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| 1 | Downregulation of caveolin-1 contributes to the synaptic plasticity deficit in the hippocampus of aged rats显示文摘Caveolin-1 is involved in the regulation of synaptic plasticity,but the relationship between its expression and cognitive function during aging remains controversial.To explore the relationship between synaptic plasticity in the aging process and changes in learning and memory,we examined caveolin-1 expression in the hippocampus,cortex and cerebellum of rats at different ages.We also examined the relationship between the expression of caveolin-1 and synaptophysin,a marker of synaptic plasticity.Hippocampal caveolin-1 and synaptophysin expression in aged(22–24 month old)rats was significantly lower than that in young(1 month old)and adult(4 months old)rats.Expression levels of both proteins were significantly greater in the cortex of aged rats than in that of young or adult rats,and levels were similar between the three age groups in the cerebellum.Linear regression analysis revealed that hippocampal expression of synaptophysin was associated with memory and learning abilities.Moreover,synaptophysin expression correlated positively with caveolin-1 expression in the hippocampus,cortex and cerebellum.These results confirm that caveolin-1 has a regulatory effect on synaptic plasticity,and suggest that the downregulation of hippocampal caveolin-1 expression causes a decrease in synaptic plasticity during physiological aging. | Yang Liu Zhanhua Liang Jing Liu Wei Zou Xiaoyan Li Yachen Wang Lijia An | 2013 | Neural Regeneration Research2013，8，29： | 6 |
| 2 | Myotoxic activity of a Gln-49 phospholipase A_2 from Agkistrodon blomhoffii ussurensis snake venom显示文摘新奇 myotoxic 蛋白质 phospholipase A 2( 作为作为 Gln49-PLA 2, 表示的 Gln49-PLA 2, 表示的 PLA 2), 从 Agkistrodon blomhoffii ussurensis 的蛇恶意被孤立,它有弱致命的效果和明显的抗凝剂活动,但是缺乏 PLA 2 和 hemorrhagenic 活动。Gln49-PLA 2 显然在老鼠在肌内的注射之上血浆 creatine-kinase (CK ) 增加,建议它可以导致剂量依赖者 myonecrosis。组织学的研究也在老鼠揭示词法变化在对待的动物的骨胳的肌肉,包括的广泛的 myonecrosis,出血和嗜中性的渗入。Gln49-PLA 2 导致的 myotoxic 能力能被肝磷脂部分禁止。 | BAO Yongming BU Pengcheng YANG Jun YANG Wei JIA Peilin AN Lijia | 2006 | Progress in Natural Science:Materials International2006，16，2： | 3 |
| 3 | Separation and Purification of Thrombin-like Enzymes by Affinity Adsorbents显示文摘An affinity adsorbent, benzamidine Sepharose 4B, was used to separate and purify thrombin like enzymes. The p aminobenzamidine as a specific ligand was coupled to the matrix-Sepharose 4B. The recombinant thrombin like enzyme-defibrase was used as a model in order to evaluate the efficiency of this biospecific affinity adsorbent. The homogeneity of the enzyme preparation was comfirmed as one band on sodium dodecyl sulfate polyacrylamide gel electrophoresis. | 杨青 Xu Xiaoming Hu Xuejun Gao Xiaorong Dong Xinyan Su Zhiguo An Lijia | 2001 | High Technology Letters2001，7，4： | 2 |
| 4 | Synthesis of Cu-In-S ternary nanocrystals with tunable structure and composition显示文摘 | Pan Daocheng An Lijia Sun Zhongming | | 0，，17： | 1 |
