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| 1 | The Tea Tree Genome Provides Insights into Tea Flavor and Independent Evolution of Caffeine Biosynthesis显示文摘茶是世界有巨大的经济、药用、文化的重要性的最旧、很流行的包含咖啡因的饮料。这里,我们在场第一个高质量的核苷酸序列充满重复(80.9%) ,栽培的茶树山茶 sinensis 的 3.02-Gb 染色体。我们证明茶树的一种非常地大的染色体尺寸从一些 LTR retrotransposon 家庭的慢、稳定、长期的扩大被结果。除了一个最近的整个染色体的复制事件,基因的系特定的扩大把新陈代谢的生合成与 flavonoid 联系了被发现,它提高 catechin 生产,萜烯酶激活,和应力公差,为茶风味和改编的重要特征。我们相对可可子和咖啡表明一个独立人士和茶咖啡因合成小径的快速的进化。在 25 山茶种类之中的比较研究表明那更高的表情大多数 flavonoid- 和咖啡因铺平 -- 然而并非 theanine 相关的基因贡献 catechins 和咖啡因的增加的生产并且因此提高处理茶的适用性和茶质量。这些新奇调查结果为进一步的 metabolomic 和典型生合成小径的功能的 genomic 精炼铺平道路并且将帮助开发将最后满足并且吸引世界范围的更多的茶喝酒者的茶风味的一个更多样化的集合。 | En-Hua Xia Hai-Bin Zhang Jun Sheng Kui Li Qun-Jie Zhang Changhoon Kim Yun Zhang Yuan Liu Ting Zhu Wei Li Hui Huang Yan Tong Hong Nan Cong Shi Chao Shi Jian-Jun Jiang Shu-Yan Mao Jun-Ying Jiao Dan Zhang Yuan Zhao You-Jie Zhao Li-Ping Zhang Yun-Long Liu Ben-Ying Liu Yue Yu Sheng-Fu Shao De-Jiang Ni Evan E. Eichler Li-Zhi Gao | 2017 | Molecular Plant2017，10，6： | 113 |
| 2 | Iron-doped Mn-Ce/TiO_2 catalyst for low temperature selective catalytic reduction of NO with NH_3显示文摘The catalysts of iron-doped Mn-Ce/TiO 2(Fe-Mn-Ce/TiO 2) prepared by sol-gel method were investigated for low temperature selective catalytic reduction(SCR) of NO with NH 3.It was found that the NO conversion over Fe-Mn-Ce/TiO 2 was obviously improved after iron doping compared with that over Mn-Ce/TiO 2.Fe-Mn-Ce/TiO 2 with the molar ratio of Fe/Ti = 0.1 exhibited the highest activity.The results showed that 96.8% NO conversion was obtained over Fe(0.1)-Mn-Ce/TiO 2 at 180°C at a space velocity of 50,000 hr 1.Fe-Mn-Ce/TiO 2 exhibited much higher resistance to H 2 O and SO 2 than that of Mn-Ce/TiO 2.The properties of the catalysts were characterized using X-ray diffraction(XRD),N 2 adsorption,temperature programmed desorption(NH 3-TPD and NOx-TPD),and Xray photoelectron spectroscopy(XPS) techniques.BET,NH3-TPD and NOx-TPD results showed that the specific surface area and NH3 and NOx adsorption capacity of the catalysts increased with iron doping.It was known from XPS analysis that iron valence state on the surface of the catalysts were in Fe3+ state.The doping of iron enhanced the dispersion and oxidation state of Mn and Ce on the surface of the catalysts.The oxygen concentrations on the surface of the catalysts were found to increase after iron doping.Fe-Mn-Ce/TiO2 represented a promising catalyst for low temperature SCR of NO with NH3 in the presence of H2 O and SO2. | Boxiong Shen ,Ting Liu,Ning Zhao,Xiaoyan Yang,Lidan Deng College of Environmental Science and Engineering,Nankai University,Tianjin 300071,China. | 2010 | Journal of Environmental Sciences2010，22，9： | 63 |
| 3 | Paeoniflorin suppresses TGF-β mediated epithelial- mesenchymal transition in pulmonary fibrosis through a Smad-dependent pathway显示文摘 | Yu JI Yan-nong DOU Qian-wen ZHAO Ji-zhou ZHANG Yan YANG Ting WANG Yu-feng XIA Yue DAI Zhi-feng WEI | 2016 | Acta Pharmacologica Sinica2016，37，6： | 48 |
| 4 | Washed microbiota transplantation vs.manual fecal microbiota transplantation:clinical findings,animal studies and in vitro screening显示文摘Fecal microbiota transplantation(FMT)by manual preparation has been applied to treat diseases for thousands of years.However,this method still endures safety risks and challenges the psychological endurance and acceptance of doctors,patients and donors.Population evidence showed the washed microbiota preparation with microfiltration based on an automatic purification system followed by repeated centrifugation plus suspension for three times significantly reduced FMT-related adverse events.This