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| 1 | P16免疫染色可以提高子宫平滑肌肿瘤的组织学分类显示文摘 | Atkins K A Arronte N Darus C J 黄文斌(摘译) | 2008 | 临床与实验病理学杂志2008，24，1： | 13 |
| 2 | 肌萎缩性侧索硬化蛋白激活小胶质细胞NLRP3炎性小体显示文摘小胶质细胞NLRP3炎性小体激活正在成为神经退行性变过程中神经炎症的关键因素。诸如β-淀粉样蛋白和α-突触核蛋白之类的致病性蛋白质聚集体触发小胶质NLRP3激活,从而导致半胱天冬酶-1激活和IL-1β的分泌。在小鼠肌萎缩性侧索硬化症(ALS)的SOD1G93A模型中,半胱天冬酶-1和IL-1β均促进疾病进展,提示小胶质NLRP3在该进程中发挥作用。然而先前的研究表明,SOD1G93A小鼠小胶质细胞不表达NLRP3,SOD1G93A蛋白在小胶质细胞中产生独立于NLRP3的IL-1β。本研究论证了使用Nlrp3-GFP基因敲入小鼠,在SOD1G93A小鼠中小胶质细胞表达NLRP3。本研究显示聚集和可溶性SOD1G93A均可激活小鼠原代小胶质细胞中的炎性小体,导致半胱天冬酶-1和IL-1β裂解,ASC斑点形成以及呈剂量和时间依赖性的IL-1β分泌。重要的是,SOD1G93A无法从缺乏Nlrp3的小胶质细胞或者用特异性NLRP3抑制剂MCC950预处理的小胶质细胞中诱导IL-1β分泌,从而证实NLRP3是介导SOD1诱导的小胶质细胞IL-1β分泌的关键炎症小体复合物。在TDP-43Q331K ALS小鼠模型中也观察到小胶质NLRP3上调,TDP-43野生型和突变蛋白亦可以NLRP3依赖性的方式激活小胶质炎性小体。从机制上讲,本研究确定了活性氧簇和ATP的生成是SOD1G93A介导的NLRP3激活所需的关键事件。总之,本研究的数据表明ALS小胶质细胞表达NLRP3,而病理ALS蛋白激活小胶质NLRP3炎性小体。因此,NLRP3抑制可能是阻止小胶质细胞神经炎症和ALS疾病进展的潜在治疗方法。 | Vandana Deora John D Lee Eduardo AAlbornoz Luke McAlary Cyril J Jagaraj Avril A B Robertson Julie D Atkin Matthew A Cooper Kate Schroder Justin J Yerbury Richard Gordon Trent MWoodruff 杜一星(编译) | 2020 | 神经损伤与功能重建2020，15，9： | 13 |
| 3 | Role of polyethylene particles in peri-prosthetic osteolysis:A review显示文摘There is convincing evidence that particles produced by the wear of joint prostheses are causal in the periprosthetic loss of bone,or osteolysis,which,if it progresses,leads to the phenomenon of aseptic loosening.It is important to fully understand the biology of this bone loss because it threatens prosthesis survival,and loosened implants can result in peri-prosthetic fracture,which is disastrous for the patient and presents a difficult surgical scenario.The focus of this review is the bioactivity of polyethylene(PE)particles,since there is evidence that these are major players in the development and progression of osteolysis around prostheses which use PE as the bearing surface.The review describes the biological consequences of interaction of PE particles with macrophages,osteoclasts and cells of the osteoblast lineage,including osteocytes.It explores the possible cellular mechanisms of action of PE and seeks to use the findings to date to propose potential nonsurgical treatments for osteolysis.In particular,a nonsurgical approach is likely to be applicable to implants containing newer,highly cross-linked PEs(HXLPEs),for which osteolysis seems to occur with much reduced PE wear compared with conventional PEs.The caveat here is that we know little as yet about the bioactivity of HXLPE particles and addressing this constitutes our next challenge. | Gerald J Atkins David R Haynes Donald W Howie David M Findlay | 2011 | World Journal of Orthopedics2011，2，10： | 11 |
| 4 | Computed tomographic colonography versus colonoscopy for investigation of patients with symptoms suggestive of colorectal cancer (SIGGAR): a multicentre randomised trial显示文摘 | Wendy Atkin Edward Dadswell Kate Wooldrage Ines Kralj-Hans Christian von Wagner Rob Edwards Guiqing Yao Clive Kay David Burling Omar Faiz Julian Teare Richard J Lilford Dion Morton Jane Wardle Steve Halligan | 2013 | The Lancet2013，，： | 3 |
