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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Pericytes synthesize renin显示文摘AIM: To investigate renin expression in pericytes during normal kidney development and after deletion of angiotensinogen, the precursor for all angiotensins.METHODS: We examined the distribution of renin expressing cells by immunoshistochemistry in the interstitial compartment of wild type(WT) and angiotensinogen deficient(AGT-/-) mice at different developmental stages from embryonic day 18(E18: WT, n = 4; AGT-/-, n = 5) and at day 1(P1: WT, n = 5; AGT-/-, n = 5), 5(P5: WT, n = 7; AGT-/-, n = 8), 10(P10: WT, n = 3; AGT-/-, n = 5), 21(P21: WT, n = 7; AGT-/-, n = 5), 45(P45: WT, n = 3; AGT-/-, n = 3), and 70(P70: WT, n = 2; AGT-/-, n = 2) of postnatal life. We quantified the number of pericytes positive for renin at all the developmental stages mentioned above and comparedthe results of AGT-/- mice to their WT counterparts.RESULTS: In WT mice, renal interstitial pericytes synthesize renin in early life supporting a lineage relationship with renin cells in the vasculature. The number of pericytes positive for renin per area of 0.32 mm2(density) in WT mice was maintained from fetal life till weaning age(E18 = 4.25 ± 0.63, P1 = 3.75 ± 0.48, P5 = 3.75 ± 0.48, P10 = 4 ± 0.71, P21 = 3.8 ± 0.58) and markedly decreased in adult life(P45 = 1.2 ± 0.37, P70 = 0.8 ± 0.20). On the other hand, in AGT-/- mice the density of pericytes expressing renin was not significantly different from WT mice at E18 and P1: E18 = 5.75 ± 0.50 vs 4.25 ± 0.63(P = 0.106), P1 = 9.25 ± 3.50 vs 3.75 ± 0.48(P = 0.175) but significantly increased from P5 till P70: P5 = 38.25 ± 5 vs 3.75 ± 0.48(P = 0.0004), P10 = 173 ± 7.50 vs 4 ± 0.70(P = 5.24567 × 10-7), P21 = 83 ± 6.70 vs 3.8 ± 0.58(P = 2.97358 × 10-6), P45 = 49 ± 3.50 vs 1.2 ± 0.37(P = 8.18274 x 10-7) and P70 = 17.8 ± 2.30 vs 0.8 ± 0.20(P = 3.51151 × 10-5). The AGT-/- mice showed a marked increase in the number of pericytes per field studied starting from P5, reaching its peak at P10, and then a gradually decreasing until P70. CONCLUSION: Interstitial pericytes synthesize renin during development and the number of renin-expressing pericytes increases in response to a homeostatic threat imposed early in life such as lack of angiotensinogen. | Alison C Berg Catalina Chernavvsky-Sequeira Jennifer Lindsey R Ariel Gomez Maria Luisa S Sequeira-Lopez | 2013 | World Journal of Nephrology2013，2，1： | 2 |
| 3 | Pluripotential liver stem cells: facultative stem cells located in the biliary tree显示文摘 | ALISON M R GOLDIN M H SARRAF C E | 1996 | Cell Prolif1996，29，7： | 1 |
| 4 | Com-parative toxicity and carcinogenicity of two chlorinated paraffins in F344N rats and B6C3F1 mice显示文摘 | Bucher J R Alison R H Montgomery C A | | 0，，03： | 1 |
| 5 | Application of liver stem cells for cell therapy显示文摘 | ALISON M R CHOONG C LIM S | 2007 | Semin Cell Dev Biol2007，18，6： | 1 |
| 6 | Spatiotemporal patterning of reactive oxygen production and Ca^2+ wave propagation in Fucus Rhizoid cells 显示文摘 | Susana M C Alison R T Keith P R | 2002 | Plant Cell2002，14，： | 1 |
| 7 | Comparative toxicity and carcinogenicity of two chlorinated paraffins in F344/N rats and B6C3F1 mice显示文摘 | Bucher J R Alison R H Montgomery C A | 1987 | Fundamental and Applied Toxicology:Official Journal of the Society of Toxicology1987，9，3： | 1 |
| 8 | Liver damage in the ret induces hepatocyte stem cell from biliary epithelial cells显示文摘 | Alison M R Golding M Sarraf C E | 1996 | Gastroenterology1996，110，： | 1 |
| 9 | Lunasin in cereal seeds:What is the origin?显示文摘 | Rowan A C Mitchell Alison Lovegrove Peter R Shewry | 2013 | Journal of Cereal Science2013，57，： | 1 |
| 10 | Liver cell death, patterns and mechanisms 显示文摘 | ALISON M R SARRAF C E | 1994 | Gut1994，35，： | 1 |
| 11 | Structural magnetic strain model for magnetostrictive transducers 显示文摘 | Dapino M J Smith R C Flatan Alison B | 2000 | IEEE Trans Magn2000，36，3： | 1 |
| 12 | Characteristics of Helicobacter pylori attachmentto human primary antral epithelial cells显示文摘 | Ursula Heczko Valerie C Smith R Mark Meloche Alison M.J Buchan B.Brett Finlay | 2000 | Microbes and Infection2000，，14： | 1 |
| 13 | Functional genomic analysis of the A UXIN/INDOLE-3-ACET1C ACID gene family members in Arabidopsis thaliana显示文摘 | Paul J O Yoko O Jos6 M A April C Chang C Joseph R E Beth H Liu A Courtney O Hong Q Alison S Yu G X Athanasios T | 2005 | Plant Cell2005，，17： | 1 |
| 14 | Does elevated CO2 ameliorate the impact of O3 on chlorophyll content and photosynthesis in potato (Solarium tuberosum )? 显示文摘 | ALISON D JIM C COLIN R B | 2001 | Physiologia Plantarum2001，111，4： | 1 |
| 15 | Direct atomic spectrometric analysis by slurry atomization part 5: Analysis of kaolin using inductively coupled plasma atomic emission spectrometry显示文摘 | EBDON L ALISON R C | 1988 | J Anal At Spectrometry1988，3，： | 1 |
| 16 | Pluripotential liver stem cells: facultative stem cells located in the biliary tree 显示文摘 | Alison M R Golding M H Sarraf C E | 1996 | Cell Prolif1996，29，7： | 1 |
| 17 | Lu- nasin in eereal seeds: What is the origin? 显示文摘 | Rowan A C Mitchell Alison Lovegrove Peter R Shewry | 2013 | Journal of Cere- al Science2013，57，3： | 1 |
| 18 | Comparative toxicity and carcinogenicity of two chlorinated paraffins in F344/N rats and B6C3F1 mice显示文摘 | BUCHER J R ALISON R H MONTGOMERY C A | 1987 | Fund Appl Toxicol1987，9，3： | 1 |
| 19 | Neoadjuvant capecitabine and oxaliplatin before chemoradiotherapy and total mesorectal excision in MRI-defined poor-risk rectal cancer: a phase 2 trial显示文摘 | Yu Jo Chua Yolanda Barbachano David Cunningham Jacqui R Oates Gina Brown Andrew Wotherspoon Diana Tait Alison Massey Niall C Tebbutt Ian Chau | 2010 | Lancet Oncology2010，，3： | 1 |
| 20 | Distinguishing between anxiety and depression using the Mood and Anxiety Symptoms Questionnaire(MASQ) 显示文摘 | Joe A B Alison R Y Elizabeth M C | 2007 | British Journal of Clinical Psychology2007，46，： | 1 |
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