washing preparation makes delivering a precise dose of the enriched microbiota feasible,instead of using the weight of stool.Intraperitoneal injection in mice with the fecal microbiota supernatant obtained after repeated centrifugation plus suspension for three times induced less toxic reaction than that by the first centrifugation following the microfiltration.The toxic reactions that include death,the change in the level of peripheral white blood cells,and the proliferation of germinal center in secondary lymphoid follicles in spleen were noted.The metagenomic next-generation sequencing(NGS)indicated the increasing types and amount of viruses could be washed out during the washing process.Metabolomics analysis indicated metabolites with pro-inflammatory effects in the fecal microbiota supernatant such as leukotriene B4,corticosterone,and prostaglandin G2 could be removed by repeated washing.Near-infrared absorption spectroscopy could be served as a rapid detection method to control the quality of the washingprocess.In conclusion,this study for the first time provides evidence linking clinical findings and animal experiments to support that washed microbiota transplantation(WMT)is safer,more precise and more quality-controllable than the crude FMT by manual. | Ting Zhang Gaochen Lu Zhe Zhao Yafei Liu Quan Shen Pan Li Yaoyao Chen Haoran Yin Huiquan Wang Cicilia Marcella Bota Cui Lei Cheng Guozhong Ji Faming Zhang | 2020 | Protein & Cell2020，11，4： | 44 |
| 5 | Administration of imatinib in the first 90 days after allogeneic hematopoietic cell transplantation in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia显示文摘背景恶化在 allogeneic 以后经常发生在有费城染色体积极的尖锐成淋巴细胞的白血病的病人的造血的房间移植( allo-HCT )(Ph+所有)在 allo-HCT 前后的最小的剩余疾病( MRD )的 .Detection rate.Early 与更高的恶化被联系在 allo-HCT 以后的 imatinib 的管理可以阻止周期性的Ph+ ALL.The 目的这研究是当时,在阻止 hematological 恶化评估 imatinib 的安全和功效 imatinib | CHEN Huan LIU Kai-yan XU Lan-ping LIU Dai-hong CHEN Yu-hong SHI Hong-xia HAN Wei ZHAN Xiao-hui WANG Yu ZHAO Ting HUANG Xiao-jun | 2011 | Chinese Medical Journal2011，，2： | 23 |
| 6 | Kinetics and equilibrium of adsorption of dissolved organic matter fractions from secondary effluent by fly ash显示文摘Fly ash was used as a low-cost adsorbent for removing dissolved organic matter (DOM) in secondary effluent. Batch experiments were conducted under various adsorbent dosages, pH, contact time, temperatures and DOM fractional characteristics. Under the optimum conditions of fly ash dosage of 15 g/L, temperature of 303 K and contact time of 180 min, a removal of 22.5% of the dissolved organic carbon (DOC), 23.7% of UV-254, 25.9% of the trihalomethanes precursors in secondary effluent was obtained. The adsorption of DOM fractions onto fly ash all followed the pseudo second-order kinetic model, and the hydrophilic fraction adsorption by fly ash also fitted the intraparticle diffusion model quite well. Freundlich and Langmuir models were applicable to the fly ash adsorption and their constants were evaluated. The maximum adsorption capacities of the adsorptions revealed that fly ash was more effective in adsorbing hydrophilic fraction than the acidic fractions. Structure changes of the DOM fractions after fly ash adsorption were also characterized via spectrum analyzing. Those mechanisms presented critical step toward improved efficiencies of fly ash adsorption via further surface-modification. | Liangliang Wei Kun Wang Qingliang Zhao Chunmei Xie Wei Qiu Ting Jia | 2011 | Journal of Environmental Sciences2011，23，7： | 21 |
