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| 1 | 对称四取代六元瓜环的合成及其2,2-联吡啶主客体化合物显示文摘利用二甲基取代甘脲的二醚与甘脲二聚体成功合成了新型取代六元瓜环——对称四甲基六元瓜环. 该瓜环的结构已被晶体结构鉴定、核磁共振谱以及质谱方法所证实, 分子中所含两个二甲基取代甘脲处于对位. 1H NMR表明该瓜环容易与吡啶衍生物形成主客体配合物. | 赵云洁 薛赛凤 祝黔江 陶朱 张建新 魏赞斌 龙腊生 胡茂林 肖洪平 Day Anthony I | 2004 | 科学通报2004，49，11： | 22 |
| 2 | Severe scrub typhus infection: Clinical features, diagnostic challenges and management显示文摘Scrub typhus infection is an important cause of acute undifferentiated fever in South East Asia. The clinical picture is characterized by sudden onset fever with chills and non-specific symptoms that include headache, myalgia, sweating and vomiting. The presence of an eschar, in about half the patients with proven scrub typhus infection and usually seen in the axilla, groin or inguinal region, is characteristic of scrub typhus. Common laboratory findings are elevated liver transaminases, thrombocytopenia and leukocytosis. About a third of patients admitted to hospital with scrub typhus infection have evidence of organ dysfunction that may include respiratory failure, circulatory shock, mild renal or hepatic dysfunction, central nervous system involvement or hematological abnormalities. Since the symptoms and signs are non-specific and resemble other tropical infections like malaria, enteric fever, dengue or leptospirosis, appropriate laboratory tests are necessary to confirm diagnosis. Serological assays are the mainstay of diagnosis as they are easy to perform; the reference test is the indirect immunofluorescence assay(IFA) for the detection of Ig M antibodies. However in clinical practice, the enzyme-linked immuno-sorbent assay is done due to the ease of performing this test and a good sensitivity and sensitivity when compared with the IFA. Paired samples, obtained at least two weeks apart, demonstrating a ≥ 4 fold rise in titre, is necessary for confirmation of serologic diagnosis. The mainstay of treatment is the tetracycline group of antibiotics or chloramphenicol although macrolides are used alternatively. In mild cases, recovery is complete. In severe cases with multi-organ failure, mortality may be as high as 24%. | John Victor Peter Thomas I Sudarsan John Anthony J Prakash George M Varghese | 2015 | World Journal of Critical Care Medicine2015，4，3： | 13 |
| 3 | 八元瓜环与啡咯啉及其衍生物主客体配合物的研究显示文摘利用 H NMR 技术、荧光光谱法, 对八元瓜环与多种啡咯啉及衍生物相互作用形成的主 1客体配合物实体的结构进行了考察. 研究结果显示, 1,10-啡咯啉及其异构体 1,7-啡咯啉、4,7-啡咯啉的盐酸盐“钻”进八元瓜环内腔, 形成 2︰1 自组装主客体包结物; 2,9 二甲基-1,10-啡咯啉的盐酸盐部分进入八元瓜环形成一种比较稳定的主客体配合物; 而 4,7-二甲基-1,10-啡咯啉、3,4,7,8-四甲基-1,10-啡咯啉以两种不同的π-π 堆砌方式部分进入八元瓜环内腔, 形成包结比也是 2︰1 的两种较稳定的自组装主客体配合物异构体. | 付海燕 薛赛凤 牟兰 杜莹 祝黔江 陶朱 张建新 Day Anthony I | 2004 | 中国科学(B辑)2004，34，6： | 12 |
| 4 | Relationship between the exocrine and endocrine pancreas after acute pancreatitis显示文摘AIM:To determine the prevalence and time course of pancreatic exocrine insufficiency in individuals with newly diagnosed prediabetes or diabetes mellitus after acute pancreatitis.METHODS:Relevant literature cited in three major biomedical journal databases(EMBASE,MEDLINE,and Scopus)was reviewed independently by two authors.There were no language constraints but the search was limited to human studies.Studies included were cohort studies of adult patients who were discharged after an attack of acute pancreatitis.Patients were excluded if they were under 18 years of age or had a previous diagnosis of prediabetes or diabetes mellitus,pancreatic exocrine insufficiency,or chronic pancreatitis.The main outcome measure was the prevalence of concomitant pancreatic exocrine insufficiency in patients who were diagnosed with prediabetes and diabetes mellitus after an attack of acute pancreatitis.Subgroup analysis was conducted for patients who were diagnosed with prediabetes only and those who were diagnosed withdiabetes mellitus only.Subgroup analysis looking at the time course of concomitant pancreatic exocrine and endocrine insufficiency was also conducted.Pooled prevalence and corresponding 95%confidence intervals were calculated for all outcome measures and P-values<0.05 were deemed