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| 1 | Modern stalagmite oxygen isotopic composition and its implications of climatic change from a high-elevation cave in the eastern Qinghai-Tibet Plateau over the past 50 years显示文摘An oxygen isotope record of a stalagmite from Huanglong Cave in the eastern Qinghai-Tibet Plateau dated with 230Th and 210Pb methods provides variations of the Asian monsoon with an average resolu-tion of 1 year over the past 50 years. This study shows that the δ18O of dripwater in the cave represents the annual mean δ18O of local meteoric precipitation and the stalagmites were deposited in isotopic equilibrium. A comparison of the stalagmite δ18O record with instrumentally meteorological data indi-cates that shifts of the δ18O are largely controlled by the amount effect of meteoric precipitation con-veyed through the southwest monsoon(the Indian monsoon) and less affected by temperature. Therefore,the variations of δ18O record reflect the changes in monsoon precipitation on inter-annual time scales under the influence of the southwest monsoon. Like many other stalagmite δ18O records in the Asian monsoon regions,the δ18O record of the stalagmite from Huanglong Cave also reveals a gradually enriched trend during the past 50 years,i.e. relatively enriched in 18O. This trend may indicate the decline of the Asian monsoon intensity which is consistent with the decrease of monsoon indices. The weakening of the modern Asian monsoon well matched with the temperature changes in strato-sphere,which may illustrate that the weakening of the monsoon mainly results from the lowering of solar radiation. | YANG XunLin ZHANG PingZhong CHEN FaHu HUH Chih-an LI HongChun CHENG Hai Kathleen R. JOHNSON LIU JingHua AN ChunLei | 2007 | Chinese Science Bulletin2007，52，9： | 20 |
| 2 | Asian summer monsoon precipitation recorded by stalagmite oxygen isotopic composition in the western Loess Plateau during AD1875―2003 and its linkage with ocean-atmosphere system显示文摘Based on 5 high-precision 230Th dates and 103 stable oxygen isotope ratios (δ18O) obtained from the top 16 mm of a stalagmite collected from Wanxiang Cave,Wudu,Gansu,variation of monsoonal precipita-tion in the modern Asian Monsoon (AM) marginal zone over the past 100 years was reconstructed. Comparison of the speleothem δ18O record with instrumental precipitation data at Wudu in the past 50 years indicates a high parallelism between the two curves,suggesting that the speleothem δ18O is a good proxy for the AM strength and associated precipitation,controlled by 'amount effect' of the pre-cipitation. Variation of the monsoonal precipitation during the past 100 years can be divided into three stages,increasing from AD 1875 to 1900,then decreasing from AD 1901 to 1946,and increasing again thereafter. This variation is quite similar to that of the Drought/Flooding index archived from Chinese historical documents. This speleothem-derived AM record shows a close association with the Pacific Decadal Oscillation (PDO) between AD 1875 and 1977,with higher monsoonal precipitation corre-sponding to cold PDO phase and vice versa at decadal timescale. The monsoonal precipitation varia-tion is out of phase with the PDO after AD 1977,probably resulting from the decadal climate jump in the north Pacific occurring at around AD 1976/77. These results demonstrate a strong linkage between the AM and associated precipitation and the Pacific Ocean via ocean/atmosphere interaction. This rela-tionship will aid to forecast future hydrological cycle for the AM monsoon region,and to improve forecasting potential of climatic model with observation data from cave. | LIU JingHua ZHANG PingZhong CHENG Hai CHEN FaHu YANG XunLin ZHANG DeZhong ZHOU Jing JIA JiHong AN ChunLei SANG WenCui Kathleen R. JOHNSON | 2008 | Chinese Science Bulletin2008，53，13： | 13 |
