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| 1 | The human application of gene therapy to re-program T-cell specificity using chimeric antigen receptors显示文摘The adoptive transfer of T cells is a promising approach to treat cancers. Primary human T cells can be modified using viral and non-viral vectors to promote the specific targeting of cancer cells via the introduction of exogenous T-cell receptors(TCRs) or chimeric antigen receptors(CARs). This gene transfer displays the potential to increase the specificity and potency of the anticancer response while decreasing the systemic adverse effects that arise from conventional treatments that target both cancerous and healthy cells. This review highlights the generation of clinical-grade T cells expressing CARs for immunotherapy, the use of these cells to target B-cell malignancies and, particularly, the first clinical trials deploying the Sleeping Beauty gene transfer system, which engineers T cells to target CD19+ leukemia and non-Hodgkin's lymphoma. | Alan D Guerrero Judy S Moyes Laurence JN Cooper | 2014 | Chinese Journal of Cancer2014，33，9： | 4 |
| 2 | Single vs dual(en bloc) kidney transplants from donors ≤ 5 years of age: A single center experience显示文摘AIM: To compare outcomes between single and dual en bloc(EB) kidney transplants(KT) from small pediatric donors. METHODS: Monocentric nonprospective review of KTs from pediatric donors ≤ 5 years of age. Dual EB KT was defined as keeping both donor kidneys attached tothe inferior vena cava and aorta, which were then used as venous and arterial conduits for the subsequent transplant into a single recipient. Donor age was less useful than either donor weight or kidney size in decision-making for kidney utilization as kidneys from donors < 8 kg or kidneys < 6 cm in length were not transplanted. Post-transplant management strategies were standardized in all patients.RESULTS: From 2002-2015, 59 KTs were performed including 34 dual EB and 25 single KTs. Mean age of donors(17 mo vs 38 mo, P < 0.001), mean weight(11.0 kg vs 17.4 kg, P = 0.046) and male donors(50% vs 84%, P = 0.01) were lower in the dual EB compared to the single KT group, respectively. Mean cold ischemia time(21 h), kidney donor profile index(KDPI; 73% vs 62%) and levels of serum creatinine(SCr, 0.37 mg/d L vs 0.49 mg/d L, all P = NS) were comparable in the dual EB and single KT groups, respectively. Actuarial graft and patient survival rates at 5-years follow-up were comparable. There was one case of thrombosis resulting in graft loss in each group. Delayed graft function incidence(12% dual EB vs 20% single KT, P = NS) was slightly lower in dual EB KT recipients. Initial duration of hospital stay(mean 5.4 d vs 5.6 d) and the one-year incidences of acute rejection(6% vs 16%), operative complications(3% vs 4%), and major infection were comparable in the dual EB and single KT groups, respectively(all P = NS). Mean 12 mo SCr and abbreviated MDRD levels were 1.17 mg/d L vs 1.35 mg/d L and 72.5 m L/min per 1.73 m^2 vs 60.5 m L/min per 1.73 m^2(both P = NS) in the dual EB and single KT groups, respectively. CONCLUSION: By transplanting kidneys from young pediatric donors into adult recipients, one can effectively expand the limited donor pool and achieve excellent medium-term outcomes. | Yousef Al-Shraideh Umar Farooq Hany El-Hennawy Alan C Farney Amudha Palanisamy Jeffrey Rogers Giuseppe Orlando Muhammad Khan Amber Reeves-Daniel William Doares Scott Kaczmorski Michael D Gautreaux Samy S Iskandar Gloria Hairston Elizabeth Brim Margaret Mangus Robert J Stratta | 2016 | World Journal of Transplantation2016，6，1： | 3 |
| 3 | Dietary approaches following endoscopic retrograde cholangiopancreatography: A survey of selected endoscopists显示文摘AIM: To describe the dietary recommendations of experienced endoscopists for patients who have undergone endoscopic retrograde cholangiopancreatography (ERCP) and the factors that influence these recommendations. METHODS: Selected U.S. endoscopists with ERCP experience were surveyed by e-mail. A questionnaire with three hypothetical ERCP cases of patients at low, medium and high risk for development of post-ERCP pancreatitis (PEP) was shown. For each scenario, respondents were asked to recommend a post-procedure diet and time to first oral intake. Respondents were also asked about the effect of various clinical factors on their recommendations, including risk of PEP.RESULTS: 97/187 