| 7 | Mutual Impact of Diabetes Mellitus and Tuberculosis in China显示文摘China has a double burden of diabetes mellitus and tuberculosis, and many studies have been carried out on the mutual impact of these two diseases. This paper systematically reviewed studies conducted in China covering the mutual impact of epidemics of diabetes and tuberculosis, the impact of diabetes on multi-drug resistant tuberculosis and on the tuberculosis clinical manifestation and treatment outcome, the yields of bi-directional screening, and economic evaluation for tuberculosis screening among diabetes patients. | CHENG Jun ZHANG Hui ZHAO Yan Lin WANG Li Xia CHEN Ming Ting | 2017 | Biomedical and Environmental Sciences2017，30，5： | 21 |
| 8 | Serum uric acid levels correlate with atrial fibrillation in patients with chronic systolic heart failure显示文摘 | ZHAO Qing-yan YU Sheng-bo HUANG He CUI Hong-ying QIN Mu HUANG Ting HUANG Cong-xin | 2012 | Chinese Medical Journal2012，，10： | 20 |
| 9 | A Pilot Study of the Therapeutic Efficacy and Mechanism of Artesunate in the MRL/lpr Murine Model of Systemic Lupus Erythematosus显示文摘Recent evidence indicates that artesunate has immunomodulatory properties that might be useful for treating autoimmune disease.In this study,we conducted a pilot study and explored the effect and mechanism of artesunate on the treatment of systemic lupus erythematosus using an MRL/lpr murine model.MRL/lpr mice were divided into control,cyclophosphamide(CTX)and artesunate treatment groups.Blood was collected to measure serum levels of creatinine,antinuclear antibody(ANA)and anti-double-stranded DNA(anti-dsDNA)antibody.Twenty-four-hour urine was collected to measure levels of proteinuria.The concentration of monocyte chemotactic protein-1(MCP-1)in serum and urine was measured.The expression of MCP-1 in kidney was detected by Western blot and immunohistochemistry assay,respectively.The expression of B cell activating factor(BAFF)in spleen was determined by real time-PCR and immunoblotting.We found that artesunate significantly increased the survival rate,body weight and blood leukocyte counts,and reduced the serum levels of ANA and anti-dsDNA antibody titer,24 h urinary protein,and serum creatinine.Our results indicated that artesunate could decrease MCP-1,major pro-inflammation cytokine,in serum,urine and kidney.We also found that the level of BAFF,the major B cell activation factor,was decreased in artesunate treated MRL/lpr mice.Its efficacy was comparable with that of CTX in this study.Taken together,we have demonstrated that artesunate can inhibit the progression of disease and reverse the pathologic lesion of lupus nephritis. | Ouyang Jin Huayong Zhang Zhifeng Gu Shengnan Zhao Ting Xu Kangxing Zhou Bo Jiang Jie Wang Xiaofeng Zeng Lingyun Sun | 2009 | Cellular & Molecular Immunology2009，6，6： | 20 |
| 10 | Precise nanomedicine for intelligent therapy of cancer显示文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. | Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao | 2018 | Science China Chemistry2018，61，12： | 19 |
| 11 | Dihydromyricetin protects neurons in an MPTPinduced model of Parkinson's disease by suppressing glycogen synthase kinase-3 beta activity显示文摘瞄准:它是相信的将军那个 mitochondrial 机能障碍和氧化应力在 Parkinsons 疾病(PD ) 的病理起关键作用。Dihydromyricetin (DHM ) ,从白蔹属 grossedentata 提取的自然 flavonoid,最近被发现得到有势力抗氧化效果。在现在的学习,我们在保护 dopaminergic neurons.Methods 探索了 DHM 的角色:男 C57BL/6 老鼠 intraperitoneally 与 1-methyl4-phenyl-1,2,3,6-tetrahydropyridine (MPTP ) 被注射让 7 d 导致 PD。另外,老鼠为 13 d 的一个总数与 5 或 10 mg/kg DHM 被对待(在 MPTP 的开始前的 3 d,在 MPTP 管理(7 d ) 和在 MPTP 的结束以后的 3 d 期间) 。为盐或 DHM 独自一个的处理组,老鼠被注射与盐或为 13 d 的 DHM。在 d 上 14,行为的测试(运动活动, rotarod 测试和杆测试) 被管理。在行为的测试以后,老鼠被牺牲,并且大脑织物为 immunofluorescence 染色并且西方的弄污是镇定的。另外, MES23.5 细胞与 MPP + 和 DHM 被对待,并且评估了使用细胞生存能力试金,反应的氧种(ROS ) 大小, apoptosis 分析和西方的 blotting.Results:DHM 显著地稀释了导致 MPTP 的老鼠行为的缺陷和 dopaminergic 神经原损失。在 MES23.5 房间, DHM 以一种剂量依赖者方式稀释了 MPP +-induced 房间损害和 ROS 生产。另外, DHM 在一个剂量依赖者和时间依赖者举止增加了肝糖 synthase kinase-3 贝它 phosphorylation,它可以与导致 DHM 的 dopaminergic neuronal protection.Conclusion 被联系:现在的学习证明 DHM 是为由 modulating 的 DA 神经原的一个有势力 neuroprotective 代理人 Akt/GSK-3β小径,它建议那 DHM 可以是 PD 的一个有希望的治疗学的候选人。 | Zhao-xiang REN Ya-fei ZHAO Ting CAO Xue-chu ZHEN | 2016 | Acta Pharmacologica Sinica2016，37，10： | 19 |
