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| 1 | Effect of Clostridium butyricum on fecal flora in Helicobacter pylori eradication therapy显示文摘AIM: To investigate the effect of probiotic bacterium,Clostridium butyricum MIYAIRI 588 strain (CBM) on the changes of the fecal flora in Helicobacter pylori(H pylori)treatment.METHODS: Thirty-five patients with gastric or duodenal ulcers positive for Hpylori were randomized either to 1 wk amoxicillin, clarithromycin, lansoprazole (Group 1) or to the same regimen supplemented with CBM 7 dahead of the triple therapy (Group 2). Stool samples were collected before and 2, 4, 7, 15, and 22 d after the starting eradication therapy, and were examined intestinal flora. Patients were required to keep a diary record of their condition. RESULTS: Obligate anaerobes decreased significantly on d 2, 4, 8 and 15 in Group 1. On the other hand, they did not decrease significantly in Group 2. The Escherichiacoli was dominant bacterium in Enterobacteriaceae, butthat was replaced by other species such as Klebsiella and Enterobacter after eradication in Group 1. The change was suppressed in Group 2. Abdominal symptoms were less frequent in Group 2 than in Group 1.CONCLUSION: The combined use of CBM reduced the changes in the intestinal flora and decreased the incidence of gastrointestinal side effects. | Izumi Shimbo Taketo Yamaguchi Takeo Odaka Kenichi Nakajima Akinori Koide Hidehiko Koyama Hiromitsu Saisho | 2005 | World Journal of Gastroenterology2005，11，47： | 18 |
| 2 | Lifestyle-related disease in Crohn’s disease: Relapse prevention by a semi-vegetarian diet显示文摘AIM: To investigate whether semi-vegetarian diet (SVD) has a preventive effect against relapse of Crohn’s disease (CD) in patients who have achieved remission,who are a high-risk group for relapse.METHODS: A prospective,single center,2-year clinical trial was conducted.Twenty-two adult CD patients who achieved clinical remission either medically (n = 17) or surgically (n = 5) and consumed an SVD during hospitalization were advised to continue with an SVD and avoid known high-risk foods for inflammatory bowel disease.The primary endpoint was clinical relapse defi ned as the appearance of active symptoms of CD.Kaplan-Meier survival analysis was used to calculate the cumulative proportion of patients who had a relapse.A 2-year analysis of relapse rates of patients who followed an SVD and those who did not (an omnivorous diet group) was undertaken.RESULTS: SVD was continued by 16 patients (compliance 73%).Remission was maintained in 15 of 16 patients (94%) in the SVD group vs two of six (33%)in the omnivorous group.Remission rate with SVD was 100% at 1 year and 92% at 2 years.SVD showed signif icant prevention in the time to relapse compared to that in the omnivorous group (P = 0.0003,log rank test).The concentration of C-reactive protein was normal at the f inal visit in more than half of the patients in remission who were taking an SVD,who maintained remission during the study (9/15;60%),who terminated follow-up (8/12;67%),and who completed 2 years follow-up (7/10;70%).There was no untoward effect of SVD.CONCLUSION: SVD was highly effective in preventing relapse in CD. | Mitsuro Chiba Toru Abe Hidehiko Tsuda Takeshi Sugawara Satoko Tsuda Haruhiko Tozawa Katsuhiko Fujiwara Hideo Imai | 2010 | World Journal of Gastroenterology2010，16，20： | 17 |
| 3 | Short-type single balloon enteroscope for endoscopic retrograde cholangiopancreatography with altered gastrointestinal anatomy显示文摘AIM:To evaluate the effectiveness of a short-type single-balloon-enteroscope(SBE) for endoscopic retrograde cholangiopancreatography(ERCP) in patients with a reconstructed intestine.METHODS:Short-type SBE was developed to perform ERCP in postoperative patients with a reconstructed intestine.Short-type SBE is a direct-viewing endoscope with the following specifications:working length,1520 mm;total length,1840 mm;channel diameter,3.2 mm.In addition,short-type SBE has a water-jet channel.The study group comprised 22 patients who underwent 31 sessions of short-type SBE-assisted ERCP from June 2011 through May 2012.Reconstruction was performed by Billroth-Ⅱ(B-Ⅱ) gastrectomy in 6 patients(8 sessions),Roux-en-Y(R-Y) gastrectomy in 14 patients(21 sessions),and R-Y hepaticojejunostomy in 2 patients(2 sessions).We retrospectively