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| 1 | Insight to drug delivery aspects for colorectal cancer显示文摘Colorectal cancer(CRC) is the third most common cancer diagnosed worldwide in human beings. Surgery, chemotherapy, radiotherapy and targeted therapiesare the conventional four approaches which are currently used for the treatment of CRC. The site specific delivery of chemotherapeutics to their site of action would increase effectiveness with reducing side effects. Targeted oral drug delivery systems based on polysaccharides are being investigated to target and deliver chemotherapeutic and chemopreventive agents directly to colon and rectum. Site-specific drug delivery to colon increases its concentration at the target site, and thus requires a lower dose and hence abridged side effects. Some novel therapies are also briefly discussed in article such as receptor(epidermal growth factor receptor, folate receptor, wheat germ agglutinin, VEGF receptor, hyaluronic acid receptor) based targeting therapy; colon targeted proapoptotic anticancer drug delivery system, gene therapy. Even though good treatment options are available for CRC, the ultimate therapeutic approach is to avert the incidence of CRC. It was also found that CRCs could be prevented by diet and nutrition such as calcium, vitamin D, curcumin, quercetin and fish oil supplements. Immunotherapy and vaccination are used nowadays which are showing better results against CRC. | Arvind Gulbake Aviral Jain Ashish Jain Ankit Jain Sanjay K Jain | 2016 | World Journal of Gastroenterology2016，22，2： | 3 |
| 2 | Intra-islet endothelial cell and β-cell crosstalk: Implication for islet cell transplantation显示文摘The intra-islet microvasculature is a critical interface between the blood and islet endocrine cells governing a number of cellular and pathophysiological processes associated with the pancreatic tissue. A growing body of evidence indicates a strong functional and physical interdependency of β-cells with endothelial cells(ECs), the building blocks of islet microvasculature. Intra-islet ECs, actively regulate vascular permeability and appear to play a role in fine-tuning blood glucose sensing and regulation. These cells also tend to behave as 'guardians', controlling the expression and movement of a number of important immune mediators, thereby strongly contributing to the physiology of islets. This review will focus on the molecular signalling and crosstalk between the intra-islet ECs and β-cells and how their relationship can be a potential target for intervention strategies in islet pathology and islet transplantation. | Siddharth Narayanan Gopalakrishnan Loganathan Maheswaran Dhanasekaran William Tucker Ankit Patel Venugopal Subhashree SriPrakash Mokshagundam Michael G Hughes Stuart K Williams Appakalai N Balamurugan | 2017 | World Journal of Transplantation2017，7，2： | 1 |
| 3 | Opportunistic infections in patients with pulmonary alveolar proteinosis显示文摘 | Ankit DP Shimon K Holenarasipur RV | 2012 | J Infect2012，65，2： | 1 |
| 4 | Lifestyle Associated Risk Factors in Adolescents 显示文摘 | AKHIL K S ANKIT M NIDHI S | 2006 | Indian Journal of Pediatrics2006，73，10： | 1 |
| 5 | Theoretical and Numerical Study of Lamellar Eutectoid Growth Influenced by Volume Diffusion 显示文摘 | ANKIT K CJPIDJIRU A QIN C | 2013 | Acta Mater2013，61，11： | 1 |
| 6 | Selective loss of lin genes from hexachlorocyclohexane-degrading pseudomonas aeruginosa ITRC-5 under different growth conditions显示文摘 | Pankaj C Ankit S M | 2007 | Appl Microbiol Biotechno12007，76，： | 1 |
| 7 | Docetaxel loaded chitosan nanoparticles:Formulation,characterization and cytotoxicity studies显示文摘 | ANKIT J KANIKA T PREETI K | 2014 | International Journal of Biological Macromolecules2014，69，： | 1 |
| 8 | Morphological development and oxidation of elongated 13- SiA1ON material 显示文摘 | HOU X M YUE C S ANKIT K S | 2011 | Corrosion Science2011，53，6： | 1 |
