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| 1 | Reliability analysis of stochastic structural system considering static strength, stiffness and fatigue显示文摘Multi-failures are possible to appear in the process of using the structural system, such as dead load failure, fatigue failure and stiffness failure. The expression of residual resistance is given based on the impact of random crack propagation in- duced by the fatigue load on the critical limit stress and section modulus in this paper. The failure modes of every element of the structural system are analyzed under dead and fatigue loads, and the influence of the correlation of failure modes on reliability of the element is considered. Failure mechanism and the correlation of failure modes under dead and fatigue loads are discussed, and the method of reli- ability analysis considering static strength, fatigue and stiffness is given. A nu- merical example is analyzed, which indicates that the failure probability is different for different use life and the influence of dead and fatigue loads on reliability of the structural system is different as well. This method of reliability analysis, in the pa- per, is better than the method only considering a single factor (or static strength, or fatigue, or stiffness, etc.) in the case of practical engineering. | AN WeiGuang ZHAO WeiTao AN Hai | 2007 | Science China(Physics,Mechanics & Astronomy)2007，50，3： | 5 |
| 2 | Experimental and LES investigation of flame propagation in a hydrogen/air mixture in a combustion vessel显示文摘This work presents an experimental and numerical investigation of premixed flame propagation in a hydrogen/air mixture in a closed combustion vessel.In the experiment,high-speed schlieren video photography and pressure sensor are used to examine the flame dynamics and pressure transient.In the numerical study,a large eddy simulation(LES)based on a RNG sub-grid approach and a LES combustion model is applied to reproduce experimental observations.The effects of four physical phenomena on the burning velocity are considered in the combustion model,and the impact of grid type on the combustion dynamics is examined in the LES calculations.The flame experiences four stages both in experiment and LES calculations with structured and unstructured grids,i.e.,spherical flame,finger-shaped flame,flame with its skirt in contact with the sidewalls,and tulip-shaped flame.The flame speed and pressure in the vessel develop with periodical oscillations in both the experiment and LES simulations due to the interaction of flame front with pressure wave.The numerical simulations compare well with the detailed experimental measurements,especially in term of the flame shape and position,pressure build-up,and periodical oscillation behaviors.The LES combustion model is successfully validated against the bench-scale experiment.It is put into evidence that mesh type has an impact to a certain extent on the numerical combustion dynamics,and the LES calculation on structured grid canpredict the flame dynamics and pressure rise more accurately than that on unstructured grid with the same mesh resolution.The flame shape is more asymmetrical in the LES on an unstructured grid than that on a structured grid,and both the flame speed and the pressure rise at the later flame stage are underestimated in the LES on the unstructured grid. | Huahua Xiao Zhanli Mao Weiguang An Jinhua Sun | 2014 | Chinese Science Bulletin2014，59，20： | 2 |
| 3 | Ent-kaurane and ent-abietane diterpenoids from Isodon phyllostachys显示文摘Four new diterpenoids, phyllostachysins I–L(1–4), along with a known one, hebeiabinin B(5), were isolated from the aerial parts of Isodon phyllostachys(I. phyllostachys). Compounds 1 and 2 feature an ent-kaurane backbone, and 3, 4 and 5 bear an ent-abietane skeleton. Their structures were elucidated by means of spectroscopic analysis. Compounds 3 and 4 exhibited significant cytotoxic activity against human tumor cell lines(HL-60, SMMC-7721, A-549, MCF-7 and SW-480), and strongly inhibited NO production in LPS-stimulated RAW264.7 cells. | Jin Yang Yaqi An Haiyan Wu Miao Liu Weiguang Wang Xue Du Yan Li Jianxin Pu Handong Sun | 2016 | Science China Chemistry2016，59，9： | 2 |
| 4 | Silicon saturation coefficient changes in hydrogarnets during the Bayer process with lime addition显示文摘The relationship between the silicon saturation coefficient of hydrogarnets and Bayer reaction parameters was studied. The peak position, crystal plane spacing, and cell edge length of typical hydrogarnet patterns were calculated to find the key factors influencing the relationship. The results showed that the crystal face(420) is the optimal garnet growth direction during hydration and crystal growth along the faces(521) and(611) were not affected significantly by the varying experimental conditions. The reaction temperature significantly influenced the silicon saturation coefficient of hydrogarnets. The silicon saturation coefficient of hydrogarnets increased from 0.2 to about 1.0 in the temperature range of 30–270 °C and a rapid expansion process was observed in the temperature range of 120–150 °C. Moreover, the reaction time, alumina concentration, and C/S were shown to be less important factors. Averaging the results obtained by the 3 methods was shown suitable for calculating the SiO2 saturation coefficient of hydrogarnets. The calculated results of the Al2O3 and SiO2 contents matched the actual ones. However, the actual SiO2 content was about10 % less than the calculated one for SiO2 saturation coefficients higher than 1. | Guozhi Lü Ting’an Zhang Xiaofeng Zhu Chaozhen Zheng Yanxiu Wang Weiguang Zhang Zimu Zhang | 2019 | Chinese Journal of Chemical Engineering2019，27，8： | 2 |
