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| 1 | Clinical scenarios for the use of S100β as a marker of hepatic encephalopathy显示文摘AIM: To evaluate the association between serum concentrations of S100β in patients with cirrhosis and the presence of low grade hepatic encephalopathy(HE).METHODS: This was a cross-sectional study. The population was categorized into four groups healthy subjects, cirrhosis without HE, cirrhosis with covert hepatic encephalopathy(CHE) and cirrhosis with overt HE. Kruskal-Wallis, Mann Whitney's U with Bonferroni adjustment Spearman correlations and area under the ROC were used as appropriate.RESULTS: A total of 61 subjects were included, 46 cirrhotic patients and 15 healthy volunteers. S100β values were different among all groups, and differences remained significant between groups 1 and 2(P < 0.001), and also between groups 2 and 3(P = 0.016), but not between groups 3 and 4. In cirrhotic patients with HE S100β was higher than in patients without HE [0.18(0.14-0.28) ng/m L vs 0.11(0.06-0.14) ng/m L, P < 0.001]. There was a close correlation between serum concentrations of S100β and psychometric hepatic encephalopathy score in patients with cirrhosis without HE compared to the patients with cirrhosis with CHE(r =-0.413, P = 0.019). ROC curve analysis yielded > 0.13 ng/m L as the best cutoff value of S100β for the diagnosis of HE(sensitivity 83.3%, specificity 63.6%).CONCLUSION: Serum concentrations of S100β are higher in patients with cirrhosis than in healthy volunteers, and are further increased in the presence of hepatic encephalopathy. The results suggest that serum biomarkers such as S100β could help in the correct characterization of incipient stages of HE. | Andrés Duarte-Rojo Astrid Ruiz-Margáin Ricardo U Macias-Rodriguez Francisco Javier Cubero José Estradas-Trujillo Rosa Ma Munoz-Fuentes Aldo Torre | 2016 | World Journal of Gastroenterology2016，22，17： | 4 |
| 2 | Low phase angle is associated with the development of hepatic encephalopathy in patients with cirrhosis显示文摘AIM Evaluate the association between phase angle and the development of hepatic encephalopathy in the longterm follow-up of cirrhotic patients.METHODS This was a prospective cohort study. Clinical, nutritional and biochemical evaluations were performed. MannWhitney's U and χ2 tests were used as appropriate. Kaplan-Meier curves and Cox proportional Hazards analysis were used to evaluate the prediction and incidence of hepatic encephalopathy.RESULTS Two hundred and twenty were included; the most frequent etiology of cirrhosis was hepatitis C infection, 52% of the patients developed hepatic encephalopathy(18.6% covert and 33.3% overt); the main precipitating factors were infections and variceal bleeding. KaplanMeier curves showed a higher proportion of HE in the group with low phase angle(39%) compared to the normal phase angle group(13%)(P = 0.012). Furthermore, creatinine and phase angle remained independently associated to hepatic encephalopathy in the Cox regression multivariate analysis [hazard ratio = 1.80(1.07-3.03)]. CONCLUSION In our cohort of patients low phase angle was associated with an increased incidence of hepatic encephalopathy. Phase angle is a useful nutritional marker that evaluates cachexia and could be used as a part of the integral assessment in patients with cirrhosis. | Astrid Ruiz-Margáin Ricardo Ulises Macías-Rodríguez Javier Ampuero Francisco Javier Cubero Luis Chi-Cervera Silvia L Ríos-Torres Andrés Duarte-Rojo Ángeles Espinosa-Cuevas Manuel Romero-Gómez Aldo Torre | 2016 | World Journal of Gastroenterology2016，22，45： | 4 |
| 3 | An α‐E‐catenin ( CTNNA1 ) mutation in hereditary diffuse gastric cancer显示文摘 | Ian J Majewski Irma Kluijt Annemieke Cats Thomas S Scerri Daphne Jong Roelof JC Kluin Samantha Hansford Frans BL Hogervorst Astrid J Bosma Ingrid Hofland Marcel Winter David Huntsman Jos Jonkers Melanie Bahlo René Bernards | 2013 | J. Pathol2013，，4： | 2 |