| 12 | Immunogenicity noninferiority study of 2 doses and 3 doses of an Escherichia coli-produced HPV bivalent vaccine in girls vs.3 doses in young women显示文摘A new HPV-16/18 bivalent vaccine expressed by the Escherichia coli has been proven to be efficacious in adult women.A randomized,immunogenicity noninferiority study of this candidate vaccine was conducted in December 2015 in China.Girls aged 9–14 years were randomized to receive 2 doses at months 0 and 6(n=301)or 3 doses at months 0,1 and 6(n=304).Girls aged 15–17 years(n=149)and women aged 18–26 years(n=225)received 3 doses.The objectives included noninferiority analysis of the IgG geometric mean concentration(GMC)ratio(95%CI,lower bound>0.5)to HPV-16 and HPV-18 at month 7 in girls compared with women.In the per-protocol set,the GMC ratio of IgG was noninferior for girls aged 9–17 years receiving 3 doses compared with women(1.76(95%CI,1.56,1.99)for HPV-16 and 1.93(95%CI,1.69,2.21)for HPV-18)and noninferior for girls aged 9–14 years receiving 2 doses compared with women(1.45(95%CI,1.25,1.62)for HPV-16 and 1.17(95%CI,1.02,1.33)for HPV-18).Noninferiority was also demonstrated for neutralizing antibodies.The immunogenicity of the HPV vaccine in girls receiving 3 or 2 doses was noninferior compared with that in young adult women. | Yue-Mei Hu Meng Guo Chang-Gui Li Kai Chu Wen-Gang He Jing Zhang Jian-Xiang Gu Juan Li Hui Zhao Xiang-Hong Wu Bi-Zhen Lin Zhi-Jie Lin Xing-Mei Yao Ya-Fei Li Fei-Xue Wei Yue Huang Ying-Ying Su Feng-Cai Zhu Shou-Jie Huang Hui-Rong Pan Ting Wu Jun Zhang Ning-Shao Xia | 2020 | Science China(Life Sciences)2020，63，4： | 19 |
| 13 | Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC)is a poor-prognosis cancer type with limited understanding of its molecular etiology.Using 508 ESCC genomes,we identified five novel significantly mutated genes and uncovered mutational signature clusters associated with metastasis and patients’outcomes.Several functional assays implicated that NFE2L2 may act as a tumor suppressor in ESCC and that mutations in NFE2L2 probably impaired its tumor-suppressive function,or even conferred oncogenic activities.Additionally,we found that the NFE2L2 mutations were significantly associated with worse prognosis of ESCC.We also identified potential noncoding driver mutations including hotspot mutations in the promoter region of SLC35E2 that were correlated with worse survival.Approximately 5.9%and 15.2%of patients had high tumor mutation burden or actionable mutations,respectively,and may benefit from immunotherapy or targeted therapies.We found clinically relevant coding and noncoding genomic alterations and revealed three major subtypes that robustly predicted patients’outcomes.Collectively,we report the largest dataset of genomic profiling of ESCC useful for developing ESCC-specific biomarkers for diagnosis and treatment. | Yongping Cui Hongyan Chen Ruibin Xi Heyang Cui Yahui Zhao Enwei Xu Ting Yan Xiaomei Lu Furong Huang Pengzhou Kong Yang Li Xiaolin Zhu Jiawei Wang Wenjie Zhu Jie Wang Yanchun Ma Yong Zhou Shiping Guo Ling Zhang Yiqian Liu Bin Wang Yanfeng Xi Ruifang Sun Xiao Yu Yuanfang Zhai Fang Wang Jian Yang Bin Yang Caixia Cheng Jing Liu Bin Song Hongyi Li Yi Wang Yingchun Zhang Xiaolong Cheng Qimin Zhan Yanhong Li Zhihua Liu-Show | 2020 | Cell Research2020，30，10： | 19 |