| 9 | Gastric intestinal metaplasia development in African American predominant United States population显示文摘BACKGROUND Gastric cancer significantly contributes to cancer mortality globally.Gastric intestinal metaplasia(GIM)is a stage in the Correa cascade and a premalignant lesion of gastric cancer.The natural history of GIM formation and progression over time is not fully understood.Currently,there are no clear guidelines on GIM surveillance or management in the United States.AIM To investigate factors associated with GIM development over time in African American-predominant study population.METHODS This is a retrospective longitudinal study in a single tertiary hospital in Washington DC.We retrieved upper esophagogastroduodenoscopies(EGDs)with gastric biopsies from the pathology department database from January 2015 to December 2020.Patients included in the study had undergone two or more EGDswith gastric biopsy.Patients with no GIM at baseline were followed up until they developed GIM or until the last available EGD.Exclusion criteria consisted of patients age<18,pregnancy,previous diagnosis of gastric cancer,and missing data including pathology results or endoscopy reports.The study population was divided into two groups based on GIM status.Univariate and multivariate Cox regression was used to estimate the hazard induced by patient demographics,EGD findings,and Helicobacter pylori(H.pylori)status on the GIM status.RESULTS Of 2375 patients who had at least 1 EGD with gastric biopsy,579 patients were included in the study.138 patients developed GIM during the study follow-up period of 1087 d on average,compared to 857 d in patients without GIM(P=0.247).The average age of GIM group was 64 years compared to 56 years in the non-GIM group(P<0.001).In the GIM group,adding one year to the age increases the risk for GIM formation by 4%(P<0.001).Over time,African Americans,Hispanic,and other ethnicities/races had an increased risk of GIM compared to Caucasians with a hazard ratio(HR)of 2.12(1.16,3.87),2.79(1.09,7.13),and 3.19(1.5,6.76)respectively.No gender difference was observed between the study populations.Gastritis was associated with an increased risk for GIM development with an HR of 1.62(1.07,2.44).On the other hand,H.pylori infection did not increase the risk for GIM.CONCLUSION An increase in age and non-Caucasian race/ethnicity are associated with an increased risk of GIM formation.The effect of H.pylori on GIM is limited in low prevalence areas. | Akram I Ahmad Arielle Lee Claire Caplan Colin Wikholm Ioannis Pothoulakis Zaynab Almothafer NishthaRaval Samantha Marshall Ankit Mishra Nicole Hodgins In Guk Kang Raymond K Chang Zachary Dailey Arvin Daneshmand Anjani Kapadia Jae Hak Oh Brittney Rodriguez Abhinav Sehgal Matthew Sweeney Christopher B Swisher Daniel F Childers Corinne O'Connor Lynette M Sequeira Won Cho | 2022 | World Journal of Gastrointestinal Endoscopy2022，14，10： | 1 |
| 10 | Growth of SnO2/WisO49 nanowire hierarchical heterostructure and their application as chemical sensor 显示文摘 | SEN S PRAJAKTA K ANKIT S | 2010 | Sens Actuators B2010，147，2： | 1 |
| 11 | Targeted chromosomal deletions and inversions in zebrafish 显示文摘 | Ankit Gupta Victoria L Hall Fatma O K | 2013 | Gennme Research2013，23，： | 1 |
| 12 | Dual-role self-assembling nanoplexes for efficient gene transfection and sustained gene delivery显示文摘 | Ankit A Robert C U Surya K M | 2008 | Biomaterials2008，29，5： | 1 |
| 13 | Estimation of factor of safety of rooted slope using an evolutionary approach显示文摘 | Akhil Garg Ankit Garg K Tai | 2014 | Eco- logical Engineering2014，64，： | 1 |
| 14 | Microbial and chemical sources of phosphorus supply modulate the yield and chemical composition of essential oil of rose - scented geranium ( Pelargonium species) in sodic soil 显示文摘 | ARUN P SANJAY K ANKIT P | 2012 | Biology and Fertility of Soils2012，48，： | 1 |
| 15 | Cluster Head Election for Energy and Delay Con- straint Applications of Wireless Sensor Network 显示文摘 | ANKIT T KETAN K | 2014 | IEEE Sensors Journal2014，14，8： | 1 |
| 16 | Detection of a case of cervical dysplasia with co-existent cervical tuberculosis by pap smear examination显示文摘 | Ankit S Madhur K Kusum G | 2014 | Indian J Cancer2014，51，3： | 1 |
| 17 | Performance analysis of a multi-hop power line communication system over log-normal fading in presence of impulsive noise显示文摘 | ANKIT D MALLIK R K SCHOBER R | 2015 | IET Communications2015，9，1： | 1 |
| 18 | Fabric defect detection based on GLCM and Gabor filter: A comparison 显示文摘 | LAL R J SUNIL K ANKIT C | 2013 | Optik-international journal for light and electron opt_ics2013，124，23： | 1 |
| 19 | EXTRACTION & IDENTIFICATION OF ENDOSULFAN FROM VISCERA, URINE & BLOOD BY USING DIFFERENT SOLVENT SYSTEM显示文摘 | Ankit Srivastavat V K Yadav | 2014 | US-China Law Review2014，11，6： | 0 |
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