathologic study in the elderly显示文摘 | Yamanouchi H Nagura H Mizutani T et ah Embolic brain infarc- tion in nonrheumatic atrial fibrillation | 1997 | Neurology1997，48，6： | 1 |
| 13 | Primary chylous vaginal discharge in a 9-year-old girl:CT-lymphangiogram and MR appearance显示文摘 | Shahlaee AH Burton EM Sabio H | 1997 | Pediatr Radiol1997，27，9： | 1 |
| 14 | Long term results of holmium laser ablation of the prostate显示文摘 | Tan AH Gilling PJ Fletcher H | 2003 | B J Uint2003，92，： | 1 |
| 15 | coli using anodic stripping vohammetry based on Cu@Au nanoparticles as antibody labels显示文摘 | Zhang XN Geng P Liu H J et ah Development of an electrochemical immunoassay for rapid detection of E | 2009 | Biosensors and Bioelectron- ics2009，24，7： | 1 |
| 16 | A phase II randomized study of cetuximab and bevacizumab alone or in combination with gemcitabine as first-line therapy for metastatic pancreatic adenocarcinoma显示文摘 | Ko AH Youssoufian H Gurtler J | 2012 | Invest NewDrugs2012，30，4： | 1 |
| 17 | Preclinical and clinical pharmacology of cerivastatin显示文摘 | Heller AH | 1998 | Am J Cardiol1998，82，： | 1 |
| 18 | Promotion of wellswitching to mitigate the current arsenic crisis in bangladesh 显示文摘 | VAN G A AHSAN H HOMEMAN AH | 2002 | Bull World Health Organ2002，80，9： | 1 |
| 19 | Preclinical and clinical pharmacology of cerivastatin显示文摘 | Bischoff H Heller AH | 1998 | Am J Cardiol1998，27，： | 1 |
| 20 | Molecular genetic evidencethat endometriosis is a precursor of ovarian cancer显示文摘 | Prowse AH Manek S Varma H | 2006 | Int J Canc-er2006，119，3： | 1 |
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