| 3 | Establishing a human pancreatic stem cell line and transplanting induced pancreatic islets to reverse experimental diabetes in rats显示文摘The major obstacle in using pancreatic islet transplantation to cure type I and some type II diabetes is the shortage of the donors. One of ways to overcome such obstacle is to isolate and clone pancreatic stem cells as 'seed cells' and induce their differentiation into functional islets as an abundant trans-plantation source. In this study, a monoclonal human pancreatic stem cell (mhPSC) line was obtained from abortive fetal pancreatic tissues. Pancreatic tissues were taken from abortive fetus by sterile procedures, and digested into single cells and cell clusters with 0.1% type IV collagenase. Cultured in modified glucose-low DMEM with 10% fetal bovine serum (FBS), these single cells and cell clusters adhered to culture dishes, and then primary epidermal-like pancreatic stem cells started to clone. After digesting with 0.25% trypsin and 0.04% EDTA, fibroblasts and other cells were gradually eliminated and epithelioid pancreatic stem cells were gradually purified during generations. Using clone-ring selection, the mhPSCs were obtained. After addition of 10 ng/mL epidermal growth factor (EGF) in cell culture medium, the mhPSCs quickly grew and formed a gravelstone-like monolayer. Continuously proliferated, a mhPSC line, which was derived from a male abortive fetus of 4 months old, has been passed through 50 generations. More than 1×109 mhPSCs were cryo-preserved in liquid nitrogen. Karyotype analysis showed that the chromosome set of the mhPSC line was normal diploid. Immunocytochemistry results demonstrated that the mhPSC line was positive for the pdx1, glucagon, nestin and CK19, and negative for the insulin, CD34, CD44 and CD45 protein expression. RT-PCR revealed further that the mhPSCs expressed transcription factors of the pdx1, glucagon, nestin and CK19. Also, in vitro induced with β-mercaptoethanol, the mhPSCs differentiated into nerve cells that expressed the NF protein. Induced with nicotinamide, the mhPSCs differentiated into functional islet-like clusters, as identified by di-thizone staining, which expressed the transcription factor of the insulin and secreted the insulin and C-peptide. Furthermore, the transplantation of mhPSCs-induced pancreatic islets into the subcapsular region of the kidney in streptozotocin-induced diabetic rats could reduce blood glucose levels and prolong the life time. | XIAO Mei AN LiLong YANG XueYi GE Xin QIAO Hai ZHAO Ting MA XiaoFei FAN JingZhuang ZHU MengYang DOU ZhongYing | 2008 | Science China(Life Sciences)2008，51，9： | 9 |
| 4 | Study of Static Adsorption Capacity of ACF for Xenon at 201 K显示文摘The static adsorption performances of a series of active carbon fiber(ACF)for xenon at 201 K were measured with a model ASAP2010M specific surface area and aperture distribution instrument by changing the working gas of instrument from N 2 to Xenon. Compared with grain active carbon(GAC): (1) the adsorption performance of Viscose based ACF(VACF) adsorbents is better than that of GAC; (2) owing to the difference of aperture distribution, the adsorption performance of ACF with different radicales is different under the same experiment conditions though the specific surface area is similar; (3) there is no definite relationship between adsorption performance and specific surface area; (4) the VACF A2 is the superior xenon adsorbent at the experimental temperature. | WANG Ya long ** , ZHANG Hai tao, WANG Xu hui, ZHANG Li xing, CHEN Li yun, XIE Jin chuan (Northwest Institute of Nuclear Technology, Xian 710024, P. R. China) | 2002 | Chemical Research in Chinese Universities2002，18，2： | 9 |
| 5 | Mechanism of exogenous nucleic acids and their precursors improving the repair of intestinal epithelium after 7-irradiation in mice显示文摘AIM To clone expressed genes associated withrepair of irradiation-damaged mice intestinalgland cells treated by small intestinal RNA,andto explore the molecular mechanism ofexogenous nucleic acids improving repair ofintestinal crypt.METHODS The animal mode of test group andcontrol group was established,forty-five micebeing irradiated by γ ray were treated with smallintestinal RNA as test group,forty mice beingirradiated by γ ray were treated withphysiological saline as control group,five micewithout irradiation were used as normal control,their jejunal specimens