| 4 | Osteogenic differentiation of human bone marrow mesenchymal stem cells in hydrogel containing nacre powder显示文摘 | Alicia Flausse Christel Henrionnet Manuel Dossot Dominique Dumas Sébastien Hupont Astrid Pinzano Didier Mainard Laurent Galois Jacques Magdalou Evelyne Lopez Pierre Gillet Marthe Rousseau | 2013 | J. Biomed. Mater. Res2013，，11： | 2 |
| 5 | Micro RNA-29,a key regulator of collagen expression in systemic sclerosis显示文摘 | Britta M Joanna S Astrid J | 2010 | Arthritis&Rheumatism2010，62，6： | 1 |
| 6 | Xyr1 receives the lactose induction signal and regulates lactose metabolism in Hypocereajecorina 显示文摘 | Astrid R S Matthias G S | 2007 | FEBS Letters2007，581，21： | 1 |
| 7 | Storage stability of freeze-dried starter cultures(Streptococcus thermophilus)as related to physical state of freezing matrix显示文摘 | Astrid B A Mette S F Heidi L et a1 | 1999 | Lebensmittel-Wissenschaft und-Technologie1999，32，： | 1 |
| 8 | Topical lidocaine re-duces the risk of perioperative airway complications in children with upper respiratory tract infections 显示文摘 | Karl S Elisabeth G Astrid C | 2010 | Can J Anesth2010，57，8： | 1 |
| 9 | Stochastic vehicle routing with random travel times显示文摘 | Astrid S K | 2003 | Transportation Science2003，37，2： | 1 |
| 10 | Soil respiration under elevated CO2 and its partitioning into recently assimilated and older carbon sources显示文摘 | Astrid R.B. S?e Anette Giesemann Traute-Heidi Anderson Hans-Joachim Weigel Nina Buchmann | 2004 | Plant and Soil (-)2004，，1： | 1 |
| 11 | Functional Toll-like receptors in primary first-trimester trophoblasts显示文摘 | Line H. Tanger?s Guro S. St?dle Guro D. Olsen Ann-Helen Leknes Astrid S. Gundersen Bente Skei Anne Jorunn Vikdal Liv Ryan Bj?rg Steinkjer Merete F. Myklebost Mette Langaas Rigmor Austgulen Ann-Charlotte Iversen | 2014 | Journal of Reproductive Immunology2014，，： | 1 |
| 12 | Spatial and temporal variations insoil respiration in relation to stand structure and soil parame-ters in an unmanaged beech forest显示文摘 | Astrid R B S Buchmann N | 2005 | Tree Physiology2005，25，11： | 1 |
| 13 | Student perceptions about the characteristics of an effective discussion during the reporting phase in problem - based learning显示文摘 | Astrid J Diana H Willem S | 2006 | Med Edu2006，40，9： | 1 |
| 14 | Comparison of three nonnested RT-PCR for the detection of influenza A viruses显示文摘 | ASTRID V GUILLAUME S LEZIN B | 2000 | J Clin Virol2000，17，3： | 1 |
| 15 | Ara h 2peptides containing dominant CD4+T-cell epitopes:Candidates for a peanut allergy therapeutic显示文摘 | Sara R P Astrid L V April D H Karen S | 2011 | J Allergy Clin Immunol2011，127，： | 1 |
| 16 | SOCS-1 and SOCS-3 inhibit IFN-α-induced expression of the antiviral proteins 2,5-OAS and MxA显示文摘 | George Vlotides Astrid S S?rensen Florian Kopp Kathrin Zitzmann Neziha Cengic Stephan Brand Reinhart Zachoval Christoph J Auernhammer | 2004 | Biochemical and Biophysical Research Communications2004，，3： | 1 |
| 17 | Interactions of abscisic acid and sugar signalling in the regulation of leaf senescence显示文摘 | Nathalie Pourtau Magali Marès Sarah Purdy Nicolas Quentin Alexandra Ru?l Astrid Wingler | 2004 | Planta2004，，5： | 1 |
| 18 | Comparision of three nonnested RT-PCK for the detection of influenza virus显示文摘 | GUILLAUME S | 2000 | J Clin Virol2000，17，3： | 1 |
| 19 | Analysis of isothaiazolinones in environmental waters by gas chromatography - mass spectrometry 显示文摘 | Astrid R Sabine G Frank S | 2007 | Journal of Chromatography : A2007，1164，12： | 1 |
| 20 | Ribonuclease P: the diversity of a ubiquitous RNA processing enzyme 显示文摘 | ASTRID S | 1999 | FEMS Microbiology Reviews1999，23，3： | 1 |
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