| 14 | Dynamic methylome of internal mRNA N^7-methylguanosine and its regulatory role in translation显示文摘Over 150 types of RNA modifications are identified in RNA molecules.Transcriptome profiling is one of the key steps in decoding the epitranscriptomic panorama of these chemical modifications and their potential functions.N7-methylguanosine(m7G)is one of the most abundant modifications present in tRNA,rRNA and mRNA 5’cap,and has critical roles in regulating RNA processing,metabolism and function.Besides its presence at the cap position in mRNAs,m7G is also identified in internal mRNA regions.However,its transcriptome-wide distribution and dynamic regulation within internal mRNA regions remain unknown.Here,we have established m7G individual-nucleotide-resolution cross-linking and immunoprecipitation with sequencing(m7G miCLIP-seq)to specifically detect internal mRNA m7G modification.Using this approach,we revealed that m7G is enriched at the 5’UTR region and AG-rich contexts,a feature that is well-conserved across different human/mouse cell lines and mouse tissues.Strikingly,the internal m7G modification is dynamically regulated under both H2O2 and heat shock treatments,with remarkable accumulations in the CDS and 3’UTR regions,and functions in promoting mRNA translation efficiency.Consistently,a PCAW 3’UTR minigene reporter harboring the native m7G modification site displays both enriched m7G modification and increased mRNA translation upon H2O2 treatment compared to the m7G site-mutated minigene reporter(G to A).Taken together,our findings unravel the dynamic profiles of internal mRNA m7G methylome and highlight m7G as a novel epitranscriptomic marker with regulatory roles in translation. | Lionel Malbec Ting Zhang Yu-Sheng Chen Ying Zhang Bao-Fa Sun Bo-Yang Shi Yong-Liang Zhao Ying Yang Yun-Gui Yang | 2019 | Cell Research2019，29，11： | 17 |
| 15 | Spatial concentration,congener profiles and inhalation risk assessment of PCDD/Fs and PCBs in the atmosphere of Tianjin,China显示文摘Polychlorinated dibenzo-p-dioxins/dibenzofurans(PCDD/Fs) and polychlorinated biphenyls(PCBs) were monitored in a seasonal passive sampling scheme during June 2008 and January 2009 to investigate the spatial concentration,congener profiles and evaluate the potential inhalation risk in different functional areas in Tianjin,China.The spatial air concentrations and I-TEQs ranged 1.08×102-8.19×10 3 fg m-3(average 2.63×103 fg m-3) and 4.08-325 fg I-TEQ m-3(average 91.4 fg I-TEQ m-3) respectively for PCDD/Fs.The concentration and I-TEQs of PCBs were 3.08×104-3.01×105 fg m-3(average 1.39×105 fg m-3) and 1.72-49.6 fg I-TEQ m-3(average 18.5 fg I-TEQ m-3).It is obvious that PCB concentrations were several hundred times higher than the PCDD/Fs.However,the ambient air PCDD/Fs contributed a major part to the total toxicity equivalents,varying from 72.7% to 89.0%(average 81.8%).The atmospheric PCDD/F levels were observed to be higher in winter for most of sampling sites in the downtown.Besides,inhalation risk assessment showed that local residents might suffer more risk near the point sources than those in living area,industrial zones and background area in Tianjin City.However,the total daily dioxin intake was approximately several to hundreds of times lower than the WHO criteria,showing relatively low exposure risks from the impact of industry point sources in Tianjin City. | DING Lei LI YingMing WANG Pu LI XiaoMin ZHAO ZongShan RUAN Ting ZHANG QingHua | 2013 | Chinese Science Bulletin2013，58，9： | 17 |