studied the rate of reaching the blind end(papilla of Vater or choledochojejunal anastomosis),mean time required to reach the blind end,diagnostic success rate(defined as the rate of successfully imaging the bile and pancreatic ducts),therapeutic success rate(defined as the rate of successfully completing endoscopic treatment),mean procedure time,and complications.RESULTS:Among the 31 sessions of ERCP,the rate of reaching the blind end was 88% in B-Ⅱ gastrectomy,91% in R-Y gastrectomy,and 100% in R-Y hepaticojejunostomy.The mean time required to reach the papilla was 18.3 min in B-Ⅱ gastrectomy,21.1 min in R-Y gastrectomy,and 32.5 min in R-Y hepaticojejunostomy.The diagnostic success rates in all patients and those with an intact papilla were respectively 86% and 86% in B-Ⅱ gastrectomy,90% and 87% in R-Y gastrectomy,and 100% in R-Y hepaticojejunostomy.The therapeutic success rates in all patients and those with an intact papilla were respectively 100% and 100% in B-Ⅱ gastrectomy,94% and 92% in R-Y gastrectomy,and 100% in R-Y hepaticojejunostomy.Because the channel diameter was 3.2 mm,stone extraction could be performed with a wire-guided basket in 12 sessions,and wireguided intraductal ultrasonography could be performed in 8 sessions.As for complications,hyperamylasemia(defined as a rise in serum amylase levels to more than 3 times the upper limit of normal) occurred in 1 patient(7 sessions) with a B-Ⅱ gastrectomy and 4 patients(19 sessions) with an R-Y gastrectomy.After ERCP in patients with an R-Y gastrectomy,2 patients(19 sessions) had pancreatitis,1 patient(21 sessions) had gastrointestinal perforation,and 1 patient(19 sessions) had papillary bleeding.Pancreatitis and bleeding were both mild.Gastrointestinal perforation improved after conservative treatment.CONCLUSION:Short-type SBE is effective for ERCP in patients with a reconstructed intestine and allows most conventional ERCP devices to be used. | Hiroshi Yamauchi Mitsuhiro Kida Kosuke Okuwaki Shiro Miyazawa Tomohisa Iwai Miyoko Takezawa Hidehiko Kikuchi Maya Watanabe Hiroshi Imaizumi Wasaburo Koizumi | 2013 | World Journal of Gastroenterology2013，19，11： | 10 |
| 4 | Lansoprazole-associated collagenous colitis:Diffuse mucosal cloudiness mimicking ulcerative colitis显示文摘There have only been a few reports on lansoprazole-associated collagenous colitis. Colonic mucosa of collagenous colitis is known to be endoscopically normal. We present a case of collagenous colitis where the mucosa showed diffuse cloudiness mimicking ulcerative colitis. A 70-year-old woman developed watery diarrhea four to nine times a day. She had interstitial pneumonia at 67 and reflux esophagitis at 70 years. Lansoprazole 30 mg/d had been prescribed for reflux esophagitis for nearly 6 mo. Lansoprazole was withdrawn due to its possible side effect of diarrhea. Colonoscopy disclosed diffuse cloudiness of the mucosa which suggested ulcerative colitis. Consequently sulfasalazine 2 g/d was started. The patient's diarrhea dramatically disappeared on the following day. However, biopsy specimens showed subepithelial collagenous thickening and infi ltration of inflammatory cells in the lamina propria, confirming the diagnosis of collagenous colitis. One month after sulfasalazine therapy was initiated, colonoscopic and histological abnormalities resolved completely. Five months later the diarrhea recurred. The findings on colonoscopy and histology were the same as before, confirming a diagnosis of collagenous colitis relapse. We found that the patient had begun to take lansoprazole again 3 mo ahead of the recent diarrhea. Withdrawal of lansoprazole promptly resolved the diarrhea. Endoscopic and histological abnormalities were also completely resolved, similar to the first episode. Retrospectively, the date of commencement of sulfasalazine and discontinuation of lansoprazole in the first episode was found to be the same. We conclude that this patient had lansoprazole-associated collagenous colitis. | Mitsuro Chiba Takeshi Sugawara Haruhiko Tozawa Hidehiko Tsuda Toru Abe Takuo Tokairin Iwao Ono Eriko Ushiyama | 2009 | World Journal of Gastroenterology2009，15，17： | 5 |