| 5 | Computed tomographic colonography versus barium enema for diagnosis of colorectal cancer or large polyps in symptomatic patients (SIGGAR): a multicentre randomised trial显示文摘 | Steve Halligan Kate Wooldrage Edward Dadswell Ines Kralj-Hans Christian von Wagner Rob Edwards Guiqing Yao Clive Kay David Burling Omar Faiz Julian Teare Richard J Lilford Dion Morton Jane Wardle Wendy Atkin | 2013 | The Lancet2013，，： | 2 |
| 6 | Leaf respiration of show gum in light and dark interaction between temperature and irradiance 显示文摘 | ATKIN O K EVANS J R BALL M C | 2000 | Plant Physiology2000，122，： | 1 |
| 7 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 8 | Cellular cardiomyo- plasty improves diastolic properties of injured heart显示文摘 | Atkins BZ Hueman Mr Meuchel J | 1999 | J Surq Res1999，85，2： | 1 |
| 9 | A systemic review of treatments for the painful heel 显示文摘 | Atkins D Crawford F Edwards J | 1999 | Rheumatology (Oxford)1999，，38： | 1 |
| 10 | Phase Ⅲ trial comparing concurrent biochemotherapy with cisplatin, vinblastine, dacarbazine, interleukin-2, and interferon alfa-2b with cis- platin, vinblastine, and dacarbazine alone in patients with metastatic malignant melanoma (E3695): a trial coordinat- ed by the Eastern Cooperative Oncology Group 显示文摘 | Atkins MB Hsu J Lee S | 2008 | J Clin Oncol2008，26，35： | 1 |
| 11 | Antizyme expression: A subversion of triplet decoding, which is remarkably conserved by evolution is a sensor for an autoregulatory circuit显示文摘 | Ivanov I P Gesteland R F Atkins J F | 2000 | Nucleic Acids Res2000，，28： | 1 |
| 12 | TGF - 13 in the context of an inflammatory cytokine milieu supports de novo differentia- tion ofiL- 17 producing T cells显示文摘 | Veldhoen M Hocking R J Atkins C J | 2006 | Immunity2006，24，5： | 1 |
| 13 | Isolation, biochemical characterization,and culture of lung type Ⅱ cells of the rat显示文摘 | Richards RJ Davies N Atkins J | 1987 | Lung1987，165，： | 1 |
| 14 | TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells显示文摘 | Veldhoen M Hocking R J Atkins C J | 2006 | Immunity2006，24，2： | 1 |
| 15 | Chronic kidney disease as a global public health problem:approaches and initiatives-a position statement from Kidney Disease Improving Global Outcomes显示文摘 | Levey AS Atkins R Coresh J | 2007 | Kidney Int2007，72，3： | 1 |
| 16 | TGF - beta in the context of an infla - mmatory cytokine milieu sup- ports de novo differentiation of IL - 17 - producing T cells 显示文摘 | Veldhoen M Hocking R J Atkins C J | 2006 | Immunity2006，24，2： | 1 |
| 17 | A systemic review of the treatment of painful heel显示文摘 | Atkins D Crawford F Edward J | | 0，，： | 1 |
| 18 | Joint optimization of maintenance and inventory policies for a simple system显示文摘 | Armstrong M J Atkins D R | 1996 | IIE Transactions1996，28，5： | 1 |
| 19 | Long-term risk of colorectal cancer after excision of rectosigmoid adenomas 显示文摘 | Morson BC Cuzick J | 1992 | N Engl J Med 19921992，326，10： | 1 |
| 20 | Results of a multicenter, randomized, double-blind,dose-evaluating phase 2/3 study of lenalidomide in the treatment of metastatic malignanl melanoma 显示文摘 | Glaspy J Atkins MB Richards JM | 2009 | Cancer2009，115，22： | 1 |
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