were collectedrespectively at 6h,12h,24h,4d and 8d afterirradiation.Then by using LD-PCR based onsubtractive hybridization,these gene fragmentsdifferentially expressed between test group andcontrol group were obtained,and then werecloned into T vectors as well as beingsequenced.Obtained sequences were screenedagainst.GeneBank,if being new sequences,they were submitted to GeneBank.RESULTS Ninety clones were associated withrepair of irradiation-damaged intestinal glandcells treated by intestinal RNA.These clonesfrom test group of 6h,12h,24h,4d and 8dwere respectively 18,22,25,13,12.By screening against GeneBank,18 of which werenew sequences,the others were dramaticallysimilar to the known sequences,mainly similarto hsp,Nmi,Dutt1,alkaline phosphatase,homeobox,anti-CEA ScFv antibody,arginine/serine kinase and BMP-4,repA.Eighteen genefragments were new sequences,their acceptnumbers in GeneBank were respectivelyAF240164-AF240181.CONCLUSION Ninety clones were obtained tobe associated with repair of irradiation-damagedmice intestinal gland cells treated by smallintestinal RNA,which may be related toabnormal expression of genes and matchedproteins of hsp,Nmi,Duttl,Na,K-ATPase,alkalineph-osphatase,glkA,single strandedreplicative centromeric gene as well as 18 newsequences. | Da Xiang Cui~1 Guei Ying Zeng~2 Feng Wang~1 Jun Rong Xu~1 Dong Qing Ren~2 Yan Hai Guo~1 Fu Rong Tian~2 Xiao Jun Yan~1 Yu Hou~1 Cheng Zhi Su~1 1 Institute of Genetic Diagnosis of the Fourth Military Medical University,Xi’an 710032,China 2 Department of Irradiation Medicine of the Fourth Military Medical University,Xi’an 710032,China | 2000 | World Journal of Gastroenterology2000，6，5： | 8 |
| 6 | The oldest shale gas reservoirs in southern margin of Huangling uplift,Yichang, Hubei,China显示文摘1.Objective Large-scale commercial production of shale gas started in Fuling,Changning and Weiyuan areas of the Sichuan Basin (Zou et al.,2016)since 2010.The most notable shale gas success is the Longmaxi organic rich Shale in Jiaoshiba field, Sichuan Basin.The Yichang slope is located in the north of middle Yangtze region.This eastward dipping slope is a new prospective area for shale gas exploration in recent 5 years. | Xiao-hong Chen Sheng-yuan Luo An Liu Hai Li | 2018 | China Geology2018，1，1： | 7 |
| 7 | Spatial pattern of modern sedimentation rate of Qinghai Lake and a preliminary estimate of the sediment flux显示文摘We investigated the spatiotemporal distribution of1 37Cs radioactivity in surface sediment of Qinghai Lake,and developed the spatial pattern of sedimentation rate.The1 37Cs inventory is higher near the estuary/bank area,but lower at the central lake.On the other hand,the average1 37Cs activity is lower near the estuary/bank area,but higher at the central lake.The mass accumulation rate(MAR) and the fluxes and contents of the terrestrial detritus(e.g.SiO2,Fe2O3,and Ti) are higher near the estuary/bank area,but lower at the central lake.The chemical/biogenic deposits(e.g.the autogenic carbonates) take up higher fractions at the central lake.These suggest that the spatial pattern of recent sedimentation rate is dominated by the deposition of terrestrial detritus.The average MAR(0.0337 g cm-2a-1) was estimated based on those of different cores of Qinghai Lake and was verified by a Ca mass-balance method.The fluxes of total lake sediments,terrestrial detritus,and direct atmospheric deposits were also estimated. | XU Hai LIU XiaoYan AN ZhiSheng HOU ZhaoHua DONG JiBao LIU Bin | 2010 | Chinese Science Bulletin2010，55，7： | 6 |
