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| 1 | Endoscopic ultrasonography guided celiac plexus neurolysis and celiac plexus block in the management of pain due to pancreatic cancer and chronic pancreatitis显示文摘Pain is a common symptom of pancreatic disease and is frequently difficult to manage. Pain relief provided by narcotics is often suboptimal and is associated with significant side effects. An alternative approach to pain management in pancreatic disease is the use of celiac plexus block (CPB) or neurolysis (CPN). Originally performed by anesthesiologists and radiologists via a posterior approach,recent advances in endoscopic ultrasonography (EUS) have made this technique an attractive alternative. EUS guided celiac plexus block/ neurolysis is simple to perform and avoids serious complications such as paraplegia or pneumothorax that are associated with the posterior approach. EUS guided CPN should be considered first line therapy in patients with pain due to pancreatic cancer. It provides superior pain control compared to traditional management with narcotics. A trend for improved survival in pancreatic cancer patients treated with CPN has been reported,but larger studies are needed to confirm this finding. At this time,the use of EUS guided CPB cannot be recommended as routine therapy for pain in chronic pancreatitis since only one-half of the patients experience pain reduction and the beneficial effect tends to be short lived. EUS guided CPB and CPN should be used as part of a multidisciplinary team approach for pain management. | Anthony J Michaels Peter V Draganov | 2007 | World Journal of Gastroenterology2007，13，26： | 10 |
| 2 | Non-alcoholic fatty liver disease in the Philippines:Comparable with other nations?显示文摘AIM: To evaluate the prevalence and determined the common characteristics of patients diagnosed with non- alcoholic fatty liver disease (NAFLD) at the Philippine General Hospital, Manila, from January 1999 to December 2004. METHODS: NAFLD was diagnosed in 134 from a total of 1102 patients, based on clinical, ultrasonographic and/or histopathological findings. Patients with conditions associated with secondary NAFLD were excluded. Chart review was done to note demographics, co- morbid illnesses, physical characteristics, hepatomegaly, aspartate/alanine aminotransferase (AST/ALT) levels, albumin, lipid levels, alkaline phosphatase, prothrombin time, and partial thromboplastin time. Data obtained were analyzed using the statistical program SPSS version 10. RESULTS: Of the 134 patients included, 71% were female and 29% male. Mean patient age was 42.2 years. Sixty percent of patients were obese, 56% had hepatomegaly, and 69% had diabetes. AST levels were elevated in 45% of subjects and ALT levels in 64%. CONCLUSION: The prevalence of NAFLD at our institution was 12.2%. Patients diagnosed appear to be younger in age in contrast to previous studies. Female sex, obesity, elevated liver enzymes, and diabetes were characteristic features of our NAFLD patients, which is comparable to previous studies from other countries. | Mark Anthony A De Lusong E Labio L Daez V Gloria | 2008 | World Journal of Gastroenterology2008，14，6： | 3 |
| 3 | Appropriateness of systemic treatments in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors显示文摘AIM:To evaluate systemic treatment choices in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors(PNETs)and provide consensus treatment recommendations.METHODS:Systemic treatment options for pancreatic neuroendocrine tumors have expanded in recent years to include somatostatin analogs,angiogenesis inhibitors,inhibitors of mammalian target of rapamycinand cytotoxic agents.At this time,there is little data to guide treatment selection and sequence.We therefore assembled a panel of expert physicians to evaluate systemic treatment choices and provide consensus treatment recommendations.Treatment appropriateness ratings were collected using the RAND/UCLA modified Delphi process.After studying the literature,a multidisciplinary panel of 10 physicians assessed the appropriateness of various medical treatment scenarios on a 1-9 scale.Ratings were done both before and after an extended discussion of the evidence.Quantitative measurements of agreement were made and consensus statements developed from the second round ratings.RESULTS:Specialties represented were medical and surgical oncology,interventional radiology,and gastroenterology.Panelists had practiced for a mean of15.5 years(range:6-33).Among 202 rated scenarios,disagreement decreased from 13.2%(26 scenarios)before the face-to-face discussion of evidence to 1%(2)after.In the final ratings,46.5%(94 scenarios)were rated inappropriate,21.8%(44)were uncertain,and30.7%(62)were