| 5 | Rapid Amplification of 5′ cDNA End of S. Liaotungensis Choline Monooxygenase Using Inverse PCR RACE显示文摘Based on part of a known cDNA sequence of Suaeda Liaotungensis choline monooxygenase, the authors successfully cloned the 5′ cDNA end of Suaeda Lianotungensis choline monooxygenase using Inverse PCR RACE with a specially designed 5′-phosphated RT primer and two pairs of specific inverse PCR primers. Compared with the anchored PCR RACE, inverse PCR RACE has better specificity and higher amplification. | 李秋莉 Gao Xiaorong FAN Qi Yuan Xiaodong Liu Dawei An Lijia | 2002 | High Technology Letters2002，8，1： | 1 |
| 6 | Cloning and expression of defibrase cDNA from the venom of Gloydius shedaoensis * *显示文摘 | Qing Yang Xiaoming Xu Min Li Xiaodong Yuan Zhiguo Su Jan-Christer Janson Lijia An | 2002 | Biotechnology Letters2002，，2： | 1 |
| 7 | Oscillation effects on the crystallization behavior of iPP显示文摘 | Hong Huo Shichun Jiang Lijia An | 2005 | Polymer2005，46，11： | 1 |
| 8 | Synthesis of asymmetric Hshaped block copolymer by the combination of atom transfer radical polymerization and living anionic polymerization显示文摘 | Xifei Yu Tongfei Shi Guo Zhang Lijia An | 2006 | Polymer2006，47，： | 1 |
| 9 | Identification of a novel thrombin-like phospholipase A2 from Gloydius ussuriensis snake venom显示文摘 | Qiuyan Zhang Jingyun Wang Ying Han Qun Xie Lijia An Yongming Bao | 2007 | Blood Coagulation & Fibrinolysis2007，，8： | 1 |
| 10 | Purification, characterization and gene cloning of a novel phospholipase A 2 from the venom of Agkistrodon blomhoffii ussurensis显示文摘 | Yongming Bao Pengcheng Bu Liji Jin Wang Hongxia Qing Yang Lijia An | 2004 | International Journal of Biochemistry and Cell Biology2004，，3： | 1 |
| 11 | Mechanical and thermal properties of high-density polyethylene toughened with glass beads显示文摘 | Yuan Qiang Jiang Wei An Lijia | 2003 | Journal of Applied Polymer Science2003，89，8： | 1 |
| 12 | Crystallization behavior of PCL in hybrid confined environment显示文摘 | Jiang Shichun Ji Xiangling An Lijia | 2001 | Polymer2001，42，8： | 1 |
| 13 | Investigation of PET Depolymerization by Microwave in Pure Water显示文摘 | Lixin LIU Dong ZHANG Lijia An | 2005 | Journal of Applied Polymer Science2005，95，3： | 1 |
| 14 | competing effect between filled glass bead and induced β crystal on the tensile properties of polypropylene/glass bead blends 显示文摘 | YUAN Qiang JIANG Wei AN Lijia | 2005 | J Appl Polym Sci2005，96，5： | 1 |
| 15 | Controllable synthesis of highly luminescent and monodisperse CdS nanocrystals by a two-phase approach under mild conditions显示文摘 | PAN Daocheng JIANG Shichun AN Lijia | 2004 | Adv Mater2004，16，： | 1 |
| 16 | Crystallization behavior of PCL in hybrid confined environment 显示文摘 | Jiang Shichun Ji Xiangling An Lijia | 2001 | Polymer2001，42，8： | 1 |
| 17 | Hydrolytic depolymerization of PET under microwave irradiation显示文摘 | Liu Lixin Zhang Dong An Lijia | 2005 | Journal of applied polymer science2005，95，3： | 1 |
| 18 | Influence of Molecular Topology on the Static and Dynamic Proper- ties of a Single Polymer Chain in Solution 显示文摘 | Fu Cuiliu Ouyang Wenze Lijia An | 2007 | J Chem Phys2007，127，04： | 1 |
| 19 | Monte carlo simulation of the grafting of maleic anhydride onto polypropylene at higher temperature显示文摘 | Zhu Yutian An Lijia Jiang Wei | 2003 | Macromolecules2003，36，10： | 1 |
| 20 | Transfer of a minimal lin- ear marker-free and vector-free smGFP cassette into soybean vi- a ovary-drip transformation显示文摘 | Liu Jianfeng Su Qiao An Lijia | 2009 | Biotechnology Letters2009，31，2： | 1 |
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