| 8 | Revealing the synergistic mechanism of Shenfu Decoction for anti-heart failure through network pharmacology strategy显示文摘The present study was designed to investigate the targets and synergistic mechanism of Shenfu Decoction(SFD) in the treatment of heart failure.A heart failure animal models was established to evaluate the pharmacological effects of SFD for anti-heart failure, then constructed ingredient-target interaction network by developing ingredient and target databases, the Discovery sdudio software was used for molecular docking.In addition, we validated the predicted protein targets of active ingredients in SFD by using surface plasmon resonance(SPR) technology.Our results demonstrated that SFD could enhance ejection fraction, alleviate myocardial histopathological characteristics, and reduce the level of angiotensin converting enzyme(ACE), aldosterone(ALD), atrial natriuretic polypeptide(ANP) and Renin(REN) in heart failure rat model.In addition, the ingredient database including 349 constituents and target database including 236 proteins were established, and 75 proteins were screened and identified by molecular docking strategy.22 core target proteins were identified through network pharmacology, and the component-core target network was constructed.Finally,the affinity between the compounds and targets were verified by the SPR analysis method.The present study suggested that SFD may act on ACE 2, REN, ACE, ICAM-1, EGF, HTR2B, PARP1, NPPB and other proteins through AC, BAC, ACN, Re, Rg1, Rb1 to exert synergistic effects against heart failure. | XU Yan-Wen XU Zhen-Dong AN Rui ZHANG Hai WANG Xin-Hong | 2020 | Chinese Journal of Natural Medicines2020，18，7： | 6 |
| 9 | Reliability analysis of stochastic structural system considering static strength, stiffness and fatigue显示文摘Multi-failures are possible to appear in the process of using the structural system, such as dead load failure, fatigue failure and stiffness failure. The expression of residual resistance is given based on the impact of random crack propagation in- duced by the fatigue load on the critical limit stress and section modulus in this paper. The failure modes of every element of the structural system are analyzed under dead and fatigue loads, and the influence of the correlation of failure modes on reliability of the element is considered. Failure mechanism and the correlation of failure modes under dead and fatigue loads are discussed, and the method of reli- ability analysis considering static strength, fatigue and stiffness is given. A nu- merical example is analyzed, which indicates that the failure probability is different for different use life and the influence of dead and fatigue loads on reliability of the structural system is different as well. This method of reliability analysis, in the pa- per, is better than the method only considering a single factor (or static strength, or fatigue, or stiffness, etc.) in the case of practical engineering. | AN WeiGuang ZHAO WeiTao AN Hai | 2007 | Science China(Physics,Mechanics & Astronomy)2007，50，3： | 5 |
| 10 | A high-resolution, absolute-dated Holocene and deglacial Asian monsoon record from Dongge Cave, China显示文摘 | Carolyn A. Dykoski R. Lawrence Edwards Hai Cheng Daoxian Yuan Yanjun Cai Meiliang Zhang Yushi Lin Jiaming Qing Zhisheng An Justin Revenaugh | 2005 | Earth and Planetary Science Letters2005，，1： | 3 |
| 11 | Novel dihydropyrazole derivatives linked with multi(hetero)aromatic ring:Synthesis and antibacterial activity显示文摘八新奇代替 heterocycle 的 dihydropyrazole 衍生物被 ESIMS 综合并且描绘, 1 H NMR 和 13 C NMR。所有对杆菌在 vitro 为他们的抗菌剂潜力混合物被屏蔽了敏锐,葡萄球菌 aureus, Escherichia 关口 i 和 Pseudomonas aeruginosa。加重 9b, 9g 和 9h 的结果表演在 0.39 – 的范围与 MIC 价值显示了重要活动; 1.562 μ对 B 的 g/mL。敏锐。 | Lin Shan Bai Yan Wang Xin Hua Liu Hai Liang Zhu Bao An Song | 2009 | Chinese Chemical Letters2009，20，4： | 3 |
| 12 | Reliability analysis of ship structure system with multi-defects显示文摘This paper analyzes the influence of multi-defects including the initial distortions,welding residual stresses,cracks and local dents on the ultimate strength of the plate element,and has worked out expressions of reliability calculation and sensitivity analysis of the plate element.Reliability analysis is made for the system with multi-defects plate elements.Failure mechanism,failure paths and the calculating approach to global reliability index are also worked out.After plate elements with multi-defects fail,the formula of reverse node forces which affect the residual structure is deduced,so are the sensitivity expressions of the system reliability index.This ensures calculating accuracy and rationality for reliability analysis,and makes it convenient to find weakness plate elements