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| 1 | Determinants of the impact of blood pressure variability on neurological outcome after acute ischaemic stroke显示文摘Introduction: Increased blood pressure variability (BPV) is detrimental after acute ischaemic stroke, but the interaction between BPV and neuroimaging factors that directly influence stroke outcome has not been explored. Methods: We retrospectively reviewed inpatients from 2007 to 2014 with acute anterior circulation ischaemic stroke, CT perfusion and angiography at hospital admission, and a modified Rankin Scale (MRS) 30- 365 days after stroke onset. BPV indices included SD, coefficient of variation and successive variation of the systolic blood pressure between 0 and 120 hours after admission. Ordinal logistic regression models were fitted to MRS with predictor variables of BPV indices. Models were further stratified by CT perfusion volumetric measurements, proximal vessel occlusion and collateral score. Results: 110 patients met the inclusion criteria. The likelihood of a 1-point rise in the MRS increased with every 10 mm Hg increase in BPV (OR for the 3 BPV indices ranged from 2.27 to 5.54), which was more pronounced in patients with larger ischaemic core volumes (OR 8.37 to 18.0) and larger hypoperfused volumes (OR 6.02 to 15.4). This association also held true for patients with larger mismatch volume, proximal vessel occlusion and good collateral vessels. Conclusions: These results indicate that increased BPV is associated with worse neurological outcome after stroke, particularly in patients with a large lesion core volume, concurrent viable ischaemic penumbra, proximal vessel occlusion and good collaterals. This subset of patients, who are often not candidates for or fail acute stroke therapies such as intravenous tissue plasminogen activator or endovascular thrombectomy, may benefit from interventions aimed at reducing BPV. | Adam de Havenon Alicia Bennett Gregory J Stoddard Gordon Smith Lee Chung Steve O’Donnell J Scott McNally David Tirschwell Jennifer J Majersik | 2017 | Stroke & Vascular Neurology2017，2，1： | 6 |
| 2 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 3 | Effects of sleep bruxism on functional and occlusal parameters:a prospective controlled investigation显示文摘This study was conducted to verify the results of a preceding retrospective pilot study by means of a prospective controlled investigation including a larger sample size.Therefore,the aim of this clinical investigation was to analyze the relationship between sleep bruxism and several functional and occlusal parameters.The null hypothesis of this study was that there would be no differences among sleep bruxism subjects and non-sleep bruxism controls regarding several functional and occlusal parameters.Fifty-eight sleep bruxism subjects and 31 controls participated in this study.The diagnosis sleep bruxism was based on clinical criteria of the American Academy of Sleep Medicine.Sixteen functional and occlusal parameters were recorded clinically or from dental study casts.Similar to the recently published retrospective pilot study,with a mean slide of 0.77 mm(s.d.,0.69 mm) in the sleep bruxism group and a mean slide of 0.4 mm(s.d.,0.57 mm) in the control group,the evaluation of the mean comparison between the two groups demonstrated a larger slide from centric occlusion to maximum intercuspation in sleep bruxism subjects(Mann-Whitney U-test;P50.008).However,following Bonferroni adjustment,none of the 16 occlusal and functional variables differed significantly between the sleep bruxism subjects and the non-sleep bruxism controls.The present study shows that