| 16 | Saponins from Panax japonicus attenuate age-related neuroinflammation via regulation of the mitogen-activated protein kinase and nuclear factor kappa B signaling pathways显示文摘Neuroinflammation is recognized as an important pathogenic factor for aging and related cognitive disorders. Mitogen-activated protein kinase and nuclear factor kappa B signaling pathways may mediate neuroinflammation. Saponins from Panax japonicus are the most abundant and bioactive members in rhizomes of Panax japonicus, and show anti-inflammatory activity. However, it is not known whether saponin from Panax japonicus has an anti-inflammatory effect in the aging brain, and likewise its underlying mechanisms. Sprague-Dawley rats were divided into control groups(3-, 9-, 15-, and 24-month-old groups) and saponins from Panax japonicus-treated groups. Saponins from Panax japonicus-treated groups were orally administrated saponins from Panax japonicus at three doses of 10, 30, and 60 mg/kg once daily for 6 months until the rats were 24 months old. Immunohistochemical staining and western blot assay results demonstrated that many microglia were activated in 24-month-old rats compared with 3-and 9-month-old rats. Expression of interleukin-1β, tumor necrosis factor-α, cyclooxygenase-2, and inducible nitric oxide synthase increased. Each dose of saponins from Panax japonicus visibly suppressed microglial activation in the aging rat brain, and inhibited expression levels of the above factors. Each dose of saponins from Panax japonicus markedly diminished levels of nuclear factor kappa B, IκBα, extracellular signal-regulated kinase, c-Jun N-terminal kinase, and p38. These results confirm that saponins from Panax japonicus can mitigate neuroinflammation in the aging rat brain by inhibition of the mitogen-activated protein kinase and nuclear factor kappa B signaling pathways. | Li-li Deng Ding Yuan Zhi-yong Zhou Jing-zhi Wan Chang-cheng Zhang Chao-qi Liu Yao-yan Dun Hai-xia Zhao Bo Zhao Yuan-jian Yang Ting Wang | 2017 | Neural Regeneration Research2017，12，11： | 17 |
| 17 | An HBV-encoded miRNA activates innate immunity to restrict HBV replication显示文摘We previously identified that hepatitis B virus(HBV)encodes a microRNA(HBV-miR-3)that restrains HBV replication by targeting the HBV transcript.However,whether HBV-miR-3 affects host innate immunity to modulate HBV replication remains unclear.Here,we examined the vital functions of HBV-miR-3 in the innate immune response after HBV infection.We found that HBV-miR-3 expression gradually increased in a dose-and time-dependent manner in HBV-infected HepG2-NTCP cells.HBV-miR-3 activated the JAK/STAT signaling pathway by downregulating SOCS5 in hepatocytes,thereby enhancing the IFN-induced anti-HBV effect.In addition,HBVmiR-3 in exosomes facilitated the Ml polarization of macrophages.Furthermore,exosomes containing HBV-miR-3 enhanced the secretion of IL-6 via inhibiting the SOCS5-mediated ubiquitination of EGFR.In short,these results demonstrate that HBV-miR-3 activates the innate immune response to restrain HBV replication by multiple pathways,which may suppress HBV-induced acute liver cell injury and affect the progression of persistent HBV infection. | Xiaoqing Zhao Lu Sun Ting Mu Jianying Yi Chaoqun Ma Hong Xie Min Liu Hua Tang | 2020 | Journal of Molecular Cell Biology2020，12，4： | 17 |