which affect the reliability of the structure system.Finally,for the validity of the approach proposed,we take the numerical example of a ship cabin to compare and contrast the reliability and the sensitivity analysis of the structure system with multi-defects with those of the structure system with no defects.The approach has implications for the structure design,rational maintenance and renewing strategy. | AN Hai 1,AN WeiGang 1 & ZHAO WeiTao 2 1 School of Aerospace and Civil Engineering,Harbin Engineering University,Harbin 150001,China 2 School of Aeronautics and Astronautics,Shenyang Institute of Aeronautical Engineering,Shenyang 110034,China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，11： | 3 |
| 13 | Evaluation of Shale Reservoir Quality by Geophysical Logging for Shuijingtuo Formation of Lower Cambrian in Yichang Area, Central Yangtze显示文摘Taking the shale of Shuijingtuo Formation of Lower Cambrian in Yichang area as the research object,the shale reservoir characteristics are comprehensively evaluated and classified by fitting regression and formula calculation method in this study,using laboratory testing and geophysical logging data.The results show that the interpretation data of ECS(elemental capture spectroscopy)logging has a high correlation with the measured minerals data,which can be a good method to evaluate the minerals component of the shale.The calculated content of brittle minerals at the lower part of Shuijingtuo Formation is the relatively highest,generally more than 40%,which is the most favorable segment for fracturing.The correlation coefficient between the interpretation data of CMR(combinable nuclear magnetic resonance)logging and the result of laboratory porosity test is 0.97,which can effectively and accurately evaluate the reservoir porosity.The evaluation results show that the porosity of the lower member of Shuijingtuo Formation is generally greater than 3%,while that of the upper member is generally less than 3%.The lower segment is with the relative optimal physical conditions.There is a good correlation between the acoustic logging data and the gas bearing content testing results.A gas bearing content evaluation model is established.The results show that the gas bearing content of the lower 20 m shale is generally more than 2%,indicating that the lower part is a shale gas enrichment segment.Mechanical parameters such as Young modulus,Poisson ratio and brittleness index of shale reservoir are evaluated by using the logging data of P-wave time difference and S-wave time difference.The continuous 15 m shale at the lower part is with the relatively optimal low Poisson ratio,high Young modulus and high brittleness index,developing the optimum brittle condition.Based on the evaluation and classification of above parameters,the shale is divided into three types.The TypeⅠis the optimal,mainly located at the bottom.Its thickness is 8.5 m in total.The TypeⅡmainly develops at the middle part.The TypeⅢis the worst,mainly at the upper part. | Xiaohong Chen Lin Chen Shu Jiang An Liu Shengyuan Luo Hai Li Peijun Li Ping Chen | 2021 | Journal of Earth Science2021，32，4： | 3 |
| 14 | Drug Resistance to HIV-1 Integrase Inhibitors among Treatment-naive Patients in Jiangsu, China显示文摘Integrase strand transfer inhibitors (In STIs) have been widely used in recent years because of their high genetic barrier to resistance.The World Health Organization (WHO) has recommended dolutegravir(DTG)-containing regimens as the preferred first-and second-line antiretroviral therapy (ART) regimens for people living with human immunodeficiency virus(HIV)[1]. | YIN Yue Qi LU Jing ZHOU Ying SHI Ling En YUAN De Fu CHEN Jian Shuang XU AN Yan HU Hai Yang ZHANG Zhi XU Xiao Qin FU Geng Feng WANG Bei | 2021 | Biomedical and Environmental Sciences2021，34，5： | 2 |