| 5 | Structural dynamic reliability on supercavity vehicle 显示文摘 | I L|U Ming AN Weiguang | 2011 | Advanced Materials Research2011，，230231232： | 1 |
| 6 | Optimum design based on improved hybrid genetic algorithm显示文摘 | Jiang Feng guo An Weiguang Zhao Yanlin | 2007 | Fourth International Conference on Information Technology and Applications2007，28，7： | 1 |
| 7 | Mechanistic engineering of celastrol liposomes induces ferroptosis and apoptosis by directly targeting VDAC2 in hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is one of most common and deadliest malignancies.Celastrol(Cel),a natural product derived from the Tripterygium wilfordii plant,has been extensively researched for its potential effectiveness in fighting cancer.However,its clinical application has been hindered by the unclear mechanism of action.Here,we used chemical proteomics to identify the direct targets of Cel and enhanced its targetability and antitumor capacity by developing a Cel-based liposomes in HCC.We demonstrated that Cel selectively targets the voltage-dependent anion channel 2(VDAC2).Cel directly binds to the cysteine residues of VDAC2,and induces cytochrome C release via dysregulating VDAC2-mediated mitochondrial permeability transition pore(mPTP)function.We further found that Cel induces ROS-mediated ferroptosis and apoptosis in HCC cells.Moreover,coencapsulation of Cel into alkyl glucoside-modified liposomes(AGCL)improved its antitumor efficacy and minimized its side effects.AGCL has been shown to effectively suppress the proliferation of tumor cells.In a xenograft nude mice experiment,AGCL significantly inhibited tumor growth and promoted apoptosis.Our findings reveal that Cel directly targets VDAC2 to induce mitochondria-dependent cell death,while the Cel liposomes enhance its targetability and reduces side effects.Overall,Cel shows promise as a therapeutic agent for HCC. | Piao Luo Qian Zhang Shuo Shen Yehai An Lixia Yuan Yin-Kwan Wong Sizhe Huang Shaohui Huang Jingnan Huang Guangqing Cheng Jiahang Tian Yu Chena Xiaoyong Zhang Weiguang Li Songqi He Jigang Wang Qingfeng Du | 2023 | Asian Journal of Pharmaceutical Sciences2023，18，6： | 0 |
| 8 | Mulberry leaf flavonoids activate BAT and induce browning of WAT to improve type 2 diabetes via regulating the AMPK/SIRT1/PGC-1α signaling pathway显示文摘Mulberry (Morus alba L.) leaf is a well-established traditional Chinese botanical and culinary resource. It has found widespread application in the management of diabetes. The bioactive constituents of mulberry leaf, specifically mulberry leaf flavonoids (MLFs), exhibit pronounced potential in the amelioration of type 2 diabetes (T2D). This potential is attributed to their ability to safeguard pancreatic β cells, enhance insulin resistance, and inhibit α-glucosidase activity. Our antecedent research findings underscore the substantial therapeutic efficacy of MLFs in treating T2D. However, the precise mechanistic underpinnings of MLF’s anti-T2D effects remain the subject of inquiry. Activation of brown/beige adipocytes is a novel and promising strategy for T2D treatment. In the present study, our primary objective was to elucidate the impact of MLFs on adipose tissue browning in db/db mice and 3T3-L1 cells and elucidate its underlying mechanism. The results manifested that MLFs reduced body weight and food intake, alleviated hepatic steatosis, improved insulin sensitivity, and increased lipolysis and thermogenesis in db/db mice. Moreover, MLFs activated brown adipose tissue (BAT) and induced the browning of inguinal white adipose tissue (IWAT) and 3T3-L1 adipocytes by increasing the expressions of brown adipocyte marker genes and proteins such as uncoupling protein 1 (UCP1) and beige adipocyte marker genes such as transmembrane protein 26 (Tmem26), thereby promoting mitochondrial biogenesis. Mechanistically, MLFs facilitated the activation of BAT and the induction of WAT browning to ameliorate T2D primarily through the activation of AMP-activated protein kinase (AMPK)/sirtuin 1 (SIRT1)/peroxisome proliferator-activated receptor-gamma coactivator 1α (PGC-1α) signaling pathway. These findings highlight the unique capacity of MLF to counteract T2D by enhancing BAT activation and inducing browning of IWAT, thereby ameliorating glucose and lipid metabolism disorders. As such, MLFs emerge as a prospective and innovative browning agent for the treatment of T2D. | CHENG Long SHI Lu HE Changhao WANG Chen LV Yinglan LI Huimin AN Yongcheng DUAN Yuhui DAI Hongyu ZHANG Huilin HUANG Yan FU Wanxin SUN Weiguang ZHAO Baosheng | 2023 | Chinese Journal of Natural Medicines2023，21，11： | 0 |
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