the occlusal and functional parameters evaluated do not differ between sleep bruxism subjects and non-sleep bruxism subjects.However,as the literature reveals a possible association between bruxism and certain subgroups of temporomandibular disorders,it appears advisable to incorporate the individual adaptive capacity of the stomatognathic system into future investigations. | Michelle Alicia Ommerborn Maria Giraki Christine Schneider Lars Michael Fuck Jrg Handschel Matthias Franz Wolfgang Hans-Michael Raab Ralf Schfer | 2012 | International Journal of Oral Science2012，4，3： | 4 |
| 4 | Reproducibility of the diagnosis of dysplasia in Barrett esophagus: A reaffirmation显示文摘 | Elizabeth Montgomery Mary P Bronner John R Goldblum Joel K Greenson Marian M Haber John Hart Laura W Lamps Gregory Y Lauwers Audrey J Lazenby David N Lewin Marie E Robert Alicia Y Toledano Yu Shyr Kay Washington | 2001 | Human Pathology2001，，4： | 3 |
| 5 | Association of homocysteine and smoking with cerebral microemboli in patients with mechanical heart valves:a transcranial Doppler study显示文摘Objectives Microembolic signals(MES)on transcranial Doppler(TCD)predict stroke and cognitive decline.Plasma levels of total homocysteine(tHcy),a prothrombotic factor,are higher in patients with microemboli in carotid stenosis and in patients with paradoxical embolism.In this study we assessed the association between the level of tHcy and the number of MES in patients with mechanical heart valves(MHVs).Methods TCD monitoring was performed to detect MES before and after breathing 100% oxygen and repeated every 2-4 weeks up to six times.results Twenty-five patients with MHVs(mean age:63.60±10.15 years)participated in this study;15 were men(66.47±7.25 years)and 10 were women(59.30±12.60 years).In total,there were 126 study visits.In multiple regression,higher tHcy was associated with more MES in both preoxygenation(OR 1.34(95%CI 1.07 to 1.68,P=0.009))and postoxygenation(OR 1.40(95% CI 1.07 to 1.83,P=0.01))phases.Current smoking and the length of time between the operation and monitoring also correlated with a higher number of MES before and after breathing oxygen,particularly in women.conclusions Higher tHcy and smoking were associated with a higher MES count in both preoxygenation and postoxygenation phases.Because smoking can be stopped and hyperhomocysteinaemia is treatable,these are clinically important findings. | Alicia Mattia M Reza Azarpazhooh Claudio Munoz Chrysi Bogiatzi Mackenzie A Quantz J David Spence | 2017 | Stroke & Vascular Neurology2017，2，4： | 2 |
| 6 | Folic acid supplementation, MTHFR and MTRR polymorphisms, and the risk of childhood leukemia: the ESCALE study (SFCE)显示文摘 | Alicia Amigou Jérémie Rudant Laurent Orsi Stéphanie Goujon-Bellec Guy Leverger André Baruchel Yves Bertrand Brigitte Nelken Geneviève Plat Gérard Michel Stéphanie Haouy Pascal Chastagner Stéphane Ducassou Xavier Rialland Denis Hémon Jacqueline Clavel | 2012 | Cancer Causes & Control2012，，8： | 2 |
| 7 | Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) supports adhesion and migration of mesenchymal stem cells and tenocytes显示文摘AIM: To establish the potential of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) as a material for tendon repair. METHODS: The biocompatibility of PHBHHx with both rat tenocytes (rT) and human mesenchymal stem cells (hMSC) was explored by monitoring adhesive characteristics on films of varying weight/volume ratios coupled to a culture atmosphere of either 21% O2 (air) or 2% O2 (physiological normoxia). The diameter and stiffness of PHBHHx films was established using optical coherence tomography and mechanical testing, respectively. RESULTS: