|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Clinical relevance of sarcopenia in patients with cirrhosis显示文摘The most commonly recognized complications in cirrhotic patients include ascites, hepatic encephalopathy, variceal bleeding, susceptibility for infections, kidney dysfunction, and hepatocellular carcinoma; however, severe muscle wasting or sarcopenia are the most common and frequently unseen complications which negatively impact survival, quality of life, and response to stressor, such as infections and surgeries. At present, D'Amico stage classification, Child-Pugh, and MELD scores constitute the best tools to predict mortality in patients with cirrhosis; however, one of their main limitations is the lack of assessing the nutritional and functional status. Currently, numerous methods are available to evaluate the nutrition status of the cirrhotic patient; nevertheless, most of these techniques have limitations primarily because lack of objectivity, reproducibility, and prognosis discrimination. In this regard, an objective and reproducible technique, such as muscle mass quantification with cross-sectional imaging studies(computed tomography scan or magnetic resonance imaging) constitute an attractive index of nutritional status in cirrhosis. Sarcopenia is part of the frailty complex present in cirrhotic patients, resulting from cumulative declines across multiple physiologic systems and characterized by impaired functionalcapacity, decreased reserve, resistance to stressors, and predisposition to poor outcomes. In this review, we discuss the current accepted and new methods to evaluate prognosis in cirrhosis. Also, we analyze the current knowledge regarding incidence and clinical impact of malnutrition and sarcopenia in patients with cirrhosis and their impact after liver transplantation. Finally, we discuss existing and potential novel therapeutic approaches for malnutrition in cirrhosis, emphasizing the recognition of sarcopenia in an effort to reduced morbidity related and improved survival in cirrhosis. | Aldo J Montano-Loza | 2014 | World Journal of Gastroenterology2014，20，25： | 17 |
| 2 | Combination antiretroviral studies for patients with primary biliary cirrhosis显示文摘Following the characterization of a human betaretrovirus in patients with primary biliary cirrhosis(PBC),pilot studies using antiretroviral therapy have been conducted as proof of principal to establish a link of virus with disease and with the eventual aim to find better adjunct therapies for patients unresponsive to ursodeoxycholic acid.In the first open label pilot study,the reverse transcriptase inhibitor lamivudine had little demonstrable biochemical or histological effect after 1 year.Whereas,lamivudine in combination with zidovudine was associated with a significant reduction in alkaline phosphatase as well as improvement in necroinflammatory score,cholangitis and ductopenia over a 12 mo period.A double blind,multi-center randomized controlled trial using lamivudine with zidovudine for 6 mo confirmed a significant reduction in alkaline phosphatase,ALT and AST in patients on antiviral therapy.However,none of the patients achieved the stringent endpoint criteria for normalization of alkaline phosphatase.Furthermore,some patients developed biochemical rebound consistent with drug resistance.A major fault of these studies has been the inability to measure the viral load in peripheral blood and therefore,provide a direct correlation between improvement of hepatic biochemistry and reduction in viral load.Nevertheless,viral mutants to lamivudine with zidovudine were later characterized in the NOD.c3c4 mouse model of PBC that has been used to test other antiretroviral regimens to betaretrovirus.The combination of tenofovir and emtricitabine reverse transcriptase inhibitors and the HIV protease inhibitor,lopinavir were found to abrogate cholangitis in the NOD.c3c4 mouse model and the same regimen normalized the liver tests in a PBC patient with HIV and human betaretrovirus infection.This combination antiretroviral therapy has now been used in a double blind randomized controlled crossover study for patients with PBC followed by an open label extension study.Only a third of the PBC patients were able to tolerate the lopinavir but those maintained on tenofovir,emtricitabine and lopinavir experienced sustained and clinically meaningful reduction in hepatic biochemistry.While we await the histological and virological evaluation,it is clear that better tolerated regimens of antiretroviral treatment will be required in future clinical trials. | Ellina Lytvyak Aldo J Montano-Loza Andrew L Mason | 2016 | World Journal of Gastroenterology2016，22，1： | 2 |