| 5 | Double balloon enteroscopy to retrieve an accidentally swallowed dental reamer deep in the jejunum显示文摘Accidentally swallowed foreign objects are not uncommon but difficult to manage without complications. We describe the case of a 68 year old man who accidentally a swallowed sharp-pointed dental reamer that had reached deep in his jejunum. Double balloon enteroscopic retrieval was performed with polypectomy snare but the reamer was entangled in the wire loop of the snare and penetrated the jejunal wall. After releasing the reamer by pushing and pulling the snare for approximately 30 min, the reamer was retrieved with biopsy forceps. This is the first report of double balloon enteroscopic removal of a dental reamer. Furthermore, this is a novel case with regard to decision making in situations when sharp objects are swallowed. | Shingo Kato Kazuhito Kani Hidehiko Takabayashi Ryuichi Yamamoto Koji Yakabi | 2011 | World Journal of Gastrointestinal Endoscopy2011，3，4： | 4 |
| 6 | Incidence and Characteristics of Carpal Fractures Occurring Concurrently With Distal Radius Fractures显示文摘 | Shingo Komura Tatsuo Yokoi Hidehiko Nonomura Hiroyuki Tanahashi Takashi Satake Norihito Watanabe | 2012 | Journal of Hand Surgery2012，，3： | 2 |
| 7 | Utilization of theγ-glutamyltranspeptidase reaction for glutathione synthesis 显示文摘 | Hidehiko Kumagai Hideyuki Suzuki Miho Shimizu | 1989 | Journal of Biotechnology1989，9，： | 1 |
| 8 | Association between intronic SNP in urate-anion exchanger gene,SLC22A12,and serum uric acid levels in Japanese显示文摘 | Yukio S Koji T Hidehiko O | 2006 | ELSEVIER2006，79，： | 1 |
| 9 | Improvement of the bitter taste of amino acids through the transpeptidation reaction of bacterial γ-glutamyltranspeptidase显示文摘 | Hideyuki S Yoko K Hidehiko K | 2002 | Agric Food Chem2002，50，2： | 1 |
| 10 | Contact-damage-resistant ceramic-single-wall carbon nanotubes and ceramic/graphite composites显示文摘 | Xiaotong Wang Nitin P Padture Hidehiko Tanaka | 2004 | Nature Materials2004，，2： | 1 |
| 11 | Enzymatic production of γ-L-glutamyltaurine through the transpeptidation reaction of γ-glutamyltranspeptidase from Escherichia coli K - 12显示文摘 | Hideyuki Suzuki Nobukazu Miyakawa Hidehiko Kumagai | 2002 | Enzyme and Microbial Technology2002，30，： | 1 |
| 12 | Inflammatory pseudotumor of the Liver Associated with Acute myelomonocytic Leukemia显示文摘 | Yoshihiro Nishi | 1991 | Am J of Gastroenterology1991，86，2： | 1 |
| 13 | Beam quality factor of higher order modes in a step-index fiber显示文摘 | HIDEHIKO Y PAVEL P MASUD M | 2006 | IEEE J Lightwave Technology2006，24，3： | 1 |
| 14 | Effect of Theanine, r-Glutamylethylamide, on Brain Monoamines and Striatal Dopamine Release in Conscious Rats显示文摘 | Hidehiko Yokogoshi Miki Kobayashi Mikiko Mochizuki Takehiko Terashima | 1998 | Neurochemical Research1998，，5： | 1 |
| 15 | Increased Expression of Plasminogen Activator Inhibitor-1 with Fibrin Deposition in a Murine Model of Aging, 'Klotho' Mouse显示文摘 | Kyosuke Takeshita Koji Yamamoto Masafumi Ito Takahisa Kondo Tadashi Matsushita Makoto Hirai Tetsuhito Kojima Masahiko Nishimura Yoichi Nabeshima David Loskutoff Hidehiko Saito Toyoaki Murohara | 2002 | Semin Thromb Hemost2002，，06： | 1 |
| 16 | Improvement of the bitter taste of amino acids through the transpeptidation reaction of bacterial γ-Glutamyl-transpeptidase 显示文摘 | Hideyuki Suzuki Yoko Kajimoto Hidehiko Kumagai | 2002 | Journal of Agricultural and Food Chemistry2002，50，： | 1 |
| 17 | Use of the “supercharge” technique in esophageal and pharyngeal reconstruction to augment microvascular blood flow显示文摘 | Mitsuru Sekido Yuhei Yamamoto Hidehiko Minakawa Satoru Sasaki Hiroshi Furukawa Tsuneki Sugihara Kunihiko Nohira Kazuyoshi Yajima Yoshihisa Shintomi Syunichi Okushiba Hiroyuki Kato Masao Hosokawa | 2003 | Surgery2003，，3： | 1 |
| 18 | Matching as an Econometric Evaluation Estimator: Evidence from Evaluating a Job Training Programme显示文摘 | Heckman James Hidehiko Ichimura Petra Todd | 1997 | Review of Economic Studies1997，64，4： | 1 |
| 19 | Development of an efficient enzymatic production of γ-D-glutamyl-L-tryptophan (SCV-07),a prospective medicine for tuberculosis,with bacterial-glutamyltranspeptidase显示文摘 | Hideyuki S Kenji K Hidehiko K | 2004 | Journal of Biotechnology2004，111，3： | 1 |
| 20 | Optical performance monitoring of phase-modulated signals using asynchronous amplitude histogram analysis 显示文摘 | Bartlomiej Kozicki Ohara Takuya Takara Hidehiko | 2008 | Journal of Lightwave Technology2008，26，10： | 1 |
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