Film thickness correlated directly with weight/volume PHBHHx (r2 = 0.9473) ranging from 0.1 mm (0.8% weight/volume) to 0.19 mm (2.4% weight/volume). Film stiffness on the other hand displayed a biphasic response which increased rapidly at values > 1.6% weight/volume. Optimal cell attachment of rT required films of ≥ 1.6% and ≥ 2.0% weight/volume PHBHHx in 2% O2 and 21% O2 respectively. A qualitative adhesion increase was noted for hMSC in films ≥ 1.2% weight/volume, becoming significant at 2% weight/volume in 2% O2. An increase in cell adhesion was also noted with ≥ 2% weight/volume PHBHHx in 21% O2. Cell migration into films was not observed. CONCLUSION: This evaluation demonstrates that PHBHHx is a suitable polymer for future cell/polymer replacement strategies in tendon repair. | Alex J Lomas George GQ Chen Alicia J El Haj Nicholas R Forsyth | 2012 | World Journal of Stem Cells2012，4，9： | 2 |
| 8 | Gemini surfactants from alkyl glueosides显示文摘 | Castro Mariano J L Kovensky José Cirelli Alicia Fernéndez | 1997 | Tetrahedron Letters1997，38，23： | 1 |
| 9 | New Dimeric Surfactants from Alkyl Glucosides显示文摘 | Mariano J L Jos K Alicia F | 1999 | Tetrahedron1999，55，12： | 1 |
| 10 | A theory of self-esteem 显示文摘 | Cast Alicia D Burke Peter J | 2002 | So- cial Forces2002，80，10： | 1 |
| 11 | Review of srvere vaso-occlusive ret- inopathy in systemic lupus erythematosus and antiphos- pholipid syndrome: associations, visual outcomes, compli- cations and treatment显示文摘 | Alicia AM Franzco J | 2004 | Clin Exp Ophthalmol2004，32，1： | 1 |
| 12 | Mitochondria and reactive oxygen species 显示文摘 | ALICIA J KOWALTOWSKI N C | 2009 | Free Radical Biology and Medicine2009，47，： | 1 |
| 13 | Multiscale structure and properties of cast and deformation processed polycrystalline NiTi shape memory alloys 显示文摘 | Frick Carl P Ortega Alicia M Jeffrey Tyber Ken Gall Hans J Maler | 2004 | Metallurgical and Materials Transactions A2004，35，： | 1 |
| 14 | Reproducibility of the diagnosis of dysplasia in Barrett esophagus: A reaffirmation显示文摘 | Elizabeth Montgomery Mary P Bronner John R Goldblum Joel K Greenson Marian M Haber John Hart Laura W Lamps Gregory Y Lauwers Audrey J Lazenby David N Lewin Marie E Robert Alicia Y Toledano Yu Shyr Kay Washington | 2001 | Human Pathology2001，，： | 1 |
| 15 | Hypolycemic effect of the water extract of Smallantus sonchifolius (yacon) leaves in normal and diabetic rats 显示文摘 | Manuel J Aybar Alicia N Sa' nchez Riera Affredo Grau | 2001 | Journal of Ethnopharmacology2001，，6： | 1 |
| 16 | Cancer statistics显示文摘 | Ahmedin J Taylor M Alicia S | 2003 | CA Cancer J Clin2003，53，1： | 1 |
| 17 | Post-transcriptional regulation of glucose transporter-1 by an AU-rich element in the 3 ′ UTR and by hnRNP A2显示文摘 | Mary E Griffin B.JoNell Hamilton Kristen M Roy Min Du Alicia M Willson Benjamin J Keenan Xiao Wei Wang Ralph C Nichols | 2004 | Biochemical and Biophysical Research Communications2004，，4： | 1 |
| 18 | Nonparametric model comparison and uncertainty evaluation for signal strength indoor location显示文摘 | Carlos K F Inmaculada M J Alicia G C | 2009 | IEEE Transactions on Mobile Computing2009，8，9： | 1 |
| 19 | Plasminogen activator inhibitor-1 activity in type 2 diabtetes: a different relationship with coronary heart disease and diabetic retinopathy显示文摘 | Laima B Kevin R Alicia J | 2008 | Arterioscler Thromb Vasc Biol2008，28，4： | 1 |
| 20 | The SCR of NO with methane over In,H- and Co,In,H-ZSM-5 catalysts: The promotional effect of cobalt显示文摘 | Ferenc Lónyi Hanna E. Solt József Valyon Alicia Boix Laura B. Gutierrez | 2012 | Applied Catalysis B, Environmental2012，，： | 1 |
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