selected ASGE members (51.9%) responded. When risk of PEP was either low, medium or high, 53%, 88% and 96% recommended a diet of clear liquids/NPO respectively, and 2%, 5% and 18% recommended delaying first oral intake until the following day. About 88% of respondents gave the same type of diet to patients at high as those with moderate-risk of PEP (P = 0.04). However, 37% and 43% of respondents gave different types of diet to patients at low vs moderate-risk and low-risk vs high-risk of PEP respectively (P < 0.001). No statistically significant associations were found regarding the effect of other clinical factors or respondent demographics.CONCLUSION: Most experienced endoscopists limit diet to NPO/clear liquids after ERCP for patients at high or moderate risk of post-ERCP pancreatitis. About half allow a low-fat or regular diet in patients at low risk. | Lincoln EVVC Ferreira Mark D Topazian William S Harmsen Alan R Zinsmeister Todd H Baron | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，12： | 3 |
| 4 | Global malaria mortality between 1980 and 2010: a systematic analysis显示文摘 | Christopher JL Murray Lisa C Rosenfeld Stephen S Lim Kathryn G Andrews Kyle J Foreman Diana Haring Nancy Fullman Mohsen Naghavi Rafael Lozano Alan D Lopez | 2012 | The Lancet2012，，9814： | 2 |
| 5 | An experiment model of carotid occlusive disease显示文摘 | JASON S SLAKTER ALAN D | 1997 | Am J Ophthalmology1997，，2： | 1 |
| 6 | Deposition of anatase on the surface of activated carbon显示文摘 | AMJAD H E S ALAN P N HAFID A D | 2004 | Surface Coatings Technology2004，187，23： | 1 |
| 7 | Exopolysaccharides from lactic acid bacteriaz perspectives and challenges显示文摘 | Alan D Welman Lan S Maddox | 2003 | Trends in Biotechnology2003，21，6： | 1 |
| 8 | Estimates of the elasticities of substitution between imports and home goods for the United States显示文摘 | Clinton R S Robert M S Alan V D | | 0，，03： | 1 |
| 9 | 查看详情显示文摘 | Christopher A S Rasmus H Arfa R.M Warwick B D Gillian M S Royston G Alan J D | | 0，，01： | 1 |
| 10 | Valuing increments and decrements in natural resource service flows 显示文摘 | BROOKSHIRE D ALAN R JOHN S | 1980 | American journal of agricultural economics1980，62，3： | 1 |
| 11 | Diffusion-tensor MR imaging of intracranial neoclasia and associated peritumoral edema: introduction of the tumor infiltration index显示文摘 | Lu S Alan D Johnson G | 2004 | Radiology2004，232，： | 1 |
| 12 | Global malaria mortality between 1980 and 2010: a systematic analysis显示文摘 | Christopher JL Murray Lisa C Rosenfeld Stephen S Lim Kathryn G Andrews Kyle J Foreman Diana Haring Nancy Fullman Mohsen Naghavi Rafael Lozano Alan D Lopez | 2012 | 2012 (9814)2012，，9814： | 1 |
| 13 | The impaet of evaluating platelet transfusion need by platelet mass index on redueing the unnecessary transfusions in newborns显示文摘 | Kahveeioglu D Erdeve O Alan S | 2014 | J Matern Fetal Neonatal Med2014，27，17： | 1 |
| 14 | The impact of complications on outcomes after resection for esophageal and gastroesophageal junction carcinoma显示文摘 | Nabil P Rizk Peter B Bach Deborah Schrag Manjit S Bains Alan D Turnbull Martin Karpeh Murray F Brennan Valerie W Rusch | 2004 | Journal of the American College of Surgeons2004，，1： | 1 |
| 15 | A Model of HIV-I Pathogenesis that Includes an Intracellular Delay 显示文摘 | Patrick W Nelson James D Murray Alan S Perelson | 2000 | Mathematical Biosciences2000，163，2： | 1 |
| 16 | Induction of autoantibodies against tyrosinase-related proteins following DNA vaccination:Unexpected reactivity to a protein paralogue显示文摘 | Roopa S Alan NH Jedd D | 2002 | Cancer Immunity2002，2，8： | 1 |
| 17 | Microwave pyrolysis,a novel process for recycling waste automotive engine oil显示文摘 | SU S L ALAN D R HOWARD A C | | 0，，35： | 1 |
| 18 | Complexed prostate-specific antigen as a staging tool: results based on a multicenter prospective evaluation of complexed prostate-specific antigen in cancer diagnosis显示文摘 | Samir S Taneja Elias I Hsu Carol D Cheli Paul Walden Georg Bartsch Wolfgang Horninger Richard J Babaian Herbert A Fritsche Stacy Childs Thomas A Stamey Lori J Sokoll Daniel W Chan Michael K Brawer Alan W Partin Herbert Lepor | 2002 | Urology2002，，4： | 1 |
| 19 | A QTL affecting daily feed intake maps to Chromosome2in pigs显示文摘 | Ross D H Chris S H Alan L A | 2005 | Mammalian Genome2005，16，6： | 1 |
| 20 | 显示文摘 | Song M Y Alan D S Park H R | 1999 | Journal of Power Sources1999，83，12： | 1 |
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