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| 1 | Low phase angle is associated with the development of hepatic encephalopathy in patients with cirrhosis显示文摘AIM Evaluate the association between phase angle and the development of hepatic encephalopathy in the longterm follow-up of cirrhotic patients.METHODS This was a prospective cohort study. Clinical, nutritional and biochemical evaluations were performed. MannWhitney's U and χ2 tests were used as appropriate. Kaplan-Meier curves and Cox proportional Hazards analysis were used to evaluate the prediction and incidence of hepatic encephalopathy.RESULTS Two hundred and twenty were included; the most frequent etiology of cirrhosis was hepatitis C infection, 52% of the patients developed hepatic encephalopathy(18.6% covert and 33.3% overt); the main precipitating factors were infections and variceal bleeding. KaplanMeier curves showed a higher proportion of HE in the group with low phase angle(39%) compared to the normal phase angle group(13%)(P = 0.012). Furthermore, creatinine and phase angle remained independently associated to hepatic encephalopathy in the Cox regression multivariate analysis [hazard ratio = 1.80(1.07-3.03)]. CONCLUSION In our cohort of patients low phase angle was associated with an increased incidence of hepatic encephalopathy. Phase angle is a useful nutritional marker that evaluates cachexia and could be used as a part of the integral assessment in patients with cirrhosis. | Astrid Ruiz-Margáin Ricardo Ulises Macías-Rodríguez Javier Ampuero Francisco Javier Cubero Luis Chi-Cervera Silvia L Ríos-Torres Andrés Duarte-Rojo Ángeles Espinosa-Cuevas Manuel Romero-Gómez Aldo Torre | 2016 | World Journal of Gastroenterology2016，22，45： | 4 |
| 2 | Combination antiretroviral studies for patients with primary biliary cirrhosis显示文摘Following the characterization of a human betaretrovirus in patients with primary biliary cirrhosis(PBC),pilot studies using antiretroviral therapy have been conducted as proof of principal to establish a link of virus with disease and with the eventual aim to find better adjunct therapies for patients unresponsive to ursodeoxycholic acid.In the first open label pilot study,the reverse transcriptase inhibitor lamivudine had little demonstrable biochemical or histological effect after 1 year.Whereas,lamivudine in combination with zidovudine was associated with a significant reduction in alkaline phosphatase as well as improvement in necroinflammatory score,cholangitis and ductopenia over a 12 mo period.A double blind,multi-center randomized controlled trial using lamivudine with zidovudine for 6 mo confirmed a significant reduction in alkaline phosphatase,ALT and AST in patients on antiviral therapy.However,none of the patients achieved the stringent endpoint criteria for normalization of alkaline phosphatase.Furthermore,some patients developed biochemical rebound consistent with drug resistance.A major fault of these studies has been the inability to measure the viral load in peripheral blood and therefore,provide a direct correlation between improvement of hepatic biochemistry and reduction in viral load.Nevertheless,viral mutants to lamivudine with zidovudine were later characterized in the NOD.c3c4 mouse model of PBC that has been used to test other antiretroviral regimens to betaretrovirus.The combination of tenofovir and emtricitabine reverse transcriptase inhibitors and the HIV protease inhibitor,lopinavir were found to abrogate cholangitis in the NOD.c3c4 mouse model and the same regimen normalized the liver tests in a PBC patient with HIV and human betaretrovirus infection.This combination antiretroviral therapy has now been used in a double blind randomized controlled crossover study for patients with PBC followed by an open label extension study.Only a third of the PBC patients were able to tolerate the lopinavir but those maintained on tenofovir,emtricitabine and lopinavir experienced sustained and clinically meaningful reduction in hepatic biochemistry.While we await the histological and virological evaluation,it is clear that better tolerated regimens of antiretroviral treatment will be required in future clinical trials. | Ellina Lytvyak Aldo J Montano-Loza Andrew L Mason | 2016 | World Journal of Gastroenterology2016，22，1： | 2 |
| 3 | A simple and rapid confirmatory assay for analyzing antibiotic residues of the macrolide class and lincomycin in bovine milk and yo- ghurt: hot water extraction followed by liquid chromatog- raphy/tandem mass spectrometry显示文摘 | Sara B Antonio DC Aldo L | 2007 | Rapid Communica- tions in Mass Spectrometry2007，21，2： | 1 |