appropriate.Consensus statements from the scenarios included:(1)it is appropriate to use somatostatin analogs as first line therapy in patients with hormonally functional tumors and may be appropriate in patients who are asymptomatic;(2)it is appropriate to use everolimus,sunitinib,or cytotoxic chemotherapy therapy as first line therapy in patients with symptomatic or progressive tumors;and(3)beyond first line,these same agents can be used.In patients with uncontrolled secretory symptoms,octreotide LAR doses can be titrated up to 60 mg every4 wk or up to 40 mg every 3 or 4 wk.CONCLUSION:Using the Delphi process allowed physician experts to systematically obtain a consensus on the appropriateness of a variety of medical therapies in patients with PNETs. | Jonathan R Strosberg George A Fisher Al B Benson Lowell B Anthony Bulent Arslan John F Gibbs Edward Greeno Renuka V Iyer Michelle K Kim William J Maples Philip A Philip Edward M Wolin Dasha Cherepanov Michael S Broder | 2015 | World Journal of Gastroenterology2015，21，8： | 2 |
| 4 | Human acute myelogenous leukemia stem cells are rare and heterogeneous when assayed in NOD/SCID/IL2R[gamma]c-deficient mice显示文摘 | Sarry Jean-Emmanuel Murphy Kathleen Perry Robin Sanchez Patricia V Secreto Anthony Keefer Cathy Swider Cezary R Strzelecki Anne-Claire Cavelier Cindy Récher Christian Mansat-De Mas Véronique Delabesse Eric Danet-Desnoyers G Carroll Martin | 2011 | Journal of Clinical Investigation2011，，1： | 2 |
| 5 | Flexible transgastric peritoneoscopy: a novel approach to diagnostic and therapeutic interventions in the peritoneal cavity显示文摘 | Anthony N Kalloo Vikesh K Singh Sanjay B Jagannath Hideaki Niiyama Susan L Hill Cheryl A Vaughn Carolyn A Magee Sergey V Kantsevoy | 2004 | Gastrointestinal Endoscopy2004，，1： | 2 |
| 6 | Posterolateral Transfibular Approach to Tibial Plateau Fractures: Technique, Results, and Rationale显示文摘 | Lucian B Solomon Aaron W Stevenson Robert P V Baird Anthony P Pohl | 2010 | Journal of Orthopaedic Trauma2010，，8： | 2 |
| 7 | Powder inhaler delivery of an antitubercular drug显示文摘 | VASU V S ANTHONY J H | 2002 | AAPS Pharm Scitech2002，3，4： | 1 |
| 8 | Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals显示文摘 | Scheid J F Mouquet H Feldhahn N Seaman M S Velinzon K Pietzsch J Ott R G Anthony R M Zebroski H Hurley A Phogat A Chakrabarti B Li Y Connors M Pereyra F Walker B D Wardemann H Ho D Wyatt R T Mascola J R Ravetch J V Nussenzweig M C | 2009 | Nature2009，458，7238： | 1 |
| 9 | Reactivity of calcium sulfate from FBC systems显示文摘 | Iribarne A P iribarne J V Anthony E J | 1997 | Fuel1997，76，32： | 1 |
| 10 | Risk attitude reversals in drivers' route choice when range of travel time is provided 显示文摘 | Katsikopoulos K V Fisher D L Duse Anthony | 2002 | Human Factors2002，44，3： | 1 |
| 11 | Reactivity ofcalcium sulfate from FBC systems显示文摘 | Iribame A P Iribame J V Anthony E J | 1997 | Fuel1997，76，4： | 1 |
| 12 | Flexible transgastric peritoneoscopy: a novel approach to diagnostic and therapeutic interventions in the peritoneal cavity显示文摘 | Anthony N Kalloo Vikesh K Singh Sanjay B Jagannath Hideaki Niiyama Susan L Hill Cheryl A Vaughn Carolyn A Magee Sergey V Kantsevoy | 2004 | Gastrointestinal Endoscopy2004，，1： | 1 |
| 13 | A study on the activity of CaO-based sorbents for capturing COs in clean energy processes 显示文摘 | Wang J Manovic V Wu Y Anthony E J | 2010 | Applied Energy2010，87，4： | 1 |
| 14 | A systematic study of the kinetics of lignin pyrolysis 显示文摘 | Jiang G Z Daniel J N Anthony V B | 2010 | Thermochimica Acta2010，498，： | 1 |
| 15 | Integration, specializa- tion, and adjustment 显示文摘 | Krugman P Anthony J V | 1996 | European Economic Re- view1996，40，35： | 1 |
| 16 | Agalactosylated IgG antibodies depend on cellular Fc receptors for in vivo activity显示文摘 | Nimmerjahn F Anthony R M Ravetch J V | 2007 | Proc Natl Acad Sci USA2007，104，： | 1 |
| 17 | Recent advance in techniques for hyperspectral image processing显示文摘 | Antonio P Jon A B Joseph W B Jason B Lorenzo B Gustavo C V Jocelyn C Mathieu F Paolo G Anthony G Mattia M James C T Giovanna T | 2009 | Remote Sensing of Environment2009，113，： | 1 |
| 18 | Isolation and characterization of a lectin with exclusive specificity towards mannose from snowdrop (Galanthus nivalis) bulbs显示文摘 | Dammea E J M V Anthony K A Willy P J | 1987 | FEBS Lett1987，，215： | 1 |
| 19 | Mechanistic insights on the conversion of sugars into 5-hydroxym- ethylfurfural 显示文摘 | Joseph B Binder Anthony V Cefali Jacqueline J Blank | 2010 | Energy Environmental Science2010，3，6： | 1 |
| 20 | Steam reactivation of spentCaO-based sorbent for multiple C02 capture cycles 显示文摘 | Manovic V Anthony E J | 2007 | Environmental Science and Technology2007，41，5： | 1 |
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