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| 1 | Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。 | Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 3 |
| 2 | Solubilities and thermodynamic properties of gases in the ionic liquid 1-n-butyl-3-methylimidazolium hexafluorophosphate显示文摘 | Anthony J L Maginn E J Brennecke J F | 2002 | J Phys Chem B2002，106，29： | 1 |
| 3 | Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs显示文摘 | SCOTT F ANTHONY L NANCY L | 2007 | Human Molecular Genetics2007，16，1： | 1 |
| 4 | Metal-ion recognition: competitive bulk membrane transport of transition and post transition metal ions using oxygen-nitrogen donor macrocycles as ionphores显示文摘 | JINHO K ANTHONY J F LEONARD F L | 2000 | J Chem Soc Dalton Trans2000，，19： | 1 |
| 5 | A view of cloud computing显示文摘 | MICHAEL A ARMANDO F REAN Q ANTHONY D J RANDY K ANDY K GUNHO L DAVID P ARIEL R ION S MATEI Z | 2010 | Communications of the ACM2010，53，4： | 1 |
| 6 | Study of Coal and Coke Ignit Ion in Fluidized Beds 显示文摘 | Jia L F Anthony E J Lau I | 2005 | Fuel2005，85，56： | 1 |
| 7 | Solution thermodynamics of imidazolium-based ionic liquids and water显示文摘 | Anthony J L Maginn E J Brennecke J F | 2001 | J Phys Chem B2001，105，10： | 1 |
| 8 | Solubility of p-t-butylcalixarenes in supercritical carbon dioxide:a comparison of static and dynamic measurement techniques显示文摘 | BRENDAN F G ANTHONY F L THOMAS J B | 1998 | Fluid Phase Equilibria1998，15，0151： | 1 |
| 9 | Steam hydration of CFBC ash and the effect of hydration conditions on reactivation显示文摘 | Wu Y H Anthony E J Jia L F | 2004 | Fuel2004，83，10： | 1 |
| 10 | Synthesis of a CrCoAPO-5 (AFI) molecular sieve and its activity in cyclohexane oxidation in the liquid phase显示文摘 | Anthony F M James K B Roa A L | 2001 | Catal Lett2001，75，34： | 1 |
| 11 | Carbonation of fly ash in oxy-fuel CFB combustion 显示文摘 | Wang C B Jia L F Tan Y W Anthony E J | 2008 | Fuel2008，87，7： | 1 |
| 12 | Carcinoid tumour显示文摘 | Martyn E Caplin John R Buscombe Andrew J Hilson Alison L Jones Anthony F Watkinson Andrew K Burroughs | 1998 | The Lancet1998，，9130： | 1 |
| 13 | Estimated global incidence of Japanese encephalitis: a systematic review显示文摘 | Campbell Grant L Hills Susan L Fischer Marc Jacobson Julie A Hoke Charles H Hombach Joachim M Marfin Anthony A Solomon Tom Tsai Theodore F Tsu Vivien D Ginsburg Amy S | 2011 | World Health Organization. Bulletin of the World Health Organization2011，，： | 1 |
| 14 | Solubilities and thermodynamic properties of gases in the ionic liquid 1-n-butyl-3-methylimidazolium hexafluorophosphate 显示文摘 | Anthony J L Maginn E J Brennecke J F | 2002 | J Phys Chem B2002，106，29： | 1 |
| 15 | Multiple sequential insults cause post-pump syndrome显示文摘 | ANTHONY L P CHARLES J L CHRISTINE F | 1999 | Ann Thorac Surg1999，67，4： | 1 |
| 16 | Truly evil or simply angry: Individualism, collectivism, and attributions for the events of Sep?tember 11 th显示文摘 | Anthony K RosseIli F Caparyan L | 2003 | Individual Differences Research2003，，2： | 1 |
| 17 | Intravenous micro-particle injections and pulmonary hypertension in broiler chickens:acute post-injection mortality and ascites susceptibility显示文摘 | Wideman Jr R F Erf G F Chapman M E Wang W Anthony N B Xiaofang L | | 0，，08： | 1 |
| 18 | Nonlinear predictive control of spacecraft 显示文摘 | CRASSIDIS John L MARKLEYY F Landis ANTHONY Tobin C | 1997 | Journal of Guidance Control and Dynamics1997，20，6： | 1 |
| 19 | Adsorption of phenol and benzoic acid from dilute aqueous solution onto a macroreticular resin显示文摘 | David S F Anthony L H Snie W W | 1979 | J Colloid Interface Sci1979，69，2： | 1 |
| 20 | The effect of water on the sulphation of limestone 显示文摘 | Wang C B Jia L F Tan Y W Anthony E J | 2010 | Fuel2010，89，9： | 1 |
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