| 4 | A simplified thermal model for variable-speed self-cooled industrial induction motor显示文摘 | ALDO B ANDREA C MARIA L | 2003 | IEEE Transactions Industry Applications2003，39，4： | 1 |
| 5 | What does the fulture hold for BNP in cardiology? 显示文摘 | Robertol L Aldo PM Serge M | 2001 | Heart2001，86，： | 1 |
| 6 | A video camera system with enhanced zoom tracking and auto white balance显示文摘 | Yoon K K June S L Aldo W M | 2002 | IEEE Transactions on Consumer Electronics2002，48，3： | 1 |
| 7 | A simplified thermal model for variable-speed self-cooled industrial induction motor显示文摘 | Aldo D Andre C Maria L | 2003 | IEEE Transactions Industry Applications2003，39，4： | 1 |
| 8 | Antitumor activity of new substituted 3-(5-imidazothiazolylmethylene)-2-indolinones and study of their effect on the cell cycle1显示文摘 | Aldo A Massimiliano G Alberto L | 2005 | J Med Chem2005，48，： | 1 |
| 9 | Consequences of treatment withdrawal in type 1 autoimmune hepatitis 显示文摘 | Aldo J Montano L | 2007 | Liver international2007，27，4： | 1 |
| 10 | Automatie nonlinear auto-tuning method for Hammerstein modeling of electrical drives 显示文摘 | Aldo B Alberto L Mohamed O Z | 2001 | IEEE Transactions on Industrial Electronics2001，48，3： | 1 |
| 11 | Liquid Chromatography Mass Spectrometry Tandem for Multiresidue Determination of Selected Post-emergence Herbicides after Soil Column Extraction显示文摘 | ALDO L GIOVANNA F ALESSONDRA M et td | 2000 | Anal Chim Acta2000，，415： | 1 |
| 12 | A simple and rapid assay based on hot water extraction and liquid chromatography- tandem mass spectrometry for monitoring quinolone residues in bovine milk显示文摘 | GIUSEPPE D A ANTONIO D C ALDO L | 2008 | Food Chemistry2008，108，1： | 1 |
| 13 | Genetic profile of 22 pancreatic carcinoma cell lines显示文摘 | Patrick S. Moore Bence Sipos Simonetta Orlandini Claudio Sorio Francisco X. Real Nicholas R. Lemoine Thomas Gress Claudio Bassi Günter Kl?ppel Holger Kalthoff Hendrik Ungefroren Matthias L?hr Aldo Scarpa | 2001 | Virchows Archiv2001，，6： | 1 |
| 14 | An improved five-parameter model for photovohaic modules显示文摘 | VALERIO L B ALDO O GIUSEPPINA C | 2010 | Solar Energy Materials & Solar Cells2010，94，： | 1 |
| 15 | Sterol carrier protein-2 is involved in cholesterol transfer from the endoplasmic reticulum to the plasma membrane in human fibroblasts 显示文摘 | PUGLIELLI L ALDO A R SANTOS F N J | 1995 | JBiol Chem1995，270，18： | 1 |
| 16 | 雷米普利、替米沙坦或二者联用对心血管病高危人群肾脏结局的影响(ONTARGET研究):一项多中心、随机、双盲、对照试验显示文摘背景血管紧张素受体阻断剂(ARB)和血管紧张素转换酶抑制剂(ACEI)都可以减少蛋白尿,二者联用可能比单一用药更有效。目前还没有长期临床试验比较两者对肾功能的影响。本研究比较了雷米普利(一种ACEI)、替米沙坦(一种ARB)或二者联用对患有动脉粥样硬化性血管病或糖尿病合并终末器官损害的人群(年龄≥55岁)肾脏结局的影响。方法临床试验从2001年开始,到2007年结束。经过3周的导入期,25620例受试者被随机分配至10mg/d雷米普利组(n=8576)、80mg/d替米沙坦组(n=8542)或10mg/d雷米普利+80mg/d替米沙坦组(n=8502;中位随访期为56个月),同时检测肾功能和尿蛋白。主要肾脏结局为透析、血清肌酐加倍和死亡的复合终点。采用意向性治疗分析。本研究已在ClinicalTrials.gov注册,编号为NCT00153101。结果试验期间,784例患者因低血压症状提前终止随机治疗(联合用药组406例,雷米普利组149例,替米沙坦组229例)。替米沙坦组和雷米普利组发生复合终点事件的例数相近[替米沙坦组1147例(13.4%),雷米普利组1150例(13.5%);HR1.00(95%C10.92~1.09)],但在联合用药组有所增加[1233例(14.5%);HR1.09(95%CI1.01-1.18),P=0.037]。次要肾脏结局(透析或血清肌酐加倍)的发生例数在替米沙坦组(189例,2.21%)和雷米普利组(174例,2.03%)相近(HR1.09,95%C10.89~1.34),但在联合用药组显著增加(212例,2.49%:HR1.24,95%CI1.01~1.51.P=0.038)。肾小球滤过率估计值在雷米普利组下降最少,为-2.82ml/(min·1.73m^2)(s=17.2),而在替米沙坦组为-4.12ml/(min·1.73m^2)(S=17.4,P〈0.0001),在联合治疗组为-6.11ml/(min·1.73m^2)(S=17.9,P〈0.0001)。与雷米普利组相比,替米沙坦组(P=0.004)和联合用药组(P=0.001)较少发生尿蛋白排泄增加。结论在心血管病高危人群中,替米沙坦和雷米普利对肾脏结局的影响相同。尽管联合用药比单一治疗能更大程度减少蛋白尿,但总体上其增加了肾脏结局事件。基金 勃林格殷格翰公司。 | Johannes F E Mann, Roland E Schmieder Matthew McQueen Leanne Dyal Helmut Schumacher Janice Pogue Xingyu Wang Aldo Maggioni Andrzej Budaj Suphachai Chaithiraphan Kenneth Dickstein Matyas Keltai Kaj Metsarinne Ali Oto Alexander Parkhomenko Leopoldo S Piegas Tage L Svendsen Koon KTeo Salim Yusuf 刘欣(译) 王兴宇(审) | 2009 | 世界临床医学2009，，4： | 1 |
| 17 | A combinatorial property of finite prefix codes显示文摘 | ALDO D L | 1978 | Information and Control1978，37，3： | 1 |
| 18 | Mutagenie and antimutagenic proper- ties of aqueous and ethanolic extracts from fresh and irradiated Tu- ber aestivum black truffle: a preliminary study显示文摘 | Fratianni F Di L Aldo | 2007 | Food Chemistry2007，，102： | 1 |
| 19 | Determination of Diphenyl-ether Herbicides and Metabolites in Natural Waters Using High-performance Liquid Chromatography with Diode Array Tandem Mass Spectrometric Detection显示文摘 | ALDO L GIOVANNA F LAURA F | 2000 | Analytica Chimica2000，414，： | 1 |
| 20 | Determination of diphenyl- ether herbicides and metabolites in natural waters using high-per- formance liquid chromatography with diode array tandem mass spectrometric detection 显示文摘 | Aldo L Giovanna F Laura F | 2000 | Anal Chim Acta2000，414，1： | 1 |
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