| 15 | Hepatitis C virus may infect extrahepatic tissues in patients with hepatitis C显示文摘AIM To explore the status of extrahepatichepatitis C virus(HCV)infection and replicationin hepatitis C patients,and its potentialimplication in HCV infection and pathogenicity.METHODS By reverse-transcriptase poly-merase chain reaction(RT-PCR),in situhybridization(ISH)and immunohistochemistry,HCV RNA,HCV replicative intermediate(minus-strand of HCV RNA),and HCV antigens weredetected in 38 autopsy extrahepatic tissuespecimens(including 9 kidneys,9 hearts,9pancreas,5 intestines,2 adrenal glands,2spleens,1 lymph node,and 1 gallbladder)from 9hepatitis C patients,respectively;and thestatus of HCV replication in extrahepatic tissueswas studied.RESULTS By RT-PCR,all 9 patients werepositive for HCV RNA in kidney,heart,pancreas,and intestine,but only 6(66.7%)patients were positive for HCV replicativeintermediate.HCV RNA and HCV antigens weredetected in kidney,heart,pancreas,intestine,adrenal gland,lymph node,and gallbladder in 5(55.6%)and 6(66.7%)patients by ISH andimmunohistochemistry,respectively.HCV RNA and HCV antigens were not detected in theseextrahepatic organs in 3(33.3%)patients,although their livers were positive for HCV.HCVreplicative intermediate detected by RT-PCR wasconsistent with HCV RNA and HCV antigensdetected by ISH and immunohistochemistry(Kappa=0.42-0.75).HCV RNA and HCVantigens were detected in myocardial cells,epithelial cells of intestinal gladular,interstitialcells of kidney,epithelial cells of tubules andglomerulus,pancreas acinar cells and epithelialcells of pancreatic duct,epithelial cells ofmucous membrane sinus of gallbladder,cortexand medulla cells in adrenal gland,andmononuclear cells in lymph node.HCV RNA wasalso detected in bile duct epithelial cells,sinusoidal cells,and mononuclear cells in livertissues by ISH.CONCLUSION HCV can infect extrahepatictissues,and many various tissue cells maysupport HCV replication;extrahepatic HCVinfection and replication may be of'concomitantstate'in most of patients with hepatitis C.Theinfected extrahepatic tissues might act as areservoir for HCV,and play a role in both HCVpersistence and reactivation of infection.HCVas an etiologic agent replicating and expressingviral proteins in extrahepatic tissues itselfcontributes to extrahepatic syndromeassociated.HCV infection in a few patients withchronic HCV infection. | Fu Ming Yan An Shen Chen Fei Hao Xi Ping Zhao Chang Hai Gu Li Bin Zhao Dong Liang Yang Lian Jie Hao | 2000 | World Journal of Gastroenterology2000，6，6： | 2 |
| 16 | The variation of summer monsoon precipitation in central China since the last deglaciation显示文摘 | Yanjun Cai Liangcheng Tan Hai Cheng Zhisheng An R. Lawrence Edwards Megan J. Kelly Xinggong Kong Xianfeng Wang | 2009 | Earth and Planetary Science Letters2009，，1： | 2 |
| 17 | Unexpected Synthesis of 2,2'-[1-(4-Methoxyphenoxy)propane-2,2-diyl]bis(5-methoxy-3-methylbenzofuran)显示文摘A new bisbenzofuran analogue VII was achieved unexpectedly in one step procedure from 1-(4-methoxyphenoxy)acetone I by using Amberlyst 15 resin as catalyst in excellent yield. The structure was elucidated by spectroscopy analysis including 1H-NMR, 13C-NMR, DEPT, ESI-MS, element analysis. | Yu Dong SHEN Hai Qiang WU Lin Kun AN Zhi Shu HUANG Xian Zhang BU Lian Quan GU | 2005 | Chinese Chemical Letters2005，16，12： | 2 |
| 18 | Investigating Conservative Therapy of Cervical Radiculopathy by a Delphi Technique显示文摘To the Editor:Cervical radiculopathy (CR) is a common problem with an episodic course that affects a large proportion of the population.[1] The review indicated that nonoperative treatment is the main course.However,there is little high-quality evidence on the nonoperative therapy for CR.The purpose of this conservative therapy was built up to serve for the clinical practice. | Jian Li Wen-Yi Zhu Lei Zang Yong Hai Peng Du Ning Fan Yu Zhou Li-Kun An | 2015 | Chinese Medical Journal2015，，21： | 2 |
| 19 | Photocatalytic degradation kinetics and mechanism of environmental pharmaceuticals in aqueous suspension of TiO 2 : A case of sulfa drugs显示文摘 | Hai Yang Guiying Li Taicheng An Yanpeng Gao Jiamo Fu | 2010 | Catalysis Today2010，，3： | 2 |
| 20 | Kinetics and mechanism of advanced oxidation processes (AOPs) in degradation of ciprofloxacin in water显示文摘 | AN Taicheng YANG Hai LI Guiying | 2010 | Applied Catalysis B-Environmental2010，94，34： | 1 |
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