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| 1 | Celiac disease serology in patients with different pretest probabilities: Is biopsy avoidable?显示文摘AIM: To establish the diagnostic performance of sev-eral serological tests, individually and in combination, for diagnosing celiac disease (CD) in patients with different pretest probabilities, and to explore potential se- rological algorithms to reduce the necessity for biopsy. METHODS: We prospectively performed duodenal biopsy and serology in 679 adults who had either high risk (n = 161) or low risk (n = 518) for CD. Blood samples were tested using six assays (enzyme-linked immunosorbent assay) that detected antibodies to tissue transglutaminase (tTG) and deamidated gliadin peptide (DGP). RESULTS: CD prevalence was 39.1% in the high-risk population and 3.3% in the low-risk group. In high-risk patients, all individual assays had a high diagnostic efficacy [area under receiving operator characteristic curves (AU ROC): 0.968 to 0.999]. In contrast, assays had a lower diagnostic efficacy (AU ROC: 0.835 to 0.972) in the low-risk group. Using assay combinations, it would be possible to reach or rule out diagnosis of CD without biopsy in 92% of cases in both pretest populations. We observed that the new DGP/tTG Screen assay resulted in a surplus compared to more conventional assays in any clinical situation. CONCLUSION: The DGP/tTG Screen assay could be considered as the best initial test for CD. Combinations of two tests, including a DGP/tTG Screen, might be able to diagnose CD accurately in different clinical scenarios making biopsy avoidable in a high proportion of subjects. | Emilia Sugai María L Moreno Hui J Hwang Ana Cabanne Adriana Crivelli Fabio Nach-man Horacio Vázquez Sonia Niveloni Julio Argonz Roberto Mazure Graciela La Motta María E Caniggia Edgardo Smecuol Néstor Chopita Juan C Gómez Eduardo Maurińo Julio C Bai | 2010 | World Journal of Gastroenterology2010，16，25： | 4 |
| 2 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 3 | In vitro assessment of Metarhizium anisopliae isolates to control the cattle tick Boophilus microplus 显示文摘 | Ana Paula G F habajara da S V J Aoi M | 2000 | Veterinary Parasitology2000，91，： | 1 |
| 4 | Epicuticular wax content and mor- phology as related to ethylene and storage performance of 'Navelate~ orange fruit显示文摘 | Jacques F C Luis G C Ana V | 2010 | Postharvest Biology and Technology2010，55，： | 1 |
| 5 | Medina ATP-sensitive potassium channel regulates astrocytic gap junction permeability by a Ca^2+ independent mechanis 显示文摘 | ANA V ARANTXA T BEGONA G | 2000 | J Neurochem2000，27，： | 1 |
| 6 | Trypsin from viscera of vermiculated sailfin catfish, Pterygoplichthys disjunctivus, Weber, 1991:Its purification and characterization显示文摘 | Ana G V Juan C R Elisa M V | 2013 | Food Chem2013，141，2： | 1 |
| 7 | Development of a rapid method to determine phenolic and other polar compounds in walnut by capillary electrophoresis-electrospray ionization time-of-flight mass spectrometry显示文摘 | ANA M G VITO V ANTONIO S C | 2008 | Journal of Chromatography A2008，1209，1： | 1 |
| 8 | An analysis of the association between genotype and antimicrobial resistance in methicillin-resistant Staphylococcus aureus clinical isolates 显示文摘 | VICENTE A CARMEN G V ANA V | 2015 | Rev Esp Quimioter2015，28，2： | 1 |
| 9 | Evaluation of the influence of the column axial load on the behavior of monotonically loaded R/C exterior beam-column joints through nu- merical simulations 显示文摘 | Haach V G LUcia Homce De Cresce E1 Debs Ana Khalil E1 Debs M | 2008 | Engineering Structures2008，30，4： | 1 |
| 10 | From physiology to systems metabolic engineering for the production of biochemicals by lactic acid bacteria显示文摘 | PAULA G ANA L C SUSANA V | 2013 | Biotechnology Advances2013，31，6： | 1 |
| 11 | Evaluation of dispersive liquid-liquid microextraction for the determination of patulin in apple juices using micellar electrokinetic capillary chromatography显示文摘 | MARIA D V FRANCISCOJ k 'ANA M G et 'a | 2013 | Food Control2013，31，2： | 1 |
| 12 | In vitro assess-ment of Metarhizium anisopliaeisolates to control the cattle tickBoophilus microplus 显示文摘 | Ana Paula G F Itabajara da S V J Aoi M | 2000 | Veterinary Parasitology2000，94，11： | 1 |
| 13 | Improvement of wideband radio channel swept time-delay cross-correlation sounders by using Golay sequences显示文摘 | Ana V A Manuel G S and Inigo C | 2007 | IEEE Transactions on Vehicular Technology2007，56，1： | 1 |
| 14 | Procaine is a DNA-demethylating agent with growth-inhibitory effects in human cancer ceils 显示文摘 | ANA V G MARIO F FRAGA J E | 2003 | Cancer Res2003，63，： | 1 |
| 15 | Ti-MCM-41 silylation:Development of a simple methodology for its estimation silylation effect on the activity and selectivity in the limonene oxidation with H2O2显示文摘 | María V C Sandra G C Ana M A | 2005 | Catalysis Today2005，107，： | 1 |
| 16 | Dexamethasone prevents Granulocyte/macrophage colony stimulating factor-induced nuclear factor-κB activation,inducible nitric oxide synthase expression and nitric oxide production in a skin dendritic cell line显示文摘 | Ana L V Margarida G M Teresa C | 2003 | Med Inflamm2003，12，2： | 1 |
| 17 | Fluorescent aromatic polyamides with urea binding sites and fluorine or dansyl signaling units显示文摘 | Noelia S J Ana G V Pedro E | 2008 | Eur Polym J2008，44，： | 1 |
| 18 | Levels and pat- terns of expression of HIF-1α, vascular endothelial growth factor, glucose transporter-1 and CD105 in adenoid cystic carcinomas with highgrade transformation 显示文摘 | Ana F Costa MarceIo G T V Mariano | 2012 | Histopathology2012，60，5： | 1 |
| 19 | Selective removal of chloride and potassium in kraft pulp mills显示文摘 | Ferreira Licinio Manuel G A Scares Micaela A R Egas Ana Paula V | 2003 | Tappi Journal2003，，4： | 1 |
| 20 | Preparation of acetazolamide composite mieropartieles by supereritieatantisolvent techniques 显示文摘 | ANA R C D CHIIISTELLE R ARLETTE V G | 2007 | Int J Pharm2007，332，12： | 1 |
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