statistically significant.RESULTS:Eight clinical studies comprising of 234patients met all eligibility criteria.The pooled prevalence of newly diagnosed prediabetes or diabetes in individuals after acute pancreatitis was 43%(95%CI:30%-56%).The pooled prevalence of pancreatic exocrine insufficiency in individuals after acute pancreatitis was 29%(95%CI:19%-39%).The prevalence of concomitant pancreatic exocrine insufficiency in individuals with newly diagnosed prediabetes or diabetes was 40%(95%CI:25%-55%).The prevalence of concomitant pancreatic exocrine insufficiency among individuals with prediabetes alone and diabetes mellitus alone was 41%(95%CI:12%-75%)and 39%(95%CI:28%-51%),respectively.Further analysis showed that the prevalence of concomitant pancreatic exocrine insufficiency in individuals with prediabetes or diabetes decreases over time after an attack of acute pancreatitis.CONCLUSION:Pancreatic exocrine insufficiency occurs in 40%of individuals with newly diagnosed prediabetes or diabetes mellitus after acute pancreatitis.Further studies are needed to investigate the pathogenesis of diabetes in this setting. | Stephanie L M Das James I C Kennedy Rinki Murphy Anthony R J Phillips John A Windsor Maxim S Petrov | 2014 | World Journal of Gastroenterology2014，20，45： | 9 |
| 5 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 6 | Fate and Transport of Antibiotic Residues and Antibiotic Resistance Genes following Land Application of Manure Waste显示文摘 | Chee-Sanford Joanne C Mackie Roderick I Koike Satoshi Krapac Ivan G Lin Yu-Feng Yannarell Anthony C Maxwell Scott Aminov Rustam I | 2009 | Journal of Environmental Quality2009，，3： | 3 |
| 7 | Persistent risk for new, subsequent new and recurrent hepatocellular carcinoma despite successful anti-hepatitis B virus therapy and tumor ablation: The need for hepatitis B virus cure显示文摘Hepatitis B virus(HBV) is one of the most significant hepatocarcinogens. The ultimate goal of anti-HBV treatment is to prevent the development of hepatocellular carcinoma(HCC). During the last two decades, with the use of currently available anti-HBV therapies(lamivudine, entecavir and tenofovir disoproxil fumatate), there has been a decrease in the incidence of HBVassociated HCC(HBV-HCC). Furthermore, several studies have demonstrated a reduction in recurrent or new HCC development after initial HCC tumor ablation. However, during an observation period spanning 10 to 20 years, several case reports have demonstrated the development of new, subsequent new and recurrent HCC even in patients with undetectable serum HBV DNA. The persistent risk for HCC is attributed to the presence of covalently closed circular DNA(cccDNA) in the hepatocyte nucleus which continues to work as a template for HBV replication. While a functional cure(loss of hepatitis B surface antigen and undetectable viral DNA) can be attained with nucleos(t)ide analogues, these therapies do not eliminate cccDNA. Of utmost importance is successful eradication of the transcriptionally active HBV cccDNA from hepatocyte nuclei which would be considered a complete cure. The unpredictable nature of HCC development in patients with chronic HBV infection shows the need for a complete cure. Continued support and encouragement for research efforts aimed at developing curative therapies is imperative. The aims of this minireview are to highlight these observations and emphasize the need for a cure for HBV. | Brianna J Shinn Aaron Martin Robert M Coben Mitchell I Conn Jorge Prieto Howard Kroop Anthony J DiMarino Hie-Won Hann | 2019 | World Journal of Hepatology2019，11，1： | 3 |
