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| 1 | Imaging plaque inflammation in asymptomatic cocaine addicted individuals with simultaneous positron emission tomography/magnetic resonance imaging显示文摘BACKGROUND Chronic cocaine use is associated with stroke, coronary artery disease and myocardial infarction, resulting in severe impairments or sudden mortality. In the absence of clear cardiovascular symptoms, individuals with cocaine use disorder (iCUD) seeking addiction treatment receive mostly psychotherapy and psychiatric pharmacotherapy, with no attention to vascular disease (i.e., atherosclerosis). Little is known about the pre-clinical signs of cardiovascular risk in iCUD and early signs of vascular disease are undetected in this underserved population. AIM To assess inflammation, plaque burden and plaque composition in iCUD aiming to detect markers of atherosclerosis and vascular disease. METHODS The bilateral carotid arteries were imaged with positron emission tomography/magnetic resonance imaging (PET/MRI) in iCUD asymptomatic for cardiovascular disease, healthy controls, and individuals with cardiovascular risk. PET with 18F-fluorodeoxyglucose (18F-FDG) evaluated vascular inflammation and 3-D dark-blood MRI assessed plaque burden including wall area and thickness. Drug use and severity of addiction were assessed with standardized instruments. RESULTS The majority of iCUD and controls had carotid FDG-PET signal greater than 1.6 but lower than 3, indicating the presence of mild to moderate inflammation. However, the MRI measure of wall structure was thicker in iCUD as compared to the controls and cardiovascular risk group, indicating greater carotid plaque burden. iCUD had larger wall area as compared to the healthy controls but not as compared to the cardiovascular risk group, indicating structural wall similarities between the non-control study groups. In iCUD, wall area correlated with greater cocaine withdrawal and craving. CONCLUSION These preliminary results show markers of carotid artery disease burden in cardiovascular disease-asymptomatic iCUD. Broader trials are warranted to develop protocols for early detection of cardiovascular risk and preventive intervention in iCUD. | Keren Bachi Venkatesh Mani Audrey E Kaufman Nadia Alie Rita Z Goldstein Zahi A Fayad Nelly Alia-Klein | 2019 | World Journal of Radiology2019，11，5： | 2 |
| 2 | 显示文摘 | Mohamed Ali A Jansens P J | 2004 | Chemical Engineering and Processing2004，43，： | 1 |
| 3 | Swine influenza H1N1 virus induces acute inflammato- ry immune responses in pig lungs: a potential animal model for human H1N1 influenza virus显示文摘 | Khatri M Dwivedi V Krakowka S Manickam C Ali A Wang L Qin Z Renukaradhya G J Lee C W | 2010 | J Virol2010，84，11： | 1 |
| 4 | Traffic light control system for emergency vehicles using radio frequency显示文摘 | Hashim N M Z Jaafar A S Ali N A | 2013 | IOSR Journal of Engineering (IOSRJEN)2013，3，7： | 1 |
| 5 | Experimental characterization and CFD simulation of gas distribution performance of liquid redistributors and collectors in packed columns显示文摘 | Mohamed Ali A Janses P Olujic Z | 2003 | Chemical Engineering Research and Design2003，81，： | 1 |
| 6 | Inflammation,Atherosclerosis,and Coronary Artery Disease:PET/CT for the Evaluation of Atherosclerosis and Inflammation显示文摘 | Alie N Eldib M Fayad Z A | 2014 | Clin Med Insights Cardiol2014，8，3： | 1 |
| 7 | Electrochemical study on the determination of tinidazole in tablets 显示文摘 | Ali Z Abu Z Suleiman A K | 1999 | J Pharmac Biomed Anal1999，21，： | 1 |
| 8 | Fabrication of Mo/Cu multilayer and bilayer transition edge sensors 显示文摘 | Ali Z A Drury O B Cunningham M F | 2005 | IEEE Transactions on Applied Superconductivity2005，15，2： | 1 |
| 9 | Prediction of performance of a downdraft gasifier using equilihrium modeling for different biomass materials显示文摘 | Zainal Z A Ali A Lean C H Seetharamu K N | 2001 | Energy Conversion and Management2001，，42： | 1 |
| 10 | CD56 expression of neuroendocflne neoplasms on immunophenotyping by flow eytometry:a novel diagnostic approaeh to fine-needle aspiration biopsy显示文摘 | Farinola M A Weir E G Ali S Z | | 0，，4： | 1 |
| 11 | Detection of Y chromosome-specific DNA in the plasma and urine of pregnant women using nested polymerase chain reaction显示文摘 | A1-Yatama M K Mustafa A S Ali S Abraham S Khan Z Khaja N | 2001 | Prenat Diagn2001，21，： | 1 |
| 12 | Prediction of performance of a downdraft gasifier using equilibrium modeling for different biomass materials显示文摘 | ZAINAL Z A ALI R LEAN C H | 2001 | Energy Conversion and Management2001，42，12： | 1 |
| 13 | Apoptosis-inducing effect of garcinol is mediated by NF-kappaB signaling in breast cancer cells显示文摘 | Ahmad A Wang Z Ali R | 2010 | J Cellular Biochem2010，109，6： | 1 |
| 14 | Treatment of toenailonychomycosis with 2% butenafine and 5% Melaleuca altemifolia(tea tree ) oil in cream 显示文摘 | SYED T A QURESHI Z A ALI S M | 2002 | Trop Med Int Health2002，4，4： | 1 |
| 15 | 显示文摘 | Daud W M A W Ali W S W Sulaiman M Z | 2000 | Carbon2000，38，14： | 1 |
| 16 | Species composition of the pathogens of Fusarium disease of glasshouse cucumber显示文摘 | Ilieva E Mladenov M Ali A Z | | 0，，01： | 1 |
| 17 | Diterpenoid,steroid,and triterpenoid agonists of liver X receptors from diversified terrestrial plants and marine sources显示文摘 | Jayasuriya H Herath KB Ondeyka JG Guan Z Borris RP Tiwari S de Jong W Chavez F Moss J Stevenson DW Beck HT Slattery M Zamora N Schulman M Ali A Sharma N MacNaul K Hayes N Menke JG Singh SB | | 0，，08： | 1 |
| 18 | Effect of the initial gas maldistribution on the pressure drop of structured packings显示文摘 | Ali A M Jansens P J | 2003 | Chemical Engineering and Processing2003，43，3： | 1 |
| 19 | Effect of mixed feeding schedules with varying dietary protein levels on the growth of sutchi catfish, Pangasius hypophthalmus ( Sau- vage) with silver carp, Hypophthalmichthys molitrix (Va- lenciennes) in ponds 显示文摘 | ALI M Z HOSSAIN M A ABDUL M M | 2005 | Aquac Res2005，36，7： | 1 |
| 20 | Infection of Onion Leaves by Pan- toea ananatis Leads to Bulb Infection 显示文摘 | ERIC A C ALI M Z JEAN M B | 2012 | Plant Disease2012，97，12： | 1 |
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