| 3 | University patenting and its effects on tcademic: research: the emerging Europe- an evidence显示文摘 | ALDO GEUNA I IONEL J J NESTA | 2006 | Re search Policy2006，，6： | 1 |
| 4 | Phylogeography and population genetic structure of the Talas tuco-tuco (Ctenomys talarum): integrating demographic and habitat histories显示文摘 | Mora Mat?as S Cutrera Ana P Lessa Enrique P Vassallo Aldo I D’Anatro Alejandro Mapelli Fernando J | 2013 | Journal of Mammalogy2013，，2： | 1 |
| 5 | Consequences of treatment withdrawal in type 1 autoimmune hepatitis 显示文摘 | Aldo J Montano L | 2007 | Liver international2007，27，4： | 1 |
| 6 | Surgical correction of sinus of Valsalva aneurysm显示文摘 | Richard J H James M Aldo RC | 1973 | J Thoracic Cardiovasc Surg1973，19，： | 1 |
| 7 | Free-surface turbulence and mass transfer in a channel flow显示文摘 | Gulliver J S | 2002 | AICHE Journal2002，48，12： | 1 |
| 8 | Sterol carrier protein-2 is involved in cholesterol transfer from the endoplasmic reticulum to the plasma membrane in human fibroblasts 显示文摘 | PUGLIELLI L ALDO A R SANTOS F N J | 1995 | JBiol Chem1995，270，18： | 1 |
| 9 | Myocardial-Directed Overexpression of the Human β 1 -Adrenergic Receptor in Transgenic Mice显示文摘 | John D Bisognano Howard D Weinberger Teresa J Bohlmeyer Aldo Pende Mary V Raynolds Amornrate Sastravaha Robert Roden Koji Asano Burns C Blaxall Steven C Wu Catherine Communal Krishna Singh Wilson Colucci Michael R Bristow David J Port | 2000 | Journal of Molecular and Cellular Cardiology2000，，5： | 1 |
| 10 | Determination of Fusarium- Mycotoxins Beauvericin and Enniatins with Liquid Chromatography-- Tandem Mass Spectrometry(LC-MS/MS)显示文摘 | Marika J Mervi R Aldo R | 2005 | Journal of Liquid Chromatography2005，28，： | 1 |
| 11 | Prognostic Value of Cardiac Troponin I Measured With a Highly Sensitive Assay in Patients With Stable Coronary Artery Disease显示文摘 | Torbj?rn Omland Marc A. Pfeffer Scott D. Solomon James A. de Lemos Helge R?sj? Jūrat? ?altyt? Benth Aldo Maggioni Michael J. Domanski Jean L. Rouleau Marc S. Sabatine Eugene Braunwald | 2013 | Journal of the American College of Cardiology2013，，12： | 1 |
| 12 | Preparation, characterization and pyrolysis of poly(furfuryl alcohol)/porous silica glass nanocomposites: Novel route to carbon template 显示文摘 | Aldo J G Robert B Maria A O | 2002 | Carbon2002，40，： | 1 |
| 13 | Viral ssRNA induces first trimester trophoblast apoplosis through an inflammatory mechanisnl 显示文摘 | ALDO P B MULLA M J ROMERO R | 2010 | Am J Reprod Immuno12010，64，1： | 1 |
| 14 | Aging of the elastic and collagen fibers in the human cervical interspinous ligaments显示文摘 | Erika M.K.P Barros Consuelo J Rodrigues Nilson R Rodrigues Reginaldo P Oliveira Tarcisio E.P Barros Aldo J Rodrigues | 2002 | The Spine Journal2002，，： | 1 |
| 15 | Clinical consequenc-es of an individualized dialysate sodium prescrip-tion in hemodialysis patients显示文摘 | Flavio M DE Paula Aldo J ect | 2004 | Kidney Interna-tional2004，66，： | 1 |
| 16 | Myocardial-Directed Overexpression of the Human β 1 -Adrenergic Receptor in Transgenic Mice显示文摘 | John D Bisognano Howard D Weinberger Teresa J Bohlmeyer Aldo Pende Mary V Raynolds Amornrate Sastravaha Robert Roden Koji Asano Burns C Blaxall Steven C Wu Catherine Communal Krishna Singh Wilson Colucci Michael R Bristow David J Port | 2000 | Journal of Molecular and Cellular Cardiology2000，，5： | 1 |
| 17 | In vivo characterisation of a novel bioresorbable poly(lactide-co-glycolide) tubular foam scaffold for tissue engineering applications显示文摘 | Richard M. Day Aldo R. Boccaccini Veronique Maquet Sandra Shurey Alastair Forbes Simon M. Gabe Robert Jér?me | 2004 | Journal of Materials Science: Materials in Medicine2004，，6： | 1 |
| 18 | Carbon paste electrodes made from novel carbonaceous materials:Preparation and electrochemical characterizati0n显示文摘 | Edson Nossol Aldo J G Zarbin | | 0，，02： | 1 |
| 19 | Pyridine-1-oxides synthesis of some nicotinic acid derivatives显示文摘 | Taylor J R Aldo J C | 1954 | J Org Chem1954，19，10： | 1 |
| 20 | Comparison of nanoscale and microscale bioactive glass on the properties of P(3HB)/Bioglass&#reg; composites显示文摘 | Superb K M Dirk M Tobias J B Wendelin J S Sheryl E P Ipsita R Vehid S Jonathan C K Aldo R B | 2008 | Biomaterials2008，29，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员