| 18 | Novel modified pectin for heavy metal adsorption显示文摘Modified pectin cross-linked with adipic acid, was synthesized and used for heavy metal removal from wastewater. SEM and FTIR were used to investigate its structure and morphology. The modified pectin had a rough, porous phase covered with carboxy groups, resulting a high adsorption capacity. And at the room temperature, the saturated loading capacity for Pb2+, Cu2+ and Zn2+ reached 1.82 mmol/g, 1.794 mmol/g and 0.964 mmol/g, respectively. The results proved its potential application to remove of theheavy metal. | Feng Ting Li Hong Yang Yan Zhao Ran Xu | 2007 | Chinese Chemical Letters2007，18，3： | 16 |
| 19 | Seasonal trend of ambient PCDD/Fs in Tianjin City, northern China using active sampling strategy显示文摘The spatial concentrations, seasonal trends, profiles and congener pairs of ambient polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) were investigated within a seasonally active sampling scheme during Jun 2008 and Jan 2009 in Tianjin City, northern China. The PCDD/F concentrations ranged 14.2-172 fg I-TEQ/m3 (average 69.3 fg I-TEQ/m3 ) in summer and (89.8-1.01)×103 fg I-TEQ/m3 (average 509 fg I-TEQ/m3 ) in winter, respectively, except for the E-waste dismantling site where much higher values were observed (1.04×103 fg I-TEQ/m3 in summer and 7.123×103 fg I-TEQ/m3 in winter). The results indicated a significantly seasonal trend with higher TEQ values in winter as compared with summer, which could be related to increased emission sources and seasonal variations of the atmospheric boundary layer height. 2,3,4,7,8-PeCDF was the dominant contributor to the total PCDD/F toxic equivalents, and 2,3,7,8-TCDD was detected at almost all the sampling sites in winter. Most of the similarly substituted PCDD/F congener pairs exhibited high correlations, suggesting that they might have similar environmental fate or sources. But different seasonal and spatial distributions of PCDD/F concentrations indicated that the emission sources might be intermittent. | Lei Ding Yingming Li Pu Wang Xiaomin Li Zongshan Zhao Qinghua Zhang Ting Tuan Guibin Jiang | 2012 | Journal of Environmental Sciences2012，24，11： | 16 |
| 20 | Clinical significance of changes in the Th17/Treg ratio in autoimmune liver disease显示文摘AIM To investigate the levels, ratios, and clinical significance of T helper 17(Th17) cells and regulatory T(Treg) cells in the peripheral blood of patients with autoimmune liver disease(AILD). METHODS F o r t y-t w o A I L D p a t i e n t s w e r e i n c l u d e d i n t h e experimental group(group E), and 11 healthy subjects were recruited as the control group(group C). Flow cytometry was performed to determine the percentages of Th17 and Treg cells in peripheral blood lymphocytes. Furthermore, a range of biochemical indices was measured simultaneously in the blood of group E patients. RESULTS The percentage of Th17 cells and the Th17/Treg ratio were higher in group E than in group C(P < 0.01), whereas the percentage of Tregs was lower in the group E patients(P < 0.05). Patients in group E who were admitted with AILD in the active stage showed significantly higher Th17 percentages and Th17/Treg ratios than those measured in patients with AILD in remission(P < 0.05). In addition, among patients with AILD in the active stage, individuals that remained unhealed after hospitalization showed significantly higher baseline values of the Th17 percentage and the Th17/Treg ratio than those detected in patients who improved after treatment(P < 0.05). The results suggested that imbalance in the Th17/Treg ratio plays an important role in the pathogenesis and development of AILD.CONCLUSION A high Th17/Treg ratio appears to predict poor shortterm prognosis in patients with AILD in the active stage. | Ting-Ting Feng Ting Zou Xin Wang Wei-Feng Zhao Ai-Lan Qin | 2017 | World Journal of Gastroenterology2017，23，21： | 15 |
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