|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Magnetic resonance elastography is accurate in detecting advanced fibrosis in autoimmune hepatitis显示文摘To assess the value of magnetic resonance elastography(MRE) in detecting advanced fibrosis/cirrhosis in autoimmune hepatitis(AIH).METHODS In this retrospective study, 36 patients(19 treated and 17 untreated) with histologically confirmed AIH and liver biopsy performed within 3 mo of MRE were identified at a tertiary care referral center. Liver stiffness(LS) with MRE was calculated by a radiologist, and inflammation grade and fibrosis stage in liver biopsy was assessed by a pathologist in a blinded fashion. Two radiologistsevaluated morphological features of cirrhosis on conventional magnetic resonance imaging(MRI). Accuracy of MRE was compared to laboratory markers and MRI for detection of advanced fibrosis/cirrhosis.RESULTS Liver fibrosis stages of 0, 1, 2, 3 and 4 were present in 4, 6, 7, 6 and 13 patients respectively. There were no significant differences in distribution of fibrosis stage and inflammation grade between treated and untreated patient groups. LS with MRE demonstrated stronger correlation with liver fibrosis stage in comparison to laboratory markers for chronic liver disease(r = 0.88 vs-0.48-0.70). A trend of decreased mean LS in treated patients compared to untreated patients was observed(3.7 k Pa vs 3.84 k Pa) but was not statistically significant. MRE had an accuracy/sensitivity/specificity/positive predictive value/negative predictive value of 0.97/90%/100%/100%/90% and 0.98/92.3%/96%/92.3%/96% for detection of advanced fibrosis and cirrhosis, respectively. The performance of MRE was significantly better than laboratory tests for detection of advanced fibrosis(0.97 vs 0.53-0.80, P < 0.01), and cirrhosis(0.98 vs 0.58-0.80, P < 0.01) and better than conventional MRI for diagnosis of cirrhosis(0.98 vs 0.78, P = 0.002).CONCLUSION MRE is a promising modality for detection of advanced fibrosis and cirrhosis in patients with AIH with superior diagnostic accuracy compared to laboratory assessment and MRI. | Jin Wang Neera Malik Meng Yin Thomas C Smyrk Albert J Czaja Richard L Ehman Sudhakar K Venkatesh | 2017 | World Journal of Gastroenterology2017，23，5： | 15 |
| 2 | Emerging roles of the intestine in control of cholesterol metabolism显示文摘The liver is considered the major “control center” for maintenance of whole body cholesterol homeostasis. This organ is the main site for de novo cholesterol synthesis, clears cholesterol-containing chylomicron remnants and low density lipoprotein particles from plasma and is the major contributor to high density lipoprotein (HDL; good cholesterol) formation. The liver has a central position in the classical definition of the reverse cholesterol transport pathway by taking up periphery-derived cholesterol from lipoprotein particles followed by conversion into bile acids or its direct secretion into bile for eventual removal via the feces. During the past couple of years, however, an additional important role of the intestine in maintenance of cholesterol homeostasis and regulation of plasma cholesterol levels has become apparent. Firstly, molecular mechanisms of cholesterol absorption have been elucidated and novel pharmacological compounds have been identified that interfere with the process and positively impact plasma cholesterol levels. Secondly, it is now evident that the intestine itself contributes to fecal neutral sterol loss as a cholesterol-secreting organ. Finally, very recent work has unequivocally demonstrated that the intestine contributes significantly to plasma HDL cholesterol levels. Thus, the intestine is a potential target for novel anti-atherosclerotic treatment strategies that, in addition to interference with cholesterol absorption, modulate direct cholesterol excretion and plasma HDL cholesterol levels. | Janine K Kruit Albert K Groen Theo J van Berkel Folkert Kuipers | 2006 | World Journal of Gastroenterology2006，12，40： | 4 |
