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| 1 | Role of CARD15,DLG5 and OCTN genes polymorphisms in children with inflammatory bowel diseases显示文摘AIM: To investigate the contribution of variants of CARD15, OCTN1/2 and DLG5 genes in disease predispo- sition and phenotypes in a large Italian cohort of pediatric patients with inflammatory bowel diseases (IBD). METHODS: Two hundred patients with Crohn’s disease (CD), 186 ulcerative colitis (UC) patients, 434 par- ents (217 trios), and 347 healthy controls (HC) were studied. Polymorphisms of the three major variants of CARD15, 1672C/T and -207G/C SNPs for OCTN genes, IGR2096a_1 and IGR2198a_1 SNPs for the IBD5 locus, and 113G/A variant of the DLG5 gene were evaluated. Potential correlations with clinical sub-phenotypes were investigated. RESULTS: Polymorphisms of CARD15 were significantly associated with CD, and at least one variant was found in 38% of patients (15% in HC, OR = 2.7, P < 0.001). Homozygosis for both OCTN1/2 variants was more com- mon in CD patients (1672TT 24%, -207CC 29%) than in HC (16% and 21%, respectively; P = 0.03), with an in- creased frequency of the TC haplotype (44.8% vs 38.3% in HC, P = 0.04). No association with the DLG5 variant was found. CD carriers of OCTN1/2 and DLG5 variants more frequently had penetrating disease (P = 0.04 and P = 0.01), while carriers of CARD15 more frequently had ileal localization (P = 0.03). No gene-gene interaction was found. In UC patients, the TC haplotype was morefrequent (45.4%, P = 0.03), but no genotype/phenotype correlation was observed. CONCLUSION: Polymorphisms of CARD15 and OCTN genes, but not DLG5 are associated with pediatric on- set of CD. Polymorphisms of CARD15, OCTN, and DLG5 genes exert a weak influence on CD phenotype. | S Cucchiara A Latiano O Palmieri AM Staiano R D'Incà G Guariso G Vieni V Rutigliano O Borrelli MR Valvano V Annese | 2007 | World Journal of Gastroenterology2007，13，8： | 9 |
| 2 | Phamacokinetics of L-camitine in patients with end-stage renal disease undergoing longterm hemodialyses 显示文摘 | Evans AM Faull R Fomasini G | 2000 | Clin Pharmacol Ther2000，68，8： | 1 |
| 3 | Timing of Collision of the Sino-Korea and Yangtze Cratons: U - Pb Dating of Coesite-Bearing Eelogites显示文摘 | Ames L Tilton G R Zhou G | 1993 | Geology1993，21，： | 1 |
| 4 | 接受最佳治疗的高危血管病患者中C反应蛋白对脂蛋白(a)相关心血管病风险的影响显示文摘脂蛋白(a)是动脉粥样硬化性心血管病的遗传致病危险因素,但目前还不清楚哪些动脉粥样硬化性心血管病患者从脂蛋白(a)降低中受益最大。在二级预防中炎症是否会调节与脂蛋白(a)相关的心血管病风险也未知。该文旨在确定在接受最佳治疗的高危心血管病患者中,脂蛋白(a)相关的心血管病风险是否受到全身炎症的调节。 | 周卫(译) 刘莉(摘/审校) Puri R Nissen SE Arsenault BJ St John J Riesmeyer JS Ruotolo G McErlean E Menon V Cho L Wolski K Lincoff AM Nicholls SJ | 2020 | 中华高血压杂志2020，28，11： | 1 |
| 5 | Timing of collision of the Sino Korean and Yangtse craton: U-Pb zircon dating of coesite-bearing eclogites显示文摘 | Ames L Tilton G R Zhou G | 1993 | Geology1993，，： | 1 |
| 6 | Advanced glycation end products and vascular inflammation: implications for acceler- ated atherosclerosis in diabetes 显示文摘 | Basra G Schmidt AM De Caterina R | 2004 | Cardiovasc Res2004，63，4： | 1 |
| 7 | Titanium plates support for chest wall reconstruction with Gore-Tex dual mesh after sternochondral resection显示文摘 | Hamad AM Marulli G Bulf R | 2009 | Eur J Cardiothorac Surg2009，36，4： | 1 |