| 8 | Ciliated hepatic foregut cyst:an increasingly diagnosed condition显示文摘BACKGROUND:Ciliated foregut cysts of the liver are rare, with only 96 cases diagnosed since the first description in 1857.They are being increasingly diagnosed recently;the majority of the cases have been reported in the last 15 years. Although they bear a close resemblance to the simple cyst of the liver which has essentially a benign course,ciliated hepatic foregut cysts(CHFCs)can progress to malignancy with devastating consequences.It is imperative that this group of conditions be diagnosed and treated adequately. DATA SOURCES:This review includes discussion of the data from all the 96 reported cases from English and non-English literature.Analysis of the incidence rates, embryogenesis,growth,clinical features,risk of malignancy and the prognosis are highlighted systematically.The roles of various diagnostic modalities including ultrasound, CT,MRI,fine needle aspiration cytology(FNAC), immunohistochemistry and surgery are further discussed. RESULTS:The mean age of patients with CHFC was 48± 12 years.The male/female ratio was 1.1∶1.The majority of patients with CHFC(62%)were asymptomatic,and the common mode of presentation was right upper abdominal pain.The cysts occurred in the left lobe in 51 patients, with sole location in segmentⅣin 44,and in the right lobe in 26.The average size of the cysts was 3.6±2.12 cm. The majority of the cysts were unilocular,and only 7 cases were multilocular.Cyst contents were described as viscous or mucinous in 73 patients,whereas bilious fluid was noted in 3.Large cysts having squamous carcinoma were cited in 3 patients,and 2 had extensive squamous metaplasia without malignancy.Others had benign histopathology. CONCLUSIONS:Clinicians have become increasingly aware of CHFC.Imaging alone is not diagnostic per se, but when considered in the context of the global picture does provide important clues to the diagnosis.FNAC is diagnostic by the presence of the ciliated columnar aspirate but lacks sensitivity.Infantile presentation is usually accompanied by biliary communication and mandates a different surgical approach.The demonstration of malignant transformation in 3 cases and its fatal course emphasizes the need for surgical resection in all cases once the diagnosis is made. | Sharad Sharma Amanda G.Dean Ayumi Corn Vivek Kohli Harlan I Wright Anthony Sebastian Nicolas Jabbour | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，6： | 2 |
| 9 | Ocean acidification causes bleaching and productivity loss in coral reef builders显示文摘 | Anthony K R N Kline D I INaz Pulido G | 2008 | Proceedings of the National Academy of Sciences of the United States of America2008，105，17： | 1 |
| 10 | Agricultural nitrogen balance and water quality in the UK显示文摘 | LORD E I ANTHONY S G GOODLASS G | 2002 | Soil Use and Management2002，18，4： | 1 |
| 11 | The meaning of cognitive impairment in the elderly显示文摘 | Folstein M Anthony JC Parhad I | 1985 | J Am Ceriatr Soc1985，33，4： | 1 |
| 12 | Effect of diffusion on gaseous cavitation bubbles 显示文摘 | ANTHONY I E | 1975 | Journal of the Acoustical Society of America1975，57，6： | 1 |
| 13 | Tuning optical band gap of vertically aligned ZnO nanowire arrays grown by homoepitaxial eleetrodeposition显示文摘 | Anthony S P Lee J I Kim J K | | 0，，10： | 1 |
| 14 | Electron spin resonance detection of spin - trapped radicals formed during the glow- discharge electrolysis of aqueous solutions 显示文摘 | ANTHONY T DAVID L G MALCOLM D I | 1980 | J C S Faraday I1980，76，： | 1 |
| 15 | The neuropathology of HIV/AIDS 显示文摘 | ANTHONY I C BELL J E | 2008 | Int Rev Psychiatry2008，20，1： | 1 |
| 16 | Ocean acidification causes bleaching and productivity loss in coral reef builders 显示文摘 | Anthony K R N Kline D I Diaz-Pulido G | 2008 | Proceedings of the National Academy of Sciences of the United States of America2008，105，17： | 1 |
| 17 | 显示文摘 | Kbah1 A Oakley I | 1996 | J Pathol1996，179，： | 1 |
| 18 | The meaning of cognitive impairment in the elderly 显示文摘 | Folstein M Anthony JC Parhad I | 1985 | J Am Geriatr Soc1985，33，4： | 1 |
| 19 | The meaning of cognitive impairment in the elderly显示文摘 | Folstein M Anthony JC Parhad I | 1985 | J Am Ceriatr Soc1985，33，4： | 1 |
| 20 | Six-degrees-of-free- dom test rig design for simulation of mobile agricultural ma- chinel7 vibrations 显示文摘 | I Hostens J Anthonis P Kennes | 2000 | Journal of Agricultural Engineering Research2000，77，2： | 1 |
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