| 3 | Domestic Investors more Informed than Foreign Investors?显示文摘 | Chan K Albert J M Yang Z S | 2008 | Journal of Finance2008，63，1： | 1 |
| 4 | Reducing delay in seeking treatment by patients with acute coronary syndrome and stroke显示文摘 | Mose D K Kimble L P Alberts M J | 2006 | J Cardiovas Nurs2006，22，4： | 1 |
| 5 | 查看详情显示文摘 | Hill K O Malo B Bilodeau F Johnson D C Albert J | | 0，，： | 1 |
| 6 | Two structurally different defensin genes,one of them encoding a novel defensin isoform,are expressed in honeybee Apis mellifera显示文摘 | KLAUDINY J ALBERT S BACHANOVA K | 2005 | Insect Biochem Mol Biol2005，35，1： | 1 |
| 7 | Lipid peroxidation is a consequence of elicitor activity显示文摘 | ROGER K R ALBERT F ANDERSON J | 1988 | Plant Physiol1988，86，： | 1 |
| 8 | 显示文摘 | Albert K J Lewis N S Schauer C L | 2000 | Chem Rev2000，100，： | 1 |
| 9 | A low-cost and low-weight attitude Estimate System for an autonomous helicopter显示文摘 | ALBERT J B ROBERT K | 1997 | IEEE International Conference on Intelligent Engineering System1997，，： | 1 |
| 10 | The draft genome of the transgenic tropical fruit tree papaya ( Carica pap aya Linnaeus ) 显示文摘 | MING R HOU S B FENG Y YU Q DIONNE-LAPORTE A SAW J H SENIN P WANG W LY B V LEWIS K L T SALZBERG S L FENG L GONES M R SKELTON R L MURRAYJ E CHEN C QIAN W SHEN J DU P EUSTICE M TONG E TANG H LYONS E PAULL R E MICHAEL T P WALL K RICE D W ALBERT H WANG M L ZHU Y J SCHATZ M NAGARAJAN N ACOB R A GUAN P BLAS A WAI C M ACKERMAN C M REN Y LIU C WANG J M WANG J P NA J SHAKIROV E V HAAS B THIMMAPURAM J NELSON D WANG X BOWERS J E GSCHWEND A R DELCHER A L SINGH R SUZUKI J Y TRIPATHI S NEUPANE K WEI H IRIKURA B PAIDI M JIANG N ZHANG W PRESTING G WINDSOR A NAVAJAS-PEREZ R TORRES M J FELTUS A PORTER B LI Y BURROUGHS A M LUO M C LIU L CHRISTOPHER D A MOUNT S M MOORE P H SUGIMURA T JIANG J SCHULER M A FRIEDMAN V MITCHELL-OLDS T SHIPPEN D E PAMPHILIS C W PALMER J D FREELING M PATERSON A H GONSALVES D WANG L ALAM M | 2008 | Nature2008，452，： | 1 |
| 11 | Quercetiin 3- and chromones from Callrna vulgaris显示文摘 | ALAIN S ALBERT J C MOUAD K | 1994 | Photochemistry1994，36，4： | 1 |
| 12 | Ad- hesion of perichondrial cells to a polylactic acid scaffold 显示文摘 | ALEXANDER G TRAVIS J K ALBERT C C | 2003 | J Orthopaed Res2003，21，4： | 1 |
| 13 | Azithromycin for prevention of exacerbations of COPD 显示文摘 | ALBERT R K CONNETT J BAILEY W C | 2011 | NEngl J Med2011，365，8： | 1 |
| 14 | Prevalence and characteristics of multinucleoside-resistant human immunodefieieney virus type 1 among European patients receiving combinations of nucleoside analogues显示文摘 | Van Vaerenbergh K Van Laethem K Albert J | 2000 | Antimicrob Agents Chemother2000，44，8： | 1 |
| 15 | CP/MAS NMR investigations of silica gel surfaces modified with aminopropylsilane显示文摘 | Albert K Brindle R Schmid J Buszewski B Bayer E | 1994 | Chromatographia1994，38，56： | 1 |
| 16 | Total luminescence spectral characterization of natural organic matter(NOM) size fractions as defined by ultrafiltration and high performance size exclusion chromatography(HPSEC)显示文摘 | Alberts J J Tak?_ cs M Egeberg P K | 2002 | Org Geochem2002，33，7： | 1 |
| 17 | Interaction of COP1 and UVR8 regulates UV-B-induced photomorphogenesis and stress acclimation in Arabidopsis显示文摘 | Favory J Stec A Gruber H Rizzini L Oravecz A Funk M Albert A Cloix C Jenkins G I Oakeley E J Seidlitz H K Nagy F Ulm R | | 0，，： | 1 |
| 18 | Electromigration-induced mierostructure evolution in tin studied by synchrotron X-ray microdiffractiou 显示文摘 | ALBERT T W TU K N LLOYD J R | 2004 | Appl Phys Lett2004，85，13： | 1 |
| 19 | Cross-reactive chemical sensor arrays显示文摘 | ALBERT K J LEWIS N S SCHAUER C L | 2000 | Chem Rev2000，100，： | 1 |
| 20 | The metabolic syndrome - a new worldwide definition 显示文摘 | Albert K G Zimmet P Shaw J | 2005 | Ancet2005，366，9491： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员