| 8 | Forming strategies and process modelling for CNC incremental sheet forming 显示文摘 | Hirt G Ames J Bambach M Kopp R | 2004 | Ann CIRP2004，53，1： | 1 |
| 9 | Evidence of apoptosis in human primordial and primary follicles 显示文摘 | Depalo R Nappi L Loverro G Bettocchi S Caruso ML Valentini AM Selvaggi L | 2003 | Hum Reprod2003，18，： | 1 |
| 10 | Epidemiology of non-Hodgkin's lymphoma (NHL):trends,geographic distribution,and etiology显示文摘 | Muller AM Ihorst G Mertelsmann R | 2005 | Ann hematol2005，84，1： | 1 |
| 11 | Visualizing neuromodulation in vivo:TANGO-mapping of dopamine signaling reveals appetite control of sugar sensing显示文摘 | Inagaki Hidehiko K Ben-Tabou de-Leon S Wong AM Jagadish S Ishimoto H Barnea G Kitamoto T Axel R Anderson David J | | 0，，03： | 1 |
| 12 | Adefovir and lamivudine in combination compared with adefovir monotherapy in HBeAg-negative adults with chronic hepatitis B virus infection and clinical or virologic resistance to lamivudine: a retrospective, multicenter, nonrandomized, open-label study显示文摘 | Pellieelli AM Barbaro G Francavilla R | 2008 | Clin Ther2008，30，2： | 1 |
| 13 | The hypertriglyceridemias: risk and management introduetion显示文摘 | Assmann G Goteo AM Jr Paoletti R | 2002 | Introduction Am J Cardiol2002，68，： | 1 |
| 14 | Advanced glycation end products and vascular inflammation: implications for accelerated atherosclerosis in diabetes显示文摘 | Basra G Schmidt AM De Caterina R | 2004 | Cardiovasc Res2004，63，4： | 1 |
| 15 | Management strategies in isolated pancreatic trauma显示文摘 | Lochan R Sen G Barrett AM | 2009 | J Hepatobiliary Pancreat Surg2009，16，2： | 1 |
| 16 | Advanced glycation end products and vascular:Implication for accelerated atherosclerosis in diabetes显示文摘 | Basta G Schmidt AM de - Caterina R | 2004 | Cardiovasc Res2004，63，4： | 1 |
| 17 | The Ca^2 + ATPase of cardiac sarcoplasmic reticulum: Physiological role and relevance to diseases 显示文摘 | Inesi G Prasad AM Pilankatta R | 2008 | Biochem Biophys Res Commun2008，369，1： | 1 |
| 18 | Comparison and evaluation of methods for liver segmentation from CT datasets显示文摘 | Heimann T van Ginneken B Styner MA Arzhaeva Y Aurich V Bauer C Beck A Becket C Beichel R Bekes G Bello F Binnig G Bischof H Bornik A Cashman PM Chi Y Cordova A Dawant BM Fidrich M Furst JD Furukawa D Grenacher L Hornegger J Kainmuller D Kitney RI Kobatake H Lamecker H Lange T Lee J Lennon B Li R Li S Meinzer HP Nemeth G Raicu DS Rau AM van Rikxoort EM Rousson M Rusko L Saddi KA Schmidt G Seghers D Shimizu A Slagmolen P Sorantin E Soza G Susomboon R Waite JM Wimmer A Wolf I | 2009 | IEEE Transactions on Medical Imaging2009，28，8： | 1 |
| 19 | A 5-years follow-up study on one stage implants inserted concomitantly with localised alveolar ridge augmentation 显示文摘 | Juodzbalys G Raustia AM Kubilius R | 2007 | J Oral Rehabil2007，34，10： | 1 |
| 20 | Mucosal administration of HSF'65 decreases atherosclerosis and inflammation in aortic arch of low-density lipoprotein receptor-deficient mice 显示文摘 | Maron R Sukhova G Faria AM | 2002 | Circulation2002，106，13： | 1 |
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